CYB5R3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CYB5R3
Entrez Gene ID	1727
Full Name	cytochrome b5 reductase 3
Synonyms	B5R,DIA1
General protein information	Preferred Names cytochrome b5 reductase 3 Names NADH-cytochrome b5 reductase 3 NADH-cytochrome b5 reductase 3 membrane-bound form NADH-cytochrome b5 reductase 3 soluble form diaphorase-1 mutant NADH-cytochrome b5 reductase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.2
Summary	This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias. [provided by RefSeq, Jan 2010].
Disorder MIM:	613213
Disorder Html:	Methemoglobinemia, type I, 250800 (3); Methemoglobinemia, type II, 250800 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000398.6	NP_000389.1	NADH-cytochrome b5 reductase 3 isoform 1
NM_007326.4	NP_015565.1	NADH-cytochrome b5 reductase 3 isoform 2
NM_000398.7	NP_000389.1	NADH-cytochrome b5 reductase 3 isoform 1
NM_001171661.1	NP_001165132.1	NADH-cytochrome b5 reductase 3 isoform 2
NM_001129819.2	NP_001123291.1	NADH-cytochrome b5 reductase 3 isoform 2
NM_001171660.1	NP_001165131.1	NADH-cytochrome b5 reductase 3 isoform 3

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b
Amdahl MB, Sparacino-Watkins CE, Corti P, Gladwin MT, Tejero J
Biochemistry56(30)3993-4004(2017 08)

NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer.
Lund RR, Leth-Larsen R, Caterino TD, Terp MG, Nissen J, L?nkholm AV, Jensen ON, Ditzel HJ
Molecular & cellular proteomics : MCP14(11)2988-99(2015 Nov)

Genetic variation in CYB5R3 is associated with methemoglobin levels in preterm infants receiving nitric oxide therapy.
Fuller TD, Spracklen CN, Ryckman KK, Knake LA, Busch TD, Momany AM, Murray JC, Dagle JM
Pediatric research77(3)472-6(2015 Mar)

Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women.
Blanke KL, Sacco JC, Millikan RC, Olshan AF, Luo J, Trepanier LA
Cancer causes & control : CCC25(11)1513-21(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that cytochrome b5 (CYB5) and cytochrome b5 reductase 3 (CYB5R3) can reduce human cytoglobin (CYGB) and zebrafish cytoglobins at rates up to 250-fold higher than those reported for the known physiological substrates, hemoglobin and myoglobin; the three proteins (CYB5+CYB5R3+CYGB) appear to constitute a metabolon involved in generation of nitric oxide.
Title: Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b

CYB5R3 promotes colonization and metastasis formation and is a prognostic marker of disease-free and overall survival in estrogen receptor-negative breast cancer.
Title: NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer.

Genetic variation in CYB5R3 is associated with methemoglobin levels in preterm infants receiving nitric oxide therapy.
Title: Genetic variation in CYB5R3 is associated with methemoglobin levels in preterm infants receiving nitric oxide therapy.

Variants in CYB5A and CYB5R3 should be considered in the evaluation of breast cancer risk in African American women.
Title: Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women.

The results unveil a potential mechanism of action by which CYB5R3 deficiency contributes to the pathophysiological underpinnings of neurological disorders in RHM patients.
Title: Membrane-bound CYB5R3 is a common effector of nutritional and oxidative stress response through FOXO3a and Nrf2.

