CLEC14A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLEC14A
Entrez Gene ID	161198
Full Name	C-type lectin domain containing 14A
Synonyms	C14orf27,CEG1,EGFR-5
General protein information	Preferred Names C-type lectin domain containing 14A Names C-type lectin domain family 14 member A ClECT and EGF-like domain containing protein epidermal growth factor receptor 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q21.1
Summary	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]. COMPLETENESS: complete on the 3' end.
Disorder MIM:	616845

mRNA and Protein(s)

mRNA	Protein	Name
NM_175060.2	NP_778230.1	C-type lectin domain family 14 member A precursor
NM_175060.3	NP_778230.1	C-type lectin domain family 14 member A precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CLEC14A	XP_005623407.1
Pan troglodytes (chimpanzee)	CLEC14A	XP_522832.1
	CLEC14A	XP_001091540.1
Mus musculus (house mouse)	Clec14a	NP_080085.3
Homo sapiens (human)	CLEC14A	NP_778230.1
Bos taurus (cattle)	CLEC14A	NP_001071358.1
Rattus norvegicus (Norway rat)	Clec14a	NP_001014099.1

Gene Ontology
Bibliography

Related articles in PubMed

Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface.
Khan KA, Naylor AJ, Khan A, Noy PJ, Mambretti M, Lodhia P, Athwal J, Korzystka A, Buckley CD, Willcox BE, Mohammed F, Bicknell R
Oncogene36(44)6097-6108(2017 Nov)

Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth.
Noy PJ, Lodhia P, Khan K, Zhuang X, Ward DG, Verissimo AR, Bacon A, Bicknell R
Oncogene34(47)5821-31(2015 Nov)

Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
Luykx JJ, Bakker SC, Lentjes E, Neeleman M, Strengman E, Mentink L, DeYoung J, de Jong S, Sul JH, Eskin E, van Eijk K, van Setten J, Buizer-Voskamp JE, Cantor RM, Lu A, van Amerongen M, van Dongen EP, Keijzers P, Kappen T, Borgdorff P, Bruins P, Derks EM, Kahn RS, Ophoff RA
Molecular psychiatry19(2)228-34(2014 Feb)

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
Zanivan S, Maione F, Hein MY, Hern?ndez-Fernaud JR, Ostasiewicz P, Giraudo E, Mann M
Molecular & cellular proteomics : MCP12(12)3599-611(2013 Dec)

Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro.
Ki MK, Jeoung MH, Choi JR, Rho SS, Kwon YG, Shim H, Chung J, Hong HJ, Song BD, Lee S
Oncogene32(48)5449-57(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings identify novel protein interactions involving CLEC14A, CD93 and CD248 with MMRN2 as targetable components of vessel formation
Title: Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface.

Results suggest that CLEC14A-MMRN2 binding has a role in inducing sprouting angiogenesis during tumor growth, which has the potential to be manipulated in future antiangiogenic therapy design.
Title: Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth.

CLEC14A is a matrix component which binds to MMRN2 in the process of endothelial cells transformation in tumor angiogenesis.
Title: SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.

clec14a-CTLD may be a key domain in angiogenesis
Title: Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro.

In this study, they identify and characterize a novel tumor endothelial marker, CLEC14A, which has properties that suggest it is a candidate for tumor vascular targeting and anti-angiogenic approaches.
Title: Identification and angiogenic role of the novel tumor endothelial marker CLEC14A.

The following CLEC14A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLEC14A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09614	NM_175060.3 Latest version!	Homo sapiens C-type lectin domain containing 14A (CLEC14A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu09614	NM_175060.2	Homo sapiens C-type lectin domain containing 14A (CLEC14A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLEC14A ( NM_175060.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_778230.1 Homo sapiens C-type lectin domain containing 14A (CLEC14A), mRNA.

