CISD3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CISD3
Entrez Gene ID	284106
Full Name	CDGSH iron sulfur domain 3
Synonyms	Miner2
General protein information	Preferred Names CDGSH iron sulfur domain 3 Names CDGSH iron-sulfur domain-containing protein 3, mitochondrial mitoNEET related 2 mitoNEET-related protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q12
Summary	CISD3 is a member of the CDGSH domain-containing family, which may play a role in regulating electron transport and oxidative phosphorylation (Wiley et al., 2007 [PubMed 17376863]).[supplied by OMIM, Apr 2008].
Disorder MIM:	611933

mRNA and Protein(s)

mRNA	Protein	Name
NM_001136498.2	NP_001129970.1	CDGSH iron-sulfur domain-containing protein 3, mitochondrial precursor
NM_001136498.1	NP_001129970.1	CDGSH iron-sulfur domain-containing protein 3, mitochondrial precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CISD3	XP_002695996.1
Mus musculus (house mouse)	Cisd3	NP_001078969.2
Pan troglodytes (chimpanzee)	CISD3	XP_511439.1
Mus musculus (house mouse)	Gm20267	XP_006500591.1
Homo sapiens (human)	CISD3	NP_001129970.1
Canis lupus familiaris (dog)	CISD3	XP_005624642.1

Gene Ontology
Bibliography

Related articles in PubMed

Structure of the human monomeric NEET protein MiNT and its role in regulating iron and reactive oxygen species in cancer cells.
Lipper CH, Karmi O, Sohn YS, Darash-Yahana M, Lammert H, Song L, Liu A, Mittler R, Nechushtai R, Onuchic JN, Jennings PA
Proceedings of the National Academy of Sciences of the United States of America115(2)272-277(2018 Jan)

The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster.
Wiley SE, Paddock ML, Abresch EC, Gross L, van der Geer P, Nechushtai R, Murphy AN, Jennings PA, Dixon JE
The Journal of biological chemistry282(33)23745-9(2007 Aug)

MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity.
Wiley SE, Murphy AN, Ross SA, van der Geer P, Dixon JE
Proceedings of the National Academy of Sciences of the United States of America104(13)5318-23(2007 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CISD3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CISD3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13698	NM_001136498.2 Latest version!	Homo sapiens CDGSH iron sulfur domain 3 (CISD3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu13698	NM_001136498.1	Homo sapiens CDGSH iron sulfur domain 3 (CISD3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CISD3 ( NM_001136498.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001129970.1 Homo sapiens CDGSH iron sulfur domain 3 (CISD3), mRNA.

Price & Availability↑

CloneID	OHu13698
Clone ID Related Accession (Same CDS sequence)	NM_001136498.2 , NM_001136498.1
Accession Version	NM_001136498.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	CDGSH iron-sulfur domain-containing protein 3, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC006449.19. On May 17, 2019 this sequence version replaced NM_001136498.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.998108.1, SRR1660805.314775.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000613478.2/ ENSP00000483781.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCGCGGCG CGGGGGCGAT CCTGCGGCCG GCGGCGCGTG GTGCCCGGGA CCTGAACCCG 
CGGCGGGACA TCTCCTCCTG GCTGGCCCAG TGGTTCCCTA GAACCCCAGC CAGGTCCGTG 
GTGGCCCTGA AGACCCCCAT CAAGGTGGAG CTGGTGGCAG GGAAAACCTA CAGGTGGTGT 
GTGTGTGGCC GCAGCAAGAA GCAGCCCTTC TGTGACGGCT CCCACTTCTT CCAACGCACT 
GGCCTATCTC CACTCAAGTT CAAGGCCCAA GAGACCCGCA TGGTGGCACT CTGTACCTGC 
AAGGCCACTC AGAGGCCCCC GTACTGCGAT GGCACCCACA GGAGTGAGCG CGTGCAGAAG 
GCAGAAGTGG GCTCCCCACT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129970.1
CDS	19..402
Translation	MRGAGAILRPAARGARDLNPRRDISSWLAQWFPRTPARSVVALKTPIKVELVAGKTYRWCVCGRSKKQPFCDGSHFFQRTGLSPLKFKAQETRMVALCTCKATQRPPYCDGTHRSERVQKAEVGSPL

Target ORF information:

RefSeq Version	NM_001136498.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CDGSH iron sulfur domain 3 (CISD3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001136498.2

ORF Insert Sequence:

ATGCGCGGCG CGGGGGCGAT CCTGCGGCCG GCGGCGCGTG GTGCCCGGGA CCTGAACCCG 
CGGCGGGACA TCTCCTCCTG GCTGGCCCAG TGGTTCCCTA GAACCCCAGC CAGGTCCGTG 
GTGGCCCTGA AGACCCCCAT CAAGGTGGAG CTGGTGGCAG GGAAAACCTA CAGGTGGTGT 
GTGTGTGGCC GCAGCAAGAA GCAGCCCTTC TGTGACGGCT CCCACTTCTT CCAACGCACT 
GGCCTATCTC CACTCAAGTT CAAGGCCCAA GAGACCCGCA TGGTGGCACT CTGTACCTGC 
AAGGCCACTC AGAGGCCCCC GTACTGCGAT GGCACCCACA GGAGTGAGCG CGTGCAGAAG 
GCAGAAGTGG GCTCCCCACT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CISD3 ( NM_001136498.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001129970.1 Homo sapiens CDGSH iron sulfur domain 3 (CISD3), mRNA.

Price & Availability↑

CloneID	OHu13698
Clone ID Related Accession (Same CDS sequence)	NM_001136498.2 , NM_001136498.1
Accession Version	NM_001136498.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	CDGSH iron-sulfur domain-containing protein 3, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC006449.19. On or before Nov 2, 2008 this sequence version replaced XM_001718346.1, XM_001714917.1, XM_001716624.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.196098.1, SRR1660805.49934.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGCGCGGCG CGGGGGCGAT CCTGCGGCCG GCGGCGCGTG GTGCCCGGGA CCTGAACCCG 
CGGCGGGACA TCTCCTCCTG GCTGGCCCAG TGGTTCCCTA GAACCCCAGC CAGGTCCGTG 
GTGGCCCTGA AGACCCCCAT CAAGGTGGAG CTGGTGGCAG GGAAAACCTA CAGGTGGTGT 
GTGTGTGGCC GCAGCAAGAA GCAGCCCTTC TGTGACGGCT CCCACTTCTT CCAACGCACT 
GGCCTATCTC CACTCAAGTT CAAGGCCCAA GAGACCCGCA TGGTGGCACT CTGTACCTGC 
AAGGCCACTC AGAGGCCCCC GTACTGCGAT GGCACCCACA GGAGTGAGCG CGTGCAGAAG 
GCAGAAGTGG GCTCCCCACT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129970.1
CDS	103..486
Translation	MRGAGAILRPAARGARDLNPRRDISSWLAQWFPRTPARSVVALKTPIKVELVAGKTYRWCVCGRSKKQPFCDGSHFFQRTGLSPLKFKAQETRMVALCTCKATQRPPYCDGTHRSERVQKAEVGSPL

Target ORF information:

RefSeq Version	NM_001136498.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CDGSH iron sulfur domain 3 (CISD3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001136498.1

ORF Insert Sequence:

ATGCGCGGCG CGGGGGCGAT CCTGCGGCCG GCGGCGCGTG GTGCCCGGGA CCTGAACCCG 
CGGCGGGACA TCTCCTCCTG GCTGGCCCAG TGGTTCCCTA GAACCCCAGC CAGGTCCGTG 
GTGGCCCTGA AGACCCCCAT CAAGGTGGAG CTGGTGGCAG GGAAAACCTA CAGGTGGTGT 
GTGTGTGGCC GCAGCAAGAA GCAGCCCTTC TGTGACGGCT CCCACTTCTT CCAACGCACT 
GGCCTATCTC CACTCAAGTT CAAGGCCCAA GAGACCCGCA TGGTGGCACT CTGTACCTGC 
AAGGCCACTC AGAGGCCCCC GTACTGCGAT GGCACCCACA GGAGTGAGCG CGTGCAGAAG 
GCAGAAGTGG GCTCCCCACT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structure of the human monomeric NEET protein MiNT and its role in regulating iron and reactive oxygen species in cancer cells.
Proceedings of the National Academy of Sciences of the United States of America115(2)272-277(2018 Jan)
Lipper CH,Karmi O,Sohn YS,Darash-Yahana M,Lammert H,Song L,Liu A,Mittler R,Nechushtai R,Onuchic JN,Jennings PA

The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster.
The Journal of biological chemistry282(33)23745-9(2007 Aug)
Wiley SE,Paddock ML,Abresch EC,Gross L,van der Geer P,Nechushtai R,Murphy AN,Jennings PA,Dixon JE

MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity.
Proceedings of the National Academy of Sciences of the United States of America104(13)5318-23(2007 Mar)
Wiley SE,Murphy AN,Ross SA,van der Geer P,Dixon JE

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CISD3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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