SPPL2C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SPPL2C
Entrez Gene ID	162540
Full Name	signal peptide peptidase like 2C
Synonyms	IMP5
General protein information	Preferred Names signal peptide peptidase like 2C Names signal peptide peptidase-like 2C IMP-5 SPP-like 2C intramembrane protease 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.31
Disorder MIM:	608284

mRNA and Protein(s)

mRNA	Protein	Name
NM_175882.2	NP_787078.2	signal peptide peptidase-like 2C precursor
NM_175882.3	NP_787078.2	signal peptide peptidase-like 2C precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	SPPL2C	NP_787078.2
Rattus norvegicus (Norway rat)	Sppl2c	NP_001099317.1
	LOC717107	XP_001115879.1
Bos taurus (cattle)	SPPL2C	XP_002696104.1
Pan troglodytes (chimpanzee)	SPPL2C	XP_523673.2
Canis lupus familiaris (dog)	SPPL2C	XP_548046.2
Mus musculus (house mouse)	Sppl2c	NP_950184.2

Gene Ontology
Bibliography

Related articles in PubMed

Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.
Noth I, Zhang Y, Ma SF, Flores C, Barber M, Huang Y, Broderick SM, Wade MS, Hysi P, Scuirba J, Richards TJ, Juan-Guardela BM, Vij R, Han MK, Martinez FJ, Kossen K, Seiwert SD, Christie JD, Nicolae D, Kaminski N, Garcia JGN
The Lancet. Respiratory medicine1(4)309-317(2013 Jun)

Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.
Li R, Brockschmidt FF, Kiefer AK, Stefansson H, Nyholt DR, Song K, Vermeulen SH, Kanoni S, Glass D, Medland SE, Dimitriou M, Waterworth D, Tung JY, Geller F, Heilmann S, Hillmer AM, Bataille V, Eigelshoven S, Hanneken S, Moebus S, Herold C, den Heijer M, Montgomery GW, Deloukas P, Eriksson N, Heath AC, Becker T, Sulem P, Mangino M, Vollenweider P, Spector TD, Dedoussis G, Martin NG, Kiemeney LA, Mooser V, Stefansson K, Hinds DA, N?then MM, Richards JB
PLoS genetics8(5)e1002746(2012 May)

Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
Do CB, Tung JY, Dorfman E, Kiefer AK, Drabant EM, Francke U, Mountain JL, Goldman SM, Tanner CM, Langston JW, Wojcicki A, Eriksson N
PLoS genetics7(6)e1002141(2011 Jun)

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.
Martin L, Fluhrer R, Reiss K, Kremmer E, Saftig P, Haass C
The Journal of biological chemistry283(3)1644-52(2008 Jan)

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production.
Friedmann E, Hauben E, Maylandt K, Schleeger S, Vreugde S, Lichtenthaler SF, Kuhn PH, Stauffer D, Rovelli G, Martoglio B
Nature cell biology8(8)843-8(2006 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: High throughput SNP and expression analyses of candidate genes for non-syndromic oral clefts.

SPP, SPPL2a, -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis [SPPL2c]
Title: Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins.

Observational study of gene-disease association. (HuGE Navigator)
Title: Novel haplotypes in 17q21 are associated with progressive supranuclear palsy.

The following SPPL2C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPPL2C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11661	NM_175882.3 Latest version!	Homo sapiens signal peptide peptidase like 2C (SPPL2C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu11661	NM_175882.2	Homo sapiens signal peptide peptidase like 2C (SPPL2C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SPPL2C ( NM_175882.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_787078.2 Homo sapiens signal peptide peptidase like 2C (SPPL2C), mRNA.

Price & Availability↑

CloneID	OHu11661
Clone ID Related Accession (Same CDS sequence)	NM_175882.2 , NM_175882.3
Accession Version	NM_175882.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2055bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Homo sapiens(human)
Product	signal peptide peptidase-like 2C precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC217771.1. On Jan 16, 2010 this sequence version replaced NM_175882.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC025401.1, BC022041.1 [ECO:0000345] ##Evidence-Data-END##

