Kcna5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcna5
Entrez Gene ID	25470
Full Name	potassium voltage-gated channel subfamily A member 5
Synonyms	Kv1,Kv1.5
General protein information	Preferred Names potassium voltage-gated channel subfamily A member 5 Names potassium voltage-gated channel subfamily A member 5 Potassium (K+) channel protein alpha 5 RCK7 RK4 potassium channel, voltage gated shaker related subfamily A, member 5 potassium voltage-gated channel, shaker-related subfamily, member 5 voltage-gated potassium channel subunit Kv1.5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42
Summary	voltage gated potassium channel; functions as a delayed rectifier-like K+ channel [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012972.1	NP_037104.1	potassium voltage-gated channel subfamily A member 5

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	LOC100004160	XP_005171764.1
Bos taurus (cattle)	KCNA5	NP_001015552.1
Mus musculus (house mouse)	Kcna5	NP_666095.1
Rattus norvegicus (Norway rat)	Kcna5	NP_037104.1
Gallus gallus (chicken)	KCNA5	XP_417226.3
Pan troglodytes (chimpanzee)	KCNA5	XP_522330.1
Canis lupus familiaris (dog)	KCNA5	NP_001006646.1
Xenopus tropicalis (tropical clawed frog)	kcna5	XP_004912856.1
Homo sapiens (human)	KCNA5	NP_002225.2
	KCNA5	XP_001102294.1

Gene Ontology
Bibliography

Related articles in PubMed

Angiotensin II reduces the surface abundance of K
Kidd MW, Bulley S, Jaggar JH
The Journal of physiology595(5)1607-1618(2017 Mar)

Imbalance of NFATc2 and KV1.5 Expression in Rat Pulmonary Vasculature of Nitrofen-Induced Congenital Diaphragmatic Hernia.
Zimmer J, Takahashi T, Hofmann AD, Puri P
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie27(1)68-73(2017 Feb)

H
Lu G, Xu C, Tang K, Zhang J, Li Q, Peng L, Wang Y, Huang Z, Gao X
Biochemical and biophysical research communications483(1)534-540(2017 01)

AMP-activated protein kinase inhibits Kv 1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation.
Moral-Sanz J, Mahmoud AD, Ross FA, Eldstrom J, Fedida D, Hardie DG, Evans AM
The Journal of physiology594(17)4901-15(2016 09)

Intravascular pressure enhances the abundance of functional Kv1.5 channels at the surface of arterial smooth muscle cells.
Kidd MW, Leo MD, Bannister JP, Jaggar JH
Science signaling8(390)ra83(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ang II selectively stimulates degradation of KV1.5 channels to reduce functional KV1.5 channel surface abundance in mesenteric artery myocytes
Title: Angiotensin II reduces the surface abundance of K

This study demonstrates for the first time an altered gene and protein expression of NFATc2 and KV1.5 in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia. Upregulation of NFATc2 with concomitant downregulation of KV1.5 channels may contribute to abnormal vascular remodeling.
Title: Imbalance of NFATc2 and KV1.5 Expression in Rat Pulmonary Vasculature of Nitrofen-Induced Congenital Diaphragmatic Hernia.

H2S downregulates Ang II-induced atrial Kv1.5 expression by attenuating Nox4-related ROS-triggered P-Smad2/3 and P-ERK 1/2 activation during atrial fibrillation
Title: H

AMPK selectively inhibits Kv1.5 in pulmonary arterial myocytes
Title: AMP-activated protein kinase inhibits Kv 1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation.

Data indicate that intravascular pressure-induced membrane depolarization selectively increased voltage-dependent potassium channels K(v)1.5 surface abundance to increase K(v) currents in arterial myocytes, which would limit vasoconstriction.
Title: Intravascular pressure enhances the abundance of functional Kv1.5 channels at the surface of arterial smooth muscle cells.

The following Kcna5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcna5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42789	NM_012972.1 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily A member 5 (Kcna5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$356.30 $509.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcna5 ( NM_012972.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037104.1 Rattus norvegicus potassium voltage-gated channel subfamily A member 5 (Kcna5), mRNA.

