Sppl2c cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sppl2c
Entrez Gene ID	287753
Full Name	signal peptide peptidase like 2C
Synonyms	Imp5,RGD1560562
General protein information	Preferred Names signal peptide peptidase like 2C Names signal peptide peptidase-like 2C intramembrane peptidase 5 intramembrane protease 5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q32.1

mRNA and Protein(s)

mRNA	Protein	Name
XM_017597143.1	XP_017452632.1	signal peptide peptidase-like 2C isoform X1
NM_001105847.1	NP_001099317.1	signal peptide peptidase-like 2C precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	SPPL2C	NP_787078.2
Rattus norvegicus (Norway rat)	Sppl2c	NP_001099317.1
	LOC717107	XP_001115879.1
Bos taurus (cattle)	SPPL2C	XP_002696104.1
Pan troglodytes (chimpanzee)	SPPL2C	XP_523673.2
Canis lupus familiaris (dog)	SPPL2C	XP_548046.2
Mus musculus (house mouse)	Sppl2c	NP_950184.2

Gene Ontology
Bibliography

Related articles in PubMed

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.
Martin L, Fluhrer R, Reiss K, Kremmer E, Saftig P, Haass C
The Journal of biological chemistry283(3)1644-52(2008 Jan)

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production.
Friedmann E, Hauben E, Maylandt K, Schleeger S, Vreugde S, Lichtenthaler SF, Kuhn PH, Stauffer D, Rovelli G, Martoglio B
Nature cell biology8(8)843-8(2006 Aug)

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins.
Friedmann E, Lemberg MK, Weihofen A, Dev KK, Dengler U, Rovelli G, Martoglio B
The Journal of biological chemistry279(49)50790-8(2004 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Sppl2c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sppl2c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa33807	NM_001105847.1 Latest version!	Rattus norvegicus signal peptide peptidase like 2C (Sppl2c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa57257	XM_017597143.1 Latest version!	Rattus norvegicus signal peptide peptidase like 2C (Sppl2c), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sppl2c ( NM_001105847.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099317.1 Rattus norvegicus signal peptide peptidase like 2C (Sppl2c), mRNA.

Price & Availability↑

CloneID	ORa33807
Clone ID Related Accession (Same CDS sequence)	NM_001105847.1
Accession Version	NM_001105847.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2076bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	signal peptide peptidase-like 2C precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473948.1. On or before Oct 3, 2007 this sequence version replaced XM_001081559.1, XM_221017.4.