ATGGCGTGCC TGGGCTTCCT CCTCCCCGTG GGCTTCCTCC TCCTCATCAG CACCGTGGCC 
GGGGGAAAGT ACGGCGTGGC CCACGTGGTG TCGGAGAATT GGAGCAAGGA CTACTGTATC 
CTGTTCAGCT CCGACTACAT CACCCTCCCC CGGGACCTGC ACCACGCCCC ACTCCTGCCC 
CTGTATGATG GCACCAAGGC ACCCTGGTGC CCGGGTGAGG ATTCCCCCCA CCAGGCCCAG 
CTCCGCTCCC CCAGCCAGCG GCCCCTCCGC CAGACCACTG CCATGGTCAT GAGGGGTAAC 
TGCAGCTTCC ACACGAAAGG CTGGCTGGCT CAGGGCCAAG GTGCCCACGG GCTGCTCATC 
GTGAGCCGGG TCAGTGACCA ACAGTGCTCA GACACCACCC TGGCACCCCA GGATCCCCGC 
CAGCCCCTGG CAGACCTCAC CATCCCTGTG GCTATGCTCC ACTATGCTGA CATGCTGGAC 
ATCCTCAGCC ACACTCGTGG GGAGGCCGTC GTCCGCGTGG CCATGTACGC ACCCCCAGAG 
CCCATCATCG ACTACAACAT GCTGGTCATC TTCATCCTGG CTGTGGGCAC AGTGGCTGCA 
GGCGGCTACT GGGCCGGCCT GACCGAAGCC AACCGGCTAC AGCGGCGCCG TGCCCGAAGA 
GGAGGGGGGT CTGGTGGTCA CCATCAGCTG CAGGAAGCTG CAGCAGCTGA GGGAGCCCAG 
AAGGAAGATA ATGAGGACAT CCCAGTGGAC TTCACGCCGG CCATGACAGG CGTGGTGGTC 
ACCCTGTCCT GCTCGCTCAT GCTGCTGCTC TACTTCTTCT ATGACCACTT TGTCTATGTC 
ACCATTGGGA TCTTTGGCCT GGGTGCTGGC ATTGGCCTCT ACAGCTGCCT GTCACCCCTG 
GTGTGCCGCC TGTCCCTGCG GCAATACCAG AGGCCTCCGC ACAGCCTCTG GGCCTCTCTG 
CCGCTGCCTC TGCTGCTGCT GGCGAGCCTG TGCGCAACCG TGATCATCTT CTGGGTGGCC 
TACCGCAATG AGGACCGCTG GGCGTGGCTC CTGCAGGACA CACTGGGCAT TTCCTACTGC 
CTGTTCGTCC TGCACCGTGT GCGGCTGCCC ACTCTCAAGA ACTGCTCCTC CTTCCTGCTG 
GCCCTGCTGG CCTTTGATGT CTTCTTTGTC TTCGTCACCC CCTTCTTCAC CAAAACCGGT 
GAGAGCATCA TGGCGCAGGT TGCCTTGGGC CCTGCAGAGT CTTCAAGCCA TGAGAGGCTG 
CCCATGGTAC TCAAAGTGCC CCGGCTAAGA GTCTCCGCCT TGACCCTGTG CAGCCAGCCC 
TTCTCCATCC TTGGCTTCGG TGACATTGTG GTCCCCGGCT TCCTGGTTGC TTACTGTTGC 
CGCTTTGATG TGCAAGTCTG CTCCCGTCAG ATCTACTTCG TGGCCTGCAC CGTGGCCTAT 
GCTGTGGGCC TGCTGGTCAC ATTCATGGCC ATGGTCCTCA TGCAGATGGG CCAACCTGCC 
TTGCTCTACC TAGTGTCCAG CACCCTGCTC ACCAGCCTGG CTGTGGCTGC CTGCCGCCAA 
GAGCTCAGCC TCTTCTGGAC TGGCCAGGGC AGAGCTAAGA TGTGTGGGCT CGGCTGTGCC 
CCTTCAGCTG GCTCTAGGCA GAAGCAGGAG GGCGCAGCAG ATGCCCACAC AGCCAGCACA 
CTTGAGAGAG GCACCAGCCG AGGAGCAGGG GACTTAGACA GCAACCCTGG AGAAGACACC 
ACTGAGATTG TCACCATATC TGAGAATGAA GCCACCAATC CAGAGGACCG CAGTGATAGC 
TCCGAGGGCT GGAGTGACGC CCACTTGGAT CCTAATGAGC TGCCCTTCAT CCCCCCTGGG 
GCCTCGGAGG AGCTGATGCC ACTGATGCCA ATGGCCATGC TGATCCCACT CATGCCCCTG 
ATGCCCCCGC CCTCAGAGCT GGGCCATGTC CATGCCCAGG CCCAGGCCCA CGAGACTGGC 
CTGCCCTGGG CGGGACTCCA CAAGAGGAAG GGTTTGAAAG TAAGAAAGAG CATGTCGACC 
CAGGCTCCCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_787078.2
CDS	18..2072
Translation	MACLGFLLPVGFLLLISTVAGGKYGVAHVVSENWSKDYCILFSSDYITLPRDLHHAPLLPLYDGTKAPWCPGEDSPHQAQLRSPSQRPLRQTTAMVMRGNCSFHTKGWLAQGQGAHGLLIVSRVSDQQCSDTTLAPQDPRQPLADLTIPVAMLHYADMLDILSHTRGEAVVRVAMYAPPEPIIDYNMLVIFILAVGTVAAGGYWAGLTEANRLQRRRARRGGGSGGHHQLQEAAAAEGAQKEDNEDIPVDFTPAMTGVVVTLSCSLMLLLYFFYDHFVYVTIGIFGLGAGIGLYSCLSPLVCRLSLRQYQRPPHSLWASLPLPLLLLASLCATVIIFWVAYRNEDRWAWLLQDTLGISYCLFVLHRVRLPTLKNCSSFLLALLAFDVFFVFVTPFFTKTGESIMAQVALGPAESSSHERLPMVLKVPRLRVSALTLCSQPFSILGFGDIVVPGFLVAYCCRFDVQVCSRQIYFVACTVAYAVGLLVTFMAMVLMQMGQPALLYLVSSTLLTSLAVAACRQELSLFWTGQGRAKMCGLGCAPSAGSRQKQEGAADAHTASTLERGTSRGAGDLDSNPGEDTTEIVTISENEATNPEDRSDSSEGWSDAHLDPNELPFIPPGASEELMPLMPMAMLIPLMPLMPPPSELGHVHAQAQAHETGLPWAGLHKRKGLKVRKSMSTQAPL