The following CYB5R3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYB5R3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12696	NM_001129819.2 Latest version!	Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu12696	NM_007326.4 Latest version!	Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu12696	NM_001171661.1 Latest version!	Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu22339	NM_000398.7 Latest version!	Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu08152	NM_001171660.1 Latest version!	Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu22339	NM_000398.6	Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CYB5R3 ( NM_007326.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_015565.1 Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu12696
Clone ID Related Accession (Same CDS sequence)	NM_007326.4 , NM_001171661.1 , NM_001129819.2
Accession Version	NM_007326.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 837bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	NADH-cytochrome b5 reductase 3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB029897.1, AJ310900.1 and Z93241.11. On Jan 22, 2010 this sequence version replaced NM_007326.3. Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) is the soluble form of the enzyme, which has a shorter N-terminus when it is compared to the membrane-bound form. This isoform (2) is referred to in the literature as isoform s. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279835.8659.1, ERR279860.4679.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTGT TCCAGCGCTC CACGCCAGCC ATCACCCTCG AGAGCCCGGA CATCAAGTAC 
CCGCTGCGGC TCATCGACCG GGAGATCATC AGCCATGACA CCCGGCGCTT CCGCTTTGCC 
CTGCCGTCAC CCCAGCACAT CCTGGGCCTC CCTGTCGGCC AGCACATCTA CCTCTCGGCT 
CGAATTGATG GAAACCTGGT CGTCCGGCCC TATACACCCA TCTCCAGCGA TGATGACAAG 
GGCTTCGTGG ACCTGGTCAT CAAGGTTTAC TTCAAGGACA CCCATCCCAA GTTTCCCGCT 
GGAGGGAAGA TGTCTCAGTA CCTGGAGAGC ATGCAGATTG GAGACACCAT TGAGTTCCGG 
GGCCCCAGTG GGCTGCTGGT CTACCAGGGC AAAGGGAAGT TCGCCATCCG ACCTGACAAA 
AAGTCCAACC CTATCATCAG GACAGTGAAG TCTGTGGGCA TGATCGCGGG AGGGACAGGC 
ATCACCCCGA TGCTGCAGGT GATCCGCGCC ATCATGAAGG ACCCTGATGA CCACACTGTG 
TGCCACCTGC TCTTTGCCAA CCAGACCGAG AAGGACATCC TGCTGCGACC TGAGCTGGAG 
GAACTCAGGA ACAAACATTC TGCACGCTTC AAGCTCTGGT ACACGCTGGA CAGAGCCCCT 
GAAGCCTGGG ACTACGGCCA GGGCTTCGTG AATGAGGAGA TGATCCGGGA CCACCTTCCA 
CCCCCAGAGG AGGAGCCGCT GGTGCTGATG TGTGGCCCCC CACCCATGAT CCAGTACGCC 
TGCCTTCCCA ACCTGGACCA CGTGGGCCAC CCCACGGAGC GCTGCTTCGT CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_015565.1
CDS	153..989
Translation	MKLFQRSTPAITLESPDIKYPLRLIDREIISHDTRRFRFALPSPQHILGLPVGQHIYLSARIDGNLVVRPYTPISSDDDKGFVDLVIKVYFKDTHPKFPAGGKMSQYLESMQIGDTIEFRGPSGLLVYQGKGKFAIRPDKKSNPIIRTVKSVGMIAGGTGITPMLQVIRAIMKDPDDHTVCHLLFANQTEKDILLRPELEELRNKHSARFKLWYTLDRAPEAWDYGQGFVNEEMIRDHLPPPEEEPLVLMCGPPPMIQYACLPNLDHVGHPTERCFVF

Target ORF information:

RefSeq Version	NM_007326.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007326.4

ORF Insert Sequence:

ATGAAGCTGT TCCAGCGCTC CACGCCAGCC ATCACCCTCG AGAGCCCGGA CATCAAGTAC 
CCGCTGCGGC TCATCGACCG GGAGATCATC AGCCATGACA CCCGGCGCTT CCGCTTTGCC 
CTGCCGTCAC CCCAGCACAT CCTGGGCCTC CCTGTCGGCC AGCACATCTA CCTCTCGGCT 
CGAATTGATG GAAACCTGGT CGTCCGGCCC TATACACCCA TCTCCAGCGA TGATGACAAG 
GGCTTCGTGG ACCTGGTCAT CAAGGTTTAC TTCAAGGACA CCCATCCCAA GTTTCCCGCT 
GGAGGGAAGA TGTCTCAGTA CCTGGAGAGC ATGCAGATTG GAGACACCAT TGAGTTCCGG 
GGCCCCAGTG GGCTGCTGGT CTACCAGGGC AAAGGGAAGT TCGCCATCCG ACCTGACAAA 
AAGTCCAACC CTATCATCAG GACAGTGAAG TCTGTGGGCA TGATCGCGGG AGGGACAGGC 
ATCACCCCGA TGCTGCAGGT GATCCGCGCC ATCATGAAGG ACCCTGATGA CCACACTGTG 
TGCCACCTGC TCTTTGCCAA CCAGACCGAG AAGGACATCC TGCTGCGACC TGAGCTGGAG 
GAACTCAGGA ACAAACATTC TGCACGCTTC AAGCTCTGGT ACACGCTGGA CAGAGCCCCT 
GAAGCCTGGG ACTACGGCCA GGGCTTCGTG AATGAGGAGA TGATCCGGGA CCACCTTCCA 
CCCCCAGAGG AGGAGCCGCT GGTGCTGATG TGTGGCCCCC CACCCATGAT CCAGTACGCC 
TGCCTTCCCA ACCTGGACCA CGTGGGCCAC CCCACGGAGC GCTGCTTCGT CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYB5R3 ( NM_001171661.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001165132.1 Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu12696
Clone ID Related Accession (Same CDS sequence)	NM_007326.4 , NM_001171661.1 , NM_001129819.2
Accession Version	NM_001171661.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 837bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	NADH-cytochrome b5 reductase 3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z93241.11 and BM564146.1. Transcript Variant: This variant (4) uses an alternate exon in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) is the soluble form of the enzyme, which has a shorter N-terminus when it is compared to the membrane-bound form. This isoform (2) is referred to in the literature as isoform s. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: SRR1660805.6405.1, SRR1163658.175430.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTGT TCCAGCGCTC CACGCCAGCC ATCACCCTCG AGAGCCCGGA CATCAAGTAC 
CCGCTGCGGC TCATCGACCG GGAGATCATC AGCCATGACA CCCGGCGCTT CCGCTTTGCC 
CTGCCGTCAC CCCAGCACAT CCTGGGCCTC CCTGTCGGCC AGCACATCTA CCTCTCGGCT 
CGAATTGATG GAAACCTGGT CGTCCGGCCC TATACACCCA TCTCCAGCGA TGATGACAAG 
GGCTTCGTGG ACCTGGTCAT CAAGGTTTAC TTCAAGGACA CCCATCCCAA GTTTCCCGCT 
GGAGGGAAGA TGTCTCAGTA CCTGGAGAGC ATGCAGATTG GAGACACCAT TGAGTTCCGG 
GGCCCCAGTG GGCTGCTGGT CTACCAGGGC AAAGGGAAGT TCGCCATCCG ACCTGACAAA 
AAGTCCAACC CTATCATCAG GACAGTGAAG TCTGTGGGCA TGATCGCGGG AGGGACAGGC 
ATCACCCCGA TGCTGCAGGT GATCCGCGCC ATCATGAAGG ACCCTGATGA CCACACTGTG 
TGCCACCTGC TCTTTGCCAA CCAGACCGAG AAGGACATCC TGCTGCGACC TGAGCTGGAG 
GAACTCAGGA ACAAACATTC TGCACGCTTC AAGCTCTGGT ACACGCTGGA CAGAGCCCCT 
GAAGCCTGGG ACTACGGCCA GGGCTTCGTG AATGAGGAGA TGATCCGGGA CCACCTTCCA 
CCCCCAGAGG AGGAGCCGCT GGTGCTGATG TGTGGCCCCC CACCCATGAT CCAGTACGCC 
TGCCTTCCCA ACCTGGACCA CGTGGGCCAC CCCACGGAGC GCTGCTTCGT CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001165132.1
CDS	214..1050
Translation	MKLFQRSTPAITLESPDIKYPLRLIDREIISHDTRRFRFALPSPQHILGLPVGQHIYLSARIDGNLVVRPYTPISSDDDKGFVDLVIKVYFKDTHPKFPAGGKMSQYLESMQIGDTIEFRGPSGLLVYQGKGKFAIRPDKKSNPIIRTVKSVGMIAGGTGITPMLQVIRAIMKDPDDHTVCHLLFANQTEKDILLRPELEELRNKHSARFKLWYTLDRAPEAWDYGQGFVNEEMIRDHLPPPEEEPLVLMCGPPPMIQYACLPNLDHVGHPTERCFVF

Target ORF information:

RefSeq Version	NM_001171661.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001171661.1

ORF Insert Sequence:

ATGAAGCTGT TCCAGCGCTC CACGCCAGCC ATCACCCTCG AGAGCCCGGA CATCAAGTAC 
CCGCTGCGGC TCATCGACCG GGAGATCATC AGCCATGACA CCCGGCGCTT CCGCTTTGCC 
CTGCCGTCAC CCCAGCACAT CCTGGGCCTC CCTGTCGGCC AGCACATCTA CCTCTCGGCT 
CGAATTGATG GAAACCTGGT CGTCCGGCCC TATACACCCA TCTCCAGCGA TGATGACAAG 
GGCTTCGTGG ACCTGGTCAT CAAGGTTTAC TTCAAGGACA CCCATCCCAA GTTTCCCGCT 
GGAGGGAAGA TGTCTCAGTA CCTGGAGAGC ATGCAGATTG GAGACACCAT TGAGTTCCGG 
GGCCCCAGTG GGCTGCTGGT CTACCAGGGC AAAGGGAAGT TCGCCATCCG ACCTGACAAA 
AAGTCCAACC CTATCATCAG GACAGTGAAG TCTGTGGGCA TGATCGCGGG AGGGACAGGC 
ATCACCCCGA TGCTGCAGGT GATCCGCGCC ATCATGAAGG ACCCTGATGA CCACACTGTG 
TGCCACCTGC TCTTTGCCAA CCAGACCGAG AAGGACATCC TGCTGCGACC TGAGCTGGAG 
GAACTCAGGA ACAAACATTC TGCACGCTTC AAGCTCTGGT ACACGCTGGA CAGAGCCCCT 
GAAGCCTGGG ACTACGGCCA GGGCTTCGTG AATGAGGAGA TGATCCGGGA CCACCTTCCA 
CCCCCAGAGG AGGAGCCGCT GGTGCTGATG TGTGGCCCCC CACCCATGAT CCAGTACGCC 
TGCCTTCCCA ACCTGGACCA CGTGGGCCAC CCCACGGAGC GCTGCTTCGT CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYB5R3 ( NM_001129819.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001123291.1 Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu12696
Clone ID Related Accession (Same CDS sequence)	NM_007326.4 , NM_001171661.1 , NM_001129819.2
Accession Version	NM_001129819.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 837bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	NADH-cytochrome b5 reductase 3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z93241.11, DA548643.1, DA268749.1 and AJ310900.1. On Jan 22, 2010 this sequence version replaced NM_001129819.1. Transcript Variant: This variant (3) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is the soluble form of the enzyme, which has a shorter N-terminus when it is compared to the membrane-bound form. This isoform (2) is referred to in the literature as isoform s. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.5562.1, SRR1660805.332709.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTGT TCCAGCGCTC CACGCCAGCC ATCACCCTCG AGAGCCCGGA CATCAAGTAC 
CCGCTGCGGC TCATCGACCG GGAGATCATC AGCCATGACA CCCGGCGCTT CCGCTTTGCC 
CTGCCGTCAC CCCAGCACAT CCTGGGCCTC CCTGTCGGCC AGCACATCTA CCTCTCGGCT 
CGAATTGATG GAAACCTGGT CGTCCGGCCC TATACACCCA TCTCCAGCGA TGATGACAAG 
GGCTTCGTGG ACCTGGTCAT CAAGGTTTAC TTCAAGGACA CCCATCCCAA GTTTCCCGCT 
GGAGGGAAGA TGTCTCAGTA CCTGGAGAGC ATGCAGATTG GAGACACCAT TGAGTTCCGG 
GGCCCCAGTG GGCTGCTGGT CTACCAGGGC AAAGGGAAGT TCGCCATCCG ACCTGACAAA 
AAGTCCAACC CTATCATCAG GACAGTGAAG TCTGTGGGCA TGATCGCGGG AGGGACAGGC 
ATCACCCCGA TGCTGCAGGT GATCCGCGCC ATCATGAAGG ACCCTGATGA CCACACTGTG 
TGCCACCTGC TCTTTGCCAA CCAGACCGAG AAGGACATCC TGCTGCGACC TGAGCTGGAG 
GAACTCAGGA ACAAACATTC TGCACGCTTC AAGCTCTGGT ACACGCTGGA CAGAGCCCCT 
GAAGCCTGGG ACTACGGCCA GGGCTTCGTG AATGAGGAGA TGATCCGGGA CCACCTTCCA 
CCCCCAGAGG AGGAGCCGCT GGTGCTGATG TGTGGCCCCC CACCCATGAT CCAGTACGCC 
TGCCTTCCCA ACCTGGACCA CGTGGGCCAC CCCACGGAGC GCTGCTTCGT CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001123291.1
CDS	398..1234
Translation	MKLFQRSTPAITLESPDIKYPLRLIDREIISHDTRRFRFALPSPQHILGLPVGQHIYLSARIDGNLVVRPYTPISSDDDKGFVDLVIKVYFKDTHPKFPAGGKMSQYLESMQIGDTIEFRGPSGLLVYQGKGKFAIRPDKKSNPIIRTVKSVGMIAGGTGITPMLQVIRAIMKDPDDHTVCHLLFANQTEKDILLRPELEELRNKHSARFKLWYTLDRAPEAWDYGQGFVNEEMIRDHLPPPEEEPLVLMCGPPPMIQYACLPNLDHVGHPTERCFVF

Target ORF information:

RefSeq Version	NM_001129819.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001129819.2

ORF Insert Sequence:

ATGAAGCTGT TCCAGCGCTC CACGCCAGCC ATCACCCTCG AGAGCCCGGA CATCAAGTAC 
CCGCTGCGGC TCATCGACCG GGAGATCATC AGCCATGACA CCCGGCGCTT CCGCTTTGCC 
CTGCCGTCAC CCCAGCACAT CCTGGGCCTC CCTGTCGGCC AGCACATCTA CCTCTCGGCT 
CGAATTGATG GAAACCTGGT CGTCCGGCCC TATACACCCA TCTCCAGCGA TGATGACAAG 
GGCTTCGTGG ACCTGGTCAT CAAGGTTTAC TTCAAGGACA CCCATCCCAA GTTTCCCGCT 
GGAGGGAAGA TGTCTCAGTA CCTGGAGAGC ATGCAGATTG GAGACACCAT TGAGTTCCGG 
GGCCCCAGTG GGCTGCTGGT CTACCAGGGC AAAGGGAAGT TCGCCATCCG ACCTGACAAA 
AAGTCCAACC CTATCATCAG GACAGTGAAG TCTGTGGGCA TGATCGCGGG AGGGACAGGC 
ATCACCCCGA TGCTGCAGGT GATCCGCGCC ATCATGAAGG ACCCTGATGA CCACACTGTG 
TGCCACCTGC TCTTTGCCAA CCAGACCGAG AAGGACATCC TGCTGCGACC TGAGCTGGAG 
GAACTCAGGA ACAAACATTC TGCACGCTTC AAGCTCTGGT ACACGCTGGA CAGAGCCCCT 
GAAGCCTGGG ACTACGGCCA GGGCTTCGTG AATGAGGAGA TGATCCGGGA CCACCTTCCA 
CCCCCAGAGG AGGAGCCGCT GGTGCTGATG TGTGGCCCCC CACCCATGAT CCAGTACGCC 
TGCCTTCCCA ACCTGGACCA CGTGGGCCAC CCCACGGAGC GCTGCTTCGT CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYB5R3 ( NM_000398.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_000389.1 Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22339
Clone ID Related Accession (Same CDS sequence)	NM_000398.6 , NM_000398.7
Accession Version	NM_000398.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 906bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	NADH-cytochrome b5 reductase 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX334220.2, BC004821.1 and Z93241.11. This sequence is a reference standard in the RefSeqGene project. On Jan 22, 2010 this sequence version replaced NM_000398.5. Transcript Variant: This variant (1) encodes the membrane-bound form (isoform 1) of the enzyme. This isoform (1) is referred to in the literature as isoform m. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.6405.1, SRR1660803.73300.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGCCC AGCTCAGCAC GTTGGGCCAT ATGGTGCTCT TCCCAGTCTG GTTCCTGTAC 
AGTCTGCTCA TGAAGCTGTT CCAGCGCTCC ACGCCAGCCA TCACCCTCGA GAGCCCGGAC 
ATCAAGTACC CGCTGCGGCT CATCGACCGG GAGATCATCA GCCATGACAC CCGGCGCTTC 
CGCTTTGCCC TGCCGTCACC CCAGCACATC CTGGGCCTCC CTGTCGGCCA GCACATCTAC 
CTCTCGGCTC GAATTGATGG AAACCTGGTC GTCCGGCCCT ATACACCCAT CTCCAGCGAT 
GATGACAAGG GCTTCGTGGA CCTGGTCATC AAGGTTTACT TCAAGGACAC CCATCCCAAG 
TTTCCCGCTG GAGGGAAGAT GTCTCAGTAC CTGGAGAGCA TGCAGATTGG AGACACCATT 
GAGTTCCGGG GCCCCAGTGG GCTGCTGGTC TACCAGGGCA AAGGGAAGTT CGCCATCCGA 
CCTGACAAAA AGTCCAACCC TATCATCAGG ACAGTGAAGT CTGTGGGCAT GATCGCGGGA 
GGGACAGGCA TCACCCCGAT GCTGCAGGTG ATCCGCGCCA TCATGAAGGA CCCTGATGAC 
CACACTGTGT GCCACCTGCT CTTTGCCAAC CAGACCGAGA AGGACATCCT GCTGCGACCT 
GAGCTGGAGG AACTCAGGAA CAAACATTCT GCACGCTTCA AGCTCTGGTA CACGCTGGAC 
AGAGCCCCTG AAGCCTGGGA CTACGGCCAG GGCTTCGTGA ATGAGGAGAT GATCCGGGAC 
CACCTTCCAC CCCCAGAGGA GGAGCCGCTG GTGCTGATGT GTGGCCCCCC ACCCATGATC 
CAGTACGCCT GCCTTCCCAA CCTGGACCAC GTGGGCCACC CCACGGAGCG CTGCTTCGTC 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000389.1
CDS	85..990
Translation	MGAQLSTLGHMVLFPVWFLYSLLMKLFQRSTPAITLESPDIKYPLRLIDREIISHDTRRFRFALPSPQHILGLPVGQHIYLSARIDGNLVVRPYTPISSDDDKGFVDLVIKVYFKDTHPKFPAGGKMSQYLESMQIGDTIEFRGPSGLLVYQGKGKFAIRPDKKSNPIIRTVKSVGMIAGGTGITPMLQVIRAIMKDPDDHTVCHLLFANQTEKDILLRPELEELRNKHSARFKLWYTLDRAPEAWDYGQGFVNEEMIRDHLPPPEEEPLVLMCGPPPMIQYACLPNLDHVGHPTERCFVF

Target ORF information:

RefSeq Version	NM_000398.6
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000398.6

ORF Insert Sequence:

ATGGGGGCCC AGCTCAGCAC GTTGGGCCAT ATGGTGCTCT TCCCAGTCTG GTTCCTGTAC 
AGTCTGCTCA TGAAGCTGTT CCAGCGCTCC ACGCCAGCCA TCACCCTCGA GAGCCCGGAC 
ATCAAGTACC CGCTGCGGCT CATCGACCGG GAGATCATCA GCCATGACAC CCGGCGCTTC 
CGCTTTGCCC TGCCGTCACC CCAGCACATC CTGGGCCTCC CTGTCGGCCA GCACATCTAC 
CTCTCGGCTC GAATTGATGG AAACCTGGTC GTCCGGCCCT ATACACCCAT CTCCAGCGAT 
GATGACAAGG GCTTCGTGGA CCTGGTCATC AAGGTTTACT TCAAGGACAC CCATCCCAAG 
TTTCCCGCTG GAGGGAAGAT GTCTCAGTAC CTGGAGAGCA TGCAGATTGG AGACACCATT 
GAGTTCCGGG GCCCCAGTGG GCTGCTGGTC TACCAGGGCA AAGGGAAGTT CGCCATCCGA 
CCTGACAAAA AGTCCAACCC TATCATCAGG ACAGTGAAGT CTGTGGGCAT GATCGCGGGA 
GGGACAGGCA TCACCCCGAT GCTGCAGGTG ATCCGCGCCA TCATGAAGGA CCCTGATGAC 
CACACTGTGT GCCACCTGCT CTTTGCCAAC CAGACCGAGA AGGACATCCT GCTGCGACCT 
GAGCTGGAGG AACTCAGGAA CAAACATTCT GCACGCTTCA AGCTCTGGTA CACGCTGGAC 
AGAGCCCCTG AAGCCTGGGA CTACGGCCAG GGCTTCGTGA ATGAGGAGAT GATCCGGGAC 
CACCTTCCAC CCCCAGAGGA GGAGCCGCTG GTGCTGATGT GTGGCCCCCC ACCCATGATC 
CAGTACGCCT GCCTTCCCAA CCTGGACCAC GTGGGCCACC CCACGGAGCG CTGCTTCGTC 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYB5R3 ( NM_000398.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_000389.1 Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 1, mRNA.

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CloneID	OHu22339
Clone ID Related Accession (Same CDS sequence)	NM_000398.6 , NM_000398.7
Accession Version	NM_000398.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 906bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	NADH-cytochrome b5 reductase 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX334220.2, BC004821.1 and Z93241.11. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_000398.6. Transcript Variant: This variant (1) encodes the membrane-bound form (isoform 1) of the enzyme. This isoform (1) is referred to in the literature as isoform m. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.151933.1, SRR1660805.6405.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000352397.10/ ENSP00000338461.6 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGGCCC AGCTCAGCAC GTTGGGCCAT ATGGTGCTCT TCCCAGTCTG GTTCCTGTAC 
AGTCTGCTCA TGAAGCTGTT CCAGCGCTCC ACGCCAGCCA TCACCCTCGA GAGCCCGGAC 
ATCAAGTACC CGCTGCGGCT CATCGACCGG GAGATCATCA GCCATGACAC CCGGCGCTTC 
CGCTTTGCCC TGCCGTCACC CCAGCACATC CTGGGCCTCC CTGTCGGCCA GCACATCTAC 
CTCTCGGCTC GAATTGATGG AAACCTGGTC GTCCGGCCCT ATACACCCAT CTCCAGCGAT 
GATGACAAGG GCTTCGTGGA CCTGGTCATC AAGGTTTACT TCAAGGACAC CCATCCCAAG 
TTTCCCGCTG GAGGGAAGAT GTCTCAGTAC CTGGAGAGCA TGCAGATTGG AGACACCATT 
GAGTTCCGGG GCCCCAGTGG GCTGCTGGTC TACCAGGGCA AAGGGAAGTT CGCCATCCGA 
CCTGACAAAA AGTCCAACCC TATCATCAGG ACAGTGAAGT CTGTGGGCAT GATCGCGGGA 
GGGACAGGCA TCACCCCGAT GCTGCAGGTG ATCCGCGCCA TCATGAAGGA CCCTGATGAC 
CACACTGTGT GCCACCTGCT CTTTGCCAAC CAGACCGAGA AGGACATCCT GCTGCGACCT 
GAGCTGGAGG AACTCAGGAA CAAACATTCT GCACGCTTCA AGCTCTGGTA CACGCTGGAC 
AGAGCCCCTG AAGCCTGGGA CTACGGCCAG GGCTTCGTGA ATGAGGAGAT GATCCGGGAC 
CACCTTCCAC CCCCAGAGGA GGAGCCGCTG GTGCTGATGT GTGGCCCCCC ACCCATGATC 
CAGTACGCCT GCCTTCCCAA CCTGGACCAC GTGGGCCACC CCACGGAGCG CTGCTTCGTC 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000389.1
CDS	78..983
Translation	MGAQLSTLGHMVLFPVWFLYSLLMKLFQRSTPAITLESPDIKYPLRLIDREIISHDTRRFRFALPSPQHILGLPVGQHIYLSARIDGNLVVRPYTPISSDDDKGFVDLVIKVYFKDTHPKFPAGGKMSQYLESMQIGDTIEFRGPSGLLVYQGKGKFAIRPDKKSNPIIRTVKSVGMIAGGTGITPMLQVIRAIMKDPDDHTVCHLLFANQTEKDILLRPELEELRNKHSARFKLWYTLDRAPEAWDYGQGFVNEEMIRDHLPPPEEEPLVLMCGPPPMIQYACLPNLDHVGHPTERCFVF

