KLRK1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KLRK1
Entrez Gene ID	22914
Full Name	killer cell lectin like receptor K1
Synonyms	CD314,D12S2489E,KLR,NKG2-D,NKG2D
General protein information	Preferred Names killer cell lectin like receptor K1 Names NKG2-D type II integral membrane protein NK cell receptor D NKG2-D-activating NK receptor killer cell lectin-like receptor subfamily K, member 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.2
Summary	Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010].
Disorder MIM:	611817

mRNA and Protein(s)

mRNA	Protein	Name
NM_007360.3	NP_031386.2	NKG2-D type II integral membrane protein
NM_007360.4	NP_031386.2	NKG2-D type II integral membrane protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	KLRC4-KLRK1	NP_001186734.1
Homo sapiens (human)	KLRK1	NP_031386.2

Gene Ontology
Bibliography

Related articles in PubMed

NKG2D Signaling between Human NK Cells Enhances TACE-Mediated TNF-? Release.
Sharma N, Trinidad CV, Trembath AP, Markiewicz MA
Journal of immunology (Baltimore, Md. : 1950)199(8)2865-2872(2017 Oct)

Correlation Between NKG2DL Expression and Antitumor Effect of Protein-bound Polysaccharide-K in Tumor-bearing Mouse Models.
Konagai A, Yoshimura K, Hazama S, Yamamoto N, Aoki K, Ueno T, Fujioka M, Iijima H, Kato M, Uchida M, Wada T, Inoue M, Asao T, Fuse M, Wada S, Kuramasu A, Kamei R, Takeda S, Yamamoto S, Yoshino S, Oka M, Nagano H
Anticancer research37(8)4093-4101(2017 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data suggest that NKG2D gene polymorphisms may represent candidate biomarkers for the prediction of treatment-free remission (TFR) of chronic myeloid leukemia (CML) after dasatinib (Das) treatment.
Title: NKG2D gene polymorphisms are associated with disease control of chronic myeloid leukemia by dasatinib.

this study shows that CD20-specific immunoligands engaging NKG2D enhance gammadelta T cell-mediated lysis of lymphoma cells
Title: CD20-Specific Immunoligands Engaging NKG2D Enhance ?? T Cell-Mediated Lysis of Lymphoma Cells.

these results demonstrate that NKG2D signaling is critical for maximal TNF-alpha release by NK cells
Title: NKG2D Signaling between Human NK Cells Enhances TACE-Mediated TNF-? Release.

Blockade of NKG2D on CD8(+) T cells inhibited the migration over ligand-expressing endothelial cells. Intestinal induction of NKG2D ligands and ligand-induced down-regulation of NKG2D in Crohn's disease (CD) suggest that the NKG2D-ligand interaction may be involved in both the activation and recruitment of NKG2D(+) lymphocytes into the inflamed CD intestine.
Title: NKG2D ligand expression in Crohn's disease and NKG2D-dependent stimulation of CD8

On-treatment decrease of NKG2D correlates to early emergence of clinically evident hepatocellular carcinoma after interferon-free therapy for chronic hepatitis C
Title: On-treatment decrease of NKG2D correlates to early emergence of clinically evident hepatocellular carcinoma after interferon-free therapy for chronic hepatitis C.

The following KLRK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KLRK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07952	NM_007360.4 Latest version!	Homo sapiens killer cell lectin like receptor K1 (KLRK1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu07952	NM_007360.3	Homo sapiens killer cell lectin like receptor K1 (KLRK1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KLRK1 ( NM_007360.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_031386.2 Homo sapiens killer cell lectin like receptor K1 (KLRK1), mRNA.

