IFNG cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	IFNG
Entrez Gene ID	15978
Full Name	interferon gamma
Synonyms	IFN-g,Ifg
General protein information	Preferred Names interferon gamma Names interferon gamma IFN-gamma gamma interferon
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 10 Map Location: 10 D2\|10 66.75 cM
Summary	This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_008337.4	NP_032363.1	interferon gamma precursor
NM_008337.3	NP_032363.1	interferon gamma precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	IFNG	NP_776511.1
Rattus norvegicus (Norway rat)	Ifng	NP_620235.1
Homo sapiens (human)	IFNG	NP_000610.2
Mus musculus (house mouse)	Ifng	NP_032363.1
Pan troglodytes (chimpanzee)	IFNG	NP_001180594.1
	IFNG	NP_001028077.1
Canis lupus familiaris (dog)	IFNG	NP_001003174.1

Gene Ontology
Bibliography

Related articles in PubMed

Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.
Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradley A, Stewart TA
Science (New York, N.Y.)259(5102)1739-42(1993 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MyD88 signaling in myeloid and dendritic cells is dispensable for IFN-gamma-dependent control of type A F. tularensis infection.
Title: Hematopoietic MyD88 and IL-18 are essential for IFN-?-dependent restriction of type A

spleen-derived IFN-gamma induces generation of PD-L1(+)-suppressive neutrophils.
Title: Spleen-derived IFN-? induces generation of PD-L1

identified TIM-4 as a novel marker for B effector 1 (Be1) cells that depend on IFN-gamma for their proinflammatory activity; TIM-4(+) B cells are enriched for IFN-gamma-producing proinflammatory Be1 cells that enhance immune responsiveness and can be specifically targeted with anti-TIM-4.
Title: TIM-4 Identifies IFN-?-Expressing Proinflammatory B Effector 1 Cells That Promote Tumor and Allograft Rejection.

Using IFN-gamma-deficient Th17 cells, study demonstrates the disease-amplifying role of Th17-derived IFN-gamma in dry eye disease pathogenesis. These results clearly demonstrate that Th17 cells mediate ocular surface autoimmunity through both IL-17A and IFN-gamma.
Title: IFN-?-Expressing Th17 Cells Are Required for Development of Severe Ocular Surface Autoimmunity.

Stat3 mediates the expression of iNOS to promote IFNgamma/TNFalpha-induced muscle atrophy.
Title: STAT3 promotes IFN?/TNF?-induced muscle wasting in an NF-?B-dependent and IL-6-independent manner.

The following IFNG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IFNG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu18252	NM_008337.4 Latest version!	Mus musculus interferon gamma (Ifng), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu18252	NM_008337.3	Mus musculus interferon gamma (Ifng), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IFNG ( NM_008337.4 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_032363.1 Mus musculus interferon gamma (Ifng), mRNA.

Price & Availability↑

CloneID	OMu18252
Clone ID Related Accession (Same CDS sequence)	NM_008337.4 , NM_008337.3
Accession Version	NM_008337.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Mus musculus(house mouse)
Product	interferon gamma precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC153498.17. On Sep 10, 2015 this sequence version replaced NM_008337.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: K00083.1, M28621.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849388 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACGCTA CACACTGCAT CTTGGCTTTG CAGCTCTTCC TCATGGCTGT TTCTGGCTGT 
TACTGCCACG GCACAGTCAT TGAAAGCCTA GAAAGTCTGA ATAACTATTT TAACTCAAGT 
GGCATAGATG TGGAAGAAAA GAGTCTCTTC TTGGATATCT GGAGGAACTG GCAAAAGGAT 
GGTGACATGA AAATCCTGCA GAGCCAGATT ATCTCTTTCT ACCTCAGACT CTTTGAAGTC 
TTGAAAGACA ATCAGGCCAT CAGCAACAAC ATAAGCGTCA TTGAATCACA CCTGATTACT 
ACCTTCTTCA GCAACAGCAA GGCGAAAAAG GATGCATTCA TGAGTATTGC CAAGTTTGAG 
GTCAACAACC CACAGGTCCA GCGCCAAGCA TTCAATGAGC TCATCCGAGT GGTCCACCAG 
CTGTTGCCGG AATCCAGCCT CAGGAAGCGG AAAAGGAGTC GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032363.1
CDS	110..577
Translation	MNATHCILALQLFLMAVSGCYCHGTVIESLESLNNYFNSSGIDVEEKSLFLDIWRNWQKDGDMKILQSQIISFYLRLFEVLKDNQAISNNISVIESHLITTFFSNSKAKKDAFMSIAKFEVNNPQVQRQAFNELIRVVHQLLPESSLRKRKRSRC