Target ORF information:

RefSeq Version	NM_175882.2
Organism	Homo sapiens(human)
Definition	Homo sapiens signal peptide peptidase like 2C (SPPL2C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175882.2

ORF Insert Sequence:

ATGGCGTGCC TGGGCTTCCT CCTCCCCGTG GGCTTCCTCC TCCTCATCAG CACCGTGGCC 
GGGGGAAAGT ACGGCGTGGC CCACGTGGTG TCGGAGAATT GGAGCAAGGA CTACTGTATC 
CTGTTCAGCT CCGACTACAT CACCCTCCCC CGGGACCTGC ACCACGCCCC ACTCCTGCCC 
CTGTATGATG GCACCAAGGC ACCCTGGTGC CCGGGTGAGG ATTCCCCCCA CCAGGCCCAG 
CTCCGCTCCC CCAGCCAGCG GCCCCTCCGC CAGACCACTG CCATGGTCAT GAGGGGTAAC 
TGCAGCTTCC ACACGAAAGG CTGGCTGGCT CAGGGCCAAG GTGCCCACGG GCTGCTCATC 
GTGAGCCGGG TCAGTGACCA ACAGTGCTCA GACACCACCC TGGCACCCCA GGATCCCCGC 
CAGCCCCTGG CAGACCTCAC CATCCCTGTG GCTATGCTCC ACTATGCTGA CATGCTGGAC 
ATCCTCAGCC ACACTCGTGG GGAGGCCGTC GTCCGCGTGG CCATGTACGC ACCCCCAGAG 
CCCATCATCG ACTACAACAT GCTGGTCATC TTCATCCTGG CTGTGGGCAC AGTGGCTGCA 
GGCGGCTACT GGGCCGGCCT GACCGAAGCC AACCGGCTAC AGCGGCGCCG TGCCCGAAGA 
GGAGGGGGGT CTGGTGGTCA CCATCAGCTG CAGGAAGCTG CAGCAGCTGA GGGAGCCCAG 
AAGGAAGATA ATGAGGACAT CCCAGTGGAC TTCACGCCGG CCATGACAGG CGTGGTGGTC 
ACCCTGTCCT GCTCGCTCAT GCTGCTGCTC TACTTCTTCT ATGACCACTT TGTCTATGTC 
ACCATTGGGA TCTTTGGCCT GGGTGCTGGC ATTGGCCTCT ACAGCTGCCT GTCACCCCTG 
GTGTGCCGCC TGTCCCTGCG GCAATACCAG AGGCCTCCGC ACAGCCTCTG GGCCTCTCTG 
CCGCTGCCTC TGCTGCTGCT GGCGAGCCTG TGCGCAACCG TGATCATCTT CTGGGTGGCC 
TACCGCAATG AGGACCGCTG GGCGTGGCTC CTGCAGGACA CACTGGGCAT TTCCTACTGC 
CTGTTCGTCC TGCACCGTGT GCGGCTGCCC ACTCTCAAGA ACTGCTCCTC CTTCCTGCTG 
GCCCTGCTGG CCTTTGATGT CTTCTTTGTC TTCGTCACCC CCTTCTTCAC CAAAACCGGT 
GAGAGCATCA TGGCGCAGGT TGCCTTGGGC CCTGCAGAGT CTTCAAGCCA TGAGAGGCTG 
CCCATGGTAC TCAAAGTGCC CCGGCTAAGA GTCTCCGCCT TGACCCTGTG CAGCCAGCCC 
TTCTCCATCC TTGGCTTCGG TGACATTGTG GTCCCCGGCT TCCTGGTTGC TTACTGTTGC 
CGCTTTGATG TGCAAGTCTG CTCCCGTCAG ATCTACTTCG TGGCCTGCAC CGTGGCCTAT 
GCTGTGGGCC TGCTGGTCAC ATTCATGGCC ATGGTCCTCA TGCAGATGGG CCAACCTGCC 
TTGCTCTACC TAGTGTCCAG CACCCTGCTC ACCAGCCTGG CTGTGGCTGC CTGCCGCCAA 
GAGCTCAGCC TCTTCTGGAC TGGCCAGGGC AGAGCTAAGA TGTGTGGGCT CGGCTGTGCC 
CCTTCAGCTG GCTCTAGGCA GAAGCAGGAG GGCGCAGCAG ATGCCCACAC AGCCAGCACA 
CTTGAGAGAG GCACCAGCCG AGGAGCAGGG GACTTAGACA GCAACCCTGG AGAAGACACC 
ACTGAGATTG TCACCATATC TGAGAATGAA GCCACCAATC CAGAGGACCG CAGTGATAGC 
TCCGAGGGCT GGAGTGACGC CCACTTGGAT CCTAATGAGC TGCCCTTCAT CCCCCCTGGG 
GCCTCGGAGG AGCTGATGCC ACTGATGCCA ATGGCCATGC TGATCCCACT CATGCCCCTG 
ATGCCCCCGC CCTCAGAGCT GGGCCATGTC CATGCCCAGG CCCAGGCCCA CGAGACTGGC 
CTGCCCTGGG CGGGACTCCA CAAGAGGAAG GGTTTGAAAG TAAGAAAGAG CATGTCGACC 
CAGGCTCCCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPPL2C ( NM_175882.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_787078.2 Homo sapiens signal peptide peptidase like 2C (SPPL2C), mRNA.