ATGGCATGCC TGGGTTCCCT CCTCCCCATA GGCTCACTCC TCCTCCTCCT CCTCAGCCCC 
GAGGCCCGGG GAGAATATGG CGTGGTCCGA GTCGTGTCAA AGAACTGGAA CAAGGATTAT 
TGTGTCCTGT ATAGCTCTGA CTATGTCACC CTCCCCCGGG ACCTGAGCCA TGCCCCACTT 
CTGCCCCTGC ATGATGGCAC CAAGACACCA TGGTGTCCGG ATGAAGACTC TTTCCACCAG 
GCCCAAGACA GTTCCCTTAG TCAGCGACCC CTGCACCAGA CTACGACCAT GGTTGTGCGT 
GGCAACTGTA GCTTCTATGC CAAGGGCTGG TTGGCTCAAG ACCACGGTGC CCATGGGTTG 
CTCATTGTGA GCCGGGCCAG CAATCAGCAG TGTTCAGACA CCACCTCAAA GCCCCAGGAC 
CCCAGCAAGC CCCGGCCTGC TCTCACTATT CCAGTGGCTG TGCTCCGCTA CACTGACATG 
TTGGACATCC TCAGCCACAC TTACGGTGAC ACCAATGTCC ACATAGCCAT GTACGCTCCC 
CTAGAGCCTA TCATTGACTA TAACATGGTG ATTATCTTTA TCCTGGCTGT GGGCACGGTT 
GCCGCAGGTG GCTACTGGGC TGGTTTGATG GAGGCAGACA GGCTGCAGAG ACACCAGGCC 
CGAAGAGGAG GGGGGTTTGG TGGTCACAAT CAATCACAAA CGGTGTCAGC TGAGAGGTCC 
CCAAGGGCCT GGAAAGAGGA AGACTATGAA GACGCAGCTG TGGATTTCAC ACCAGCCATG 
ACGGGCGCTG TGGTCACCAT GTCCTGCTCT ATCATGGTTC TGCTCTACTT CTTCTACGAC 
TGCTTCGTCT ACATCATGAT TGGGATCTTC GGCTTGGGTG CCAGTACCGG CCTCTACAGC 
TGCCTGGCAC CCATAGTGCG CTACCTGCCC CTATGGCAAC ACCAGTGGGT CCTGCCTGGA 
CACCGGGCTT CTGTAAAGTT GTCATTACTG CTGCTGGCGG GCCTGTGTGC CATGGTGACT 
GTCCTCTGGG TCATCTACCG CAATGAGGAC CGTTGGGCAT GGCTCCTGCA GGACACTCTG 
GGTGTGGCCT ACTGCCTCTT TGTCCTGAGG CGGGTGCGGC TGCCCACGCT CAAGAACTGC 
ACTTCGTTCC TGCTGGCCCT GCTGGCCTTC GATGTCTTCT TCGTCTTTAT CACACCCCTG 
TTCACTAAGA CCGGGGAAAG CATTATGGTA GAGGTGGCAT CGGGCCCGGT AGACTCTTCA 
AGCCACGAGA GGTTACCTAT GGTGCTCAAA GTGCCCCGGA TGAGCTTCTC CGCCTTGACA 
TTGTGCGACC AGCCCTTCTC CATCCTTGGC TTTGGTGACA TTGTTGTCCC TGGCTTCCTA 
GTGGCCTACT GTCACCGCTT CGACGTGCAA ATCCAATCTC GCCAGGTCTA CTACAGGGCC 
TGTACAGTGG CCTATGCCAT GGGCCTGCTA GTCACCTTCG TCGCCATGGT CCTCATGCAG 
ATGGGCCAGC CCGCCCTACT CTACTTAGTG TCCAGCACCC TGCTTACCAG CCTCGTGGTG 
GCCACCTGCC GCCAAGAGCT CACCCTTTTC TGGACCGGCC AGGGCAGAGC TAAGATACCT 
GCTGAGCCTG TGGTACAGCC CTGCATTGTC TCTGCTGTAG CCTGCAGGAT GAAGCTGGAG 
GGTGTGAAGG ATTCCCGTGT GACCAACAGG TTTGAGGAGG CCATTGACAG AGAGTCAGGG 
GACTTAGACA GCAACCCCGG GGATGACATA GCAGAGATGG TCACCCTCTC TGAAGATGAA 
GCCACGAGTC CAGAGGGCCA CAGTGAGAGT TCCGAGGGCT GGAGTGACAC CAACTTAGAC 
CCCGATGAGC TACCCTCTGG GTCCCCCATG GCCCTAGAGG AGCTGATGCC TCTGGCCATG 
TTGATACCAC TGATCCCACC AATCCCACAC ACCTCCGAGT TGGGCCGCAT CCACACCCAG 
TCTCGGGTCC GTGACAGCAG CCTGCCCTGG ATGGGGATGC ACAAGAGAAA GGGCTTGAAG 
GTGAAGAAGA GTATGTCAAC CCAGGCTCCC CTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099317.1
CDS	54..2129
Translation	MACLGSLLPIGSLLLLLLSPEARGEYGVVRVVSKNWNKDYCVLYSSDYVTLPRDLSHAPLLPLHDGTKTPWCPDEDSFHQAQDSSLSQRPLHQTTTMVVRGNCSFYAKGWLAQDHGAHGLLIVSRASNQQCSDTTSKPQDPSKPRPALTIPVAVLRYTDMLDILSHTYGDTNVHIAMYAPLEPIIDYNMVIIFILAVGTVAAGGYWAGLMEADRLQRHQARRGGGFGGHNQSQTVSAERSPRAWKEEDYEDAAVDFTPAMTGAVVTMSCSIMVLLYFFYDCFVYIMIGIFGLGASTGLYSCLAPIVRYLPLWQHQWVLPGHRASVKLSLLLLAGLCAMVTVLWVIYRNEDRWAWLLQDTLGVAYCLFVLRRVRLPTLKNCTSFLLALLAFDVFFVFITPLFTKTGESIMVEVASGPVDSSSHERLPMVLKVPRMSFSALTLCDQPFSILGFGDIVVPGFLVAYCHRFDVQIQSRQVYYRACTVAYAMGLLVTFVAMVLMQMGQPALLYLVSSTLLTSLVVATCRQELTLFWTGQGRAKIPAEPVVQPCIVSAVACRMKLEGVKDSRVTNRFEEAIDRESGDLDSNPGDDIAEMVTLSEDEATSPEGHSESSEGWSDTNLDPDELPSGSPMALEELMPLAMLIPLIPPIPHTSELGRIHTQSRVRDSSLPWMGMHKRKGLKVKKSMSTQAPL

