LDOC1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LDOC1
Entrez Gene ID	23641
Full Name	LDOC1, regulator of NFKB signaling
Synonyms	BCUR1,Mar7,Mart7,RTL7,SIRH7
General protein information	Preferred Names LDOC1, regulator of NFKB signaling Names protein LDOC1 Sushi-Ichi retrotransposon homolog 7 breast cancer, up-regulated 1 leucine zipper down-regulated in cancer 1 leucine zipper downregulated in cancer leucine zipper protein down-regulated in cancer cells mammalian retrotransposon-derived 7 retrotransposon Gag like 7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq27.1
Summary	The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008].
Disorder MIM:	300402

mRNA and Protein(s)

mRNA	Protein	Name
NM_012317.4	NP_036449.1	protein LDOC1
NM_012317.3	NP_036449.1	protein LDOC1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC100855971	XP_003640282.1
Bos taurus (cattle)	LDOC1	NP_001075013.1
Homo sapiens (human)	LDOC1	NP_036449.1
Pan troglodytes (chimpanzee)	LOC100614906	XP_003317782.1
	LDOC1	XP_001085397.1
Mus musculus (house mouse)	Ldoc1	NP_001018097.1
Rattus norvegicus (Norway rat)	Ldoc1	XP_006257679.1

Gene Ontology
Bibliography

Related articles in PubMed

NF-?B upregulation through epigenetic silencing of LDOC1 drives tumor biology and specific immunophenotype in Group A ependymoma.
Griesinger AM, Witt DA, Grob ST, Georgio Westover SR, Donson AM, Sanford B, Mulcahy Levy JM, Wong R, Moreira DC, DeSisto JA, Balakrishnan I, Hoffman LM, Handler MH, Jones KL, Vibhakar R, Venkataraman S, Foreman NK
Neuro-oncology19(10)1350-1360(2017 Oct)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

LDOC1 regulates Wnt5a expression and osteosarcoma cell metastasis and is correlated with the survival of osteosarcoma patients.
Yong BC, Lu JC, Xie XB, Su Q, Tan PX, Tang QL, Wang J, Huang G, Han J, Xu HW, Shen JN
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(2)1010428317691188(2017 Feb)

Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.
Thi?baut R, Esmiol S, Lecine P, Mahfouz B, Hermant A, Nicoletti C, Parnis S, Perroy J, Borg JP, Pascoe L, Hugot JP, Ollendorff V
PloS one11(11)e0165420(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data show that LDOC1 is a tumor suppressor in osteosarcoma, and that it regulates metastasis of osteosarcoma cells. Furthermore, LDOC1 might be a valuable prognostic marker in osteosarcomas.
Title: LDOC1 regulates Wnt5a expression and osteosarcoma cell metastasis and is correlated with the survival of osteosarcoma patients.

GNL3L-LDOC1 interplay regulates cell proliferation through the modulation of NF-kappaB pathway during tumorigenesis.
Title: Leucine Zipper Down-regulated in Cancer-1 (LDOC1) interacts with Guanine nucleotide binding protein-like 3-like (GNL3L) to modulate Nuclear Factor-kappa B (NF-?B) signaling during cell proliferation.

These finding of this study suggested that the hypothesize that LDOC1 gene upregulation may play a role in the spermatogenesis derangement observed in patients with Klinefelter Syndrome.
Title: LDOC1 Gene Expression in Men With Klinefelter Syndrome.

LDOC1 inhibits proliferation and promotes apoptosis by repressing NF-kappaB activation in papillary thyroid carcinoma
Title: LDOC1 inhibits proliferation and promotes apoptosis by repressing NF-?B activation in papillary thyroid carcinoma.

Cigarette smoke-induced promoter methylation may contribute to LDOC1 downregulation, thereby conferring oncogenic features to oral cells.
Title: LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation.