Price & Availability↑

CloneID	OHu09614
Clone ID Related Accession (Same CDS sequence)	NM_175060.2 , NM_175060.3
Accession Version	NM_175060.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1473bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	C-type lectin domain family 14 member A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX423057.2, AY358395.1 and AY606132.1. On Jan 6, 2012 this sequence version replaced NM_175060.1. COMPLETENESS: complete on the 3' end.

ATGAGGCCGG CGTTCGCCCT GTGCCTCCTC TGGCAGGCGC TCTGGCCCGG GCCGGGCGGC 
GGCGAACACC CCACTGCCGA CCGTGCTGGC TGCTCGGCCT CGGGGGCCTG CTACAGCCTG 
CACCACGCTA CCATGAAGCG GCAGGCGGCC GAGGAGGCCT GCATCCTGCG AGGTGGGGCG 
CTCAGCACCG TGCGTGCGGG CGCCGAGCTG CGCGCTGTGC TCGCGCTCCT GCGGGCAGGC 
CCAGGGCCCG GAGGGGGCTC CAAAGACCTG CTGTTCTGGG TCGCACTGGA GCGCAGGCGT 
TCCCACTGCA CCCTGGAGAA CGAGCCTTTG CGGGGTTTCT CCTGGCTGTC CTCCGACCCC 
GGCGGTCTCG AAAGCGACAC GCTGCAGTGG GTGGAGGAGC CCCAACGCTC CTGCACCGCG 
CGGAGATGCG CGGTACTCCA GGCCACCGGT GGGGTCGAGC CCGCAGGCTG GAAGGAGATG 
CGATGCCACC TGCGCGCCAA CGGCTACCTG TGCAAGTACC AGTTTGAGGT CTTGTGTCCT 
GCGCCGCGCC CCGGGGCCGC CTCTAACTTG AGCTATCGCG CGCCCTTCCA GCTGCACAGC 
GCCGCTCTGG ACTTCAGTCC ACCTGGGACC GAGGTGAGTG CGCTCTGCCG GGGACAGCTC 
CCGATCTCAG TTACTTGCAT CGCGGACGAA ATCGGCGCTC GCTGGGACAA ACTCTCGGGC 
GATGTGTTGT GTCCCTGCCC CGGGAGGTAC CTCCGTGCTG GCAAATGCGC AGAGCTCCCT 
AACTGCCTAG ACGACTTGGG AGGCTTTGCC TGCGAATGTG CTACGGGCTT CGAGCTGGGG 
AAGGACGGCC GCTCTTGTGT GACCAGTGGG GAAGGACAGC CGACCCTTGG GGGGACCGGG 
GTGCCCACCA GGCGCCCGCC GGCCACTGCA ACCAGCCCCG TGCCGCAGAG AACATGGCCA 
ATCAGGGTCG ACGAGAAGCT GGGAGAGACA CCACTTGTCC CTGAACAAGA CAATTCAGTA 
ACATCTATTC CTGAGATTCC TCGATGGGGA TCACAGAGCA CGATGTCTAC CCTTCAAATG 
TCCCTTCAAG CCGAGTCAAA GGCCACTATC ACCCCATCAG GGAGCGTGAT TTCCAAGTTT 
AATTCTACGA CTTCCTCTGC CACTCCTCAG GCTTTCGACT CCTCCTCTGC CGTGGTCTTC 
ATATTTGTGA GCACAGCAGT AGTAGTGTTG GTGATCTTGA CCATGACAGT ACTGGGGCTT 
GTCAAGCTCT GCTTTCACGA AAGCCCCTCT TCCCAGCCAA GGAAGGAGTC TATGGGCCCG 
CCGGGCCTGG AGAGTGATCC TGAGCCCGCT GCTTTGGGCT CCAGTTCTGC ACATTGCACA 
AACAATGGGG TGAAAGTCGG GGACTGTGAT CTGCGGGACA GAGCAGAGGG TGCCTTGCTG 
GCGGAGTCCC CTCTTGGCTC TAGTGATGCA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_778230.1
CDS	349..1821
Translation	MRPAFALCLLWQALWPGPGGGEHPTADRAGCSASGACYSLHHATMKRQAAEEACILRGGALSTVRAGAELRAVLALLRAGPGPGGGSKDLLFWVALERRRSHCTLENEPLRGFSWLSSDPGGLESDTLQWVEEPQRSCTARRCAVLQATGGVEPAGWKEMRCHLRANGYLCKYQFEVLCPAPRPGAASNLSYRAPFQLHSAALDFSPPGTEVSALCRGQLPISVTCIADEIGARWDKLSGDVLCPCPGRYLRAGKCAELPNCLDDLGGFACECATGFELGKDGRSCVTSGEGQPTLGGTGVPTRRPPATATSPVPQRTWPIRVDEKLGETPLVPEQDNSVTSIPEIPRWGSQSTMSTLQMSLQAESKATITPSGSVISKFNSTTSSATPQAFDSSSAVVFIFVSTAVVVLVILTMTVLGLVKLCFHESPSSQPRKESMGPPGLESDPEPAALGSSSAHCTNNGVKVGDCDLRDRAEGALLAESPLGSSDA

