CLEC9A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLEC9A
Entrez Gene ID	283420
Full Name	C-type lectin domain containing 9A
Synonyms	CD370,DNGR-1,DNGR1,UNQ9341
General protein information	Preferred Names C-type lectin domain containing 9A Names C-type lectin domain family 9 member A HEEE9341
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.2
Summary	CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008].
Disorder MIM:	612252

mRNA and Protein(s)

mRNA	Protein	Name
NM_207345.4	NP_997228.1	C-type lectin domain family 9 member A
NM_207345.3	NP_997228.1	C-type lectin domain family 9 member A

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CLEC9A	XP_001143778.1
Canis lupus familiaris (dog)	CLEC9A	XP_854151.2
Mus musculus (house mouse)	Clec9a	NP_001192292.1
Rattus norvegicus (Norway rat)	Clec9a	NP_001102824.1
Homo sapiens (human)	CLEC9A	NP_997228.1
	CLEC9A	XP_001114857.1
Bos taurus (cattle)	LOC616060	XP_002687852.1

Gene Ontology
Bibliography

Related articles in PubMed

CLEC9A modulates macrophage-mediated neutrophil recruitment in response to heat-killed Mycobacterium tuberculosis H37Ra.
Cheng AC, Yang KY, Chen NJ, Hsu TL, Jou R, Hsieh SL, Tseng PH
PloS one12(10)e0186780(2017)

A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy.
Yan Z, Wu Y, Du J, Li G, Wang S, Cao W, Zhou X, Wu C, Zhang D, Jing X, Li Y, Wang H, Gao Y, Qi Y
Oncotarget7(26)40437-40450(2016 Jun)

BDCA3(+)CLEC9A(+) human dendritic cell function and development.
van der Aa E, van Montfoort N, Woltman AM
Seminars in cell & developmental biology4139-48(2015 May)

Increased tubulointerstitial recruitment of human CD141(hi) CLEC9A(+) and CD1c(+) myeloid dendritic cell subsets in renal fibrosis and chronic kidney disease.
Kassianos AJ, Wang X, Sampangi S, Muczynski K, Healy H, Wilkinson R
American journal of physiology. Renal physiology305(10)F1391-401(2013 Nov)

The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.
Zhang JG, Czabotar PE, Policheni AN, Caminschi I, Wan SS, Kitsoulis S, Tullett KM, Robin AY, Brammananth R, van Delft MF, Lu J, O'Reilly LA, Josefsson EC, Kile BT, Chin WJ, Mintern JD, Olshina MA, Wong W, Baum J, Wright MD, Huang DC, Mohandas N, Coppel RL, Colman PM, Nicola NA, Shortman K, Lahoud MH
Immunity36(4)646-57(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings demonstrate that CLEC9A is a specialized receptor that modulates the innate immune response when there is a mycobacterial infection
Title: CLEC9A modulates macrophage-mediated neutrophil recruitment in response to heat-killed Mycobacterium tuberculosis H37Ra.

Clec9a is responsible for the antigen cross-presentation of dendritic cell subsets and may be a target of immunotherapy
Title: A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy.

Data indicate that blood dendritic cell antigen 3 BDCA3(+) and C-type lectin domain family 9, member A CLEC9A(+) dendritic cells (DC) are of major importance in the induction of anti-viral and anti-tumor immunity.
Title: BDCA3(+)CLEC9A(+) human dendritic cell function and development.

Activated dendritic cell subsets expressing CD141/CLEA9A/CD1c, likely recruited into the tubulointerstitium, are positioned to play a role in the development of fibrosis and, thus, progression to chronic kidney disease.
Title: Increased tubulointerstitial recruitment of human CD141(hi) CLEC9A(+) and CD1c(+) myeloid dendritic cell subsets in renal fibrosis and chronic kidney disease.

propose that Clec9A provides targeted recruitment of the adaptive immune system during infection and can also be utilized to enhance immune responses generated by vaccines.
Title: The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.