Target ORF information:

RefSeq Version	NM_000398.7
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000398.7

ORF Insert Sequence:

ATGGGGGCCC AGCTCAGCAC GTTGGGCCAT ATGGTGCTCT TCCCAGTCTG GTTCCTGTAC 
AGTCTGCTCA TGAAGCTGTT CCAGCGCTCC ACGCCAGCCA TCACCCTCGA GAGCCCGGAC 
ATCAAGTACC CGCTGCGGCT CATCGACCGG GAGATCATCA GCCATGACAC CCGGCGCTTC 
CGCTTTGCCC TGCCGTCACC CCAGCACATC CTGGGCCTCC CTGTCGGCCA GCACATCTAC 
CTCTCGGCTC GAATTGATGG AAACCTGGTC GTCCGGCCCT ATACACCCAT CTCCAGCGAT 
GATGACAAGG GCTTCGTGGA CCTGGTCATC AAGGTTTACT TCAAGGACAC CCATCCCAAG 
TTTCCCGCTG GAGGGAAGAT GTCTCAGTAC CTGGAGAGCA TGCAGATTGG AGACACCATT 
GAGTTCCGGG GCCCCAGTGG GCTGCTGGTC TACCAGGGCA AAGGGAAGTT CGCCATCCGA 
CCTGACAAAA AGTCCAACCC TATCATCAGG ACAGTGAAGT CTGTGGGCAT GATCGCGGGA 
GGGACAGGCA TCACCCCGAT GCTGCAGGTG ATCCGCGCCA TCATGAAGGA CCCTGATGAC 
CACACTGTGT GCCACCTGCT CTTTGCCAAC CAGACCGAGA AGGACATCCT GCTGCGACCT 
GAGCTGGAGG AACTCAGGAA CAAACATTCT GCACGCTTCA AGCTCTGGTA CACGCTGGAC 
AGAGCCCCTG AAGCCTGGGA CTACGGCCAG GGCTTCGTGA ATGAGGAGAT GATCCGGGAC 
CACCTTCCAC CCCCAGAGGA GGAGCCGCTG GTGCTGATGT GTGGCCCCCC ACCCATGATC 
CAGTACGCCT GCCTTCCCAA CCTGGACCAC GTGGGCCACC CCACGGAGCG CTGCTTCGTC 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYB5R3 ( NM_001171660.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001165131.1 Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu08152
Clone ID Related Accession (Same CDS sequence)	NM_001171660.1
Accession Version	NM_001171660.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	NADH-cytochrome b5 reductase 3 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z93241.11 and AK302204.1. Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has a distinct N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK302204.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATAGGA GTTTGCTGGT TGGATGCATG CAGAGCAAGG ACATTTGGGG CAGAGAGGAG 
AGCATATGCG AACGCCTGAA GCAAGATGGG CTTGATGTTG AAAGAGCAGA GAGCTGGGAG 
TTGGGCCATA TGGTGCTCTT CCCAGTCTGG TTCCTGTACA GTCTGCTCAT GAAGCTGTTC 
CAGCGCTCCA CGCCAGCCAT CACCCTCGAG AGCCCGGACA TCAAGTACCC GCTGCGGCTC 
ATCGACCGGG AGATCATCAG CCATGACACC CGGCGCTTCC GCTTTGCCCT GCCGTCACCC 
CAGCACATCC TGGGCCTCCC TGTCGGCCAG CACATCTACC TCTCGGCTCG AATTGATGGA 
AACCTGGTCG TCCGGCCCTA TACACCCATC TCCAGCGATG ATGACAAGGG CTTCGTGGAC 
CTGGTCATCA AGGTTTACTT CAAGGACACC CATCCCAAGT TTCCCGCTGG AGGGAAGATG 
TCTCAGTACC TGGAGAGCAT GCAGATTGGA GACACCATTG AGTTCCGGGG CCCCAGTGGG 
CTGCTGGTCT ACCAGGGCAA AGGGAAGTTC GCCATCCGAC CTGACAAAAA GTCCAACCCT 
ATCATCAGGA CAGTGAAGTC TGTGGGCATG ATCGCGGGAG GGACAGGCAT CACCCCGATG 
CTGCAGGTGA TCCGCGCCAT CATGAAGGAC CCTGATGACC ACACTGTGTG CCACCTGCTC 
TTTGCCAACC AGACCGAGAA GGACATCCTG CTGCGACCTG AGCTGGAGGA ACTCAGGAAC 
AAACATTCTG CACGCTTCAA GCTCTGGTAC ACGCTGGACA GAGCCCCTGA AGCCTGGGAC 
TACGGCCAGG GCTTCGTGAA TGAGGAGATG ATCCGGGACC ACCTTCCACC CCCAGAGGAG 
GAGCCGCTGG TGCTGATGTG TGGCCCCCCA CCCATGATCC AGTACGCCTG CCTTCCCAAC 
CTGGACCACG TGGGCCACCC CACGGAGCGC TGCTTCGTCT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001165131.1
CDS	126..1130
Translation	MNRSLLVGCMQSKDIWGREESICERLKQDGLDVERAESWELGHMVLFPVWFLYSLLMKLFQRSTPAITLESPDIKYPLRLIDREIISHDTRRFRFALPSPQHILGLPVGQHIYLSARIDGNLVVRPYTPISSDDDKGFVDLVIKVYFKDTHPKFPAGGKMSQYLESMQIGDTIEFRGPSGLLVYQGKGKFAIRPDKKSNPIIRTVKSVGMIAGGTGITPMLQVIRAIMKDPDDHTVCHLLFANQTEKDILLRPELEELRNKHSARFKLWYTLDRAPEAWDYGQGFVNEEMIRDHLPPPEEEPLVLMCGPPPMIQYACLPNLDHVGHPTERCFVF