Price & Availability↑

CloneID	OHu11661
Clone ID Related Accession (Same CDS sequence)	NM_175882.2 , NM_175882.3
Accession Version	NM_175882.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2055bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	signal peptide peptidase-like 2C precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC217771.1. On May 17, 2019 this sequence version replaced NM_175882.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC022041.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000329196.7/ ENSP00000332488.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCGTGCC TGGGCTTCCT CCTCCCCGTG GGCTTCCTCC TCCTCATCAG CACCGTGGCC 
GGGGGAAAGT ACGGCGTGGC CCACGTGGTG TCGGAGAATT GGAGCAAGGA CTACTGTATC 
CTGTTCAGCT CCGACTACAT CACCCTCCCC CGGGACCTGC ACCACGCCCC ACTCCTGCCC 
CTGTATGATG GCACCAAGGC ACCCTGGTGC CCGGGTGAGG ATTCCCCCCA CCAGGCCCAG 
CTCCGCTCCC CCAGCCAGCG GCCCCTCCGC CAGACCACTG CCATGGTCAT GAGGGGTAAC 
TGCAGCTTCC ACACGAAAGG CTGGCTGGCT CAGGGCCAAG GTGCCCACGG GCTGCTCATC 
GTGAGCCGGG TCAGTGACCA ACAGTGCTCA GACACCACCC TGGCACCCCA GGATCCCCGC 
CAGCCCCTGG CAGACCTCAC CATCCCTGTG GCTATGCTCC ACTATGCTGA CATGCTGGAC 
ATCCTCAGCC ACACTCGTGG GGAGGCCGTC GTCCGCGTGG CCATGTACGC ACCCCCAGAG 
CCCATCATCG ACTACAACAT GCTGGTCATC TTCATCCTGG CTGTGGGCAC AGTGGCTGCA 
GGCGGCTACT GGGCCGGCCT GACCGAAGCC AACCGGCTAC AGCGGCGCCG TGCCCGAAGA 
GGAGGGGGGT CTGGTGGTCA CCATCAGCTG CAGGAAGCTG CAGCAGCTGA GGGAGCCCAG 
AAGGAAGATA ATGAGGACAT CCCAGTGGAC TTCACGCCGG CCATGACAGG CGTGGTGGTC 
ACCCTGTCCT GCTCGCTCAT GCTGCTGCTC TACTTCTTCT ATGACCACTT TGTCTATGTC 
ACCATTGGGA TCTTTGGCCT GGGTGCTGGC ATTGGCCTCT ACAGCTGCCT GTCACCCCTG 
GTGTGCCGCC TGTCCCTGCG GCAATACCAG AGGCCTCCGC ACAGCCTCTG GGCCTCTCTG 
CCGCTGCCTC TGCTGCTGCT GGCGAGCCTG TGCGCAACCG TGATCATCTT CTGGGTGGCC 
TACCGCAATG AGGACCGCTG GGCGTGGCTC CTGCAGGACA CACTGGGCAT TTCCTACTGC 