Target ORF information:

RefSeq Version	NM_175060.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-type lectin domain containing 14A (CLEC14A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175060.2

ORF Insert Sequence:

ATGAGGCCGG CGTTCGCCCT GTGCCTCCTC TGGCAGGCGC TCTGGCCCGG GCCGGGCGGC 
GGCGAACACC CCACTGCCGA CCGTGCTGGC TGCTCGGCCT CGGGGGCCTG CTACAGCCTG 
CACCACGCTA CCATGAAGCG GCAGGCGGCC GAGGAGGCCT GCATCCTGCG AGGTGGGGCG 
CTCAGCACCG TGCGTGCGGG CGCCGAGCTG CGCGCTGTGC TCGCGCTCCT GCGGGCAGGC 
CCAGGGCCCG GAGGGGGCTC CAAAGACCTG CTGTTCTGGG TCGCACTGGA GCGCAGGCGT 
TCCCACTGCA CCCTGGAGAA CGAGCCTTTG CGGGGTTTCT CCTGGCTGTC CTCCGACCCC 
GGCGGTCTCG AAAGCGACAC GCTGCAGTGG GTGGAGGAGC CCCAACGCTC CTGCACCGCG 
CGGAGATGCG CGGTACTCCA GGCCACCGGT GGGGTCGAGC CCGCAGGCTG GAAGGAGATG 
CGATGCCACC TGCGCGCCAA CGGCTACCTG TGCAAGTACC AGTTTGAGGT CTTGTGTCCT 
GCGCCGCGCC CCGGGGCCGC CTCTAACTTG AGCTATCGCG CGCCCTTCCA GCTGCACAGC 
GCCGCTCTGG ACTTCAGTCC ACCTGGGACC GAGGTGAGTG CGCTCTGCCG GGGACAGCTC 
CCGATCTCAG TTACTTGCAT CGCGGACGAA ATCGGCGCTC GCTGGGACAA ACTCTCGGGC 
GATGTGTTGT GTCCCTGCCC CGGGAGGTAC CTCCGTGCTG GCAAATGCGC AGAGCTCCCT 
AACTGCCTAG ACGACTTGGG AGGCTTTGCC TGCGAATGTG CTACGGGCTT CGAGCTGGGG 
AAGGACGGCC GCTCTTGTGT GACCAGTGGG GAAGGACAGC CGACCCTTGG GGGGACCGGG 
GTGCCCACCA GGCGCCCGCC GGCCACTGCA ACCAGCCCCG TGCCGCAGAG AACATGGCCA 
ATCAGGGTCG ACGAGAAGCT GGGAGAGACA CCACTTGTCC CTGAACAAGA CAATTCAGTA 
ACATCTATTC CTGAGATTCC TCGATGGGGA TCACAGAGCA CGATGTCTAC CCTTCAAATG 
TCCCTTCAAG CCGAGTCAAA GGCCACTATC ACCCCATCAG GGAGCGTGAT TTCCAAGTTT 
AATTCTACGA CTTCCTCTGC CACTCCTCAG GCTTTCGACT CCTCCTCTGC CGTGGTCTTC 
ATATTTGTGA GCACAGCAGT AGTAGTGTTG GTGATCTTGA CCATGACAGT ACTGGGGCTT 
GTCAAGCTCT GCTTTCACGA AAGCCCCTCT TCCCAGCCAA GGAAGGAGTC TATGGGCCCG 
CCGGGCCTGG AGAGTGATCC TGAGCCCGCT GCTTTGGGCT CCAGTTCTGC ACATTGCACA 
AACAATGGGG TGAAAGTCGG GGACTGTGAT CTGCGGGACA GAGCAGAGGG TGCCTTGCTG 
GCGGAGTCCC CTCTTGGCTC TAGTGATGCA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLEC14A ( NM_175060.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_778230.1 Homo sapiens C-type lectin domain containing 14A (CLEC14A), mRNA.

