KCNMB4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNMB4
Entrez Gene ID	27345
Full Name	potassium calcium-activated channel subfamily M regulatory beta subunit 4
General protein information	Preferred Names potassium calcium-activated channel subfamily M regulatory beta subunit 4 Names calcium-activated potassium channel subunit beta-4 BK channel beta subunit 4 BK channel subunit beta-4 BKbeta4 MaxiK channel beta-subunit 4 big potassium channel beta subunit 4 calcium-activated potassium channel, subfamily M subunit beta-4 charybdotoxin receptor subunit beta-4 hbeta4 k(VCA)beta-4 large conductance calcium-dependent potassium ion channel beta 4 subunit maxi K channel subunit beta-4 potassium channel subfamily M regulatory beta subunit 4 potassium large conductance calcium-activated channel, subfamily M, beta member 4 slo-beta-4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q15
Summary	MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008].
Disorder MIM:	605223

mRNA and Protein(s)

mRNA	Protein	Name
XM_011538188.2	XP_011536490.1	calcium-activated potassium channel subunit beta-4 isoform X1
NM_014505.5	NP_055320.4	calcium-activated potassium channel subunit beta-4
NM_014505.6	NP_055320.4	calcium-activated potassium channel subunit beta-4

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	KCNMB4	NP_001186559.1
Homo sapiens (human)	KCNMB4	NP_055320.4
Mus musculus (house mouse)	Kcnmb4	NP_067427.1
	LOC717360	XP_002798706.1
Canis lupus familiaris (dog)	KCNMB4	XP_005625718.1
Xenopus tropicalis (tropical clawed frog)	kcnmb4	NP_001017211.1
Pan troglodytes (chimpanzee)	KCNMB4	XP_001156630.1
Bos taurus (cattle)	KCNMB4	NP_001179452.1
Rattus norvegicus (Norway rat)	Kcnmb4	NP_076450.1

Gene Ontology
Bibliography

Related articles in PubMed

Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor cell motility in human osteosarcoma.
Yang J, Annala M, Ji P, Wang G, Zheng H, Codgell D, Du X, Fang Z, Sun B, Nykter M, Chen K, Zhang W
Journal of hematology & oncology776(2014 Oct)

Large conductance voltage- and Ca2+-gated potassium (BK) channel ?4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases.
Vel?zquez-Marrero C, Seale GE, Treistman SN, Martin GE
The Journal of biological chemistry289(42)29261-72(2014 Oct)

Recombinant expression and functional characterization of martentoxin: a selective inhibitor for BK channel (? + ?4).
Tao J, Zhou ZL, Wu B, Shi J, Chen XM, Ji YH
Toxins6(4)1419-33(2014 Apr)

IFN-?-mediated reduction of large-conductance, Ca2+-activated, voltage-dependent K+ (BK) channel activity in airway epithelial cells leads to mucociliary dysfunction.
Manzanares D, Srinivasan M, Salathe ST, Ivonnet P, Baumlin N, Dennis JS, Conner GE, Salathe M
American journal of physiology. Lung cellular and molecular physiology306(5)L453-62(2014 Mar)

An endoplasmic reticulum trafficking signal regulates surface expression of ?4 subunit of a voltage- and Ca??-activated K? channel.
Cox N, Toro B, Pacheco-Otalora LF, Garrido-Sanabria ER, Zarei MM
Brain research155312-23(2014 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Two recurrent fusion genes associated with the 12q locus, LRP1-SNRNP25 and KCNMB4-CCND3, were by RT-PCR, Sanger sequencing and FISH, and were found to be osteosarcoma specific in a validation cohort of 240 other sarcomas.
Title: Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor cell motility in human osteosarcoma.

BK channel beta4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases
Title: Large conductance voltage- and Ca2+-gated potassium (BK) channel ?4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases.

Recombinant martentoxin selectively blocks KCNMA1/KCNMB4 channels.
Title: Recombinant expression and functional characterization of martentoxin: a selective inhibitor for BK channel (? + ?4).

IFN-gamma changed mRNA levels of the BK beta-modulatory proteins KCNMB2 (increased) and KCNMB4 (decreased) as well as leucine-rich repeat-containing protein (LRRC)26 (decreased).
Title: IFN-?-mediated reduction of large-conductance, Ca2+-activated, voltage-dependent K+ (BK) channel activity in airway epithelial cells leads to mucociliary dysfunction.