CTGTTCGTCC TGCACCGTGT GCGGCTGCCC ACTCTCAAGA ACTGCTCCTC CTTCCTGCTG 
GCCCTGCTGG CCTTTGATGT CTTCTTTGTC TTCGTCACCC CCTTCTTCAC CAAAACCGGT 
GAGAGCATCA TGGCGCAGGT TGCCTTGGGC CCTGCAGAGT CTTCAAGCCA TGAGAGGCTG 
CCCATGGTAC TCAAAGTGCC CCGGCTAAGA GTCTCCGCCT TGACCCTGTG CAGCCAGCCC 
TTCTCCATCC TTGGCTTCGG TGACATTGTG GTCCCCGGCT TCCTGGTTGC TTACTGTTGC 
CGCTTTGATG TGCAAGTCTG CTCCCGTCAG ATCTACTTCG TGGCCTGCAC CGTGGCCTAT 
GCTGTGGGCC TGCTGGTCAC ATTCATGGCC ATGGTCCTCA TGCAGATGGG CCAACCTGCC 
TTGCTCTACC TAGTGTCCAG CACCCTGCTC ACCAGCCTGG CTGTGGCTGC CTGCCGCCAA 
GAGCTCAGCC TCTTCTGGAC TGGCCAGGGC AGAGCTAAGA TGTGTGGGCT CGGCTGTGCC 
CCTTCAGCTG GCTCTAGGCA GAAGCAGGAG GGCGCAGCAG ATGCCCACAC AGCCAGCACA 
CTTGAGAGAG GCACCAGCCG AGGAGCAGGG GACTTAGACA GCAACCCTGG AGAAGACACC 
ACTGAGATTG TCACCATATC TGAGAATGAA GCCACCAATC CAGAGGACCG CAGTGATAGC 
TCCGAGGGCT GGAGTGACGC CCACTTGGAT CCTAATGAGC TGCCCTTCAT CCCCCCTGGG 
GCCTCGGAGG AGCTGATGCC ACTGATGCCA ATGGCCATGC TGATCCCACT CATGCCCCTG 
ATGCCCCCGC CCTCAGAGCT GGGCCATGTC CATGCCCAGG CCCAGGCCCA CGAGACTGGC 
CTGCCCTGGG CGGGACTCCA CAAGAGGAAG GGTTTGAAAG TAAGAAAGAG CATGTCGACC 
CAGGCTCCCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_787078.2
CDS	27..2081
Translation	MACLGFLLPVGFLLLISTVAGGKYGVAHVVSENWSKDYCILFSSDYITLPRDLHHAPLLPLYDGTKAPWCPGEDSPHQAQLRSPSQRPLRQTTAMVMRGNCSFHTKGWLAQGQGAHGLLIVSRVSDQQCSDTTLAPQDPRQPLADLTIPVAMLHYADMLDILSHTRGEAVVRVAMYAPPEPIIDYNMLVIFILAVGTVAAGGYWAGLTEANRLQRRRARRGGGSGGHHQLQEAAAAEGAQKEDNEDIPVDFTPAMTGVVVTLSCSLMLLLYFFYDHFVYVTIGIFGLGAGIGLYSCLSPLVCRLSLRQYQRPPHSLWASLPLPLLLLASLCATVIIFWVAYRNEDRWAWLLQDTLGISYCLFVLHRVRLPTLKNCSSFLLALLAFDVFFVFVTPFFTKTGESIMAQVALGPAESSSHERLPMVLKVPRLRVSALTLCSQPFSILGFGDIVVPGFLVAYCCRFDVQVCSRQIYFVACTVAYAVGLLVTFMAMVLMQMGQPALLYLVSSTLLTSLAVAACRQELSLFWTGQGRAKMCGLGCAPSAGSRQKQEGAADAHTASTLERGTSRGAGDLDSNPGEDTTEIVTISENEATNPEDRSDSSEGWSDAHLDPNELPFIPPGASEELMPLMPMAMLIPLMPLMPPPSELGHVHAQAQAHETGLPWAGLHKRKGLKVRKSMSTQAPL

