DSC3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DSC3
Entrez Gene ID	1825
Full Name	desmocollin 3
Synonyms	CDHF3,DSC,DSC1,DSC2,DSC4,HT-CP
General protein information	Preferred Names desmocollin 3 Names desmocollin-3 cadherin family member 3 desmocollin-4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q12.1
Summary	The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014].
Disorder MIM:	600271
Disorder Html:	?Hypotrichosis and recurrent skin vesicles, 613102 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001941.4	NP_001932.2	desmocollin-3 isoform Dsc3a preproprotein
NM_001941.5	NP_001932.2	desmocollin-3 isoform Dsc3a preproprotein
NM_024423.3	NP_077741.2	desmocollin-3 isoform Dsc3b preproprotein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	DSC3	NP_001171574.1
Pan troglodytes (chimpanzee)	DSC3	XP_512076.2
Canis lupus familiaris (dog)	DSC3	XP_003434996.1
Homo sapiens (human)	DSC3	NP_001932.2
Rattus norvegicus (Norway rat)	Dsc3	NP_001100872.1
Mus musculus (house mouse)	Dsc3	NP_031908.3

Gene Ontology
Bibliography

Related articles in PubMed

Expression of Desmoglein 2, Desmocollin 3 and Plakophilin 2 in Placenta and Bone Marrow-Derived Mesenchymal Stromal Cells.
Hart ML, Rusch E, Kaupp M, Nieselt K, Aicher WK
Stem cell reviews13(2)258-266(2017 Apr)

Sonographic alteration of substantia nigra is related to parkinsonism-predominant course of X-linked dystonia-parkinsonism.
Walter U, Rosales R, Rocco A, Westenberger A, Domingo A, Go CL, Br?ggemann N, Klein C, Lee LV, Dressler D
Parkinsonism & related disorders3743-49(2017 Apr)

The role of Napsin-A and Desmocollin-3 in classifying poorly differentiating non-small cell lung carcinoma.
Ezzat Nel-S, Tahoun N
Journal of the Egyptian National Cancer Institute28(1)13-22(2016 Mar)

Desmocollin 3 mediates follicle stimulating hormone-induced ovarian epithelial cancer cell proliferation by activating the EGFR/Akt signaling pathway.
Yang X, Wang J, Li WP, Jin ZJ, Liu XJ
International journal of clinical and experimental pathology8(6)6716-23(2015)

Association of DSC3 mRNA down-regulation in prostate cancer with promoter hypermethylation and poor prognosis.
Pan J, Chen Y, Mo C, Wang D, Chen J, Mao X, Guo S, Zhuang J, Qiu S
PloS one9(3)e92815(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that fetal pMSCs (mesenchymal stromal cells) expressing the highest levels of desmoglein 2, desmocollin 3 and plakophilin 2, followed by maternal pMSCs, while bmMSCs expressed the lowest levels.
Title: Expression of Desmoglein 2, Desmocollin 3 and Plakophilin 2 in Placenta and Bone Marrow-Derived Mesenchymal Stromal Cells.

Napsin-A, and Desmocollin-3 were sensitive and specific markers for the diagnosis of AC and SCC, respectively. Both markers allowed classification of 54/60 cases into either AC or SCC.
Title: The role of Napsin-A and Desmocollin-3 in classifying poorly differentiating non-small cell lung carcinoma.

Suggest that Dsc3 can mediate FSH-induced ovarian cancer cell proliferation by activating the EGFR/Akt signaling pathway.
Title: Desmocollin 3 mediates follicle stimulating hormone-induced ovarian epithelial cancer cell proliferation by activating the EGFR/Akt signaling pathway.

Low expression of DSC 1, 2, and 3 was observed in 55, 54, and 79 % of liver metastases.
Title: The influence of desmocollin 1-3 expression on prognosis after curative resection of colorectal liver metastases.

data suggests that DNA methylation contributes to down-regulation of DSC3 in prostate cancer, and loss of DSC3 predicts poor clinical outcome.
Title: Association of DSC3 mRNA down-regulation in prostate cancer with promoter hypermethylation and poor prognosis.

The following DSC3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DSC3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25283	NM_001941.5 Latest version!	Homo sapiens desmocollin 3 (DSC3), transcript variant Dsc3a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$629.30 $899.00
OHu27923	NM_024423.3 Latest version!	Homo sapiens desmocollin 3 (DSC3), transcript variant Dsc3b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$594.30 $849.00
View Old Accession Versions >>
OHu25283	NM_001941.4	Homo sapiens desmocollin 3 (DSC3), transcript variant Dsc3a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$629.30 $899.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DSC3 ( NM_001941.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001932.2 Homo sapiens desmocollin 3 (DSC3), transcript variant Dsc3a, mRNA.