Price & Availability↑

CloneID	OHu07952
Clone ID Related Accession (Same CDS sequence)	NM_007360.3 , NM_007360.4
Accession Version	NM_007360.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-11
Organism	Homo sapiens(human)
Product	NKG2-D type II integral membrane protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA933271.1, AK292059.1, AC022075.29 and CB241686.1. This sequence is a reference standard in the RefSeqGene project. On Dec 18, 2010 this sequence version replaced NM_007360.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC039836.1, AK292059.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGTGGA TTCGTGGTCG GAGGTCTCGA CACAGCTGGG AGATGAGTGA ATTTCATAAT 
TATAACTTGG ATCTGAAGAA GAGTGATTTT TCAACACGAT GGCAAAAGCA AAGATGTCCA 
GTAGTCAAAA GCAAATGTAG AGAAAATGCA TCTCCATTTT TTTTCTGCTG CTTCATCGCT 
GTAGCCATGG GAATCCGTTT CATTATTATG GTAACAATAT GGAGTGCTGT ATTCCTAAAC 
TCATTATTCA ACCAAGAAGT TCAAATTCCC TTGACCGAAA GTTACTGTGG CCCATGTCCT 
AAAAACTGGA TATGTTACAA AAATAACTGC TACCAATTTT TTGATGAGAG TAAAAACTGG 
TATGAGAGCC AGGCTTCTTG TATGTCTCAA AATGCCAGCC TTCTGAAAGT ATACAGCAAA 
GAGGACCAGG ATTTACTTAA ACTGGTGAAG TCATATCATT GGATGGGACT AGTACACATT 
CCAACAAATG GATCTTGGCA GTGGGAAGAT GGCTCCATTC TCTCACCCAA CCTACTAACA 
ATAATTGAAA TGCAGAAGGG AGACTGTGCA CTCTATGCCT CGAGCTTTAA AGGCTATATA 
GAAAACTGTT CAACTCCAAA TACGTACATC TGCATGCAAA GGACTGTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031386.2
CDS	178..828
Translation	MGWIRGRRSRHSWEMSEFHNYNLDLKKSDFSTRWQKQRCPVVKSKCRENASPFFFCCFIAVAMGIRFIIMVTIWSAVFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV

Target ORF information:

RefSeq Version	NM_007360.3
Organism	Homo sapiens(human)
Definition	Homo sapiens killer cell lectin like receptor K1 (KLRK1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007360.3

ORF Insert Sequence:

ATGGGGTGGA TTCGTGGTCG GAGGTCTCGA CACAGCTGGG AGATGAGTGA ATTTCATAAT 
TATAACTTGG ATCTGAAGAA GAGTGATTTT TCAACACGAT GGCAAAAGCA AAGATGTCCA 
GTAGTCAAAA GCAAATGTAG AGAAAATGCA TCTCCATTTT TTTTCTGCTG CTTCATCGCT 
GTAGCCATGG GAATCCGTTT CATTATTATG GTAACAATAT GGAGTGCTGT ATTCCTAAAC 
TCATTATTCA ACCAAGAAGT TCAAATTCCC TTGACCGAAA GTTACTGTGG CCCATGTCCT 
AAAAACTGGA TATGTTACAA AAATAACTGC TACCAATTTT TTGATGAGAG TAAAAACTGG 
TATGAGAGCC AGGCTTCTTG TATGTCTCAA AATGCCAGCC TTCTGAAAGT ATACAGCAAA 
GAGGACCAGG ATTTACTTAA ACTGGTGAAG TCATATCATT GGATGGGACT AGTACACATT 
CCAACAAATG GATCTTGGCA GTGGGAAGAT GGCTCCATTC TCTCACCCAA CCTACTAACA 
ATAATTGAAA TGCAGAAGGG AGACTGTGCA CTCTATGCCT CGAGCTTTAA AGGCTATATA 
GAAAACTGTT CAACTCCAAA TACGTACATC TGCATGCAAA GGACTGTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLRK1 ( NM_007360.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_031386.2 Homo sapiens killer cell lectin like receptor K1 (KLRK1), mRNA.