The following CLEC9A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLEC9A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29183	NM_207345.4 Latest version!	Homo sapiens C-type lectin domain containing 9A (CLEC9A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
View Old Accession Versions >>
OHu29183	NM_207345.3	Homo sapiens C-type lectin domain containing 9A (CLEC9A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLEC9A ( NM_207345.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_997228.1 Homo sapiens C-type lectin domain containing 9A (CLEC9A), mRNA.

Price & Availability↑

CloneID	OHu29183
Clone ID Related Accession (Same CDS sequence)	NM_207345.4 , NM_207345.3
Accession Version	NM_207345.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	C-type lectin domain family 9 member A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY358265.1, DB090462.1, DB526089.1 and AC024224.33. On Nov 23, 2018 this sequence version replaced NM_207345.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358265.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000355819.6/ ENSP00000348074.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCACGAGG AAGAAATATA CACCTCTCTT CAGTGGGATA GCCCAGCACC AGACACTTAC 
CAGAAATGTC TGTCTTCCAA CAAATGTTCA GGAGCATGCT GTCTTGTGAT GGTGATTTCA 
TGTGTTTTCT GCATGGGATT ATTAACAGCA TCCATTTTCT TGGGCGTCAA GTTGTTGCAG 
GTGTCCACCA TTGCGATGCA GCAGCAAGAA AAACTCATCC AACAAGAGAG GGCACTGCTA 
AACTTTACAG AATGGAAGAG AAGCTGTGCC CTTCAGATGA AATATTGCCA AGCCTTCATG 
CAAAACTCAT TAAGTTCAGC CCATAACAGC AGTCCTTGTC CAAACAATTG GATTCAGAAC 
AGAGAAAGTT GTTACTATGT CTCTGAAATT TGGAGCATTT GGCACACCAG TCAAGAGAAT 
TGTTTAAAGG AAGGTTCCAC GCTGCTACAA ATAGAGAGCA AAGAAGAAAT GGATTTTATC 
ACTGGCAGCT TGAGGAAGAT TAAAGGAAGC TATGATTACT GGGTGGGGTT GTCTCAGGAT 
GGACACAGCG GACGCTGGCT TTGGCAAGAT GGCTCCTCTC CTTCTCCTGG CCTGTTGCCA 
GCAGAGAGAT CCCAGTCAGC TAACCAAGTC TGTGGATACG TGAAAAGCAA TTCCCTTCTT 
TCGTCTAACT GCAGCACGTG GAAGTATTTT ATCTGTGAGA AGTATGCGTT GAGATCCTCT 
GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997228.1
CDS	609..1334
Translation	MHEEEIYTSLQWDSPAPDTYQKCLSSNKCSGACCLVMVISCVFCMGLLTASIFLGVKLLQVSTIAMQQQEKLIQQERALLNFTEWKRSCALQMKYCQAFMQNSLSSAHNSSPCPNNWIQNRESCYYVSEIWSIWHTSQENCLKEGSTLLQIESKEEMDFITGSLRKIKGSYDYWVGLSQDGHSGRWLWQDGSSPSPGLLPAERSQSANQVCGYVKSNSLLSSNCSTWKYFICEKYALRSSV

Target ORF information:

RefSeq Version	NM_207345.4
Organism	Homo sapiens(human)
Definition	Homo sapiens C-type lectin domain containing 9A (CLEC9A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207345.4

ORF Insert Sequence:

ATGCACGAGG AAGAAATATA CACCTCTCTT CAGTGGGATA GCCCAGCACC AGACACTTAC 
CAGAAATGTC TGTCTTCCAA CAAATGTTCA GGAGCATGCT GTCTTGTGAT GGTGATTTCA 
TGTGTTTTCT GCATGGGATT ATTAACAGCA TCCATTTTCT TGGGCGTCAA GTTGTTGCAG 
GTGTCCACCA TTGCGATGCA GCAGCAAGAA AAACTCATCC AACAAGAGAG GGCACTGCTA 
AACTTTACAG AATGGAAGAG AAGCTGTGCC CTTCAGATGA AATATTGCCA AGCCTTCATG 
CAAAACTCAT TAAGTTCAGC CCATAACAGC AGTCCTTGTC CAAACAATTG GATTCAGAAC 
AGAGAAAGTT GTTACTATGT CTCTGAAATT TGGAGCATTT GGCACACCAG TCAAGAGAAT 
TGTTTAAAGG AAGGTTCCAC GCTGCTACAA ATAGAGAGCA AAGAAGAAAT GGATTTTATC 
ACTGGCAGCT TGAGGAAGAT TAAAGGAAGC TATGATTACT GGGTGGGGTT GTCTCAGGAT 
GGACACAGCG GACGCTGGCT TTGGCAAGAT GGCTCCTCTC CTTCTCCTGG CCTGTTGCCA 
GCAGAGAGAT CCCAGTCAGC TAACCAAGTC TGTGGATACG TGAAAAGCAA TTCCCTTCTT 
TCGTCTAACT GCAGCACGTG GAAGTATTTT ATCTGTGAGA AGTATGCGTT GAGATCCTCT 
GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLEC9A ( NM_207345.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_997228.1 Homo sapiens C-type lectin domain containing 9A (CLEC9A), mRNA.

Price & Availability↑

CloneID	OHu29183
Clone ID Related Accession (Same CDS sequence)	NM_207345.4 , NM_207345.3
Accession Version	NM_207345.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-19
Organism	Homo sapiens(human)
Product	C-type lectin domain family 9 member A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY358265.1, DB090462.1 and DB526089.1. On Feb 12, 2015 this sequence version replaced NM_207345.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358265.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGCACGAGG AAGAAATATA CACCTCTCTT CAGTGGGATA GCCCAGCACC AGACACTTAC 
CAGAAATGTC TGTCTTCCAA CAAATGTTCA GGAGCATGCT GTCTTGTGAT GGTGATTTCA 
TGTGTTTTCT GCATGGGATT ATTAACAGCA TCCATTTTCT TGGGCGTCAA GTTGTTGCAG 
GTGTCCACCA TTGCGATGCA GCAGCAAGAA AAACTCATCC AACAAGAGAG GGCACTGCTA 
AACTTTACAG AATGGAAGAG AAGCTGTGCC CTTCAGATGA AATATTGCCA AGCCTTCATG 
CAAAACTCAT TAAGTTCAGC CCATAACAGC AGTCCTTGTC CAAACAATTG GATTCAGAAC 
AGAGAAAGTT GTTACTATGT CTCTGAAATT TGGAGCATTT GGCACACCAG TCAAGAGAAT 
TGTTTAAAGG AAGGTTCCAC GCTGCTACAA ATAGAGAGCA AAGAAGAAAT GGATTTTATC 
ACTGGCAGCT TGAGGAAGAT TAAAGGAAGC TATGATTACT GGGTGGGGTT GTCTCAGGAT 
GGACACAGCG GACGCTGGCT TTGGCAAGAT GGCTCCTCTC CTTCTCCTGG CCTGTTGCCA 
GCAGAGAGAT CCCAGTCAGC TAACCAAGTC TGTGGATACG TGAAAAGCAA TTCCCTTCTT 
TCGTCTAACT GCAGCACGTG GAAGTATTTT ATCTGTGAGA AGTATGCGTT GAGATCCTCT 
GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997228.1
CDS	614..1339
Translation	MHEEEIYTSLQWDSPAPDTYQKCLSSNKCSGACCLVMVISCVFCMGLLTASIFLGVKLLQVSTIAMQQQEKLIQQERALLNFTEWKRSCALQMKYCQAFMQNSLSSAHNSSPCPNNWIQNRESCYYVSEIWSIWHTSQENCLKEGSTLLQIESKEEMDFITGSLRKIKGSYDYWVGLSQDGHSGRWLWQDGSSPSPGLLPAERSQSANQVCGYVKSNSLLSSNCSTWKYFICEKYALRSSV