Study shows that beta4 subunit of the MaxiK channel has no potential endocytic signal and 2 specific amino acids in the functional basic motif retention/retrieval trafficking signal at the C-terminus may play a role in controlling cellular excitability
Title: An endoplasmic reticulum trafficking signal regulates surface expression of ?4 subunit of a voltage- and Ca??-activated K? channel.

The following KCNMB4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNMB4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14220	NM_014505.6 Latest version!	Homo sapiens potassium calcium-activated channel subfamily M regulatory beta subunit 4 (KCNMB4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu67224	XM_011538188.2 Latest version!	Homo sapiens potassium calcium-activated channel subfamily M regulatory beta subunit 4 (KCNMB4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu14220	NM_014505.5	Homo sapiens potassium calcium-activated channel subfamily M regulatory beta subunit 4 (KCNMB4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNMB4 ( NM_014505.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055320.4 Homo sapiens potassium calcium-activated channel subfamily M regulatory beta subunit 4 (KCNMB4), mRNA.

Price & Availability↑

CloneID	OHu14220
Clone ID Related Accession (Same CDS sequence)	NM_014505.5 , NM_014505.6
Accession Version	NM_014505.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	calcium-activated potassium channel subunit beta-4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC025569.37 and BC042446.2. On Jul 29, 2011 this sequence version replaced NM_014505.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.193257.1, SRR1660803.206977.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGAAGC TCCGGGTGGC TTACGAGTAC ACGGAAGCCG AGGACAAGAG CATCCGGCTC 
GGCTTGTTTC TCATCATCTC CGGCGTCGTG TCGCTCTTCA TCTTCGGCTT CTGCTGGCTG 
AGTCCCGCGC TGCAGGATCT GCAAGCCACG GAGGCCAATT GCACGGTGCT GTCGGTGCAG 
CAGATCGGCG AGGTGTTCGA GTGCACCTTC ACCTGTGGCG CCGACTGCAG GGGCACCTCG 
CAGTACCCCT GCGTCCAGGT CTACGTGAAC AACTCTGAGT CCAACTCTAG GGCGCTGCTG 
CACAGCGACG AGCACCAGCT CCTGACCAAC CCCAAGTGCT CCTATATCCC TCCCTGTAAG 
AGAGAAAATC AGAAGAATTT GGAAAGTGTC ATGAATTGGC AACAGTACTG GAAAGATGAG 
ATTGGTTCCC AGCCATTTAC TTGCTATTTT AATCAACATC AAAGACCAGA TGATGTGCTT 
CTGCATCGCA CTCATGATGA GATTGTCCTC CTGCATTGCT TCCTCTGGCC CCTGGTGACA 
TTTGTGGTGG GCGTTCTCAT TGTGGTCCTG ACCATCTGTG CCAAGAGCTT GGCGGTCAAG 
GCGGAAGCCA TGAAGAAGCG CAAGTTCTCT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055320.4
CDS	454..1086
Translation	MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVTFVVGVLIVVLTICAKSLAVKAEAMKKRKFS

Target ORF information:

RefSeq Version	NM_014505.5
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium calcium-activated channel subfamily M regulatory beta subunit 4 (KCNMB4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014505.5

ORF Insert Sequence:

ATGGCGAAGC TCCGGGTGGC TTACGAGTAC ACGGAAGCCG AGGACAAGAG CATCCGGCTC 
GGCTTGTTTC TCATCATCTC CGGCGTCGTG TCGCTCTTCA TCTTCGGCTT CTGCTGGCTG 
AGTCCCGCGC TGCAGGATCT GCAAGCCACG GAGGCCAATT GCACGGTGCT GTCGGTGCAG 
CAGATCGGCG AGGTGTTCGA GTGCACCTTC ACCTGTGGCG CCGACTGCAG GGGCACCTCG 
CAGTACCCCT GCGTCCAGGT CTACGTGAAC AACTCTGAGT CCAACTCTAG GGCGCTGCTG 
CACAGCGACG AGCACCAGCT CCTGACCAAC CCCAAGTGCT CCTATATCCC TCCCTGTAAG 
AGAGAAAATC AGAAGAATTT GGAAAGTGTC ATGAATTGGC AACAGTACTG GAAAGATGAG 
ATTGGTTCCC AGCCATTTAC TTGCTATTTT AATCAACATC AAAGACCAGA TGATGTGCTT 
CTGCATCGCA CTCATGATGA GATTGTCCTC CTGCATTGCT TCCTCTGGCC CCTGGTGACA 
TTTGTGGTGG GCGTTCTCAT TGTGGTCCTG ACCATCTGTG CCAAGAGCTT GGCGGTCAAG 
GCGGAAGCCA TGAAGAAGCG CAAGTTCTCT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNMB4 ( NM_014505.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_055320.4 Homo sapiens potassium calcium-activated channel subfamily M regulatory beta subunit 4 (KCNMB4), mRNA.