Price & Availability↑

CloneID	OHu25283
Clone ID Related Accession (Same CDS sequence)	NM_001941.4 , NM_001941.5
Accession Version	NM_001941.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2691bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-12
Organism	Homo sapiens(human)
Product	desmocollin-3 isoform Dsc3a preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA860471.1, D17427.1, AC025212.5 and AI123917.1. On Apr 24, 2014 this sequence version replaced NM_001941.3. Transcript Variant: This variant (Dsc3a) represents the shorter transcript but encodes the longer isoform (Dsc3a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D17427.1, X83929.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCCGCCG CTGGGCCCCG GCGCTCCGTG CGCGGAGCCG TCTGCCTGCA TCTGCTGCTG 
ACCCTCGTGA TCTTCAGTCG TGCTGGTGAA GCCTGCAAAA AGGTGATACT TAATGTACCT 
TCTAAACTAG AGGCAGACAA AATAATTGGC AGAGTTAATT TGGAAGAGTG CTTCAGGTCT 
GCAGACCTCA TCCGGTCAAG TGATCCTGAT TTCAGAGTTC TAAATGATGG GTCAGTGTAC 
ACAGCCAGGG CTGTTGCGCT GTCTGATAAG AAAAGATCAT TTACCATATG GCTTTCTGAC 
AAAAGGAAAC AGACACAGAA AGAGGTTACT GTGCTGCTAG AACATCAGAA GAAGGTATCG 
AAGACAAGAC ACACTAGAGA AACTGTTCTC AGGCGTGCCA AGAGGAGATG GGCACCTATT 
CCTTGCTCTA TGCAAGAGAA TTCCTTGGGC CCTTTCCCAT TGTTTCTTCA ACAAGTTGAA 
TCTGATGCAG CACAGAACTA TACTGTCTTC TACTCAATAA GTGGACGTGG AGTTGATAAA 
GAACCTTTAA ATTTGTTTTA TATAGAAAGA GACACTGGAA ATCTATTTTG CACTCGGCCT 
GTGGATCGTG AAGAATATGA TGTTTTTGAT TTGATTGCTT ATGCGTCAAC TGCAGATGGA 
TATTCAGCAG ATCTGCCCCT CCCACTACCC ATCAGGGTAG AGGATGAAAA TGACAACCAC 
CCTGTTTTCA CAGAAGCAAT TTATAATTTT GAAGTTTTGG AAAGTAGTAG ACCTGGTACT 
ACAGTGGGGG TGGTTTGTGC CACAGACAGA GATGAACCGG ACACAATGCA TACGCGCCTG 
AAATACAGCA TTTTGCAGCA GACACCAAGG TCACCTGGGC TCTTTTCTGT GCATCCCAGC 
ACAGGCGTAA TCACCACAGT CTCTCATTAT TTGGACAGAG AGGTTGTAGA CAAGTACTCA 
TTGATAATGA AAGTACAAGA CATGGATGGC CAGTTTTTTG GATTGATAGG CACATCAACT 
TGTATCATAA CAGTAACAGA TTCAAATGAT AATGCACCCA CTTTCAGACA AAATGCTTAT 
GAAGCATTTG TAGAGGAAAA TGCATTCAAT GTGGAAATCT TACGAATACC TATAGAAGAT 
AAGGATTTAA TTAACACTGC CAATTGGAGA GTCAATTTTA CCATTTTAAA GGGAAATGAA 
AATGGACATT TCAAAATCAG CACAGACAAA GAAACTAATG AAGGTGTTCT TTCTGTTGTA 
AAGCCACTGA ATTATGAAGA AAACCGTCAA GTGAACCTGG AAATTGGAGT AAACAATGAA 
GCGCCATTTG CTAGAGATAT TCCCAGAGTG ACAGCCTTGA ACAGAGCCTT GGTTACAGTT 
CATGTGAGGG ATCTGGATGA GGGGCCTGAA TGCACTCCTG CAGCCCAATA TGTGCGGATT 
AAAGAAAACT TAGCAGTGGG GTCAAAGATC AACGGCTATA AGGCATATGA CCCCGAAAAT 
AGAAATGGCA ATGGTTTAAG GTACAAAAAA TTGCATGATC CTAAAGGTTG GATCACCATT 
GATGAAATTT CAGGGTCAAT CATAACTTCC AAAATCCTGG ATAGGGAGGT TGAAACTCCC 
AAAAATGAGT TGTATAATAT TACAGTCCTG GCAATAGACA AAGATGATAG ATCATGTACT 
GGAACACTTG CTGTGAACAT TGAAGATGTA AATGATAATC CACCAGAAAT ACTTCAAGAA 
TATGTAGTCA TTTGCAAACC AAAAATGGGG TATACCGACA TTTTAGCTGT TGATCCTGAT 
GAACCTGTCC ATGGAGCTCC ATTTTATTTC AGTTTGCCCA ATACTTCTCC AGAAATCAGT 
AGACTGTGGA GCCTCACCAA AGTTAATGAT ACAGCTGCCC GTCTTTCATA TCAGAAAAAT 
GCTGGATTTC AAGAATATAC CATTCCTATT ACTGTAAAAG ACAGGGCCGG CCAAGCTGCA 
ACAAAATTAT TGAGAGTTAA TCTGTGTGAA TGTACTCATC CAACTCAGTG TCGTGCGACT 
TCAAGGAGTA CAGGAGTAAT ACTTGGAAAA TGGGCAATCC TTGCAATATT ACTGGGTATA 
GCACTGCTCT TTTCTGTATT GCTAACTTTA GTATGTGGAG TTTTTGGTGC AACTAAAGGG 
AAACGTTTTC CTGAAGATTT AGCACAGCAA AACTTAATTA TATCAAACAC AGAAGCACCT 
GGAGACGATA GAGTGTGCTC TGCCAATGGA TTTATGACCC AAACTACCAA CAACTCTAGC 
CAAGGTTTTT GTGGTACTAT GGGATCAGGA ATGAAAAATG GAGGGCAGGA AACCATTGAA 
ATGATGAAAG GAGGAAACCA GACCTTGGAA TCCTGCCGGG GGGCTGGGCA TCATCATACC 
CTGGACTCCT GCAGGGGAGG ACACACGGAG GTGGACAACT GCAGATACAC TTACTCGGAG 
TGGCACAGTT TTACTCAACC CCGTCTCGGT GAAAAATTGC ATCGATGTAA TCAGAATGAA 
GACCGCATGC CATCCCAAGA TTATGTCCTC ACTTATAACT ATGAGGGAAG AGGATCTCCA 
GCTGGTTCTG TGGGCTGCTG CAGTGAAAAG CAGGAAGAAG ATGGCCTTGA CTTTTTAAAT 
AATTTGGAAC CCAAATTTAT TACATTAGCA GAAGCATGCA CAAAGAGATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001932.2
CDS	156..2846
Translation	MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEACTKR

Target ORF information:

RefSeq Version	NM_001941.4
Organism	Homo sapiens(human)
Definition	Homo sapiens desmocollin 3 (DSC3), transcript variant Dsc3a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001941.4

ORF Insert Sequence:

ATGGCCGCCG CTGGGCCCCG GCGCTCCGTG CGCGGAGCCG TCTGCCTGCA TCTGCTGCTG 
ACCCTCGTGA TCTTCAGTCG TGCTGGTGAA GCCTGCAAAA AGGTGATACT TAATGTACCT 
TCTAAACTAG AGGCAGACAA AATAATTGGC AGAGTTAATT TGGAAGAGTG CTTCAGGTCT 
GCAGACCTCA TCCGGTCAAG TGATCCTGAT TTCAGAGTTC TAAATGATGG GTCAGTGTAC 
ACAGCCAGGG CTGTTGCGCT GTCTGATAAG AAAAGATCAT TTACCATATG GCTTTCTGAC 
AAAAGGAAAC AGACACAGAA AGAGGTTACT GTGCTGCTAG AACATCAGAA GAAGGTATCG 
AAGACAAGAC ACACTAGAGA AACTGTTCTC AGGCGTGCCA AGAGGAGATG GGCACCTATT 
CCTTGCTCTA TGCAAGAGAA TTCCTTGGGC CCTTTCCCAT TGTTTCTTCA ACAAGTTGAA 
TCTGATGCAG CACAGAACTA TACTGTCTTC TACTCAATAA GTGGACGTGG AGTTGATAAA 
GAACCTTTAA ATTTGTTTTA TATAGAAAGA GACACTGGAA ATCTATTTTG CACTCGGCCT 
GTGGATCGTG AAGAATATGA TGTTTTTGAT TTGATTGCTT ATGCGTCAAC TGCAGATGGA 
TATTCAGCAG ATCTGCCCCT CCCACTACCC ATCAGGGTAG AGGATGAAAA TGACAACCAC 
CCTGTTTTCA CAGAAGCAAT TTATAATTTT GAAGTTTTGG AAAGTAGTAG ACCTGGTACT 
ACAGTGGGGG TGGTTTGTGC CACAGACAGA GATGAACCGG ACACAATGCA TACGCGCCTG 
AAATACAGCA TTTTGCAGCA GACACCAAGG TCACCTGGGC TCTTTTCTGT GCATCCCAGC 
ACAGGCGTAA TCACCACAGT CTCTCATTAT TTGGACAGAG AGGTTGTAGA CAAGTACTCA 
TTGATAATGA AAGTACAAGA CATGGATGGC CAGTTTTTTG GATTGATAGG CACATCAACT 
TGTATCATAA CAGTAACAGA TTCAAATGAT AATGCACCCA CTTTCAGACA AAATGCTTAT 
GAAGCATTTG TAGAGGAAAA TGCATTCAAT GTGGAAATCT TACGAATACC TATAGAAGAT 
AAGGATTTAA TTAACACTGC CAATTGGAGA GTCAATTTTA CCATTTTAAA GGGAAATGAA 
AATGGACATT TCAAAATCAG CACAGACAAA GAAACTAATG AAGGTGTTCT TTCTGTTGTA 
AAGCCACTGA ATTATGAAGA AAACCGTCAA GTGAACCTGG AAATTGGAGT AAACAATGAA 
GCGCCATTTG CTAGAGATAT TCCCAGAGTG ACAGCCTTGA ACAGAGCCTT GGTTACAGTT 
CATGTGAGGG ATCTGGATGA GGGGCCTGAA TGCACTCCTG CAGCCCAATA TGTGCGGATT 
AAAGAAAACT TAGCAGTGGG GTCAAAGATC AACGGCTATA AGGCATATGA CCCCGAAAAT 
AGAAATGGCA ATGGTTTAAG GTACAAAAAA TTGCATGATC CTAAAGGTTG GATCACCATT 
GATGAAATTT CAGGGTCAAT CATAACTTCC AAAATCCTGG ATAGGGAGGT TGAAACTCCC 
AAAAATGAGT TGTATAATAT TACAGTCCTG GCAATAGACA AAGATGATAG ATCATGTACT 
GGAACACTTG CTGTGAACAT TGAAGATGTA AATGATAATC CACCAGAAAT ACTTCAAGAA 
TATGTAGTCA TTTGCAAACC AAAAATGGGG TATACCGACA TTTTAGCTGT TGATCCTGAT 
GAACCTGTCC ATGGAGCTCC ATTTTATTTC AGTTTGCCCA ATACTTCTCC AGAAATCAGT 
AGACTGTGGA GCCTCACCAA AGTTAATGAT ACAGCTGCCC GTCTTTCATA TCAGAAAAAT 
GCTGGATTTC AAGAATATAC CATTCCTATT ACTGTAAAAG ACAGGGCCGG CCAAGCTGCA 
ACAAAATTAT TGAGAGTTAA TCTGTGTGAA TGTACTCATC CAACTCAGTG TCGTGCGACT 
TCAAGGAGTA CAGGAGTAAT ACTTGGAAAA TGGGCAATCC TTGCAATATT ACTGGGTATA 
GCACTGCTCT TTTCTGTATT GCTAACTTTA GTATGTGGAG TTTTTGGTGC AACTAAAGGG 
AAACGTTTTC CTGAAGATTT AGCACAGCAA AACTTAATTA TATCAAACAC AGAAGCACCT 
GGAGACGATA GAGTGTGCTC TGCCAATGGA TTTATGACCC AAACTACCAA CAACTCTAGC 
CAAGGTTTTT GTGGTACTAT GGGATCAGGA ATGAAAAATG GAGGGCAGGA AACCATTGAA 
ATGATGAAAG GAGGAAACCA GACCTTGGAA TCCTGCCGGG GGGCTGGGCA TCATCATACC 
CTGGACTCCT GCAGGGGAGG ACACACGGAG GTGGACAACT GCAGATACAC TTACTCGGAG 
TGGCACAGTT TTACTCAACC CCGTCTCGGT GAAAAATTGC ATCGATGTAA TCAGAATGAA 
GACCGCATGC CATCCCAAGA TTATGTCCTC ACTTATAACT ATGAGGGAAG AGGATCTCCA 
GCTGGTTCTG TGGGCTGCTG CAGTGAAAAG CAGGAAGAAG ATGGCCTTGA CTTTTTAAAT 
AATTTGGAAC CCAAATTTAT TACATTAGCA GAAGCATGCA CAAAGAGATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DSC3 ( NM_001941.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001932.2 Homo sapiens desmocollin 3 (DSC3), transcript variant Dsc3a, mRNA.