Price & Availability↑

CloneID	OHu09614
Clone ID Related Accession (Same CDS sequence)	NM_175060.2 , NM_175060.3
Accession Version	NM_175060.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1473bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	C-type lectin domain family 14 member A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY358395.1 and AY606132.1. On May 17, 2019 this sequence version replaced NM_175060.2. ##Evidence-Data-START## Transcript is intronless :: AY606132.1, SRR1660803.154150.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000342213.3/ ENSP00000353013.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGCCGG CGTTCGCCCT GTGCCTCCTC TGGCAGGCGC TCTGGCCCGG GCCGGGCGGC 
GGCGAACACC CCACTGCCGA CCGTGCTGGC TGCTCGGCCT CGGGGGCCTG CTACAGCCTG 
CACCACGCTA CCATGAAGCG GCAGGCGGCC GAGGAGGCCT GCATCCTGCG AGGTGGGGCG 
CTCAGCACCG TGCGTGCGGG CGCCGAGCTG CGCGCTGTGC TCGCGCTCCT GCGGGCAGGC 
CCAGGGCCCG GAGGGGGCTC CAAAGACCTG CTGTTCTGGG TCGCACTGGA GCGCAGGCGT 
TCCCACTGCA CCCTGGAGAA CGAGCCTTTG CGGGGTTTCT CCTGGCTGTC CTCCGACCCC 
GGCGGTCTCG AAAGCGACAC GCTGCAGTGG GTGGAGGAGC CCCAACGCTC CTGCACCGCG 
CGGAGATGCG CGGTACTCCA GGCCACCGGT GGGGTCGAGC CCGCAGGCTG GAAGGAGATG 
CGATGCCACC TGCGCGCCAA CGGCTACCTG TGCAAGTACC AGTTTGAGGT CTTGTGTCCT 
GCGCCGCGCC CCGGGGCCGC CTCTAACTTG AGCTATCGCG CGCCCTTCCA GCTGCACAGC 
GCCGCTCTGG ACTTCAGTCC ACCTGGGACC GAGGTGAGTG CGCTCTGCCG GGGACAGCTC 
CCGATCTCAG TTACTTGCAT CGCGGACGAA ATCGGCGCTC GCTGGGACAA ACTCTCGGGC 
