TMEM74 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TMEM74
Entrez Gene ID	157753
Full Name	transmembrane protein 74
Synonyms	NET36
General protein information	Preferred Names transmembrane protein 74 Names transmembrane protein 74
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q23.1
Disorder MIM:	613935

mRNA and Protein(s)

mRNA	Protein	Name
NM_153015.2	NP_694560.1	transmembrane protein 74
NM_153015.1	NP_694560.1	transmembrane protein 74
NM_153015.3	NP_694560.1	transmembrane protein 74

Pathways from BioSystems

Homologies

	TMEM74	XP_001091064.1
Canis lupus familiaris (dog)	TMEM74	XP_005627930.1
Mus musculus (house mouse)	Tmem74	NP_780711.1
Xenopus tropicalis (tropical clawed frog)	tmem74	XP_002938960.1
Bos taurus (cattle)	TMEM74	XP_005215657.1
Rattus norvegicus (Norway rat)	Tmem74	XP_006241672.1
Danio rerio (zebrafish)	LOC100331423	XP_005158297.1
Homo sapiens (human)	TMEM74	NP_694560.1
Pan troglodytes (chimpanzee)	TMEM74	XP_001135992.1
Gallus gallus (chicken)	LOC100858101	XP_004940055.1

Gene Ontology
Bibliography

Related articles in PubMed

TMEM74 promotes tumor cell survival by inducing autophagy via interactions with ATG16L1 and ATG9A.
Sun Y, Chen Y, Zhang J, Cao L, He M, Liu X, Zhao N, Yin A, Huang H, Wang L
Cell death & disease8(8)e3031(2017 Aug)

Autophagy regulatory molecule, TMEM74, interacts with BIK and inhibits BIK-induced apoptosis.
Sun Y, Li Q, Zhang J, Chen Z, He Q, Liu X, Zhao N, Yin A, Huang H, He M, Cao L, Wang L
Cellular signalling3634-41(2017 Aug)

TMEM74, a lysosome and autophagosome protein, regulates autophagy.
Yu C, Wang L, Lv B, Lu Y, Zeng L, Chen Y, Ma D, Shi T, Wang L
Biochemical and biophysical research communications369(2)622-9(2008 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings demonstrate that TMEM74 may be involved in promoting functional autophagy during cell starvation and other stress conditions.
Title: TMEM74, a lysosome and autophagosome protein, regulates autophagy.

The following TMEM74 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMEM74 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06847	NM_153015.3 Latest version!	Homo sapiens transmembrane protein 74 (TMEM74), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu06847	NM_153015.1	Homo sapiens transmembrane protein 74 (TMEM74), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu06847	NM_153015.2	Homo sapiens transmembrane protein 74 (TMEM74), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMEM74 ( NM_153015.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_694560.1 Homo sapiens transmembrane protein 74 (TMEM74), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06847
Clone ID Related Accession (Same CDS sequence)	NM_153015.2 , NM_153015.1 , NM_153015.3
Accession Version	NM_153015.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	transmembrane protein 74
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC030710.2, AK055230.1, AC104247.5 and D60265.1. On Apr 13, 2016 this sequence version replaced NM_153015.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC030710.2, SRR1660809.177279.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCTCC ACTACCTTGC TAAGAAGAGC AACCAGGCAG ACCTCTGTGA TGCCAGGGAC 
TGGAGTTCAA GAGGGCTGCC TGGTGACCAG GCAGATACAG CAGCCACAAG AGCTGCTCTC 
TGCTGTCAGA AACAGTGTGC ATCCACCCCA AGAGCAACCG AGATGGAAGG GTCTAAACTT 
AGTTCTTCTC CAGCATCCCC CTCCTCCTCT CTGCAAAACA GTACTCTTCA GCCAGATGCC 
TTTCCACCAG GACTTCTCCA CTCAGGGAAC AACCAAATAA CAGCGGAACG GAAAGTCTGT 
AACTGCTGCA GCCAGGAATT AGAAACTTCT TTTACCTATG TGGACAAAAA CATCAACTTG 
GAGCAGCGGA ACCGGAGCTC GCCATCAGCA AAAGGGCATA ATCACCCTGG GGAGCTTGGC 
TGGGAAAATC CAAATGAGTG GTCCCAAGAG GCTGCCATAT CTTTGATATC TGAAGAGGAG 
GATGATACAA GTTCAGAAGC CACGTCTTCA GGGAAGTCTA TAGACTATGG TTTCATCAGC 
GCCATCTTGT TCTTGGTCAC TGGGATCCTG CTCGTGATCA TCTCTTACAT CGTCCCACGG 
GAAGTGACTG TGGACCCCAA CACTGTGGCA GCCCGGGAGA TGGAGCGCCT GGAGAAGGAG 
AGTGCGAGGC TGGGGGCTCA CCTGGACCGC TGTGTGATTG CGGGGCTCTG CCTCCTCACG 
CTGGGGGGCG TCATCCTGTC CTGCTTGTTA ATGATGTCCA TGTGGAAGGG GGAGCTCTAT 
CGTCGAAACA GATTTGCCTC TTCCAAAGAG TCTGCAAAAC TCTATGGTTC TTTCAACTTC 
AGGATGAAAA CCAGCACGAA TGAAAACACT CTGGAACTGT CCTTGGTAGA GGAAGATGCG 
CTTGCTGTAC AGAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694560.1
CDS	180..1097
Translation	MELHYLAKKSNQADLCDARDWSSRGLPGDQADTAATRAALCCQKQCASTPRATEMEGSKLSSSPASPSSSLQNSTLQPDAFPPGLLHSGNNQITAERKVCNCCSQELETSFTYVDKNINLEQRNRSSPSAKGHNHPGELGWENPNEWSQEAAISLISEEEDDTSSEATSSGKSIDYGFISAILFLVTGILLVIISYIVPREVTVDPNTVAAREMERLEKESARLGAHLDRCVIAGLCLLTLGGVILSCLLMMSMWKGELYRRNRFASSKESAKLYGSFNFRMKTSTNENTLELSLVEEDALAVQS