Target ORF information:

RefSeq Version	NM_001105847.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus signal peptide peptidase like 2C (Sppl2c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001105847.1

ORF Insert Sequence:

ATGGCATGCC TGGGTTCCCT CCTCCCCATA GGCTCACTCC TCCTCCTCCT CCTCAGCCCC 
GAGGCCCGGG GAGAATATGG CGTGGTCCGA GTCGTGTCAA AGAACTGGAA CAAGGATTAT 
TGTGTCCTGT ATAGCTCTGA CTATGTCACC CTCCCCCGGG ACCTGAGCCA TGCCCCACTT 
CTGCCCCTGC ATGATGGCAC CAAGACACCA TGGTGTCCGG ATGAAGACTC TTTCCACCAG 
GCCCAAGACA GTTCCCTTAG TCAGCGACCC CTGCACCAGA CTACGACCAT GGTTGTGCGT 
GGCAACTGTA GCTTCTATGC CAAGGGCTGG TTGGCTCAAG ACCACGGTGC CCATGGGTTG 
CTCATTGTGA GCCGGGCCAG CAATCAGCAG TGTTCAGACA CCACCTCAAA GCCCCAGGAC 
CCCAGCAAGC CCCGGCCTGC TCTCACTATT CCAGTGGCTG TGCTCCGCTA CACTGACATG 
TTGGACATCC TCAGCCACAC TTACGGTGAC ACCAATGTCC ACATAGCCAT GTACGCTCCC 
CTAGAGCCTA TCATTGACTA TAACATGGTG ATTATCTTTA TCCTGGCTGT GGGCACGGTT 
GCCGCAGGTG GCTACTGGGC TGGTTTGATG GAGGCAGACA GGCTGCAGAG ACACCAGGCC 
CGAAGAGGAG GGGGGTTTGG TGGTCACAAT CAATCACAAA CGGTGTCAGC TGAGAGGTCC 
CCAAGGGCCT GGAAAGAGGA AGACTATGAA GACGCAGCTG TGGATTTCAC ACCAGCCATG 
ACGGGCGCTG TGGTCACCAT GTCCTGCTCT ATCATGGTTC TGCTCTACTT CTTCTACGAC 
TGCTTCGTCT ACATCATGAT TGGGATCTTC GGCTTGGGTG CCAGTACCGG CCTCTACAGC 
TGCCTGGCAC CCATAGTGCG CTACCTGCCC CTATGGCAAC ACCAGTGGGT CCTGCCTGGA 
CACCGGGCTT CTGTAAAGTT GTCATTACTG CTGCTGGCGG GCCTGTGTGC CATGGTGACT 
GTCCTCTGGG TCATCTACCG CAATGAGGAC CGTTGGGCAT GGCTCCTGCA GGACACTCTG 
GGTGTGGCCT ACTGCCTCTT TGTCCTGAGG CGGGTGCGGC TGCCCACGCT CAAGAACTGC 
ACTTCGTTCC TGCTGGCCCT GCTGGCCTTC GATGTCTTCT TCGTCTTTAT CACACCCCTG 
TTCACTAAGA CCGGGGAAAG CATTATGGTA GAGGTGGCAT CGGGCCCGGT AGACTCTTCA 
AGCCACGAGA GGTTACCTAT GGTGCTCAAA GTGCCCCGGA TGAGCTTCTC CGCCTTGACA 
TTGTGCGACC AGCCCTTCTC CATCCTTGGC TTTGGTGACA TTGTTGTCCC TGGCTTCCTA 
GTGGCCTACT GTCACCGCTT CGACGTGCAA ATCCAATCTC GCCAGGTCTA CTACAGGGCC 
TGTACAGTGG CCTATGCCAT GGGCCTGCTA GTCACCTTCG TCGCCATGGT CCTCATGCAG 