Target ORF information:

RefSeq Version	NM_008337.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus interferon gamma (Ifng), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008337.4

ORF Insert Sequence:

ATGAACGCTA CACACTGCAT CTTGGCTTTG CAGCTCTTCC TCATGGCTGT TTCTGGCTGT 
TACTGCCACG GCACAGTCAT TGAAAGCCTA GAAAGTCTGA ATAACTATTT TAACTCAAGT 
GGCATAGATG TGGAAGAAAA GAGTCTCTTC TTGGATATCT GGAGGAACTG GCAAAAGGAT 
GGTGACATGA AAATCCTGCA GAGCCAGATT ATCTCTTTCT ACCTCAGACT CTTTGAAGTC 
TTGAAAGACA ATCAGGCCAT CAGCAACAAC ATAAGCGTCA TTGAATCACA CCTGATTACT 
ACCTTCTTCA GCAACAGCAA GGCGAAAAAG GATGCATTCA TGAGTATTGC CAAGTTTGAG 
GTCAACAACC CACAGGTCCA GCGCCAAGCA TTCAATGAGC TCATCCGAGT GGTCCACCAG 
CTGTTGCCGG AATCCAGCCT CAGGAAGCGG AAAAGGAGTC GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IFNG ( NM_008337.3 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_032363.1 Mus musculus interferon gamma (Ifng), mRNA.

Price & Availability↑

CloneID	OMu18252
Clone ID Related Accession (Same CDS sequence)	NM_008337.4 , NM_008337.3
Accession Version	NM_008337.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	interferon gamma precursor
Comment

ATGAACGCTA CACACTGCAT CTTGGCTTTG CAGCTCTTCC TCATGGCTGT TTCTGGCTGT 
TACTGCCACG GCACAGTCAT TGAAAGCCTA GAAAGTCTGA ATAACTATTT TAACTCAAGT 
GGCATAGATG TGGAAGAAAA GAGTCTCTTC TTGGATATCT GGAGGAACTG GCAAAAGGAT 
GGTGACATGA AAATCCTGCA GAGCCAGATT ATCTCTTTCT ACCTCAGACT CTTTGAAGTC 
TTGAAAGACA ATCAGGCCAT CAGCAACAAC ATAAGCGTCA TTGAATCACA CCTGATTACT 
ACCTTCTTCA GCAACAGCAA GGCGAAAAAG GATGCATTCA TGAGTATTGC CAAGTTTGAG 
GTCAACAACC CACAGGTCCA GCGCCAAGCA TTCAATGAGC TCATCCGAGT GGTCCACCAG 
CTGTTGCCGG AATCCAGCCT CAGGAAGCGG AAAAGGAGTC GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032363.1
Translation	MNATHCILALQLFLMAVSGCYCHGTVIESLESLNNYFNSSGIDVEEKSLFLDIWRNWQKDGDMKILQSQIISFYLRLFEVLKDNQAISNNISVIESHLITTFFSNSKAKKDAFMSIAKFEVNNPQVQRQAFNELIRVVHQLLPESSLRKRKRSRC

Target ORF information:

RefSeq Version	NM_008337.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus interferon gamma (Ifng), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008337.3

ORF Insert Sequence:

ATGAACGCTA CACACTGCAT CTTGGCTTTG CAGCTCTTCC TCATGGCTGT TTCTGGCTGT 
TACTGCCACG GCACAGTCAT TGAAAGCCTA GAAAGTCTGA ATAACTATTT TAACTCAAGT 
GGCATAGATG TGGAAGAAAA GAGTCTCTTC TTGGATATCT GGAGGAACTG GCAAAAGGAT 
GGTGACATGA AAATCCTGCA GAGCCAGATT ATCTCTTTCT ACCTCAGACT CTTTGAAGTC 
TTGAAAGACA ATCAGGCCAT CAGCAACAAC ATAAGCGTCA TTGAATCACA CCTGATTACT 
ACCTTCTTCA GCAACAGCAA GGCGAAAAAG GATGCATTCA TGAGTATTGC CAAGTTTGAG 
GTCAACAACC CACAGGTCCA GCGCCAAGCA TTCAATGAGC TCATCCGAGT GGTCCACCAG 
CTGTTGCCGG AATCCAGCCT CAGGAAGCGG AAAAGGAGTC GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.
Science (New York, N.Y.)259(5102)1739-42(1993 Mar)
Dalton DK,Pitts-Meek S,Keshav S,Figari IS,Bradley A,Stewart TA

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IFNG cDNA ORF clone, Mus musculus(House mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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