Target ORF information:

RefSeq Version	NM_175882.3
Organism	Homo sapiens(human)
Definition	Homo sapiens signal peptide peptidase like 2C (SPPL2C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175882.3

ORF Insert Sequence:

ATGGCGTGCC TGGGCTTCCT CCTCCCCGTG GGCTTCCTCC TCCTCATCAG CACCGTGGCC 
GGGGGAAAGT ACGGCGTGGC CCACGTGGTG TCGGAGAATT GGAGCAAGGA CTACTGTATC 
CTGTTCAGCT CCGACTACAT CACCCTCCCC CGGGACCTGC ACCACGCCCC ACTCCTGCCC 
CTGTATGATG GCACCAAGGC ACCCTGGTGC CCGGGTGAGG ATTCCCCCCA CCAGGCCCAG 
CTCCGCTCCC CCAGCCAGCG GCCCCTCCGC CAGACCACTG CCATGGTCAT GAGGGGTAAC 
TGCAGCTTCC ACACGAAAGG CTGGCTGGCT CAGGGCCAAG GTGCCCACGG GCTGCTCATC 
GTGAGCCGGG TCAGTGACCA ACAGTGCTCA GACACCACCC TGGCACCCCA GGATCCCCGC 
CAGCCCCTGG CAGACCTCAC CATCCCTGTG GCTATGCTCC ACTATGCTGA CATGCTGGAC 
ATCCTCAGCC ACACTCGTGG GGAGGCCGTC GTCCGCGTGG CCATGTACGC ACCCCCAGAG 
CCCATCATCG ACTACAACAT GCTGGTCATC TTCATCCTGG CTGTGGGCAC AGTGGCTGCA 
GGCGGCTACT GGGCCGGCCT GACCGAAGCC AACCGGCTAC AGCGGCGCCG TGCCCGAAGA 
GGAGGGGGGT CTGGTGGTCA CCATCAGCTG CAGGAAGCTG CAGCAGCTGA GGGAGCCCAG 
AAGGAAGATA ATGAGGACAT CCCAGTGGAC TTCACGCCGG CCATGACAGG CGTGGTGGTC 
ACCCTGTCCT GCTCGCTCAT GCTGCTGCTC TACTTCTTCT ATGACCACTT TGTCTATGTC 
ACCATTGGGA TCTTTGGCCT GGGTGCTGGC ATTGGCCTCT ACAGCTGCCT GTCACCCCTG 
GTGTGCCGCC TGTCCCTGCG GCAATACCAG AGGCCTCCGC ACAGCCTCTG GGCCTCTCTG 
CCGCTGCCTC TGCTGCTGCT GGCGAGCCTG TGCGCAACCG TGATCATCTT CTGGGTGGCC 
TACCGCAATG AGGACCGCTG GGCGTGGCTC CTGCAGGACA CACTGGGCAT TTCCTACTGC 
CTGTTCGTCC TGCACCGTGT GCGGCTGCCC ACTCTCAAGA ACTGCTCCTC CTTCCTGCTG 
GCCCTGCTGG CCTTTGATGT CTTCTTTGTC TTCGTCACCC CCTTCTTCAC CAAAACCGGT 
GAGAGCATCA TGGCGCAGGT TGCCTTGGGC CCTGCAGAGT CTTCAAGCCA TGAGAGGCTG 
CCCATGGTAC TCAAAGTGCC CCGGCTAAGA GTCTCCGCCT TGACCCTGTG CAGCCAGCCC 
TTCTCCATCC TTGGCTTCGG TGACATTGTG GTCCCCGGCT TCCTGGTTGC TTACTGTTGC 
CGCTTTGATG TGCAAGTCTG CTCCCGTCAG ATCTACTTCG TGGCCTGCAC CGTGGCCTAT 
GCTGTGGGCC TGCTGGTCAC ATTCATGGCC ATGGTCCTCA TGCAGATGGG CCAACCTGCC 
TTGCTCTACC TAGTGTCCAG CACCCTGCTC ACCAGCCTGG CTGTGGCTGC CTGCCGCCAA 
GAGCTCAGCC TCTTCTGGAC TGGCCAGGGC AGAGCTAAGA TGTGTGGGCT CGGCTGTGCC 