The following LDOC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LDOC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14307	NM_012317.4 Latest version!	Homo sapiens LDOC1 regulator of NFKB signaling (LDOC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu14307	NM_012317.3	Homo sapiens LDOC1 regulator of NFKB signaling (LDOC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LDOC1 ( NM_012317.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036449.1 Homo sapiens LDOC1 regulator of NFKB signaling (LDOC1), mRNA.

Price & Availability↑

CloneID	OHu14307
Clone ID Related Accession (Same CDS sequence)	NM_012317.4 , NM_012317.3
Accession Version	NM_012317.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	protein LDOC1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC234778.5. On May 17, 2019 this sequence version replaced NM_012317.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR7410570.694082.1, SRR7410570.694085.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370526.5/ ENSP00000359557.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGGATG AGTTGGTGCT GCTGCTGCAC GCGCTCCTGA TGCGGCACCG CGCCCTGAGC 
ATCGAGAACA GCCAGCTCAT GGAACAGCTG CGGCTGCTGG TGTGCGAGAG GGCCAGCCTG 
CTGCGCCAGG TACGTCCGCC GAGCTGCCCG GTGCCCTTCC CCGAAACGTT TAATGGCGAG 
AGCTCCCGGC TCCCCGAGTT TATCGTGCAG ACGGCGTCTT ACATGCTCGT GAACGAGAAC 
CGATTCTGCA ACGACGCCAT GAAGGTGGCA TTCCTAATCA GCCTCCTCAC CGGGGAAGCC 
GAGGAGTGGG TGGTGCCCTA CATCGAGATG GATAGCCCCA TCCTAGGTGA TTACCGGGCC 
TTCCTCGATG AGATGAAACA GTGCTTTGGC TGGGATGACG ACGAAGACGA CGACGACGAA 
GAAGAGGAGG ATGATTATTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036449.1
CDS	109..549
Translation	MVDELVLLLHALLMRHRALSIENSQLMEQLRLLVCERASLLRQVRPPSCPVPFPETFNGESSRLPEFIVQTASYMLVNENRFCNDAMKVAFLISLLTGEAEEWVVPYIEMDSPILGDYRAFLDEMKQCFGWDDDEDDDDEEEEDDY

Target ORF information:

RefSeq Version	NM_012317.4
Organism	Homo sapiens(human)
Definition	Homo sapiens LDOC1 regulator of NFKB signaling (LDOC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012317.4

ORF Insert Sequence:

ATGGTGGATG AGTTGGTGCT GCTGCTGCAC GCGCTCCTGA TGCGGCACCG CGCCCTGAGC 
ATCGAGAACA GCCAGCTCAT GGAACAGCTG CGGCTGCTGG TGTGCGAGAG GGCCAGCCTG 
CTGCGCCAGG TACGTCCGCC GAGCTGCCCG GTGCCCTTCC CCGAAACGTT TAATGGCGAG 
AGCTCCCGGC TCCCCGAGTT TATCGTGCAG ACGGCGTCTT ACATGCTCGT GAACGAGAAC 
CGATTCTGCA ACGACGCCAT GAAGGTGGCA TTCCTAATCA GCCTCCTCAC CGGGGAAGCC 
GAGGAGTGGG TGGTGCCCTA CATCGAGATG GATAGCCCCA TCCTAGGTGA TTACCGGGCC 
TTCCTCGATG AGATGAAACA GTGCTTTGGC TGGGATGACG ACGAAGACGA CGACGACGAA 
GAAGAGGAGG ATGATTATTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LDOC1 ( NM_012317.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036449.1 Homo sapiens LDOC1 regulator of NFKB signaling (LDOC1), mRNA.