Price & Availability↑

CloneID	OHu25283
Clone ID Related Accession (Same CDS sequence)	NM_001941.4 , NM_001941.5
Accession Version	NM_001941.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2691bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	desmocollin-3 isoform Dsc3a preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA860471.1, D17427.1, AC025212.5 and AI123917.1. On Nov 23, 2018 this sequence version replaced NM_001941.4. Transcript Variant: This variant (Dsc3a) represents the shorter transcript but encodes the longer isoform (Dsc3a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D17427.1, X83929.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000360428.9/ ENSP00000353608.4 RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGCCG CTGGGCCCCG GCGCTCCGTG CGCGGAGCCG TCTGCCTGCA TCTGCTGCTG 
ACCCTCGTGA TCTTCAGTCG TGCTGGTGAA GCCTGCAAAA AGGTGATACT TAATGTACCT 
TCTAAACTAG AGGCAGACAA AATAATTGGC AGAGTTAATT TGGAAGAGTG CTTCAGGTCT 
GCAGACCTCA TCCGGTCAAG TGATCCTGAT TTCAGAGTTC TAAATGATGG GTCAGTGTAC 
ACAGCCAGGG CTGTTGCGCT GTCTGATAAG AAAAGATCAT TTACCATATG GCTTTCTGAC 
AAAAGGAAAC AGACACAGAA AGAGGTTACT GTGCTGCTAG AACATCAGAA GAAGGTATCG 
AAGACAAGAC ACACTAGAGA AACTGTTCTC AGGCGTGCCA AGAGGAGATG GGCACCTATT 
CCTTGCTCTA TGCAAGAGAA TTCCTTGGGC CCTTTCCCAT TGTTTCTTCA ACAAGTTGAA 
TCTGATGCAG CACAGAACTA TACTGTCTTC TACTCAATAA GTGGACGTGG AGTTGATAAA 
GAACCTTTAA ATTTGTTTTA TATAGAAAGA GACACTGGAA ATCTATTTTG CACTCGGCCT 
GTGGATCGTG AAGAATATGA TGTTTTTGAT TTGATTGCTT ATGCGTCAAC TGCAGATGGA 
TATTCAGCAG ATCTGCCCCT CCCACTACCC ATCAGGGTAG AGGATGAAAA TGACAACCAC 
CCTGTTTTCA CAGAAGCAAT TTATAATTTT GAAGTTTTGG AAAGTAGTAG ACCTGGTACT 
ACAGTGGGGG TGGTTTGTGC CACAGACAGA GATGAACCGG ACACAATGCA TACGCGCCTG 
AAATACAGCA TTTTGCAGCA GACACCAAGG TCACCTGGGC TCTTTTCTGT GCATCCCAGC 
ACAGGCGTAA TCACCACAGT CTCTCATTAT TTGGACAGAG AGGTTGTAGA CAAGTACTCA 
TTGATAATGA AAGTACAAGA CATGGATGGC CAGTTTTTTG GATTGATAGG CACATCAACT 
TGTATCATAA CAGTAACAGA TTCAAATGAT AATGCACCCA CTTTCAGACA AAATGCTTAT 
GAAGCATTTG TAGAGGAAAA TGCATTCAAT GTGGAAATCT TACGAATACC TATAGAAGAT 
AAGGATTTAA TTAACACTGC CAATTGGAGA GTCAATTTTA CCATTTTAAA GGGAAATGAA 
AATGGACATT TCAAAATCAG CACAGACAAA GAAACTAATG AAGGTGTTCT TTCTGTTGTA 
AAGCCACTGA ATTATGAAGA AAACCGTCAA GTGAACCTGG AAATTGGAGT AAACAATGAA 
GCGCCATTTG CTAGAGATAT TCCCAGAGTG ACAGCCTTGA ACAGAGCCTT GGTTACAGTT 
CATGTGAGGG ATCTGGATGA GGGGCCTGAA TGCACTCCTG CAGCCCAATA TGTGCGGATT 
AAAGAAAACT TAGCAGTGGG GTCAAAGATC AACGGCTATA AGGCATATGA CCCCGAAAAT 
AGAAATGGCA ATGGTTTAAG GTACAAAAAA TTGCATGATC CTAAAGGTTG GATCACCATT 
GATGAAATTT CAGGGTCAAT CATAACTTCC AAAATCCTGG ATAGGGAGGT TGAAACTCCC 
AAAAATGAGT TGTATAATAT TACAGTCCTG GCAATAGACA AAGATGATAG ATCATGTACT 
GGAACACTTG CTGTGAACAT TGAAGATGTA AATGATAATC CACCAGAAAT ACTTCAAGAA 
TATGTAGTCA TTTGCAAACC AAAAATGGGG TATACCGACA TTTTAGCTGT TGATCCTGAT 
GAACCTGTCC ATGGAGCTCC ATTTTATTTC AGTTTGCCCA ATACTTCTCC AGAAATCAGT 
AGACTGTGGA GCCTCACCAA AGTTAATGAT ACAGCTGCCC GTCTTTCATA TCAGAAAAAT 
GCTGGATTTC AAGAATATAC CATTCCTATT ACTGTAAAAG ACAGGGCCGG CCAAGCTGCA 
ACAAAATTAT TGAGAGTTAA TCTGTGTGAA TGTACTCATC CAACTCAGTG TCGTGCGACT 
TCAAGGAGTA CAGGAGTAAT ACTTGGAAAA TGGGCAATCC TTGCAATATT ACTGGGTATA 
GCACTGCTCT TTTCTGTATT GCTAACTTTA GTATGTGGAG TTTTTGGTGC AACTAAAGGG 
AAACGTTTTC CTGAAGATTT AGCACAGCAA AACTTAATTA TATCAAACAC AGAAGCACCT 
GGAGACGATA GAGTGTGCTC TGCCAATGGA TTTATGACCC AAACTACCAA CAACTCTAGC 
CAAGGTTTTT GTGGTACTAT GGGATCAGGA ATGAAAAATG GAGGGCAGGA AACCATTGAA 
ATGATGAAAG GAGGAAACCA GACCTTGGAA TCCTGCCGGG GGGCTGGGCA TCATCATACC 
CTGGACTCCT GCAGGGGAGG ACACACGGAG GTGGACAACT GCAGATACAC TTACTCGGAG 
TGGCACAGTT TTACTCAACC CCGTCTCGGT GAAAAATTGC ATCGATGTAA TCAGAATGAA 
GACCGCATGC CATCCCAAGA TTATGTCCTC ACTTATAACT ATGAGGGAAG AGGATCTCCA 
GCTGGTTCTG TGGGCTGCTG CAGTGAAAAG CAGGAAGAAG ATGGCCTTGA CTTTTTAAAT 
AATTTGGAAC CCAAATTTAT TACATTAGCA GAAGCATGCA CAAAGAGATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001932.2
CDS	83..2773
Translation	MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEACTKR

Target ORF information:

RefSeq Version	NM_001941.5
Organism	Homo sapiens(human)
Definition	Homo sapiens desmocollin 3 (DSC3), transcript variant Dsc3a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001941.5

ORF Insert Sequence:

ATGGCCGCCG CTGGGCCCCG GCGCTCCGTG CGCGGAGCCG TCTGCCTGCA TCTGCTGCTG 
ACCCTCGTGA TCTTCAGTCG TGCTGGTGAA GCCTGCAAAA AGGTGATACT TAATGTACCT 
TCTAAACTAG AGGCAGACAA AATAATTGGC AGAGTTAATT TGGAAGAGTG CTTCAGGTCT 
GCAGACCTCA TCCGGTCAAG TGATCCTGAT TTCAGAGTTC TAAATGATGG GTCAGTGTAC 
ACAGCCAGGG CTGTTGCGCT GTCTGATAAG AAAAGATCAT TTACCATATG GCTTTCTGAC 
AAAAGGAAAC AGACACAGAA AGAGGTTACT GTGCTGCTAG AACATCAGAA GAAGGTATCG 
AAGACAAGAC ACACTAGAGA AACTGTTCTC AGGCGTGCCA AGAGGAGATG GGCACCTATT 
CCTTGCTCTA TGCAAGAGAA TTCCTTGGGC CCTTTCCCAT TGTTTCTTCA ACAAGTTGAA 
TCTGATGCAG CACAGAACTA TACTGTCTTC TACTCAATAA GTGGACGTGG AGTTGATAAA 
GAACCTTTAA ATTTGTTTTA TATAGAAAGA GACACTGGAA ATCTATTTTG CACTCGGCCT 
GTGGATCGTG AAGAATATGA TGTTTTTGAT TTGATTGCTT ATGCGTCAAC TGCAGATGGA 
TATTCAGCAG ATCTGCCCCT CCCACTACCC ATCAGGGTAG AGGATGAAAA TGACAACCAC 
CCTGTTTTCA CAGAAGCAAT TTATAATTTT GAAGTTTTGG AAAGTAGTAG ACCTGGTACT 
ACAGTGGGGG TGGTTTGTGC CACAGACAGA GATGAACCGG ACACAATGCA TACGCGCCTG 
AAATACAGCA TTTTGCAGCA GACACCAAGG TCACCTGGGC TCTTTTCTGT GCATCCCAGC 
ACAGGCGTAA TCACCACAGT CTCTCATTAT TTGGACAGAG AGGTTGTAGA CAAGTACTCA 
TTGATAATGA AAGTACAAGA CATGGATGGC CAGTTTTTTG GATTGATAGG CACATCAACT 
TGTATCATAA CAGTAACAGA TTCAAATGAT AATGCACCCA CTTTCAGACA AAATGCTTAT 
GAAGCATTTG TAGAGGAAAA TGCATTCAAT GTGGAAATCT TACGAATACC TATAGAAGAT 
AAGGATTTAA TTAACACTGC CAATTGGAGA GTCAATTTTA CCATTTTAAA GGGAAATGAA 
AATGGACATT TCAAAATCAG CACAGACAAA GAAACTAATG AAGGTGTTCT TTCTGTTGTA 
AAGCCACTGA ATTATGAAGA AAACCGTCAA GTGAACCTGG AAATTGGAGT AAACAATGAA 
GCGCCATTTG CTAGAGATAT TCCCAGAGTG ACAGCCTTGA ACAGAGCCTT GGTTACAGTT 
CATGTGAGGG ATCTGGATGA GGGGCCTGAA TGCACTCCTG CAGCCCAATA TGTGCGGATT 
AAAGAAAACT TAGCAGTGGG GTCAAAGATC AACGGCTATA AGGCATATGA CCCCGAAAAT 
AGAAATGGCA ATGGTTTAAG GTACAAAAAA TTGCATGATC CTAAAGGTTG GATCACCATT 
GATGAAATTT CAGGGTCAAT CATAACTTCC AAAATCCTGG ATAGGGAGGT TGAAACTCCC 
AAAAATGAGT TGTATAATAT TACAGTCCTG GCAATAGACA AAGATGATAG ATCATGTACT 
GGAACACTTG CTGTGAACAT TGAAGATGTA AATGATAATC CACCAGAAAT ACTTCAAGAA 
TATGTAGTCA TTTGCAAACC AAAAATGGGG TATACCGACA TTTTAGCTGT TGATCCTGAT 
GAACCTGTCC ATGGAGCTCC ATTTTATTTC AGTTTGCCCA ATACTTCTCC AGAAATCAGT 
AGACTGTGGA GCCTCACCAA AGTTAATGAT ACAGCTGCCC GTCTTTCATA TCAGAAAAAT 
GCTGGATTTC AAGAATATAC CATTCCTATT ACTGTAAAAG ACAGGGCCGG CCAAGCTGCA 
ACAAAATTAT TGAGAGTTAA TCTGTGTGAA TGTACTCATC CAACTCAGTG TCGTGCGACT 
TCAAGGAGTA CAGGAGTAAT ACTTGGAAAA TGGGCAATCC TTGCAATATT ACTGGGTATA 
GCACTGCTCT TTTCTGTATT GCTAACTTTA GTATGTGGAG TTTTTGGTGC AACTAAAGGG 
AAACGTTTTC CTGAAGATTT AGCACAGCAA AACTTAATTA TATCAAACAC AGAAGCACCT 
GGAGACGATA GAGTGTGCTC TGCCAATGGA TTTATGACCC AAACTACCAA CAACTCTAGC 
CAAGGTTTTT GTGGTACTAT GGGATCAGGA ATGAAAAATG GAGGGCAGGA AACCATTGAA 
ATGATGAAAG GAGGAAACCA GACCTTGGAA TCCTGCCGGG GGGCTGGGCA TCATCATACC 
CTGGACTCCT GCAGGGGAGG ACACACGGAG GTGGACAACT GCAGATACAC TTACTCGGAG 
TGGCACAGTT TTACTCAACC CCGTCTCGGT GAAAAATTGC ATCGATGTAA TCAGAATGAA 
GACCGCATGC CATCCCAAGA TTATGTCCTC ACTTATAACT ATGAGGGAAG AGGATCTCCA 
GCTGGTTCTG TGGGCTGCTG CAGTGAAAAG CAGGAAGAAG ATGGCCTTGA CTTTTTAAAT 
AATTTGGAAC CCAAATTTAT TACATTAGCA GAAGCATGCA CAAAGAGATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DSC3 ( NM_024423.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_077741.2 Homo sapiens desmocollin 3 (DSC3), transcript variant Dsc3b, mRNA.