CCTTCAGCTG GCTCTAGGCA GAAGCAGGAG GGCGCAGCAG ATGCCCACAC AGCCAGCACA 
CTTGAGAGAG GCACCAGCCG AGGAGCAGGG GACTTAGACA GCAACCCTGG AGAAGACACC 
ACTGAGATTG TCACCATATC TGAGAATGAA GCCACCAATC CAGAGGACCG CAGTGATAGC 
TCCGAGGGCT GGAGTGACGC CCACTTGGAT CCTAATGAGC TGCCCTTCAT CCCCCCTGGG 
GCCTCGGAGG AGCTGATGCC ACTGATGCCA ATGGCCATGC TGATCCCACT CATGCCCCTG 
ATGCCCCCGC CCTCAGAGCT GGGCCATGTC CATGCCCAGG CCCAGGCCCA CGAGACTGGC 
CTGCCCTGGG CGGGACTCCA CAAGAGGAAG GGTTTGAAAG TAAGAAAGAG CATGTCGACC 
CAGGCTCCCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.
The Lancet. Respiratory medicine1(4)309-317(2013 Jun)
Noth I,Zhang Y,Ma SF,Flores C,Barber M,Huang Y,Broderick SM,Wade MS,Hysi P,Scuirba J,Richards TJ,Juan-Guardela BM,Vij R,Han MK,Martinez FJ,Kossen K,Seiwert SD,Christie JD,Nicolae D,Kaminski N,Garcia JGN

Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.
PLoS genetics8(5)e1002746(2012 May)
Li R,Brockschmidt FF,Kiefer AK,Stefansson H,Nyholt DR,Song K,Vermeulen SH,Kanoni S,Glass D,Medland SE,Dimitriou M,Waterworth D,Tung JY,Geller F,Heilmann S,Hillmer AM,Bataille V,Eigelshoven S,Hanneken S,Moebus S,Herold C,den Heijer M,Montgomery GW,Deloukas P,Eriksson N,Heath AC,Becker T,Sulem P,Mangino M,Vollenweider P,Spector TD,Dedoussis G,Martin NG,Kiemeney LA,Mooser V,Stefansson K,Hinds DA,N?then MM,Richards JB

Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
PLoS genetics7(6)e1002141(2011 Jun)
Do CB,Tung JY,Dorfman E,Kiefer AK,Drabant EM,Francke U,Mountain JL,Goldman SM,Tanner CM,Langston JW,Wojcicki A,Eriksson N

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.
The Journal of biological chemistry283(3)1644-52(2008 Jan)
Martin L,Fluhrer R,Reiss K,Kremmer E,Saftig P,Haass C

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production.
Nature cell biology8(8)843-8(2006 Aug)
Friedmann E,Hauben E,Maylandt K,Schleeger S,Vreugde S,Lichtenthaler SF,Kuhn PH,Stauffer D,Rovelli G,Martoglio B

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SPPL2C cDNA ORF clone, Homo sapiens(human)

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