Price & Availability↑

CloneID	OHu14307
Clone ID Related Accession (Same CDS sequence)	NM_012317.4 , NM_012317.3
Accession Version	NM_012317.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-22
Organism	Homo sapiens(human)
Product	protein LDOC1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC234778.5. On Sep 5, 2013 this sequence version replaced NM_012317.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGGTGGATG AGTTGGTGCT GCTGCTGCAC GCGCTCCTGA TGCGGCACCG CGCCCTGAGC 
ATCGAGAACA GCCAGCTCAT GGAACAGCTG CGGCTGCTGG TGTGCGAGAG GGCCAGCCTG 
CTGCGCCAGG TACGTCCGCC GAGCTGCCCG GTGCCCTTCC CCGAAACGTT TAATGGCGAG 
AGCTCCCGGC TCCCCGAGTT TATCGTGCAG ACGGCGTCTT ACATGCTCGT GAACGAGAAC 
CGATTCTGCA ACGACGCCAT GAAGGTGGCA TTCCTAATCA GCCTCCTCAC CGGGGAAGCC 
GAGGAGTGGG TGGTGCCCTA CATCGAGATG GATAGCCCCA TCCTAGGTGA TTACCGGGCC 
TTCCTCGATG AGATGAAACA GTGCTTTGGC TGGGATGACG ACGAAGACGA CGACGACGAA 
GAAGAGGAGG ATGATTATTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036449.1
CDS	194..634
Translation	MVDELVLLLHALLMRHRALSIENSQLMEQLRLLVCERASLLRQVRPPSCPVPFPETFNGESSRLPEFIVQTASYMLVNENRFCNDAMKVAFLISLLTGEAEEWVVPYIEMDSPILGDYRAFLDEMKQCFGWDDDEDDDDEEEEDDY

Target ORF information:

RefSeq Version	NM_012317.3
Organism	Homo sapiens(human)
Definition	Homo sapiens LDOC1 regulator of NFKB signaling (LDOC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012317.3

ORF Insert Sequence:

ATGGTGGATG AGTTGGTGCT GCTGCTGCAC GCGCTCCTGA TGCGGCACCG CGCCCTGAGC 
ATCGAGAACA GCCAGCTCAT GGAACAGCTG CGGCTGCTGG TGTGCGAGAG GGCCAGCCTG 
CTGCGCCAGG TACGTCCGCC GAGCTGCCCG GTGCCCTTCC CCGAAACGTT TAATGGCGAG 
AGCTCCCGGC TCCCCGAGTT TATCGTGCAG ACGGCGTCTT ACATGCTCGT GAACGAGAAC 
CGATTCTGCA ACGACGCCAT GAAGGTGGCA TTCCTAATCA GCCTCCTCAC CGGGGAAGCC 
GAGGAGTGGG TGGTGCCCTA CATCGAGATG GATAGCCCCA TCCTAGGTGA TTACCGGGCC 
TTCCTCGATG AGATGAAACA GTGCTTTGGC TGGGATGACG ACGAAGACGA CGACGACGAA 
GAAGAGGAGG ATGATTATTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NF-?B upregulation through epigenetic silencing of LDOC1 drives tumor biology and specific immunophenotype in Group A ependymoma.
Neuro-oncology19(10)1350-1360(2017 Oct)
Griesinger AM,Witt DA,Grob ST,Georgio Westover SR,Donson AM,Sanford B,Mulcahy Levy JM,Wong R,Moreira DC,DeSisto JA,Balakrishnan I,Hoffman LM,Handler MH,Jones KL,Vibhakar R,Venkataraman S,Foreman NK

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

LDOC1 regulates Wnt5a expression and osteosarcoma cell metastasis and is correlated with the survival of osteosarcoma patients.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(2)1010428317691188(2017 Feb)
Yong BC,Lu JC,Xie XB,Su Q,Tan PX,Tang QL,Wang J,Huang G,Han J,Xu HW,Shen JN

Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.
PloS one11(11)e0165420(2016)
Thi?baut R,Esmiol S,Lecine P,Mahfouz B,Hermant A,Nicoletti C,Parnis S,Perroy J,Borg JP,Pascoe L,Hugot JP,Ollendorff V

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LDOC1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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