ATGGGCCAGC CCGCCCTACT CTACTTAGTG TCCAGCACCC TGCTTACCAG CCTCGTGGTG 
GCCACCTGCC GCCAAGAGCT CACCCTTTTC TGGACCGGCC AGGGCAGAGC TAAGATACCT 
GCTGAGCCTG TGGTACAGCC CTGCATTGTC TCTGCTGTAG CCTGCAGGAT GAAGCTGGAG 
GGTGTGAAGG ATTCCCGTGT GACCAACAGG TTTGAGGAGG CCATTGACAG AGAGTCAGGG 
GACTTAGACA GCAACCCCGG GGATGACATA GCAGAGATGG TCACCCTCTC TGAAGATGAA 
GCCACGAGTC CAGAGGGCCA CAGTGAGAGT TCCGAGGGCT GGAGTGACAC CAACTTAGAC 
CCCGATGAGC TACCCTCTGG GTCCCCCATG GCCCTAGAGG AGCTGATGCC TCTGGCCATG 
TTGATACCAC TGATCCCACC AATCCCACAC ACCTCCGAGT TGGGCCGCAT CCACACCCAG 
TCTCGGGTCC GTGACAGCAG CCTGCCCTGG ATGGGGATGC ACAAGAGAAA GGGCTTGAAG 
GTGAAGAAGA GTATGTCAAC CCAGGCTCCC CTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sppl2c ( XM_017597143.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017452632.1 Rattus norvegicus signal peptide peptidase like 2C (Sppl2c), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa57257
Clone ID Related Accession (Same CDS sequence)	XM_017597143.1
Accession Version	XM_017597143.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1818bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	signal peptide peptidase-like 2C isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCATGCC TGGGTTCCCT CCTCCCCATA GGCTCACTCC TCCTCCTCCT CCTCAGCCCC 
GAGGCCCGGG GAGAATATGG CGTGGTCCGA GTCGTGTCAA AGAACTGGAA CAAGGATTAT 
TGTGTCCTGT ATAGCTCTGA CTATGTCACC CTCCCCCGGG ACCTGAGCCA TGCCCCACTT 
CTGCCCCTGC ATGATGGCAC CAAGACACCA TGGTGTCCGG ATGAAGACTC TTTCCACCAG 
GCCCAAGACA GTTCCCTTAG TCAGCGACCC CTGCACCAGA CTACGACCAT GGTTGTGCGT 
GGCAACTGTA GCTTCTATGC CAAGGGCTGG TTGGCTCAAG ACCACGGTGC CCATGGGTTG 
CTCATTGTGA GCCGGGCCAG CAATCAGCAG TGTTCAGACA CCACCTCAAA GCCCCAGGAC 
CCCAGCAAGC CCCGGCCTGC TCTCACTATT CCAGTGGCTG TGCTCCGCTA CACTGACATG 
TTGGACATCC TCAGCCACAC TTACGGTGAC ACCAATGTCC ACATAGCCAT GTACGCTCCC 
CTAGAGCCTA TCATTGACTA TAACATGGTG ATTATCTTTA TCCTGGCTGT GGGCACGGTT 
GCCGCAGGTG GCTACTGGGC TGGTTTGATG GAGGCAGACA GGCTGCAGAG ACACCAGGCC 
CGAAGAGGAG GGGGGTTTGG TGGTCACAAT CAATCACAAA CGGTGTCAGC TGAGAGGTCC 