Price & Availability↑

CloneID	OHu07952
Clone ID Related Accession (Same CDS sequence)	NM_007360.3 , NM_007360.4
Accession Version	NM_007360.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	NKG2-D type II integral membrane protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA933271.1, AK292059.1, AC022075.29 and CB241686.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_007360.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC039836.1, AK292059.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000240618.11/ ENSP00000240618.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGTGGA TTCGTGGTCG GAGGTCTCGA CACAGCTGGG AGATGAGTGA ATTTCATAAT 
TATAACTTGG ATCTGAAGAA GAGTGATTTT TCAACACGAT GGCAAAAGCA AAGATGTCCA 
GTAGTCAAAA GCAAATGTAG AGAAAATGCA TCTCCATTTT TTTTCTGCTG CTTCATCGCT 
GTAGCCATGG GAATCCGTTT CATTATTATG GTAACAATAT GGAGTGCTGT ATTCCTAAAC 
TCATTATTCA ACCAAGAAGT TCAAATTCCC TTGACCGAAA GTTACTGTGG CCCATGTCCT 
AAAAACTGGA TATGTTACAA AAATAACTGC TACCAATTTT TTGATGAGAG TAAAAACTGG 
TATGAGAGCC AGGCTTCTTG TATGTCTCAA AATGCCAGCC TTCTGAAAGT ATACAGCAAA 
GAGGACCAGG ATTTACTTAA ACTGGTGAAG TCATATCATT GGATGGGACT AGTACACATT 
CCAACAAATG GATCTTGGCA GTGGGAAGAT GGCTCCATTC TCTCACCCAA CCTACTAACA 
ATAATTGAAA TGCAGAAGGG AGACTGTGCA CTCTATGCCT CGAGCTTTAA AGGCTATATA 
GAAAACTGTT CAACTCCAAA TACGTACATC TGCATGCAAA GGACTGTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031386.2
CDS	165..815
Translation	MGWIRGRRSRHSWEMSEFHNYNLDLKKSDFSTRWQKQRCPVVKSKCRENASPFFFCCFIAVAMGIRFIIMVTIWSAVFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV

Target ORF information:

RefSeq Version	NM_007360.4
Organism	Homo sapiens(human)
Definition	Homo sapiens killer cell lectin like receptor K1 (KLRK1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007360.4

ORF Insert Sequence:

ATGGGGTGGA TTCGTGGTCG GAGGTCTCGA CACAGCTGGG AGATGAGTGA ATTTCATAAT 
TATAACTTGG ATCTGAAGAA GAGTGATTTT TCAACACGAT GGCAAAAGCA AAGATGTCCA 
GTAGTCAAAA GCAAATGTAG AGAAAATGCA TCTCCATTTT TTTTCTGCTG CTTCATCGCT 
GTAGCCATGG GAATCCGTTT CATTATTATG GTAACAATAT GGAGTGCTGT ATTCCTAAAC 
TCATTATTCA ACCAAGAAGT TCAAATTCCC TTGACCGAAA GTTACTGTGG CCCATGTCCT 
AAAAACTGGA TATGTTACAA AAATAACTGC TACCAATTTT TTGATGAGAG TAAAAACTGG 
TATGAGAGCC AGGCTTCTTG TATGTCTCAA AATGCCAGCC TTCTGAAAGT ATACAGCAAA 
GAGGACCAGG ATTTACTTAA ACTGGTGAAG TCATATCATT GGATGGGACT AGTACACATT 
CCAACAAATG GATCTTGGCA GTGGGAAGAT GGCTCCATTC TCTCACCCAA CCTACTAACA 
ATAATTGAAA TGCAGAAGGG AGACTGTGCA CTCTATGCCT CGAGCTTTAA AGGCTATATA 
GAAAACTGTT CAACTCCAAA TACGTACATC TGCATGCAAA GGACTGTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NKG2D Signaling between Human NK Cells Enhances TACE-Mediated TNF-? Release.
Journal of immunology (Baltimore, Md. : 1950)199(8)2865-2872(2017 Oct)
Sharma N,Trinidad CV,Trembath AP,Markiewicz MA

Correlation Between NKG2DL Expression and Antitumor Effect of Protein-bound Polysaccharide-K in Tumor-bearing Mouse Models.
Anticancer research37(8)4093-4101(2017 08)
Konagai A,Yoshimura K,Hazama S,Yamamoto N,Aoki K,Ueno T,Fujioka M,Iijima H,Kato M,Uchida M,Wada T,Inoue M,Asao T,Fuse M,Wada S,Kuramasu A,Kamei R,Takeda S,Yamamoto S,Yoshino S,Oka M,Nagano H

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KLRK1 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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