Target ORF information:

RefSeq Version	NM_207345.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-type lectin domain containing 9A (CLEC9A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207345.3

ORF Insert Sequence:

ATGCACGAGG AAGAAATATA CACCTCTCTT CAGTGGGATA GCCCAGCACC AGACACTTAC 
CAGAAATGTC TGTCTTCCAA CAAATGTTCA GGAGCATGCT GTCTTGTGAT GGTGATTTCA 
TGTGTTTTCT GCATGGGATT ATTAACAGCA TCCATTTTCT TGGGCGTCAA GTTGTTGCAG 
GTGTCCACCA TTGCGATGCA GCAGCAAGAA AAACTCATCC AACAAGAGAG GGCACTGCTA 
AACTTTACAG AATGGAAGAG AAGCTGTGCC CTTCAGATGA AATATTGCCA AGCCTTCATG 
CAAAACTCAT TAAGTTCAGC CCATAACAGC AGTCCTTGTC CAAACAATTG GATTCAGAAC 
AGAGAAAGTT GTTACTATGT CTCTGAAATT TGGAGCATTT GGCACACCAG TCAAGAGAAT 
TGTTTAAAGG AAGGTTCCAC GCTGCTACAA ATAGAGAGCA AAGAAGAAAT GGATTTTATC 
ACTGGCAGCT TGAGGAAGAT TAAAGGAAGC TATGATTACT GGGTGGGGTT GTCTCAGGAT 
GGACACAGCG GACGCTGGCT TTGGCAAGAT GGCTCCTCTC CTTCTCCTGG CCTGTTGCCA 
GCAGAGAGAT CCCAGTCAGC TAACCAAGTC TGTGGATACG TGAAAAGCAA TTCCCTTCTT 
TCGTCTAACT GCAGCACGTG GAAGTATTTT ATCTGTGAGA AGTATGCGTT GAGATCCTCT 
GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CLEC9A modulates macrophage-mediated neutrophil recruitment in response to heat-killed Mycobacterium tuberculosis H37Ra.
PloS one12(10)e0186780(2017)
Cheng AC,Yang KY,Chen NJ,Hsu TL,Jou R,Hsieh SL,Tseng PH

A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy.
Oncotarget7(26)40437-40450(2016 Jun)
Yan Z,Wu Y,Du J,Li G,Wang S,Cao W,Zhou X,Wu C,Zhang D,Jing X,Li Y,Wang H,Gao Y,Qi Y

BDCA3(+)CLEC9A(+) human dendritic cell function and development.
Seminars in cell & developmental biology4139-48(2015 May)
van der Aa E,van Montfoort N,Woltman AM

Increased tubulointerstitial recruitment of human CD141(hi) CLEC9A(+) and CD1c(+) myeloid dendritic cell subsets in renal fibrosis and chronic kidney disease.
American journal of physiology. Renal physiology305(10)F1391-401(2013 Nov)
Kassianos AJ,Wang X,Sampangi S,Muczynski K,Healy H,Wilkinson R

The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.
Immunity36(4)646-57(2012 Apr)
Zhang JG,Czabotar PE,Policheni AN,Caminschi I,Wan SS,Kitsoulis S,Tullett KM,Robin AY,Brammananth R,van Delft MF,Lu J,O'Reilly LA,Josefsson EC,Kile BT,Chin WJ,Mintern JD,Olshina MA,Wong W,Baum J,Wright MD,Huang DC,Mohandas N,Coppel RL,Colman PM,Nicola NA,Shortman K,Lahoud MH

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CLEC9A cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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