CCAAGGGCCT GGAAAGAGGA AGACTATGAA GACGCAGCTG TGGATTTCAC ACCAGCCATG 
ACGGGCGCTG TGGTCACCAT GTCCTGCTCT ATCATGGTTC TGCTCTACTT CTTCTACGAC 
TGCTTCGTCT ACATCATGAT TGGGATCTTC GGCTTGGGTG CCAGTACCGG CCTCTACAGC 
TGCCTGGCAC CCATAGTGCG CTACCTGCCC CTATGGCAAC ACCAGTGGGT CCTGCCTGGA 
CACCGGGCTT CTGTAAAGTT GTCATTACTG CTGCTGGCGG GCCTGTGTGC CATGGTGACT 
GTCCTCTGGG TCATCTACCG CAATGAGGAC CGTTGGGCAT GGCTCCTGCA GGACACTCTG 
GGTGTGGCCT ACTGCCTCTT TGTCCTGAGG CGGGTGCGGC TGCCCACGCT CAAGAACTGC 
ACTTCGTTCC TGCTGGCCCT GCTGGCCTTC GATGTCTTCT TCGTCTTTAT CACACCCCTG 
TTCACTAAGA CCGGGGAAAG CATTATGGTA GAGGTGGCAT CGGGCCCGGT AGACTCTTCA 
AGCCACGAGA GGTTACCTAT GGTGCTCAAA GTGCCCCGGA TGAGCTTCTC CGCCTTGACA 
TTGTGCGACC AGCCCTTCTC CATCCTTGGC TTTGGTGACA TTGTTGTCCC TGGCTTCCTA 
GTGGCCTACT GTCACCGCTT CGACGTGCAA ATCCAATCTC GCCAGGTCTA CTACAGGGCC 
TGTACAGTGG CCTATGCCAT GGGCCTGCTA GTCACCTTCG TCGCCATGGT CCTCATGCAG 
ATGGGCCAGC CCGCCCTACT CTACTTAGTG TCCAGCACCC TGCTTACCAG CCTCGTGGTG 
GCCACCTGCC GCCAAGAGCT CACCCTTTTC TGGACCGGCC AGGGCAGAGC TAAGATACCT 
GCTGAGCCTG TGGTACAGCC CTGCATTGTC TCTGCTGTAG CCTGCAGGAT GAAGCTGGAG 
GGTGTGAAGG ATTCCCGTGT GACCAACAGA AAGACCCCAG CTCCAGGAAA TCAAGAGGCT 
TCCTTCAAAC CTCAGCTCAC ATGGCTTCCT GAACCCTCTG CTCAAGGCCC AGACATCAGC 
CCTTGTCCCT GTCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017452632.1
CDS	53..1870
Translation	MACLGSLLPIGSLLLLLLSPEARGEYGVVRVVSKNWNKDYCVLYSSDYVTLPRDLSHAPLLPLHDGTKTPWCPDEDSFHQAQDSSLSQRPLHQTTTMVVRGNCSFYAKGWLAQDHGAHGLLIVSRASNQQCSDTTSKPQDPSKPRPALTIPVAVLRYTDMLDILSHTYGDTNVHIAMYAPLEPIIDYNMVIIFILAVGTVAAGGYWAGLMEADRLQRHQARRGGGFGGHNQSQTVSAERSPRAWKEEDYEDAAVDFTPAMTGAVVTMSCSIMVLLYFFYDCFVYIMIGIFGLGASTGLYSCLAPIVRYLPLWQHQWVLPGHRASVKLSLLLLAGLCAMVTVLWVIYRNEDRWAWLLQDTLGVAYCLFVLRRVRLPTLKNCTSFLLALLAFDVFFVFITPLFTKTGESIMVEVASGPVDSSSHERLPMVLKVPRMSFSALTLCDQPFSILGFGDIVVPGFLVAYCHRFDVQIQSRQVYYRACTVAYAMGLLVTFVAMVLMQMGQPALLYLVSSTLLTSLVVATCRQELTLFWTGQGRAKIPAEPVVQPCIVSAVACRMKLEGVKDSRVTNRKTPAPGNQEASFKPQLTWLPEPSAQGPDISPCPCP

