IFNG cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IFNG
Entrez Gene ID	3458
Full Name	interferon gamma
Synonyms	IFG,IFI
General protein information	Preferred Names interferon gamma Names interferon gamma IFN-gamma immune interferon
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q15
Summary	This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015].
Disorder MIM:	147570
Disorder Html:	{TSC2 angiomyolipomas, renal, modifier of}, 613254 (3); {Aplastic anemia}, 609135 (3); {Tuberculosis, protection against}, 607948 (3); {AIDS, rapid progression to}, 609423 (3);{Hepatitis C virus, response to therapy of}, 609532 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000619.2	NP_000610.2	interferon gamma precursor
NM_000619.3	NP_000610.2	interferon gamma precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	IFNG	NP_776511.1
Rattus norvegicus (Norway rat)	Ifng	NP_620235.1
Homo sapiens (human)	IFNG	NP_000610.2
Mus musculus (house mouse)	Ifng	NP_032363.1
Pan troglodytes (chimpanzee)	IFNG	NP_001180594.1
	IFNG	NP_001028077.1
Canis lupus familiaris (dog)	IFNG	NP_001003174.1

Gene Ontology
Bibliography

Related articles in PubMed

High STAT4 Expression Indicates Better Disease-free Survival in Patients with Gastric Cancer.
Nishi M, Batsaikhan BE, Yoshikawa K, Higashijima J, Tokunaga T, Takasu C, Kashihara H, Ishikawa D, Shimada M
Anticancer research37(12)6723-6729(2017 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The IFNG CA microsatellite but not +874A/T may be a genetic risk factor for generalized vitiligo (GV).
Title: Involvement of interferon-gamma genetic variants and intercellular adhesion molecule-1 in onset and progression of generalized vitiligo.

novel mechanism where NK cells interact with plasmacytoid dendritc cells and monocytes, efficiently producing IFN-gamma in response to HCV-infected cells
Title: IFN-? production by human natural killer cells in response to HCV-infected hepatoma cells is dependent on accessory cells.

cross-talk between NOD1 and IFN-gamma signaling pathways contribute to H. pylori-induced inflammatory responses, potentially revealing a novel mechanism whereby virulent H. pylori strains promote more severe disease.
Title: Nucleotide oligomerization domain 1 enhances IFN-? signaling in gastric epithelial cells during Helicobacter pylori infection and exacerbates disease severity.

IFN-gamma can significantly up-regulate the expressions of chemokines such as CXCL9, CXCL10 and CXCL11 at both mRNA and protein levels in HK-2 cells.
Title: [Expressions of CXCL9, CXCL10 and CXCL11 in renal tubular epithelial cells induced by IFN-?].

Statistically significant differences in infected women (groups 1 and 2) in comparison with uninfected women (group 3) were detected: a) blood plasma concentration of IFNgamma increased in clinically manifested HPV infection
Title: [The effect of viral infections on the cytokine profile in pregnant women with obstetric complications and immunotherapy with human alpha2b interferon].

The following IFNG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IFNG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27326	NM_000619.3 Latest version!	Homo sapiens interferon gamma (IFNG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu27326	NM_000619.2	Homo sapiens interferon gamma (IFNG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IFNG ( NM_000619.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000610.2 Homo sapiens interferon gamma (IFNG), mRNA.

Price & Availability↑

CloneID	OHu27326
Clone ID Related Accession (Same CDS sequence)	NM_000619.2 , NM_000619.3
Accession Version	NM_000619.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	interferon gamma precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC070256.1 and V00543.1. This sequence is a reference standard in the RefSeqGene project. On Dec 22, 2004 this sequence version replaced NM_000619.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X01992.1, BC070256.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154529 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAATATA CAAGTTATAT CTTGGCTTTT CAGCTCTGCA TCGTTTTGGG TTCTCTTGGC 
TGTTACTGCC AGGACCCATA TGTAAAAGAA GCAGAAAACC TTAAGAAATA TTTTAATGCA 
GGTCATTCAG ATGTAGCGGA TAATGGAACT CTTTTCTTAG GCATTTTGAA GAATTGGAAA 
GAGGAGAGTG ACAGAAAAAT AATGCAGAGC CAAATTGTCT CCTTTTACTT CAAACTTTTT 
AAAAACTTTA AAGATGACCA GAGCATCCAA AAGAGTGTGG AGACCATCAA GGAAGACATG 
AATGTCAAGT TTTTCAATAG CAACAAAAAG AAACGAGATG ACTTCGAAAA GCTGACTAAT 
TATTCGGTAA CTGACTTGAA TGTCCAACGC AAAGCAATAC ATGAACTCAT CCAAGTGATG 
GCTGAACTGT CGCCAGCAGC TAAAACAGGG AAGCGAAAAA GGAGTCAGAT GCTGTTTCGA 
GGTCGAAGAG CATCCCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000610.2
CDS	127..627
Translation	MKYTSYILAFQLCIVLGSLGCYCQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTNYSVTDLNVQRKAIHELIQVMAELSPAAKTGKRKRSQMLFRGRRASQ