Price & Availability↑

CloneID	ORa42789
Clone ID Related Accession (Same CDS sequence)	NM_012972.1
Accession Version	NM_012972.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1809bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily A member 5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M27158.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGAGATCT CCCTGGTGCC CCTGGAGAAT GGCAGTGCCA TGACCCTCAG AGGAGGAGGG 
GAGGCAGGGG CAAGCTGTGT GCAGACCCCC AGGGGAGAGT GTGGGTGCCC TCCGACGTCT 
GGACTCAATA ATCAGTCCAA AGAAACACTG TTGAGGGGGC GCACAACGCT CGAGGATGCG 
AACCAGGGTG GACGGCCTTT GCCCCCTATG GCTCAGGAGC TGCCACAACC TAGAAGGCTA 
TCTGCTGAGG ATGAGGAGGG AGAAGGCGAC CCTGGCCTGG GCACAGTGGA GGAGGACCAG 
GCTCCTCAGG ATGCAGGGTC ACTCCATCAC CAGCGAGTCC TCATAAACAT CTCCGGGTTG 
CGTTTCGAGA CGCAGCTGGG CACCCTGGCA CAGTTTCCCA ACACCCTCCT GGGGGACCCA 
GCCAAGCGCC TGCACTACTT CGACCCCTTG AGAAATGAAT ACTTCTTCGA CCGCAACCGG 
CCCAGCTTCG ATGGCATTTT GTACTACTAC CAGTCTGGGG GCCGCCTGCG CAGGCCCGTC 
AATGTCTCCC TGGATGTGTT TGCAGATGAG ATCCGCTTTT ACCAGCTGGG GGACGAGGCC 
ATGGAGCGCT TCCGGGAGGA TGAGGGCTTC ATCAAGGAAG AGGAGAAGCC CCTGCCCCGC 
AACGAGTTCC AGCGCCAGGT ATGGCTTATC TTCGAATACC CAGAAAGCTC TGGGTCCGCA 
AGAGCCATCG CCATAGTGTC GGTCCTGGTC ATTCTCATCT CTATCATCAC CTTCTGCCTG 
GAGACTCTGC CTGAGTTCAG GGATGAGCGG GAGCTGCTAC GCCATCCCCC AGTGCCGCCC 
CAGCCCCCAG CCCCTGCCCC TGGGATCAAT GGCAGCGTCT CTGGAGCACT TTCCTCTGGC 
CCTACGGTGG CTCCACTCTT GCCTAGGACA CTGGCCGATC CATTCTTCAT CGTGGAGACC 
ACATGTGTGA TCTGGTTCAC TTTTGAGTTG CTCGTGCGCT TCTTTGCCTG CCCCAGCAAG 
GCAGAATTCT CTCGGAATAT CATGAACATC ATCGATGTCG TGGCCATCTT CCCCTACTTT 
ATCACCCTGG GCACCGAGCT GGCAGAGCAA CAACCAGGGG GAGGGGGTCA GAATGGGCAG 
CAGGCCATGT CCCTAGCCAT CCTCAGGGTG ATCCGCCTGG TGCGGGTGTT TCGGATCTTC 
AAGCTCTCCC GCCACTCCAA GGGACTGCAG ATCCTGGGTA AGACCTTGCA AGCATCCATG 
CGGGAACTCG GGCTACTCAT CTTCTTCCTC TTCATTGGAG TCATCCTCTT CTCCAGCGCT 
GTCTACTTCG CAGAGGCAGA CAATCACGGG TCCCATTTCT CTAGTATCCC AGATGCCTTC 
TGGTGGGCAG TAGTCACTAT GACCACTGTA GGCTATGGAG ACATGAGACC CATCACTGTA 
GGGGGCAAGA TCGTGGGTTC ACTGTGCGCC ATAGCTGGGG TCCTCACCAT TGCCCTGCCT 
GTCCCCGTCA TCGTCTCCAA CTTTAATTAC TTCTATCATC GGGAGACAGA CCACGAGGAG 
CAGGCTGCCC TGAAGGAAGA ACAAGGCAAC CAGAGGCGGG AGTCTGGGCT GGACACAGGG 
GGTCAACGGA AGGTCAGCTG CAGCAAGGCC TCCTTTTGCA AGACTGGGGG TTCCCTGGAG 
AGTTCTGACA GTATCAGAAG GGGTAGCTGT CCTCTAGAAA AGTGTCACCT CAAGGCCAAG 
AGCAACGTGG ACTTGCGGAG GTCCCTGTAT GCCCTCTGTC TGGACACTAG CCGTGAAACA 
GATTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037104.1
CDS	1..1809
Translation	MEISLVPLENGSAMTLRGGGEAGASCVQTPRGECGCPPTSGLNNQSKETLLRGRTTLEDANQGGRPLPPMAQELPQPRRLSAEDEEGEGDPGLGTVEEDQAPQDAGSLHHQRVLINISGLRFETQLGTLAQFPNTLLGDPAKRLHYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPVPPQPPAPAPGINGSVSGALSSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAEFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNHGSHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEQAALKEEQGNQRRESGLDTGGQRKVSCSKASFCKTGGSLESSDSIRRGSCPLEKCHLKAKSNVDLRRSLYALCLDTSRETDL

Target ORF information:

RefSeq Version	NM_012972.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily A member 5 (Kcna5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012972.1

ORF Insert Sequence:

ATGGAGATCT CCCTGGTGCC CCTGGAGAAT GGCAGTGCCA TGACCCTCAG AGGAGGAGGG 
GAGGCAGGGG CAAGCTGTGT GCAGACCCCC AGGGGAGAGT GTGGGTGCCC TCCGACGTCT 
GGACTCAATA ATCAGTCCAA AGAAACACTG TTGAGGGGGC GCACAACGCT CGAGGATGCG 
AACCAGGGTG GACGGCCTTT GCCCCCTATG GCTCAGGAGC TGCCACAACC TAGAAGGCTA 
TCTGCTGAGG ATGAGGAGGG AGAAGGCGAC CCTGGCCTGG GCACAGTGGA GGAGGACCAG 
GCTCCTCAGG ATGCAGGGTC ACTCCATCAC CAGCGAGTCC TCATAAACAT CTCCGGGTTG 
CGTTTCGAGA CGCAGCTGGG CACCCTGGCA CAGTTTCCCA ACACCCTCCT GGGGGACCCA 
GCCAAGCGCC TGCACTACTT CGACCCCTTG AGAAATGAAT ACTTCTTCGA CCGCAACCGG 
CCCAGCTTCG ATGGCATTTT GTACTACTAC CAGTCTGGGG GCCGCCTGCG CAGGCCCGTC 
AATGTCTCCC TGGATGTGTT TGCAGATGAG ATCCGCTTTT ACCAGCTGGG GGACGAGGCC 
ATGGAGCGCT TCCGGGAGGA TGAGGGCTTC ATCAAGGAAG AGGAGAAGCC CCTGCCCCGC 
AACGAGTTCC AGCGCCAGGT ATGGCTTATC TTCGAATACC CAGAAAGCTC TGGGTCCGCA 
AGAGCCATCG CCATAGTGTC GGTCCTGGTC ATTCTCATCT CTATCATCAC CTTCTGCCTG 
GAGACTCTGC CTGAGTTCAG GGATGAGCGG GAGCTGCTAC GCCATCCCCC AGTGCCGCCC 
CAGCCCCCAG CCCCTGCCCC TGGGATCAAT GGCAGCGTCT CTGGAGCACT TTCCTCTGGC 
CCTACGGTGG CTCCACTCTT GCCTAGGACA CTGGCCGATC CATTCTTCAT CGTGGAGACC 
ACATGTGTGA TCTGGTTCAC TTTTGAGTTG CTCGTGCGCT TCTTTGCCTG CCCCAGCAAG 
GCAGAATTCT CTCGGAATAT CATGAACATC ATCGATGTCG TGGCCATCTT CCCCTACTTT 
ATCACCCTGG GCACCGAGCT GGCAGAGCAA CAACCAGGGG GAGGGGGTCA GAATGGGCAG 
CAGGCCATGT CCCTAGCCAT CCTCAGGGTG ATCCGCCTGG TGCGGGTGTT TCGGATCTTC 
AAGCTCTCCC GCCACTCCAA GGGACTGCAG ATCCTGGGTA AGACCTTGCA AGCATCCATG 
CGGGAACTCG GGCTACTCAT CTTCTTCCTC TTCATTGGAG TCATCCTCTT CTCCAGCGCT 
GTCTACTTCG CAGAGGCAGA CAATCACGGG TCCCATTTCT CTAGTATCCC AGATGCCTTC 
TGGTGGGCAG TAGTCACTAT GACCACTGTA GGCTATGGAG ACATGAGACC CATCACTGTA 
GGGGGCAAGA TCGTGGGTTC ACTGTGCGCC ATAGCTGGGG TCCTCACCAT TGCCCTGCCT 
GTCCCCGTCA TCGTCTCCAA CTTTAATTAC TTCTATCATC GGGAGACAGA CCACGAGGAG 
CAGGCTGCCC TGAAGGAAGA ACAAGGCAAC CAGAGGCGGG AGTCTGGGCT GGACACAGGG 
GGTCAACGGA AGGTCAGCTG CAGCAAGGCC TCCTTTTGCA AGACTGGGGG TTCCCTGGAG 
AGTTCTGACA GTATCAGAAG GGGTAGCTGT CCTCTAGAAA AGTGTCACCT CAAGGCCAAG 
AGCAACGTGG ACTTGCGGAG GTCCCTGTAT GCCCTCTGTC TGGACACTAG CCGTGAAACA 
GATTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Angiotensin II reduces the surface abundance of K
The Journal of physiology595(5)1607-1618(2017 Mar)
Kidd MW,Bulley S,Jaggar JH

Imbalance of NFATc2 and KV1.5 Expression in Rat Pulmonary Vasculature of Nitrofen-Induced Congenital Diaphragmatic Hernia.
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie27(1)68-73(2017 Feb)
Zimmer J,Takahashi T,Hofmann AD,Puri P

H
Biochemical and biophysical research communications483(1)534-540(2017 01)
Lu G,Xu C,Tang K,Zhang J,Li Q,Peng L,Wang Y,Huang Z,Gao X

AMP-activated protein kinase inhibits Kv 1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation.
The Journal of physiology594(17)4901-15(2016 09)
Moral-Sanz J,Mahmoud AD,Ross FA,Eldstrom J,Fedida D,Hardie DG,Evans AM

Intravascular pressure enhances the abundance of functional Kv1.5 channels at the surface of arterial smooth muscle cells.
Science signaling8(390)ra83(2015 Aug)
Kidd MW,Leo MD,Bannister JP,Jaggar JH