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CloneID	OHu27923
Clone ID Related Accession (Same CDS sequence)	NM_024423.3
Accession Version	NM_024423.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2520bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	desmocollin-3 isoform Dsc3b preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA860471.1, D17427.1, BG697535.1, BG214334.1, AC025212.5 and AI123917.1. This sequence is a reference standard in the RefSeqGene project. On Apr 24, 2014 this sequence version replaced NM_024423.2. Transcript Variant: This variant (Dsc3b) includes an additional exon in the 3' region and it thus differs in its 3' coding region and 3' UTR, compared to variant Dsc3a. The encoded isoform (Dsc3b) has a distinct C-terminus and is shorter than isoform Dsc3a. There are no publicly available full-length transcripts representing this variant, but it is supported by mRNA annotation on DNA accession AF293359.1, and by data in PMIDs 7929347 and 11027496. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: PMID: 7929347, 11027496 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGCCG CTGGGCCCCG GCGCTCCGTG CGCGGAGCCG TCTGCCTGCA TCTGCTGCTG 
ACCCTCGTGA TCTTCAGTCG TGCTGGTGAA GCCTGCAAAA AGGTGATACT TAATGTACCT 
TCTAAACTAG AGGCAGACAA AATAATTGGC AGAGTTAATT TGGAAGAGTG CTTCAGGTCT 
GCAGACCTCA TCCGGTCAAG TGATCCTGAT TTCAGAGTTC TAAATGATGG GTCAGTGTAC 
ACAGCCAGGG CTGTTGCGCT GTCTGATAAG AAAAGATCAT TTACCATATG GCTTTCTGAC 
AAAAGGAAAC AGACACAGAA AGAGGTTACT GTGCTGCTAG AACATCAGAA GAAGGTATCG 
AAGACAAGAC ACACTAGAGA AACTGTTCTC AGGCGTGCCA AGAGGAGATG GGCACCTATT 
CCTTGCTCTA TGCAAGAGAA TTCCTTGGGC CCTTTCCCAT TGTTTCTTCA ACAAGTTGAA 
TCTGATGCAG CACAGAACTA TACTGTCTTC TACTCAATAA GTGGACGTGG AGTTGATAAA 
GAACCTTTAA ATTTGTTTTA TATAGAAAGA GACACTGGAA ATCTATTTTG CACTCGGCCT 
GTGGATCGTG AAGAATATGA TGTTTTTGAT TTGATTGCTT ATGCGTCAAC TGCAGATGGA 
TATTCAGCAG ATCTGCCCCT CCCACTACCC ATCAGGGTAG AGGATGAAAA TGACAACCAC 
CCTGTTTTCA CAGAAGCAAT TTATAATTTT GAAGTTTTGG AAAGTAGTAG ACCTGGTACT 
ACAGTGGGGG TGGTTTGTGC CACAGACAGA GATGAACCGG ACACAATGCA TACGCGCCTG 
AAATACAGCA TTTTGCAGCA GACACCAAGG TCACCTGGGC TCTTTTCTGT GCATCCCAGC 
ACAGGCGTAA TCACCACAGT CTCTCATTAT TTGGACAGAG AGGTTGTAGA CAAGTACTCA 
TTGATAATGA AAGTACAAGA CATGGATGGC CAGTTTTTTG GATTGATAGG CACATCAACT 
TGTATCATAA CAGTAACAGA TTCAAATGAT AATGCACCCA CTTTCAGACA AAATGCTTAT 
GAAGCATTTG TAGAGGAAAA TGCATTCAAT GTGGAAATCT TACGAATACC TATAGAAGAT 
AAGGATTTAA TTAACACTGC CAATTGGAGA GTCAATTTTA CCATTTTAAA GGGAAATGAA 
AATGGACATT TCAAAATCAG CACAGACAAA GAAACTAATG AAGGTGTTCT TTCTGTTGTA 
AAGCCACTGA ATTATGAAGA AAACCGTCAA GTGAACCTGG AAATTGGAGT AAACAATGAA 
GCGCCATTTG CTAGAGATAT TCCCAGAGTG ACAGCCTTGA ACAGAGCCTT GGTTACAGTT 
CATGTGAGGG ATCTGGATGA GGGGCCTGAA TGCACTCCTG CAGCCCAATA TGTGCGGATT 
AAAGAAAACT TAGCAGTGGG GTCAAAGATC AACGGCTATA AGGCATATGA CCCCGAAAAT 
AGAAATGGCA ATGGTTTAAG GTACAAAAAA TTGCATGATC CTAAAGGTTG GATCACCATT 
GATGAAATTT CAGGGTCAAT CATAACTTCC AAAATCCTGG ATAGGGAGGT TGAAACTCCC 
AAAAATGAGT TGTATAATAT TACAGTCCTG GCAATAGACA AAGATGATAG ATCATGTACT 
GGAACACTTG CTGTGAACAT TGAAGATGTA AATGATAATC CACCAGAAAT ACTTCAAGAA 
TATGTAGTCA TTTGCAAACC AAAAATGGGG TATACCGACA TTTTAGCTGT TGATCCTGAT 
GAACCTGTCC ATGGAGCTCC ATTTTATTTC AGTTTGCCCA ATACTTCTCC AGAAATCAGT 
AGACTGTGGA GCCTCACCAA AGTTAATGAT ACAGCTGCCC GTCTTTCATA TCAGAAAAAT 
GCTGGATTTC AAGAATATAC CATTCCTATT ACTGTAAAAG ACAGGGCCGG CCAAGCTGCA 
ACAAAATTAT TGAGAGTTAA TCTGTGTGAA TGTACTCATC CAACTCAGTG TCGTGCGACT 
TCAAGGAGTA CAGGAGTAAT ACTTGGAAAA TGGGCAATCC TTGCAATATT ACTGGGTATA 
GCACTGCTCT TTTCTGTATT GCTAACTTTA GTATGTGGAG TTTTTGGTGC AACTAAAGGG 
AAACGTTTTC CTGAAGATTT AGCACAGCAA AACTTAATTA TATCAAACAC AGAAGCACCT 
GGAGACGATA GAGTGTGCTC TGCCAATGGA TTTATGACCC AAACTACCAA CAACTCTAGC 
CAAGGTTTTT GTGGTACTAT GGGATCAGGA ATGAAAAATG GAGGGCAGGA AACCATTGAA 
ATGATGAAAG GAGGAAACCA GACCTTGGAA TCCTGCCGGG GGGCTGGGCA TCATCATACC 
CTGGACTCCT GCAGGGGAGG ACACACGGAG GTGGACAACT GCAGATACAC TTACTCGGAG 
TGGCACAGTT TTACTCAACC CCGTCTCGGT GAAGAATCCA TTAGAGGACA CACTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077741.2
CDS	156..2675
Translation	MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEESIRGHTG

Target ORF information:

RefSeq Version	NM_024423.3
Organism	Homo sapiens(human)
Definition	Homo sapiens desmocollin 3 (DSC3), transcript variant Dsc3b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024423.3

ORF Insert Sequence:

ATGGCCGCCG CTGGGCCCCG GCGCTCCGTG CGCGGAGCCG TCTGCCTGCA TCTGCTGCTG 
ACCCTCGTGA TCTTCAGTCG TGCTGGTGAA GCCTGCAAAA AGGTGATACT TAATGTACCT 
TCTAAACTAG AGGCAGACAA AATAATTGGC AGAGTTAATT TGGAAGAGTG CTTCAGGTCT 
GCAGACCTCA TCCGGTCAAG TGATCCTGAT TTCAGAGTTC TAAATGATGG GTCAGTGTAC 
ACAGCCAGGG CTGTTGCGCT GTCTGATAAG AAAAGATCAT TTACCATATG GCTTTCTGAC 
AAAAGGAAAC AGACACAGAA AGAGGTTACT GTGCTGCTAG AACATCAGAA GAAGGTATCG 
AAGACAAGAC ACACTAGAGA AACTGTTCTC AGGCGTGCCA AGAGGAGATG GGCACCTATT 
CCTTGCTCTA TGCAAGAGAA TTCCTTGGGC CCTTTCCCAT TGTTTCTTCA ACAAGTTGAA 
TCTGATGCAG CACAGAACTA TACTGTCTTC TACTCAATAA GTGGACGTGG AGTTGATAAA 
GAACCTTTAA ATTTGTTTTA TATAGAAAGA GACACTGGAA ATCTATTTTG CACTCGGCCT 
GTGGATCGTG AAGAATATGA TGTTTTTGAT TTGATTGCTT ATGCGTCAAC TGCAGATGGA 
TATTCAGCAG ATCTGCCCCT CCCACTACCC ATCAGGGTAG AGGATGAAAA TGACAACCAC 
CCTGTTTTCA CAGAAGCAAT TTATAATTTT GAAGTTTTGG AAAGTAGTAG ACCTGGTACT 
ACAGTGGGGG TGGTTTGTGC CACAGACAGA GATGAACCGG ACACAATGCA TACGCGCCTG 
AAATACAGCA TTTTGCAGCA GACACCAAGG TCACCTGGGC TCTTTTCTGT GCATCCCAGC 
ACAGGCGTAA TCACCACAGT CTCTCATTAT TTGGACAGAG AGGTTGTAGA CAAGTACTCA 
TTGATAATGA AAGTACAAGA CATGGATGGC CAGTTTTTTG GATTGATAGG CACATCAACT 
TGTATCATAA CAGTAACAGA TTCAAATGAT AATGCACCCA CTTTCAGACA AAATGCTTAT 
GAAGCATTTG TAGAGGAAAA TGCATTCAAT GTGGAAATCT TACGAATACC TATAGAAGAT 
AAGGATTTAA TTAACACTGC CAATTGGAGA GTCAATTTTA CCATTTTAAA GGGAAATGAA 
AATGGACATT TCAAAATCAG CACAGACAAA GAAACTAATG AAGGTGTTCT TTCTGTTGTA 
AAGCCACTGA ATTATGAAGA AAACCGTCAA GTGAACCTGG AAATTGGAGT AAACAATGAA 
GCGCCATTTG CTAGAGATAT TCCCAGAGTG ACAGCCTTGA ACAGAGCCTT GGTTACAGTT 
CATGTGAGGG ATCTGGATGA GGGGCCTGAA TGCACTCCTG CAGCCCAATA TGTGCGGATT 
AAAGAAAACT TAGCAGTGGG GTCAAAGATC AACGGCTATA AGGCATATGA CCCCGAAAAT 
AGAAATGGCA ATGGTTTAAG GTACAAAAAA TTGCATGATC CTAAAGGTTG GATCACCATT 
GATGAAATTT CAGGGTCAAT CATAACTTCC AAAATCCTGG ATAGGGAGGT TGAAACTCCC 
AAAAATGAGT TGTATAATAT TACAGTCCTG GCAATAGACA AAGATGATAG ATCATGTACT 
GGAACACTTG CTGTGAACAT TGAAGATGTA AATGATAATC CACCAGAAAT ACTTCAAGAA 