Price & Availability↑

CloneID	OHu14220
Clone ID Related Accession (Same CDS sequence)	NM_014505.5 , NM_014505.6
Accession Version	NM_014505.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	calcium-activated potassium channel subunit beta-4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC025569.37 and BC042446.2. On Nov 22, 2018 this sequence version replaced NM_014505.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.193257.1, SRR1660803.206977.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000258111.5/ ENSP00000258111.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGAAGC TCCGGGTGGC TTACGAGTAC ACGGAAGCCG AGGACAAGAG CATCCGGCTC 
GGCTTGTTTC TCATCATCTC CGGCGTCGTG TCGCTCTTCA TCTTCGGCTT CTGCTGGCTG 
AGTCCCGCGC TGCAGGATCT GCAAGCCACG GAGGCCAATT GCACGGTGCT GTCGGTGCAG 
CAGATCGGCG AGGTGTTCGA GTGCACCTTC ACCTGTGGCG CCGACTGCAG GGGCACCTCG 
CAGTACCCCT GCGTCCAGGT CTACGTGAAC AACTCTGAGT CCAACTCTAG GGCGCTGCTG 
CACAGCGACG AGCACCAGCT CCTGACCAAC CCCAAGTGCT CCTATATCCC TCCCTGTAAG 
AGAGAAAATC AGAAGAATTT GGAAAGTGTC ATGAATTGGC AACAGTACTG GAAAGATGAG 
ATTGGTTCCC AGCCATTTAC TTGCTATTTT AATCAACATC AAAGACCAGA TGATGTGCTT 
CTGCATCGCA CTCATGATGA GATTGTCCTC CTGCATTGCT TCCTCTGGCC CCTGGTGACA 
TTTGTGGTGG GCGTTCTCAT TGTGGTCCTG ACCATCTGTG CCAAGAGCTT GGCGGTCAAG 
GCGGAAGCCA TGAAGAAGCG CAAGTTCTCT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055320.4
CDS	446..1078
Translation	MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVTFVVGVLIVVLTICAKSLAVKAEAMKKRKFS

Target ORF information:

RefSeq Version	NM_014505.6
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium calcium-activated channel subfamily M regulatory beta subunit 4 (KCNMB4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014505.6

ORF Insert Sequence:

ATGGCGAAGC TCCGGGTGGC TTACGAGTAC ACGGAAGCCG AGGACAAGAG CATCCGGCTC 
GGCTTGTTTC TCATCATCTC CGGCGTCGTG TCGCTCTTCA TCTTCGGCTT CTGCTGGCTG 
AGTCCCGCGC TGCAGGATCT GCAAGCCACG GAGGCCAATT GCACGGTGCT GTCGGTGCAG 
CAGATCGGCG AGGTGTTCGA GTGCACCTTC ACCTGTGGCG CCGACTGCAG GGGCACCTCG 
CAGTACCCCT GCGTCCAGGT CTACGTGAAC AACTCTGAGT CCAACTCTAG GGCGCTGCTG 
CACAGCGACG AGCACCAGCT CCTGACCAAC CCCAAGTGCT CCTATATCCC TCCCTGTAAG 
AGAGAAAATC AGAAGAATTT GGAAAGTGTC ATGAATTGGC AACAGTACTG GAAAGATGAG 
ATTGGTTCCC AGCCATTTAC TTGCTATTTT AATCAACATC AAAGACCAGA TGATGTGCTT 
CTGCATCGCA CTCATGATGA GATTGTCCTC CTGCATTGCT TCCTCTGGCC CCTGGTGACA 
TTTGTGGTGG GCGTTCTCAT TGTGGTCCTG ACCATCTGTG CCAAGAGCTT GGCGGTCAAG 
GCGGAAGCCA TGAAGAAGCG CAAGTTCTCT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNMB4 ( XM_011538188.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011536490.1 Homo sapiens potassium calcium-activated channel subfamily M regulatory beta subunit 4 (KCNMB4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu67224
Clone ID Related Accession (Same CDS sequence)	XM_011538188.2
Accession Version	XM_011538188.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	calcium-activated potassium channel subunit beta-4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011538188.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGAAGC TCCGGGTGGC TTACGAGTAC ACGGAAGCCG AGGACAAGAG CATCCGGCTC 
GGCTTGTTTC TCATCATCTC CGGCGTCGTG TCGCTCTTCA TCTTCGGCTT CTGCTGGCTG 
AGTCCCGCGC TGCAGGATCT GCAAGCCACG GAGGCCAATT GCACGGTGCT GTCGGTGCAG 
CAGATCGGCG AGGTGTTCGA GTGCACCTTC ACCTGTGGCG CCGACTGCAG GGGCACCTCG 
CAGTACCCCT GCGTCCAGGT CTACGTGAAC AACTCTGAGT CCAACTCTAG GGCGCTGCTG 
CACAGCGACG AGCACCAGCT CCTGACCAAC CCCAAGTGCT CCTATATCCC TCCCTGTAAG 
AGAGAAAATC AGAAGAATTT GGAAAGTGTC ATGAATTGGC AACAGTACTG GAAAGATGAG 
ATTGGTTCCC AGCCATTTAC TTGCTATTTT AATCAACATC AAAGGATAAA GGCCATGCTC 
TTCCAATTCC AACTTAAACT TCTGCCATTG AATTATGTGC CAGTCAAGGA AAACCAAAGA 
CAAAACAACA AGAAAACAAC AACAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011536490.1
CDS	516..1085
Translation	MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRIKAMLFQFQLKLLPLNYVPVKENQRQNNKKTTTK