Target ORF information:

RefSeq Version	NM_001171660.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001171660.1

ORF Insert Sequence:

ATGAATAGGA GTTTGCTGGT TGGATGCATG CAGAGCAAGG ACATTTGGGG CAGAGAGGAG 
AGCATATGCG AACGCCTGAA GCAAGATGGG CTTGATGTTG AAAGAGCAGA GAGCTGGGAG 
TTGGGCCATA TGGTGCTCTT CCCAGTCTGG TTCCTGTACA GTCTGCTCAT GAAGCTGTTC 
CAGCGCTCCA CGCCAGCCAT CACCCTCGAG AGCCCGGACA TCAAGTACCC GCTGCGGCTC 
ATCGACCGGG AGATCATCAG CCATGACACC CGGCGCTTCC GCTTTGCCCT GCCGTCACCC 
CAGCACATCC TGGGCCTCCC TGTCGGCCAG CACATCTACC TCTCGGCTCG AATTGATGGA 
AACCTGGTCG TCCGGCCCTA TACACCCATC TCCAGCGATG ATGACAAGGG CTTCGTGGAC 
CTGGTCATCA AGGTTTACTT CAAGGACACC CATCCCAAGT TTCCCGCTGG AGGGAAGATG 
TCTCAGTACC TGGAGAGCAT GCAGATTGGA GACACCATTG AGTTCCGGGG CCCCAGTGGG 
CTGCTGGTCT ACCAGGGCAA AGGGAAGTTC GCCATCCGAC CTGACAAAAA GTCCAACCCT 
ATCATCAGGA CAGTGAAGTC TGTGGGCATG ATCGCGGGAG GGACAGGCAT CACCCCGATG 
CTGCAGGTGA TCCGCGCCAT CATGAAGGAC CCTGATGACC ACACTGTGTG CCACCTGCTC 
TTTGCCAACC AGACCGAGAA GGACATCCTG CTGCGACCTG AGCTGGAGGA ACTCAGGAAC 
AAACATTCTG CACGCTTCAA GCTCTGGTAC ACGCTGGACA GAGCCCCTGA AGCCTGGGAC 
TACGGCCAGG GCTTCGTGAA TGAGGAGATG ATCCGGGACC ACCTTCCACC CCCAGAGGAG 
GAGCCGCTGG TGCTGATGTG TGGCCCCCCA CCCATGATCC AGTACGCCTG CCTTCCCAAC 
CTGGACCACG TGGGCCACCC CACGGAGCGC TGCTTCGTCT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b
Biochemistry56(30)3993-4004(2017 08)
Amdahl MB,Sparacino-Watkins CE,Corti P,Gladwin MT,Tejero J

NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer.
Molecular & cellular proteomics : MCP14(11)2988-99(2015 Nov)
Lund RR,Leth-Larsen R,Caterino TD,Terp MG,Nissen J,L?nkholm AV,Jensen ON,Ditzel HJ

Genetic variation in CYB5R3 is associated with methemoglobin levels in preterm infants receiving nitric oxide therapy.
Pediatric research77(3)472-6(2015 Mar)
Fuller TD,Spracklen CN,Ryckman KK,Knake LA,Busch TD,Momany AM,Murray JC,Dagle JM

Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women.
Cancer causes & control : CCC25(11)1513-21(2014 Nov)
Blanke KL,Sacco JC,Millikan RC,Olshan AF,Luo J,Trepanier LA

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CYB5R3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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