HTR2C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HTR2C
Entrez Gene ID	3358
Full Name	5-hydroxytryptamine receptor 2C
Synonyms	5-HT1C,5-HT2C,5-HTR2C,5HTR2C,HTR1C
General protein information	Preferred Names 5-hydroxytryptamine receptor 2C Names 5-hydroxytryptamine receptor 2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-hydroxytryptamine receptor 1C serotonin 5-HT-1C receptor serotonin 5-HT-2C receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq23
Summary	This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015].
Disorder MIM:	312861

mRNA and Protein(s)

mRNA	Protein	Name
NM_000868.3	NP_000859.1	5-hydroxytryptamine receptor 2C isoform a precursor
NM_001256760.2	NP_001243689.1	5-hydroxytryptamine receptor 2C isoform a precursor
NM_001256761.2	NP_001243690.1	5-hydroxytryptamine receptor 2C isoform b precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	HTR2C	XP_005227998.1
Mus musculus (house mouse)	Htr2c	NP_032338.3
Canis lupus familiaris (dog)	HTR2C	NP_001006649.1
Anopheles gambiae (African malaria mosquito)	GPR5HT2A	XP_307953.2
Homo sapiens (human)	HTR2C	NP_001243689.1
Pan troglodytes (chimpanzee)	HTR2C	NP_001029104.2
	HTR2C	XP_001101997.1
Rattus norvegicus (Norway rat)	Htr2c	NP_036897.2

Gene Ontology
Bibliography

Related articles in PubMed

The N-terminal region of the human 5-HT?C receptor has as a cleavable signal peptide.
Jahnsen JA, Uhl?n S
European journal of pharmacology684(1-3)44-50(2012 Jun)

Identification and characterization of RNA editing events within the 5-HT2C receptor.
Niswender CM, Sanders-Bush E, Emeson RB
Annals of the New York Academy of Sciences86138-48(1998 Dec)

Regulation of serotonin-2C receptor G-protein coupling by RNA editing.
Burns CM, Chu H, Rueter SM, Hutchinson LK, Canton H, Sanders-Bush E, Emeson RB
Nature387(6630)303-8(1997 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The constitutive activity of 5HT2C is decreased by pre-mRNA editing as well as alternative pre-mRNA splicing, which generates a truncated isoform that switches off 5HT2C receptor activity through heterodimerization; showing that RNA processing regulates the constitutive activity of the 5HT2C system.
Title: The activity of the serotonin receptor 2C is regulated by alternative splicing.

findings indicate that polymorphisms rs3813929 and rs1800849 from 5-HT2C and UCP3 genes were related to type 2 diabetes mellitus prevalence among the Brazilian obese women candidates for bariatric surgery.
Title: Association of 5-HT2C (rs3813929) and UCP3 (rs1800849) gene polymorphisms with type 2 diabetes in obese women candidates for bariatric surgery.

heterodimerization with 5-HT2C receptors does not alter 5-HT2C Galphaq-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor-mediated signaling was totally blunted. This feature can be explained by a dominance of 5-HT2C on 5-HT2A and 5-HT2B receptor binding; in 5-HT2C-containing heterodimers, ligands bind and activate the 5-HT2C protomer exclusively.
Title: Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT

A significant association was established between various HTR2C polymorphisms and Hyperprolactinaemia (HPRL). The study revealed an association between HPRL and X-chromosome haplotypes comprised of the rs569959 and rs17326429 polymorphisms.
Title: Identification of 5-hydroxytryptamine receptor gene polymorphisms modulating hyperprolactinaemia in antipsychotic drug-treated patients with schizophrenia.

Authors found that 22 patients presented the -759C/T polymorphism in 5-HTR2C gene.
Title: -759C?T polymorphism of the HTR2C gene is not correlated with atypical antipsychotics-induced weight gain, among Romanian psychotic patients.