GATGTGTTGT GTCCCTGCCC CGGGAGGTAC CTCCGTGCTG GCAAATGCGC AGAGCTCCCT 
AACTGCCTAG ACGACTTGGG AGGCTTTGCC TGCGAATGTG CTACGGGCTT CGAGCTGGGG 
AAGGACGGCC GCTCTTGTGT GACCAGTGGG GAAGGACAGC CGACCCTTGG GGGGACCGGG 
GTGCCCACCA GGCGCCCGCC GGCCACTGCA ACCAGCCCCG TGCCGCAGAG AACATGGCCA 
ATCAGGGTCG ACGAGAAGCT GGGAGAGACA CCACTTGTCC CTGAACAAGA CAATTCAGTA 
ACATCTATTC CTGAGATTCC TCGATGGGGA TCACAGAGCA CGATGTCTAC CCTTCAAATG 
TCCCTTCAAG CCGAGTCAAA GGCCACTATC ACCCCATCAG GGAGCGTGAT TTCCAAGTTT 
AATTCTACGA CTTCCTCTGC CACTCCTCAG GCTTTCGACT CCTCCTCTGC CGTGGTCTTC 
ATATTTGTGA GCACAGCAGT AGTAGTGTTG GTGATCTTGA CCATGACAGT ACTGGGGCTT 
GTCAAGCTCT GCTTTCACGA AAGCCCCTCT TCCCAGCCAA GGAAGGAGTC TATGGGCCCG 
CCGGGCCTGG AGAGTGATCC TGAGCCCGCT GCTTTGGGCT CCAGTTCTGC ACATTGCACA 
AACAATGGGG TGAAAGTCGG GGACTGTGAT CTGCGGGACA GAGCAGAGGG TGCCTTGCTG 
GCGGAGTCCC CTCTTGGCTC TAGTGATGCA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_778230.1
CDS	72..1544
Translation	MRPAFALCLLWQALWPGPGGGEHPTADRAGCSASGACYSLHHATMKRQAAEEACILRGGALSTVRAGAELRAVLALLRAGPGPGGGSKDLLFWVALERRRSHCTLENEPLRGFSWLSSDPGGLESDTLQWVEEPQRSCTARRCAVLQATGGVEPAGWKEMRCHLRANGYLCKYQFEVLCPAPRPGAASNLSYRAPFQLHSAALDFSPPGTEVSALCRGQLPISVTCIADEIGARWDKLSGDVLCPCPGRYLRAGKCAELPNCLDDLGGFACECATGFELGKDGRSCVTSGEGQPTLGGTGVPTRRPPATATSPVPQRTWPIRVDEKLGETPLVPEQDNSVTSIPEIPRWGSQSTMSTLQMSLQAESKATITPSGSVISKFNSTTSSATPQAFDSSSAVVFIFVSTAVVVLVILTMTVLGLVKLCFHESPSSQPRKESMGPPGLESDPEPAALGSSSAHCTNNGVKVGDCDLRDRAEGALLAESPLGSSDA