Target ORF information:

RefSeq Version	NM_000619.2
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon gamma (IFNG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000619.2

ORF Insert Sequence:

ATGAAATATA CAAGTTATAT CTTGGCTTTT CAGCTCTGCA TCGTTTTGGG TTCTCTTGGC 
TGTTACTGCC AGGACCCATA TGTAAAAGAA GCAGAAAACC TTAAGAAATA TTTTAATGCA 
GGTCATTCAG ATGTAGCGGA TAATGGAACT CTTTTCTTAG GCATTTTGAA GAATTGGAAA 
GAGGAGAGTG ACAGAAAAAT AATGCAGAGC CAAATTGTCT CCTTTTACTT CAAACTTTTT 
AAAAACTTTA AAGATGACCA GAGCATCCAA AAGAGTGTGG AGACCATCAA GGAAGACATG 
AATGTCAAGT TTTTCAATAG CAACAAAAAG AAACGAGATG ACTTCGAAAA GCTGACTAAT 
TATTCGGTAA CTGACTTGAA TGTCCAACGC AAAGCAATAC ATGAACTCAT CCAAGTGATG 
GCTGAACTGT CGCCAGCAGC TAAAACAGGG AAGCGAAAAA GGAGTCAGAT GCTGTTTCGA 
GGTCGAAGAG CATCCCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IFNG ( NM_000619.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000610.2 Homo sapiens interferon gamma (IFNG), mRNA.

Price & Availability↑

CloneID	OHu27326
Clone ID Related Accession (Same CDS sequence)	NM_000619.2 , NM_000619.3
Accession Version	NM_000619.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	interferon gamma precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC070256.1, V00543.1 and AC007458.14. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_000619.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070256.1, SRR1163655.241293.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154529 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000229135.4/ ENSP00000229135.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAATATA CAAGTTATAT CTTGGCTTTT CAGCTCTGCA TCGTTTTGGG TTCTCTTGGC 
TGTTACTGCC AGGACCCATA TGTAAAAGAA GCAGAAAACC TTAAGAAATA TTTTAATGCA 
GGTCATTCAG ATGTAGCGGA TAATGGAACT CTTTTCTTAG GCATTTTGAA GAATTGGAAA 
GAGGAGAGTG ACAGAAAAAT AATGCAGAGC CAAATTGTCT CCTTTTACTT CAAACTTTTT 
AAAAACTTTA AAGATGACCA GAGCATCCAA AAGAGTGTGG AGACCATCAA GGAAGACATG 
AATGTCAAGT TTTTCAATAG CAACAAAAAG AAACGAGATG ACTTCGAAAA GCTGACTAAT 
TATTCGGTAA CTGACTTGAA TGTCCAACGC AAAGCAATAC ATGAACTCAT CCAAGTGATG 
GCTGAACTGT CGCCAGCAGC TAAAACAGGG AAGCGAAAAA GGAGTCAGAT GCTGTTTCGA 
GGTCGAAGAG CATCCCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000610.2
CDS	126..626
Translation	MKYTSYILAFQLCIVLGSLGCYCQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTNYSVTDLNVQRKAIHELIQVMAELSPAAKTGKRKRSQMLFRGRRASQ

Target ORF information:

RefSeq Version	NM_000619.3
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon gamma (IFNG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000619.3

ORF Insert Sequence:

ATGAAATATA CAAGTTATAT CTTGGCTTTT CAGCTCTGCA TCGTTTTGGG TTCTCTTGGC 
TGTTACTGCC AGGACCCATA TGTAAAAGAA GCAGAAAACC TTAAGAAATA TTTTAATGCA 
GGTCATTCAG ATGTAGCGGA TAATGGAACT CTTTTCTTAG GCATTTTGAA GAATTGGAAA 
GAGGAGAGTG ACAGAAAAAT AATGCAGAGC CAAATTGTCT CCTTTTACTT CAAACTTTTT 
AAAAACTTTA AAGATGACCA GAGCATCCAA AAGAGTGTGG AGACCATCAA GGAAGACATG 
AATGTCAAGT TTTTCAATAG CAACAAAAAG AAACGAGATG ACTTCGAAAA GCTGACTAAT 
TATTCGGTAA CTGACTTGAA TGTCCAACGC AAAGCAATAC ATGAACTCAT CCAAGTGATG 
GCTGAACTGT CGCCAGCAGC TAAAACAGGG AAGCGAAAAA GGAGTCAGAT GCTGTTTCGA 
GGTCGAAGAG CATCCCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High STAT4 Expression Indicates Better Disease-free Survival in Patients with Gastric Cancer.
Anticancer research37(12)6723-6729(2017 12)
Nishi M,Batsaikhan BE,Yoshikawa K,Higashijima J,Tokunaga T,Takasu C,Kashihara H,Ishikawa D,Shimada M

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IFNG cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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