SEC61G cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SEC61G
Entrez Gene ID	23480
Full Name	Sec61 translocon gamma subunit
Synonyms	SSS1
General protein information	Preferred Names Sec61 translocon gamma subunit Names protein transport protein Sec61 subunit gamma Sec61 gamma subunit protein transport protein SEC61 gamma subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p11.2
Summary	The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
Disorder MIM:	609215

mRNA and Protein(s)

mRNA	Protein	Name
NM_014302.3	NP_055117.1	protein transport protein Sec61 subunit gamma
NM_014302.4	NP_055117.1	protein transport protein Sec61 subunit gamma
NM_001012456.1	NP_001012474.1	protein transport protein Sec61 subunit gamma

Pathways from BioSystems

Homologies

	SEC61G	XP_001107920.1
Canis lupus familiaris (dog)	SEC61G	NP_001003325.1
Mus musculus (house mouse)	LOC102636652	XP_006519935.1
Mus musculus (house mouse)	LOC102640296	XP_006503573.1
Mus musculus (house mouse)	LOC102637269	XP_006496454.1
Drosophila melanogaster (fruit fly)	Sec61gamma	NP_608337.1
Mus musculus (house mouse)	Gm4184	XP_006514454.1
Caenorhabditis elegans (roundworm)	emo-1	NP_505778.1
Xenopus tropicalis (tropical clawed frog)	sec61g	XP_002939959.1
Bos taurus (cattle)	SEC61G	NP_001035676.1
Arabidopsis thaliana (thale cress)	AT4G24920	NP_194222.1
Oryza sativa (rice)	Os02g0178400	NP_001046076.1
Homo sapiens (human)	SEC61G	NP_001012474.1
Mus musculus (house mouse)	Gm10177	XP_001478570.2
Drosophila melanogaster (fruit fly)	CG8860	NP_610738.1
Arabidopsis thaliana (thale cress)	AT5G50460	NP_568728.1
Oryza sativa (rice)	Os06g0653900	NP_001058242.1
Pan troglodytes (chimpanzee)	SEC61G	XP_003318489.1
Mus musculus (house mouse)	Sec61g	NP_035473.2
Rattus norvegicus (Norway rat)	LOC499136	NP_001041402.1
Gallus gallus (chicken)	SEC61G	XP_001236152.2
Danio rerio (zebrafish)	sec61g	NP_001002499.2

Gene Ontology
Bibliography

Related articles in PubMed

Novel
Servidei T, Meco D, Muto V, Bruselles A, Ciolfi A, Trivieri N, Lucchini M, Morosetti R, Mirabella M, Martini M, Caldarelli M, Lasorella A, Tartaglia M, Riccardi R
Cancer research77(21)5860-5872(2017 Nov)

Genetic loci associated with circulating levels of very long-chain saturated fatty acids.
Lemaitre RN, King IB, Kabagambe EK, Wu JH, McKnight B, Manichaikul A, Guan W, Sun Q, Chasman DI, Foy M, Wang L, Zhu J, Siscovick DS, Tsai MY, Arnett DK, Psaty BM, Djousse L, Chen YD, Tang W, Weng LC, Wu H, Jensen MK, Chu AY, Jacobs DR Jr, Rich SS, Mozaffarian D, Steffen L, Rimm EB, Hu FB, Ridker PM, Fornage M, Friedlander Y
Journal of lipid research56(1)176-84(2015 Jan)

GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
Armstrong DL, Zidovetzki R, Alarc?n-Riquelme ME, Tsao BP, Criswell LA, Kimberly RP, Harley JB, Sivils KL, Vyse TJ, Gaffney PM, Langefeld CD, Jacob CO
Genes and immunity15(6)347-54(2014 Sep)

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.
Mackinnon AL, Paavilainen VO, Sharma A, Hegde RS, Taunton J
eLife3e01483(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sequencing of childhood ependymoma samples indicate Sec61 gamma subunit protein (SEC61G)-epidermal growth factor receptor (EGFR) chimeric mRNAs in one infratentorial ependymoma , arguing that this fusion occurs in a small proportion of these tumors.
Title: Novel

Cotransin, a substrate-selective Sec61 inhibitor, traps nascent transmembrane domains in the cytosolic vestibule, permitting detailed interrogation of an early pre-integration intermediate.
Title: An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.

The following SEC61G gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SEC61G cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04044	NM_014302.4 Latest version!	Homo sapiens SEC61 translocon subunit gamma (SEC61G), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04044	NM_001012456.1 Latest version!	Homo sapiens SEC61 translocon subunit gamma (SEC61G), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu04044	NM_014302.3	Homo sapiens Sec61 translocon gamma subunit (SEC61G), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SEC61G ( NM_014302.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055117.1 Homo sapiens Sec61 translocon gamma subunit (SEC61G), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04044
Clone ID Related Accession (Same CDS sequence)	NM_014302.3 , NM_014302.4 , NM_001012456.1
Accession Version	NM_014302.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 207bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-29
Organism	Homo sapiens(human)
Product	protein transport protein Sec61 subunit gamma
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU932672.1, AF086539.1 and CD385140.1. On Feb 24, 2005 this sequence version replaced NM_014302.2. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: BU566026.1, AF054184.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATCAGG TAATGCAGTT TGTTGAGCCA AGTCGGCAGT TTGTAAAGGA CTCCATTCGG 
CTGGTTAAAA GATGCACTAA ACCTGATAGA AAAGAATTCC AGAAGATTGC CATGGCAACA 
GCAATAGGAT TTGCTATAAT GGGATTCATT GGCTTCTTTG TGAAATTGAT CCATATTCCT 
ATTAATAACA TCATTGTTGG TGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055117.1
CDS	96..302
Translation	MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG

Target ORF information:

RefSeq Version	NM_014302.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Sec61 translocon gamma subunit (SEC61G), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014302.3

ORF Insert Sequence:

ATGGATCAGG TAATGCAGTT TGTTGAGCCA AGTCGGCAGT TTGTAAAGGA CTCCATTCGG 
CTGGTTAAAA GATGCACTAA ACCTGATAGA AAAGAATTCC AGAAGATTGC CATGGCAACA 
GCAATAGGAT TTGCTATAAT GGGATTCATT GGCTTCTTTG TGAAATTGAT CCATATTCCT 
ATTAATAACA TCATTGTTGG TGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SEC61G ( NM_014302.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055117.1 Homo sapiens SEC61 translocon subunit gamma (SEC61G), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04044
Clone ID Related Accession (Same CDS sequence)	NM_014302.3 , NM_014302.4 , NM_001012456.1
Accession Version	NM_014302.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 207bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	protein transport protein Sec61 subunit gamma
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU932672.1, AF086539.1 and CD385140.1. On Nov 23, 2018 this sequence version replaced NM_014302.3. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB107787.1, HY068417.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000352861.9/ ENSP00000341538.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATCAGG TAATGCAGTT TGTTGAGCCA AGTCGGCAGT TTGTAAAGGA CTCCATTCGG 
CTGGTTAAAA GATGCACTAA ACCTGATAGA AAAGAATTCC AGAAGATTGC CATGGCAACA 
GCAATAGGAT TTGCTATAAT GGGATTCATT GGCTTCTTTG TGAAATTGAT CCATATTCCT 
ATTAATAACA TCATTGTTGG TGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055117.1
CDS	61..267
Translation	MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG

Target ORF information:

RefSeq Version	NM_014302.4
Organism	Homo sapiens(human)
Definition	Homo sapiens SEC61 translocon subunit gamma (SEC61G), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014302.4

ORF Insert Sequence:

ATGGATCAGG TAATGCAGTT TGTTGAGCCA AGTCGGCAGT TTGTAAAGGA CTCCATTCGG 
CTGGTTAAAA GATGCACTAA ACCTGATAGA AAAGAATTCC AGAAGATTGC CATGGCAACA 
GCAATAGGAT TTGCTATAAT GGGATTCATT GGCTTCTTTG TGAAATTGAT CCATATTCCT 
ATTAATAACA TCATTGTTGG TGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SEC61G ( NM_001012456.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001012474.1 Homo sapiens SEC61 translocon subunit gamma (SEC61G), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04044
Clone ID Related Accession (Same CDS sequence)	NM_014302.3 , NM_014302.4 , NM_001012456.1
Accession Version	NM_001012456.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 207bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	protein transport protein Sec61 subunit gamma
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU932672.1, AF086539.1 and CD385140.1. Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB366286.1, CN305924.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATCAGG TAATGCAGTT TGTTGAGCCA AGTCGGCAGT TTGTAAAGGA CTCCATTCGG 
CTGGTTAAAA GATGCACTAA ACCTGATAGA AAAGAATTCC AGAAGATTGC CATGGCAACA 
GCAATAGGAT TTGCTATAAT GGGATTCATT GGCTTCTTTG TGAAATTGAT CCATATTCCT 
ATTAATAACA TCATTGTTGG TGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012474.1
CDS	92..298
Translation	MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG

Target ORF information:

RefSeq Version	NM_001012456.1
Organism	Homo sapiens(human)
Definition	Homo sapiens SEC61 translocon subunit gamma (SEC61G), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001012456.1

ORF Insert Sequence:

ATGGATCAGG TAATGCAGTT TGTTGAGCCA AGTCGGCAGT TTGTAAAGGA CTCCATTCGG 
CTGGTTAAAA GATGCACTAA ACCTGATAGA AAAGAATTCC AGAAGATTGC CATGGCAACA 
GCAATAGGAT TTGCTATAAT GGGATTCATT GGCTTCTTTG TGAAATTGAT CCATATTCCT 
ATTAATAACA TCATTGTTGG TGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel
Cancer research77(21)5860-5872(2017 Nov)
Servidei T,Meco D,Muto V,Bruselles A,Ciolfi A,Trivieri N,Lucchini M,Morosetti R,Mirabella M,Martini M,Caldarelli M,Lasorella A,Tartaglia M,Riccardi R

Genetic loci associated with circulating levels of very long-chain saturated fatty acids.
Journal of lipid research56(1)176-84(2015 Jan)
Lemaitre RN,King IB,Kabagambe EK,Wu JH,McKnight B,Manichaikul A,Guan W,Sun Q,Chasman DI,Foy M,Wang L,Zhu J,Siscovick DS,Tsai MY,Arnett DK,Psaty BM,Djousse L,Chen YD,Tang W,Weng LC,Wu H,Jensen MK,Chu AY,Jacobs DR Jr,Rich SS,Mozaffarian D,Steffen L,Rimm EB,Hu FB,Ridker PM,Fornage M,Friedlander Y

GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
Genes and immunity15(6)347-54(2014 Sep)
Armstrong DL,Zidovetzki R,Alarc?n-Riquelme ME,Tsao BP,Criswell LA,Kimberly RP,Harley JB,Sivils KL,Vyse TJ,Gaffney PM,Langefeld CD,Jacob CO

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.
eLife3e01483(2014)
Mackinnon AL,Paavilainen VO,Sharma A,Hegde RS,Taunton J

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SEC61G cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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