Target ORF information:

RefSeq Version	NM_175060.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-type lectin domain containing 14A (CLEC14A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175060.3

ORF Insert Sequence:

ATGAGGCCGG CGTTCGCCCT GTGCCTCCTC TGGCAGGCGC TCTGGCCCGG GCCGGGCGGC 
GGCGAACACC CCACTGCCGA CCGTGCTGGC TGCTCGGCCT CGGGGGCCTG CTACAGCCTG 
CACCACGCTA CCATGAAGCG GCAGGCGGCC GAGGAGGCCT GCATCCTGCG AGGTGGGGCG 
CTCAGCACCG TGCGTGCGGG CGCCGAGCTG CGCGCTGTGC TCGCGCTCCT GCGGGCAGGC 
CCAGGGCCCG GAGGGGGCTC CAAAGACCTG CTGTTCTGGG TCGCACTGGA GCGCAGGCGT 
TCCCACTGCA CCCTGGAGAA CGAGCCTTTG CGGGGTTTCT CCTGGCTGTC CTCCGACCCC 
GGCGGTCTCG AAAGCGACAC GCTGCAGTGG GTGGAGGAGC CCCAACGCTC CTGCACCGCG 
CGGAGATGCG CGGTACTCCA GGCCACCGGT GGGGTCGAGC CCGCAGGCTG GAAGGAGATG 
CGATGCCACC TGCGCGCCAA CGGCTACCTG TGCAAGTACC AGTTTGAGGT CTTGTGTCCT 
GCGCCGCGCC CCGGGGCCGC CTCTAACTTG AGCTATCGCG CGCCCTTCCA GCTGCACAGC 
GCCGCTCTGG ACTTCAGTCC ACCTGGGACC GAGGTGAGTG CGCTCTGCCG GGGACAGCTC 
CCGATCTCAG TTACTTGCAT CGCGGACGAA ATCGGCGCTC GCTGGGACAA ACTCTCGGGC 
GATGTGTTGT GTCCCTGCCC CGGGAGGTAC CTCCGTGCTG GCAAATGCGC AGAGCTCCCT 
AACTGCCTAG ACGACTTGGG AGGCTTTGCC TGCGAATGTG CTACGGGCTT CGAGCTGGGG 
AAGGACGGCC GCTCTTGTGT GACCAGTGGG GAAGGACAGC CGACCCTTGG GGGGACCGGG 
GTGCCCACCA GGCGCCCGCC GGCCACTGCA ACCAGCCCCG TGCCGCAGAG AACATGGCCA 
ATCAGGGTCG ACGAGAAGCT GGGAGAGACA CCACTTGTCC CTGAACAAGA CAATTCAGTA 
ACATCTATTC CTGAGATTCC TCGATGGGGA TCACAGAGCA CGATGTCTAC CCTTCAAATG 
TCCCTTCAAG CCGAGTCAAA GGCCACTATC ACCCCATCAG GGAGCGTGAT TTCCAAGTTT 
AATTCTACGA CTTCCTCTGC CACTCCTCAG GCTTTCGACT CCTCCTCTGC CGTGGTCTTC 
ATATTTGTGA GCACAGCAGT AGTAGTGTTG GTGATCTTGA CCATGACAGT ACTGGGGCTT 
GTCAAGCTCT GCTTTCACGA AAGCCCCTCT TCCCAGCCAA GGAAGGAGTC TATGGGCCCG 
CCGGGCCTGG AGAGTGATCC TGAGCCCGCT GCTTTGGGCT CCAGTTCTGC ACATTGCACA 
AACAATGGGG TGAAAGTCGG GGACTGTGAT CTGCGGGACA GAGCAGAGGG TGCCTTGCTG 
GCGGAGTCCC CTCTTGGCTC TAGTGATGCA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface.
Oncogene36(44)6097-6108(2017 Nov)
Khan KA,Naylor AJ,Khan A,Noy PJ,Mambretti M,Lodhia P,Athwal J,Korzystka A,Buckley CD,Willcox BE,Mohammed F,Bicknell R

Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth.
Oncogene34(47)5821-31(2015 Nov)
Noy PJ,Lodhia P,Khan K,Zhuang X,Ward DG,Verissimo AR,Bacon A,Bicknell R

Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
Molecular psychiatry19(2)228-34(2014 Feb)
Luykx JJ,Bakker SC,Lentjes E,Neeleman M,Strengman E,Mentink L,DeYoung J,de Jong S,Sul JH,Eskin E,van Eijk K,van Setten J,Buizer-Voskamp JE,Cantor RM,Lu A,van Amerongen M,van Dongen EP,Keijzers P,Kappen T,Borgdorff P,Bruins P,Derks EM,Kahn RS,Ophoff RA

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
Molecular & cellular proteomics : MCP12(12)3599-611(2013 Dec)
Zanivan S,Maione F,Hein MY,Hern?ndez-Fernaud JR,Ostasiewicz P,Giraudo E,Mann M

Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro.
Oncogene32(48)5449-57(2013 Nov)
Ki MK,Jeoung MH,Choi JR,Rho SS,Kwon YG,Shim H,Chung J,Hong HJ,Song BD,Lee S

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CLEC14A cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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