ID4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ID4
Entrez Gene ID	3400
Full Name	inhibitor of DNA binding 4, HLH protein
Synonyms	IDB4,bHLHb27
General protein information	Preferred Names inhibitor of DNA binding 4, HLH protein Names DNA-binding protein inhibitor ID-4 class B basic helix-loop-helix protein 27 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein inhibitor of differentiation 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.3
Summary	This gene encodes a member of the inhibitor of DNA binding (ID) protein family. The encoded protein lacks DNA binding ability, and instead regulates gene expression through binding to and inhibiting basic helix-loop-helix transcription factors. This protein has been implicated in the regulation of diverse cellular processes that play a role in development and tumorigenesis. [provided by RefSeq, Aug 2017].
Disorder MIM:	600581

mRNA and Protein(s)

mRNA	Protein	Name
NM_001546.3	NP_001537.1	DNA-binding protein inhibitor ID-4
NM_001546.4	NP_001537.1	DNA-binding protein inhibitor ID-4

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Id4	NP_112443.1
Xenopus tropicalis (tropical clawed frog)	id4	NP_001004839.1
Rattus norvegicus (Norway rat)	Id4	NP_783172.1
	ID4	XP_001098022.1
Danio rerio (zebrafish)	id4	NP_001035079.1
Homo sapiens (human)	ID4	NP_001537.1

Gene Ontology
Bibliography

Related articles in PubMed

Epigenetic dysregulation of ID4 predicts disease progression and treatment outcome in myeloid malignancies.
Zhou JD, Zhang TJ, Li XX, Ma JC, Guo H, Wen XM, Zhang W, Yang L, Yan Y, Lin J, Qian J
Journal of cellular and molecular medicine21(8)1468-1481(2017 Aug)

The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1.
Pruszko M, Milano E, Forcato M, Donzelli S, Ganci F, Di Agostino S, De Panfilis S, Fazi F, Bates DO, Bicciato S, Zylicz M, Zylicz A, Blandino G, Fontemaggi G
EMBO reports18(8)1331-1351(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ID4 selectively regulates AR activity through direct interaction with FKBP52.
Title: Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52.

A cell-autonomous positive-signaling circuit is associated with the PDGFB-NO-ID4-regulatory axis in glioblastoma cells.
Title: A cell-autonomous positive-signaling circuit associated with the PDGF-NO-ID4-regulatory axis in glioblastoma cells.

High ID4 expression is associated with basal breast cancer.
Title: Constitutive NOTCH3 Signaling Promotes the Growth of Basal Breast Cancers.

The expression of Id4 protein was up-regulated in tumor tissues from hepatocellular carcinoma (HCC) patients, and overexpression of Id4 promoted HCC cell proliferation, clonogenicity in vitro, and tumorigenicity in vivo.
Title: Id4 promotes cell proliferation in hepatocellular carcinoma.

In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2)early growth response (EGR)2 and NR4A2EGR3. Therefore, RUNX1, NR4A2, EGR2, EGR3 and ID4 may be key genes associated with the pathogenesis of DS.
Title: Integrated analysis of DNA methylation and RNA?sequencing data in Down syndrome.

The following ID4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ID4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12105	NM_001546.4 Latest version!	Homo sapiens inhibitor of DNA binding 4, HLH protein (ID4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu12105	NM_001546.3	Homo sapiens inhibitor of DNA binding 4, HLH protein (ID4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ID4 ( NM_001546.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001537.1 Homo sapiens inhibitor of DNA binding 4, HLH protein (ID4), mRNA.

Price & Availability↑

CloneID	OHu12105
Clone ID Related Accession (Same CDS sequence)	NM_001546.3 , NM_001546.4
Accession Version	NM_001546.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-11
Organism	Homo sapiens(human)
Product	DNA-binding protein inhibitor ID-4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB461864.1, BC014941.1, AL022726.1 and AI692586.1. On Dec 23, 2011 this sequence version replaced NM_001546.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.9507.1, SRR1803614.153180.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGGCGG TGAGCCCGGT GCGCCCCTCG GGCCGCAAGG CGCCGTCGGG CTGCGGCGGC 
GGGGAGCTGG CGCTGCGCTG CCTGGCCGAG CACGGCCACA GCCTGGGTGG CTCCGCAGCC 
GCGGCGGCGG CGGCGGCGGC AGCGCGCTGT AAGGCGGCCG AGGCGGCGGC CGACGAGCCG 
GCGCTGTGCC TGCAGTGCGA TATGAACGAC TGCTATAGCC GCCTGCGGAG GCTGGTGCCC 
ACCATCCCGC CCAACAAGAA AGTCAGCAAA GTGGAGATCC TGCAGCACGT TATCGACTAC 
ATCCTGGACC TGCAGCTGGC GCTGGAGACG CACCCGGCCC TGCTGAGGCA GCCACCACCG 
CCCGCGCCGC CACACCACCC GGCCGGGACC TGTCCAGCCG CGCCGCCGCG GACCCCGCTC 
ACTGCGCTCA ACACCGACCC GGCCGGCGCG GTGAACAAGC AGGGCGACAG CATTCTGTGC 
CGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001537.1
CDS	386..871
Translation	MKAVSPVRPSGRKAPSGCGGGELALRCLAEHGHSLGGSAAAAAAAAAARCKAAEAAADEPALCLQCDMNDCYSRLRRLVPTIPPNKKVSKVEILQHVIDYILDLQLALETHPALLRQPPPPAPPHHPAGTCPAAPPRTPLTALNTDPAGAVNKQGDSILCR

Target ORF information:

RefSeq Version	NM_001546.3
Organism	Homo sapiens(human)
Definition	Homo sapiens inhibitor of DNA binding 4, HLH protein (ID4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001546.3

ORF Insert Sequence:

ATGAAGGCGG TGAGCCCGGT GCGCCCCTCG GGCCGCAAGG CGCCGTCGGG CTGCGGCGGC 
GGGGAGCTGG CGCTGCGCTG CCTGGCCGAG CACGGCCACA GCCTGGGTGG CTCCGCAGCC 
GCGGCGGCGG CGGCGGCGGC AGCGCGCTGT AAGGCGGCCG AGGCGGCGGC CGACGAGCCG 
GCGCTGTGCC TGCAGTGCGA TATGAACGAC TGCTATAGCC GCCTGCGGAG GCTGGTGCCC 
ACCATCCCGC CCAACAAGAA AGTCAGCAAA GTGGAGATCC TGCAGCACGT TATCGACTAC 
ATCCTGGACC TGCAGCTGGC GCTGGAGACG CACCCGGCCC TGCTGAGGCA GCCACCACCG 
CCCGCGCCGC CACACCACCC GGCCGGGACC TGTCCAGCCG CGCCGCCGCG GACCCCGCTC 
ACTGCGCTCA ACACCGACCC GGCCGGCGCG GTGAACAAGC AGGGCGACAG CATTCTGTGC 
CGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ID4 ( NM_001546.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001537.1 Homo sapiens inhibitor of DNA binding 4, HLH protein (ID4), mRNA.

Price & Availability↑

CloneID	OHu12105
Clone ID Related Accession (Same CDS sequence)	NM_001546.3 , NM_001546.4
Accession Version	NM_001546.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-22
Organism	Homo sapiens(human)
Product	DNA-binding protein inhibitor ID-4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB461864.1, BC014941.1, AL022726.1 and AI692586.1. On Nov 24, 2018 this sequence version replaced NM_001546.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.9507.1, SRR1803614.153180.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000378700.8/ ENSP00000367972.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGGCGG TGAGCCCGGT GCGCCCCTCG GGCCGCAAGG CGCCGTCGGG CTGCGGCGGC 
GGGGAGCTGG CGCTGCGCTG CCTGGCCGAG CACGGCCACA GCCTGGGTGG CTCCGCAGCC 
GCGGCGGCGG CGGCGGCGGC AGCGCGCTGT AAGGCGGCCG AGGCGGCGGC CGACGAGCCG 
GCGCTGTGCC TGCAGTGCGA TATGAACGAC TGCTATAGCC GCCTGCGGAG GCTGGTGCCC 
ACCATCCCGC CCAACAAGAA AGTCAGCAAA GTGGAGATCC TGCAGCACGT TATCGACTAC 
ATCCTGGACC TGCAGCTGGC GCTGGAGACG CACCCGGCCC TGCTGAGGCA GCCACCACCG 
CCCGCGCCGC CACACCACCC GGCCGGGACC TGTCCAGCCG CGCCGCCGCG GACCCCGCTC 
ACTGCGCTCA ACACCGACCC GGCCGGCGCG GTGAACAAGC AGGGCGACAG CATTCTGTGC 
CGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001537.1
CDS	386..871
Translation	MKAVSPVRPSGRKAPSGCGGGELALRCLAEHGHSLGGSAAAAAAAAAARCKAAEAAADEPALCLQCDMNDCYSRLRRLVPTIPPNKKVSKVEILQHVIDYILDLQLALETHPALLRQPPPPAPPHHPAGTCPAAPPRTPLTALNTDPAGAVNKQGDSILCR

Target ORF information:

RefSeq Version	NM_001546.4
Organism	Homo sapiens(human)
Definition	Homo sapiens inhibitor of DNA binding 4, HLH protein (ID4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001546.4

ORF Insert Sequence:

ATGAAGGCGG TGAGCCCGGT GCGCCCCTCG GGCCGCAAGG CGCCGTCGGG CTGCGGCGGC 
GGGGAGCTGG CGCTGCGCTG CCTGGCCGAG CACGGCCACA GCCTGGGTGG CTCCGCAGCC 
GCGGCGGCGG CGGCGGCGGC AGCGCGCTGT AAGGCGGCCG AGGCGGCGGC CGACGAGCCG 
GCGCTGTGCC TGCAGTGCGA TATGAACGAC TGCTATAGCC GCCTGCGGAG GCTGGTGCCC 
ACCATCCCGC CCAACAAGAA AGTCAGCAAA GTGGAGATCC TGCAGCACGT TATCGACTAC 
ATCCTGGACC TGCAGCTGGC GCTGGAGACG CACCCGGCCC TGCTGAGGCA GCCACCACCG 
CCCGCGCCGC CACACCACCC GGCCGGGACC TGTCCAGCCG CGCCGCCGCG GACCCCGCTC 
ACTGCGCTCA ACACCGACCC GGCCGGCGCG GTGAACAAGC AGGGCGACAG CATTCTGTGC 
CGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Epigenetic dysregulation of ID4 predicts disease progression and treatment outcome in myeloid malignancies.
Journal of cellular and molecular medicine21(8)1468-1481(2017 Aug)
Zhou JD,Zhang TJ,Li XX,Ma JC,Guo H,Wen XM,Zhang W,Yang L,Yan Y,Lin J,Qian J

The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1.
EMBO reports18(8)1331-1351(2017 Aug)
Pruszko M,Milano E,Forcato M,Donzelli S,Ganci F,Di Agostino S,De Panfilis S,Fazi F,Bates DO,Bicciato S,Zylicz M,Zylicz A,Blandino G,Fontemaggi G

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

ID4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報