The following HTR2C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HTR2C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09529	NM_001256760.2 Latest version!	Homo sapiens 5-hydroxytryptamine receptor 2C (HTR2C), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu09529	NM_000868.3 Latest version!	Homo sapiens 5-hydroxytryptamine receptor 2C (HTR2C), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu09643	NM_001256761.2 Latest version!	Homo sapiens 5-hydroxytryptamine receptor 2C (HTR2C), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HTR2C ( NM_000868.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000859.1 Homo sapiens 5-hydroxytryptamine receptor 2C (HTR2C), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09529
Clone ID Related Accession (Same CDS sequence)	NM_000868.3 , NM_001256760.2
Accession Version	NM_000868.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1377bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 2C isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC233299.3, U49516.1 and BC028688.1. This sequence is a reference standard in the RefSeqGene project. On Jan 14, 2015 this sequence version replaced NM_000868.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a). This variant may undergo RNA editing. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U49516.1, SRR1660807.161524.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein undergoes RNA editing :: PMID: 9153397, 9928237 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGAACC TGAGGAATGC GGTGCATTCA TTCCTTGTGC ACCTAATTGG CCTATTGGTT 
TGGCAATGTG ATATTTCTGT GAGCCCAGTA GCAGCTATAG TAACTGACAT TTTCAATACC 
TCCGATGGTG GACGCTTCAA ATTCCCAGAC GGGGTACAAA ACTGGCCAGC ACTTTCAATC 
GTCATCATAA TAATCATGAC AATAGGTGGC AACATCCTTG TGATCATGGC AGTAAGCATG 
GAAAAGAAAC TGCACAATGC CACCAATTAC TTCTTAATGT CCCTAGCCAT TGCTGATATG 
CTAGTGGGAC TACTTGTCAT GCCCCTGTCT CTCCTGGCAA TCCTTTATGA TTATGTCTGG 
CCACTACCTA GATATTTGTG CCCCGTCTGG ATTTCTTTAG ATGTTTTATT TTCAACAGCG 
TCCATCATGC ACCTCTGCGC TATATCGCTG GATCGGTATG TAGCAATACG TAATCCTATT 
GAGCATAGCC GTTTCAATTC GCGGACTAAG GCCATCATGA AGATTGCTAT TGTTTGGGCA 
ATTTCTATAG GTGTATCAGT TCCTATCCCT GTGATTGGAC TGAGGGACGA AGAAAAGGTG 
TTCGTGAACA ACACGACGTG CGTGCTCAAC GACCCAAATT TCGTTCTTAT TGGGTCCTTC 
GTAGCTTTCT TCATACCGCT GACGATTATG GTGATTACGT ATTGCCTGAC CATCTACGTT 
CTGCGCCGAC AAGCTTTGAT GTTACTGCAC GGCCACACCG AGGAACCGCC TGGACTAAGT 
CTGGATTTCC TGAAGTGCTG CAAGAGGAAT ACGGCCGAGG AAGAGAACTC TGCAAACCCT 
AACCAAGACC AGAACGCACG CCGAAGAAAG AAGAAGGAGA GACGTCCTAG GGGCACCATG 
CAGGCTATCA ACAATGAAAG AAAAGCTTCG AAAGTCCTTG GGATTGTTTT CTTTGTGTTT 
CTGATCATGT GGTGCCCATT TTTCATTACC AATATTCTGT CTGTTCTTTG TGAGAAGTCC 
TGTAACCAAA AGCTCATGGA AAAGCTTCTG AATGTGTTTG TTTGGATTGG CTATGTTTGT 
TCAGGAATCA ATCCTCTGGT GTATACTCTG TTCAACAAAA TTTACCGAAG GGCATTCTCC 
AACTATTTGC GTTGCAATTA TAAGGTAGAG AAAAAGCCTC CTGTCAGGCA GATTCCAAGA 
GTTGCCGCCA CTGCTTTGTC TGGGAGGGAG CTTAATGTTA ACATTTATCG GCATACCAAT 
GAACCGGTGA TCGAGAAAGC CAGTGACAAT GAGCCCGGTA TAGAGATGCA AGTTGAGAAT 
TTAGAGTTAC CAGTAAATCC CTCCAGTGTG GTTAGCGAAA GGATTAGCAG TGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000859.1
CDS	729..2105
Translation	MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV

Target ORF information:

RefSeq Version	NM_000868.3
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 2C (HTR2C), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000868.3

ORF Insert Sequence:

ATGGTGAACC TGAGGAATGC GGTGCATTCA TTCCTTGTGC ACCTAATTGG CCTATTGGTT 
TGGCAATGTG ATATTTCTGT GAGCCCAGTA GCAGCTATAG TAACTGACAT TTTCAATACC 
TCCGATGGTG GACGCTTCAA ATTCCCAGAC GGGGTACAAA ACTGGCCAGC ACTTTCAATC 
GTCATCATAA TAATCATGAC AATAGGTGGC AACATCCTTG TGATCATGGC AGTAAGCATG 
GAAAAGAAAC TGCACAATGC CACCAATTAC TTCTTAATGT CCCTAGCCAT TGCTGATATG 
CTAGTGGGAC TACTTGTCAT GCCCCTGTCT CTCCTGGCAA TCCTTTATGA TTATGTCTGG 
CCACTACCTA GATATTTGTG CCCCGTCTGG ATTTCTTTAG ATGTTTTATT TTCAACAGCG 
TCCATCATGC ACCTCTGCGC TATATCGCTG GATCGGTATG TAGCAATACG TAATCCTATT 
GAGCATAGCC GTTTCAATTC GCGGACTAAG GCCATCATGA AGATTGCTAT TGTTTGGGCA 
ATTTCTATAG GTGTATCAGT TCCTATCCCT GTGATTGGAC TGAGGGACGA AGAAAAGGTG 
TTCGTGAACA ACACGACGTG CGTGCTCAAC GACCCAAATT TCGTTCTTAT TGGGTCCTTC 
GTAGCTTTCT TCATACCGCT GACGATTATG GTGATTACGT ATTGCCTGAC CATCTACGTT 
CTGCGCCGAC AAGCTTTGAT GTTACTGCAC GGCCACACCG AGGAACCGCC TGGACTAAGT 
CTGGATTTCC TGAAGTGCTG CAAGAGGAAT ACGGCCGAGG AAGAGAACTC TGCAAACCCT 
AACCAAGACC AGAACGCACG CCGAAGAAAG AAGAAGGAGA GACGTCCTAG GGGCACCATG 
CAGGCTATCA ACAATGAAAG AAAAGCTTCG AAAGTCCTTG GGATTGTTTT CTTTGTGTTT 
CTGATCATGT GGTGCCCATT TTTCATTACC AATATTCTGT CTGTTCTTTG TGAGAAGTCC 
TGTAACCAAA AGCTCATGGA AAAGCTTCTG AATGTGTTTG TTTGGATTGG CTATGTTTGT 
TCAGGAATCA ATCCTCTGGT GTATACTCTG TTCAACAAAA TTTACCGAAG GGCATTCTCC 
AACTATTTGC GTTGCAATTA TAAGGTAGAG AAAAAGCCTC CTGTCAGGCA GATTCCAAGA 
GTTGCCGCCA CTGCTTTGTC TGGGAGGGAG CTTAATGTTA ACATTTATCG GCATACCAAT 
GAACCGGTGA TCGAGAAAGC CAGTGACAAT GAGCCCGGTA TAGAGATGCA AGTTGAGAAT 
TTAGAGTTAC CAGTAAATCC CTCCAGTGTG GTTAGCGAAA GGATTAGCAG TGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTR2C ( NM_001256760.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243689.1 Homo sapiens 5-hydroxytryptamine receptor 2C (HTR2C), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09529
Clone ID Related Accession (Same CDS sequence)	NM_000868.3 , NM_001256760.2