TATGTAGTCA TTTGCAAACC AAAAATGGGG TATACCGACA TTTTAGCTGT TGATCCTGAT 
GAACCTGTCC ATGGAGCTCC ATTTTATTTC AGTTTGCCCA ATACTTCTCC AGAAATCAGT 
AGACTGTGGA GCCTCACCAA AGTTAATGAT ACAGCTGCCC GTCTTTCATA TCAGAAAAAT 
GCTGGATTTC AAGAATATAC CATTCCTATT ACTGTAAAAG ACAGGGCCGG CCAAGCTGCA 
ACAAAATTAT TGAGAGTTAA TCTGTGTGAA TGTACTCATC CAACTCAGTG TCGTGCGACT 
TCAAGGAGTA CAGGAGTAAT ACTTGGAAAA TGGGCAATCC TTGCAATATT ACTGGGTATA 
GCACTGCTCT TTTCTGTATT GCTAACTTTA GTATGTGGAG TTTTTGGTGC AACTAAAGGG 
AAACGTTTTC CTGAAGATTT AGCACAGCAA AACTTAATTA TATCAAACAC AGAAGCACCT 
GGAGACGATA GAGTGTGCTC TGCCAATGGA TTTATGACCC AAACTACCAA CAACTCTAGC 
CAAGGTTTTT GTGGTACTAT GGGATCAGGA ATGAAAAATG GAGGGCAGGA AACCATTGAA 
ATGATGAAAG GAGGAAACCA GACCTTGGAA TCCTGCCGGG GGGCTGGGCA TCATCATACC 
CTGGACTCCT GCAGGGGAGG ACACACGGAG GTGGACAACT GCAGATACAC TTACTCGGAG 
TGGCACAGTT TTACTCAACC CCGTCTCGGT GAAGAATCCA TTAGAGGACA CACTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of Desmoglein 2, Desmocollin 3 and Plakophilin 2 in Placenta and Bone Marrow-Derived Mesenchymal Stromal Cells.
Stem cell reviews13(2)258-266(2017 Apr)
Hart ML,Rusch E,Kaupp M,Nieselt K,Aicher WK

Sonographic alteration of substantia nigra is related to parkinsonism-predominant course of X-linked dystonia-parkinsonism.
Parkinsonism & related disorders3743-49(2017 Apr)
Walter U,Rosales R,Rocco A,Westenberger A,Domingo A,Go CL,Br?ggemann N,Klein C,Lee LV,Dressler D

The role of Napsin-A and Desmocollin-3 in classifying poorly differentiating non-small cell lung carcinoma.
Journal of the Egyptian National Cancer Institute28(1)13-22(2016 Mar)
Ezzat Nel-S,Tahoun N

Desmocollin 3 mediates follicle stimulating hormone-induced ovarian epithelial cancer cell proliferation by activating the EGFR/Akt signaling pathway.
International journal of clinical and experimental pathology8(6)6716-23(2015)
Yang X,Wang J,Li WP,Jin ZJ,Liu XJ

Association of DSC3 mRNA down-regulation in prostate cancer with promoter hypermethylation and poor prognosis.
PloS one9(3)e92815(2014)
Pan J,Chen Y,Mo C,Wang D,Chen J,Mao X,Guo S,Zhuang J,Qiu S

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DSC3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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