Target ORF information:

RefSeq Version	NM_153015.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 74 (TMEM74), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153015.2

ORF Insert Sequence:

ATGGAGCTCC ACTACCTTGC TAAGAAGAGC AACCAGGCAG ACCTCTGTGA TGCCAGGGAC 
TGGAGTTCAA GAGGGCTGCC TGGTGACCAG GCAGATACAG CAGCCACAAG AGCTGCTCTC 
TGCTGTCAGA AACAGTGTGC ATCCACCCCA AGAGCAACCG AGATGGAAGG GTCTAAACTT 
AGTTCTTCTC CAGCATCCCC CTCCTCCTCT CTGCAAAACA GTACTCTTCA GCCAGATGCC 
TTTCCACCAG GACTTCTCCA CTCAGGGAAC AACCAAATAA CAGCGGAACG GAAAGTCTGT 
AACTGCTGCA GCCAGGAATT AGAAACTTCT TTTACCTATG TGGACAAAAA CATCAACTTG 
GAGCAGCGGA ACCGGAGCTC GCCATCAGCA AAAGGGCATA ATCACCCTGG GGAGCTTGGC 
TGGGAAAATC CAAATGAGTG GTCCCAAGAG GCTGCCATAT CTTTGATATC TGAAGAGGAG 
GATGATACAA GTTCAGAAGC CACGTCTTCA GGGAAGTCTA TAGACTATGG TTTCATCAGC 
GCCATCTTGT TCTTGGTCAC TGGGATCCTG CTCGTGATCA TCTCTTACAT CGTCCCACGG 
GAAGTGACTG TGGACCCCAA CACTGTGGCA GCCCGGGAGA TGGAGCGCCT GGAGAAGGAG 
AGTGCGAGGC TGGGGGCTCA CCTGGACCGC TGTGTGATTG CGGGGCTCTG CCTCCTCACG 
CTGGGGGGCG TCATCCTGTC CTGCTTGTTA ATGATGTCCA TGTGGAAGGG GGAGCTCTAT 
CGTCGAAACA GATTTGCCTC TTCCAAAGAG TCTGCAAAAC TCTATGGTTC TTTCAACTTC 
AGGATGAAAA CCAGCACGAA TGAAAACACT CTGGAACTGT CCTTGGTAGA GGAAGATGCG 
CTTGCTGTAC AGAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM74 ( NM_153015.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_694560.1 Homo sapiens transmembrane protein 74 (TMEM74), mRNA.