Accession Version	NM_001256760.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1377bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 2C isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC233299.3, M81778.1, U49516.1 and BX648587.1. This sequence is a reference standard in the RefSeqGene project. On Jan 14, 2015 this sequence version replaced NM_001256760.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a). This variant may undergo RNA editing. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M81778.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2145743, SAMEA2154665 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## undergoes RNA editing :: PMID: 9153397, 9928237 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGAACC TGAGGAATGC GGTGCATTCA TTCCTTGTGC ACCTAATTGG CCTATTGGTT 
TGGCAATGTG ATATTTCTGT GAGCCCAGTA GCAGCTATAG TAACTGACAT TTTCAATACC 
TCCGATGGTG GACGCTTCAA ATTCCCAGAC GGGGTACAAA ACTGGCCAGC ACTTTCAATC 
GTCATCATAA TAATCATGAC AATAGGTGGC AACATCCTTG TGATCATGGC AGTAAGCATG 
GAAAAGAAAC TGCACAATGC CACCAATTAC TTCTTAATGT CCCTAGCCAT TGCTGATATG 
CTAGTGGGAC TACTTGTCAT GCCCCTGTCT CTCCTGGCAA TCCTTTATGA TTATGTCTGG 
CCACTACCTA GATATTTGTG CCCCGTCTGG ATTTCTTTAG ATGTTTTATT TTCAACAGCG 
TCCATCATGC ACCTCTGCGC TATATCGCTG GATCGGTATG TAGCAATACG TAATCCTATT 
GAGCATAGCC GTTTCAATTC GCGGACTAAG GCCATCATGA AGATTGCTAT TGTTTGGGCA 
ATTTCTATAG GTGTATCAGT TCCTATCCCT GTGATTGGAC TGAGGGACGA AGAAAAGGTG 
TTCGTGAACA ACACGACGTG CGTGCTCAAC GACCCAAATT TCGTTCTTAT TGGGTCCTTC 
GTAGCTTTCT TCATACCGCT GACGATTATG GTGATTACGT ATTGCCTGAC CATCTACGTT 
CTGCGCCGAC AAGCTTTGAT GTTACTGCAC GGCCACACCG AGGAACCGCC TGGACTAAGT 
CTGGATTTCC TGAAGTGCTG CAAGAGGAAT ACGGCCGAGG AAGAGAACTC TGCAAACCCT 
AACCAAGACC AGAACGCACG CCGAAGAAAG AAGAAGGAGA GACGTCCTAG GGGCACCATG 
CAGGCTATCA ACAATGAAAG AAAAGCTTCG AAAGTCCTTG GGATTGTTTT CTTTGTGTTT 
CTGATCATGT GGTGCCCATT TTTCATTACC AATATTCTGT CTGTTCTTTG TGAGAAGTCC 
TGTAACCAAA AGCTCATGGA AAAGCTTCTG AATGTGTTTG TTTGGATTGG CTATGTTTGT 
TCAGGAATCA ATCCTCTGGT GTATACTCTG TTCAACAAAA TTTACCGAAG GGCATTCTCC 
AACTATTTGC GTTGCAATTA TAAGGTAGAG AAAAAGCCTC CTGTCAGGCA GATTCCAAGA 
GTTGCCGCCA CTGCTTTGTC TGGGAGGGAG CTTAATGTTA ACATTTATCG GCATACCAAT 
GAACCGGTGA TCGAGAAAGC CAGTGACAAT GAGCCCGGTA TAGAGATGCA AGTTGAGAAT 
TTAGAGTTAC CAGTAAATCC CTCCAGTGTG GTTAGCGAAA GGATTAGCAG TGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243689.1
CDS	820..2196
Translation	MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV

Target ORF information:

RefSeq Version	NM_001256760.2
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 2C (HTR2C), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256760.2

ORF Insert Sequence:

ATGGTGAACC TGAGGAATGC GGTGCATTCA TTCCTTGTGC ACCTAATTGG CCTATTGGTT 
TGGCAATGTG ATATTTCTGT GAGCCCAGTA GCAGCTATAG TAACTGACAT TTTCAATACC 
TCCGATGGTG GACGCTTCAA ATTCCCAGAC GGGGTACAAA ACTGGCCAGC ACTTTCAATC 
GTCATCATAA TAATCATGAC AATAGGTGGC AACATCCTTG TGATCATGGC AGTAAGCATG 
GAAAAGAAAC TGCACAATGC CACCAATTAC TTCTTAATGT CCCTAGCCAT TGCTGATATG 
CTAGTGGGAC TACTTGTCAT GCCCCTGTCT CTCCTGGCAA TCCTTTATGA TTATGTCTGG 
CCACTACCTA GATATTTGTG CCCCGTCTGG ATTTCTTTAG ATGTTTTATT TTCAACAGCG 
TCCATCATGC ACCTCTGCGC TATATCGCTG GATCGGTATG TAGCAATACG TAATCCTATT 
GAGCATAGCC GTTTCAATTC GCGGACTAAG GCCATCATGA AGATTGCTAT TGTTTGGGCA 
ATTTCTATAG GTGTATCAGT TCCTATCCCT GTGATTGGAC TGAGGGACGA AGAAAAGGTG 
TTCGTGAACA ACACGACGTG CGTGCTCAAC GACCCAAATT TCGTTCTTAT TGGGTCCTTC 
GTAGCTTTCT TCATACCGCT GACGATTATG GTGATTACGT ATTGCCTGAC CATCTACGTT 
CTGCGCCGAC AAGCTTTGAT GTTACTGCAC GGCCACACCG AGGAACCGCC TGGACTAAGT 
CTGGATTTCC TGAAGTGCTG CAAGAGGAAT ACGGCCGAGG AAGAGAACTC TGCAAACCCT 
AACCAAGACC AGAACGCACG CCGAAGAAAG AAGAAGGAGA GACGTCCTAG GGGCACCATG 
CAGGCTATCA ACAATGAAAG AAAAGCTTCG AAAGTCCTTG GGATTGTTTT CTTTGTGTTT 
CTGATCATGT GGTGCCCATT TTTCATTACC AATATTCTGT CTGTTCTTTG TGAGAAGTCC 
TGTAACCAAA AGCTCATGGA AAAGCTTCTG AATGTGTTTG TTTGGATTGG CTATGTTTGT 
TCAGGAATCA ATCCTCTGGT GTATACTCTG TTCAACAAAA TTTACCGAAG GGCATTCTCC 
AACTATTTGC GTTGCAATTA TAAGGTAGAG AAAAAGCCTC CTGTCAGGCA GATTCCAAGA 
GTTGCCGCCA CTGCTTTGTC TGGGAGGGAG CTTAATGTTA ACATTTATCG GCATACCAAT 
GAACCGGTGA TCGAGAAAGC CAGTGACAAT GAGCCCGGTA TAGAGATGCA AGTTGAGAAT 
TTAGAGTTAC CAGTAAATCC CTCCAGTGTG GTTAGCGAAA GGATTAGCAG TGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTR2C ( NM_001256761.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243690.1 Homo sapiens 5-hydroxytryptamine receptor 2C (HTR2C), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu09643
Clone ID Related Accession (Same CDS sequence)	NM_001256761.2
Accession Version	NM_001256761.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 2C isoform b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC233299.3, AK295753.1, U49516.1 and BX648587.1. On Jan 14, 2015 this sequence version replaced NM_001256761.1. Transcript Variant: This variant (3, also known as 5-HT2C-tr) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.48380.1, AK295753.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## undergoes RNA editing :: PMID: 9153397, 9928237 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGAACC TGAGGAATGC GGTGCATTCA TTCCTTGTGC ACCTAATTGG CCTATTGGTT 
TGGCAATGTG ATATTTCTGT GAGCCCAGTA GCAGCTATAG TAACTGACAT TTTCAATACC 
TCCGATGGTG GACGCTTCAA ATTCCCAGAC GGGGTACAAA ACTGGCCAGC ACTTTCAATC 
GTCATCATAA TAATCATGAC AATAGGTGGC AACATCCTTG TGATCATGGC AGTAAGCATG 
GAAAAGAAAC TGCACAATGC CACCAATTAC TTCTTAATGT CCCTAGCCAT TGCTGATATG 
CTAGTGGGAC TACTTGTCAT GCCCCTGTCT CTCCTGGCAA TCCTTTATGA TTATGTCTGG 
CCACTACCTA GATATTTGTG CCCCGTCTGG ATTTCTTTAG ATGTTTTATT TTCAACAGCG 
TCCATCATGC ACCTCTGCGC TATATCGCTG GATCGGTGTA TCAGTTCCTA TCCCTGTGAT 
TGGACTGAGG GACGAAGAAA AGGTGTTCGT GAACAACACG ACGTGCGTGC TCAACGACCC 
AAATTTCGTT CTTATTGGGT CCTTCGTAGC TTTCTTCATA CCGCTGACGA TTATGGTGAT 
TACGTATTGC CTGACCATCT ACGTTCTGCG CCGACAAGCT TTGATGTTAC TGCACGGCCA 
CACCGAGGAA CCGCCTGGAC TAAGTCTGGA TTTCCTGAAG TGCTGCAAGA GGAATACGGC 
CGAGGAAGAG AACTCTGCAA ACCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243690.1
CDS	729..1475
Translation	MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRCISSYPCDWTEGRRKGVREQHDVRAQRPKFRSYWVLRSFLHTADDYGDYVLPDHLRSAPTSFDVTARPHRGTAWTKSGFPEVLQEEYGRGRELCKP