Target ORF information:

RefSeq Version	XM_017597143.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus signal peptide peptidase like 2C (Sppl2c), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017597143.1

ORF Insert Sequence:

ATGGCATGCC TGGGTTCCCT CCTCCCCATA GGCTCACTCC TCCTCCTCCT CCTCAGCCCC 
GAGGCCCGGG GAGAATATGG CGTGGTCCGA GTCGTGTCAA AGAACTGGAA CAAGGATTAT 
TGTGTCCTGT ATAGCTCTGA CTATGTCACC CTCCCCCGGG ACCTGAGCCA TGCCCCACTT 
CTGCCCCTGC ATGATGGCAC CAAGACACCA TGGTGTCCGG ATGAAGACTC TTTCCACCAG 
GCCCAAGACA GTTCCCTTAG TCAGCGACCC CTGCACCAGA CTACGACCAT GGTTGTGCGT 
GGCAACTGTA GCTTCTATGC CAAGGGCTGG TTGGCTCAAG ACCACGGTGC CCATGGGTTG 
CTCATTGTGA GCCGGGCCAG CAATCAGCAG TGTTCAGACA CCACCTCAAA GCCCCAGGAC 
CCCAGCAAGC CCCGGCCTGC TCTCACTATT CCAGTGGCTG TGCTCCGCTA CACTGACATG 
TTGGACATCC TCAGCCACAC TTACGGTGAC ACCAATGTCC ACATAGCCAT GTACGCTCCC 
CTAGAGCCTA TCATTGACTA TAACATGGTG ATTATCTTTA TCCTGGCTGT GGGCACGGTT 
GCCGCAGGTG GCTACTGGGC TGGTTTGATG GAGGCAGACA GGCTGCAGAG ACACCAGGCC 
CGAAGAGGAG GGGGGTTTGG TGGTCACAAT CAATCACAAA CGGTGTCAGC TGAGAGGTCC 
CCAAGGGCCT GGAAAGAGGA AGACTATGAA GACGCAGCTG TGGATTTCAC ACCAGCCATG 
ACGGGCGCTG TGGTCACCAT GTCCTGCTCT ATCATGGTTC TGCTCTACTT CTTCTACGAC 
TGCTTCGTCT ACATCATGAT TGGGATCTTC GGCTTGGGTG CCAGTACCGG CCTCTACAGC 
TGCCTGGCAC CCATAGTGCG CTACCTGCCC CTATGGCAAC ACCAGTGGGT CCTGCCTGGA 
CACCGGGCTT CTGTAAAGTT GTCATTACTG CTGCTGGCGG GCCTGTGTGC CATGGTGACT 
GTCCTCTGGG TCATCTACCG CAATGAGGAC CGTTGGGCAT GGCTCCTGCA GGACACTCTG 
GGTGTGGCCT ACTGCCTCTT TGTCCTGAGG CGGGTGCGGC TGCCCACGCT CAAGAACTGC 
ACTTCGTTCC TGCTGGCCCT GCTGGCCTTC GATGTCTTCT TCGTCTTTAT CACACCCCTG 
TTCACTAAGA CCGGGGAAAG CATTATGGTA GAGGTGGCAT CGGGCCCGGT AGACTCTTCA 
AGCCACGAGA GGTTACCTAT GGTGCTCAAA GTGCCCCGGA TGAGCTTCTC CGCCTTGACA 
TTGTGCGACC AGCCCTTCTC CATCCTTGGC TTTGGTGACA TTGTTGTCCC TGGCTTCCTA 
GTGGCCTACT GTCACCGCTT CGACGTGCAA ATCCAATCTC GCCAGGTCTA CTACAGGGCC 
TGTACAGTGG CCTATGCCAT GGGCCTGCTA GTCACCTTCG TCGCCATGGT CCTCATGCAG 
ATGGGCCAGC CCGCCCTACT CTACTTAGTG TCCAGCACCC TGCTTACCAG CCTCGTGGTG 
GCCACCTGCC GCCAAGAGCT CACCCTTTTC TGGACCGGCC AGGGCAGAGC TAAGATACCT 
GCTGAGCCTG TGGTACAGCC CTGCATTGTC TCTGCTGTAG CCTGCAGGAT GAAGCTGGAG 
GGTGTGAAGG ATTCCCGTGT GACCAACAGA AAGACCCCAG CTCCAGGAAA TCAAGAGGCT 
TCCTTCAAAC CTCAGCTCAC ATGGCTTCCT GAACCCTCTG CTCAAGGCCC AGACATCAGC 
CCTTGTCCCT GTCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.
The Journal of biological chemistry283(3)1644-52(2008 Jan)
Martin L,Fluhrer R,Reiss K,Kremmer E,Saftig P,Haass C

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production.
Nature cell biology8(8)843-8(2006 Aug)
Friedmann E,Hauben E,Maylandt K,Schleeger S,Vreugde S,Lichtenthaler SF,Kuhn PH,Stauffer D,Rovelli G,Martoglio B

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins.
The Journal of biological chemistry279(49)50790-8(2004 Dec)
Friedmann E,Lemberg MK,Weihofen A,Dev KK,Dengler U,Rovelli G,Martoglio B

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Sppl2c cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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