Target ORF information:

RefSeq Version	XM_011538188.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium calcium-activated channel subfamily M regulatory beta subunit 4 (KCNMB4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011538188.2

ORF Insert Sequence:

ATGGCGAAGC TCCGGGTGGC TTACGAGTAC ACGGAAGCCG AGGACAAGAG CATCCGGCTC 
GGCTTGTTTC TCATCATCTC CGGCGTCGTG TCGCTCTTCA TCTTCGGCTT CTGCTGGCTG 
AGTCCCGCGC TGCAGGATCT GCAAGCCACG GAGGCCAATT GCACGGTGCT GTCGGTGCAG 
CAGATCGGCG AGGTGTTCGA GTGCACCTTC ACCTGTGGCG CCGACTGCAG GGGCACCTCG 
CAGTACCCCT GCGTCCAGGT CTACGTGAAC AACTCTGAGT CCAACTCTAG GGCGCTGCTG 
CACAGCGACG AGCACCAGCT CCTGACCAAC CCCAAGTGCT CCTATATCCC TCCCTGTAAG 
AGAGAAAATC AGAAGAATTT GGAAAGTGTC ATGAATTGGC AACAGTACTG GAAAGATGAG 
ATTGGTTCCC AGCCATTTAC TTGCTATTTT AATCAACATC AAAGGATAAA GGCCATGCTC 
TTCCAATTCC AACTTAAACT TCTGCCATTG AATTATGTGC CAGTCAAGGA AAACCAAAGA 
CAAAACAACA AGAAAACAAC AACAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor cell motility in human osteosarcoma.
Journal of hematology & oncology776(2014 Oct)
Yang J,Annala M,Ji P,Wang G,Zheng H,Codgell D,Du X,Fang Z,Sun B,Nykter M,Chen K,Zhang W

Large conductance voltage- and Ca2+-gated potassium (BK) channel ?4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases.
The Journal of biological chemistry289(42)29261-72(2014 Oct)
Vel?zquez-Marrero C,Seale GE,Treistman SN,Martin GE

Recombinant expression and functional characterization of martentoxin: a selective inhibitor for BK channel (? + ?4).
Toxins6(4)1419-33(2014 Apr)
Tao J,Zhou ZL,Wu B,Shi J,Chen XM,Ji YH

IFN-?-mediated reduction of large-conductance, Ca2+-activated, voltage-dependent K+ (BK) channel activity in airway epithelial cells leads to mucociliary dysfunction.
American journal of physiology. Lung cellular and molecular physiology306(5)L453-62(2014 Mar)
Manzanares D,Srinivasan M,Salathe ST,Ivonnet P,Baumlin N,Dennis JS,Conner GE,Salathe M

An endoplasmic reticulum trafficking signal regulates surface expression of ?4 subunit of a voltage- and Ca??-activated K? channel.
Brain research155312-23(2014 Mar)
Cox N,Toro B,Pacheco-Otalora LF,Garrido-Sanabria ER,Zarei MM

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KCNMB4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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