Target ORF information:

RefSeq Version	NM_001256761.2
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 2C (HTR2C), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256761.2

ORF Insert Sequence:

ATGGTGAACC TGAGGAATGC GGTGCATTCA TTCCTTGTGC ACCTAATTGG CCTATTGGTT 
TGGCAATGTG ATATTTCTGT GAGCCCAGTA GCAGCTATAG TAACTGACAT TTTCAATACC 
TCCGATGGTG GACGCTTCAA ATTCCCAGAC GGGGTACAAA ACTGGCCAGC ACTTTCAATC 
GTCATCATAA TAATCATGAC AATAGGTGGC AACATCCTTG TGATCATGGC AGTAAGCATG 
GAAAAGAAAC TGCACAATGC CACCAATTAC TTCTTAATGT CCCTAGCCAT TGCTGATATG 
CTAGTGGGAC TACTTGTCAT GCCCCTGTCT CTCCTGGCAA TCCTTTATGA TTATGTCTGG 
CCACTACCTA GATATTTGTG CCCCGTCTGG ATTTCTTTAG ATGTTTTATT TTCAACAGCG 
TCCATCATGC ACCTCTGCGC TATATCGCTG GATCGGTGTA TCAGTTCCTA TCCCTGTGAT 
TGGACTGAGG GACGAAGAAA AGGTGTTCGT GAACAACACG ACGTGCGTGC TCAACGACCC 
AAATTTCGTT CTTATTGGGT CCTTCGTAGC TTTCTTCATA CCGCTGACGA TTATGGTGAT 
TACGTATTGC CTGACCATCT ACGTTCTGCG CCGACAAGCT TTGATGTTAC TGCACGGCCA 
CACCGAGGAA CCGCCTGGAC TAAGTCTGGA TTTCCTGAAG TGCTGCAAGA GGAATACGGC 
CGAGGAAGAG AACTCTGCAA ACCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The N-terminal region of the human 5-HT?C receptor has as a cleavable signal peptide.
European journal of pharmacology684(1-3)44-50(2012 Jun)
Jahnsen JA,Uhl?n S

Identification and characterization of RNA editing events within the 5-HT2C receptor.
Annals of the New York Academy of Sciences86138-48(1998 Dec)
Niswender CM,Sanders-Bush E,Emeson RB

Regulation of serotonin-2C receptor G-protein coupling by RNA editing.
Nature387(6630)303-8(1997 May)
Burns CM,Chu H,Rueter SM,Hutchinson LK,Canton H,Sanders-Bush E,Emeson RB

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HTR2C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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