Price & Availability↑

CloneID	OHu06847
Clone ID Related Accession (Same CDS sequence)	NM_153015.2 , NM_153015.1 , NM_153015.3
Accession Version	NM_153015.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	transmembrane protein 74
Comment

ATGGAGCTCC ACTACCTTGC TAAGAAGAGC AACCAGGCAG ACCTCTGTGA TGCCAGGGAC 
TGGAGTTCAA GAGGGCTGCC TGGTGACCAG GCAGATACAG CAGCCACAAG AGCTGCTCTC 
TGCTGTCAGA AACAGTGTGC ATCCACCCCA AGAGCAACCG AGATGGAAGG GTCTAAACTT 
AGTTCTTCTC CAGCATCCCC CTCCTCCTCT CTGCAAAACA GTACTCTTCA GCCAGATGCC 
TTTCCACCAG GACTTCTCCA CTCAGGGAAC AACCAAATAA CAGCGGAACG GAAAGTCTGT 
AACTGCTGCA GCCAGGAATT AGAAACTTCT TTTACCTATG TGGACAAAAA CATCAACTTG 
GAGCAGCGGA ACCGGAGCTC GCCATCAGCA AAAGGGCATA ATCACCCTGG GGAGCTTGGC 
TGGGAAAATC CAAATGAGTG GTCCCAAGAG GCTGCCATAT CTTTGATATC TGAAGAGGAG 
GATGATACAA GTTCAGAAGC CACGTCTTCA GGGAAGTCTA TAGACTATGG TTTCATCAGC 
GCCATCTTGT TCTTGGTCAC TGGGATCCTG CTCGTGATCA TCTCTTACAT CGTCCCACGG 
GAAGTGACTG TGGACCCCAA CACTGTGGCA GCCCGGGAGA TGGAGCGCCT GGAGAAGGAG 
AGTGCGAGGC TGGGGGCTCA CCTGGACCGC TGTGTGATTG CGGGGCTCTG CCTCCTCACG 
CTGGGGGGCG TCATCCTGTC CTGCTTGTTA ATGATGTCCA TGTGGAAGGG GGAGCTCTAT 
CGTCGAAACA GATTTGCCTC TTCCAAAGAG TCTGCAAAAC TCTATGGTTC TTTCAACTTC 
AGGATGAAAA CCAGCACGAA TGAAAACACT CTGGAACTGT CCTTGGTAGA GGAAGATGCG 
CTTGCTGTAC AGAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694560.1
Translation	MELHYLAKKSNQADLCDARDWSSRGLPGDQADTAATRAALCCQKQCASTPRATEMEGSKLSSSPASPSSSLQNSTLQPDAFPPGLLHSGNNQITAERKVCNCCSQELETSFTYVDKNINLEQRNRSSPSAKGHNHPGELGWENPNEWSQEAAISLISEEEDDTSSEATSSGKSIDYGFISAILFLVTGILLVIISYIVPREVTVDPNTVAAREMERLEKESARLGAHLDRCVIAGLCLLTLGGVILSCLLMMSMWKGELYRRNRFASSKESAKLYGSFNFRMKTSTNENTLELSLVEEDALAVQS

Target ORF information:

RefSeq Version	NM_153015.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens transmembrane protein 74 (TMEM74), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153015.1

ORF Insert Sequence:

ATGGAGCTCC ACTACCTTGC TAAGAAGAGC AACCAGGCAG ACCTCTGTGA TGCCAGGGAC 
TGGAGTTCAA GAGGGCTGCC TGGTGACCAG GCAGATACAG CAGCCACAAG AGCTGCTCTC 
TGCTGTCAGA AACAGTGTGC ATCCACCCCA AGAGCAACCG AGATGGAAGG GTCTAAACTT 
AGTTCTTCTC CAGCATCCCC CTCCTCCTCT CTGCAAAACA GTACTCTTCA GCCAGATGCC 
TTTCCACCAG GACTTCTCCA CTCAGGGAAC AACCAAATAA CAGCGGAACG GAAAGTCTGT 
AACTGCTGCA GCCAGGAATT AGAAACTTCT TTTACCTATG TGGACAAAAA CATCAACTTG 
GAGCAGCGGA ACCGGAGCTC GCCATCAGCA AAAGGGCATA ATCACCCTGG GGAGCTTGGC 
TGGGAAAATC CAAATGAGTG GTCCCAAGAG GCTGCCATAT CTTTGATATC TGAAGAGGAG 
GATGATACAA GTTCAGAAGC CACGTCTTCA GGGAAGTCTA TAGACTATGG TTTCATCAGC 
GCCATCTTGT TCTTGGTCAC TGGGATCCTG CTCGTGATCA TCTCTTACAT CGTCCCACGG 
GAAGTGACTG TGGACCCCAA CACTGTGGCA GCCCGGGAGA TGGAGCGCCT GGAGAAGGAG 
AGTGCGAGGC TGGGGGCTCA CCTGGACCGC TGTGTGATTG CGGGGCTCTG CCTCCTCACG 
CTGGGGGGCG TCATCCTGTC CTGCTTGTTA ATGATGTCCA TGTGGAAGGG GGAGCTCTAT 
CGTCGAAACA GATTTGCCTC TTCCAAAGAG TCTGCAAAAC TCTATGGTTC TTTCAACTTC 
AGGATGAAAA CCAGCACGAA TGAAAACACT CTGGAACTGT CCTTGGTAGA GGAAGATGCG 
CTTGCTGTAC AGAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM74 ( NM_153015.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_694560.1 Homo sapiens transmembrane protein 74 (TMEM74), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06847
Clone ID Related Accession (Same CDS sequence)	NM_153015.2 , NM_153015.1 , NM_153015.3
Accession Version	NM_153015.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	transmembrane protein 74
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC030710.2, AK055230.1, AC104247.5 and D60265.1. On Nov 23, 2018 this sequence version replaced NM_153015.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.263401.1, SRR1660809.177279.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000297459.4/ ENSP00000297459.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCTCC ACTACCTTGC TAAGAAGAGC AACCAGGCAG ACCTCTGTGA TGCCAGGGAC 
TGGAGTTCAA GAGGGCTGCC TGGTGACCAG GCAGATACAG CAGCCACAAG AGCTGCTCTC 
TGCTGTCAGA AACAGTGTGC ATCCACCCCA AGAGCAACCG AGATGGAAGG GTCTAAACTT 
AGTTCTTCTC CAGCATCCCC CTCCTCCTCT CTGCAAAACA GTACTCTTCA GCCAGATGCC 
TTTCCACCAG GACTTCTCCA CTCAGGGAAC AACCAAATAA CAGCGGAACG GAAAGTCTGT 
AACTGCTGCA GCCAGGAATT AGAAACTTCT TTTACCTATG TGGACAAAAA CATCAACTTG 
GAGCAGCGGA ACCGGAGCTC GCCATCAGCA AAAGGGCATA ATCACCCTGG GGAGCTTGGC 
TGGGAAAATC CAAATGAGTG GTCCCAAGAG GCTGCCATAT CTTTGATATC TGAAGAGGAG 
GATGATACAA GTTCAGAAGC CACGTCTTCA GGGAAGTCTA TAGACTATGG TTTCATCAGC 
GCCATCTTGT TCTTGGTCAC TGGGATCCTG CTCGTGATCA TCTCTTACAT CGTCCCACGG 
GAAGTGACTG TGGACCCCAA CACTGTGGCA GCCCGGGAGA TGGAGCGCCT GGAGAAGGAG 
AGTGCGAGGC TGGGGGCTCA CCTGGACCGC TGTGTGATTG CGGGGCTCTG CCTCCTCACG 
CTGGGGGGCG TCATCCTGTC CTGCTTGTTA ATGATGTCCA TGTGGAAGGG GGAGCTCTAT 
CGTCGAAACA GATTTGCCTC TTCCAAAGAG TCTGCAAAAC TCTATGGTTC TTTCAACTTC 
AGGATGAAAA CCAGCACGAA TGAAAACACT CTGGAACTGT CCTTGGTAGA GGAAGATGCG 
CTTGCTGTAC AGAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694560.1
CDS	159..1076
Translation	MELHYLAKKSNQADLCDARDWSSRGLPGDQADTAATRAALCCQKQCASTPRATEMEGSKLSSSPASPSSSLQNSTLQPDAFPPGLLHSGNNQITAERKVCNCCSQELETSFTYVDKNINLEQRNRSSPSAKGHNHPGELGWENPNEWSQEAAISLISEEEDDTSSEATSSGKSIDYGFISAILFLVTGILLVIISYIVPREVTVDPNTVAAREMERLEKESARLGAHLDRCVIAGLCLLTLGGVILSCLLMMSMWKGELYRRNRFASSKESAKLYGSFNFRMKTSTNENTLELSLVEEDALAVQS

Target ORF information:

RefSeq Version	NM_153015.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 74 (TMEM74), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153015.3

ORF Insert Sequence:

ATGGAGCTCC ACTACCTTGC TAAGAAGAGC AACCAGGCAG ACCTCTGTGA TGCCAGGGAC 
TGGAGTTCAA GAGGGCTGCC TGGTGACCAG GCAGATACAG CAGCCACAAG AGCTGCTCTC 
TGCTGTCAGA AACAGTGTGC ATCCACCCCA AGAGCAACCG AGATGGAAGG GTCTAAACTT 
AGTTCTTCTC CAGCATCCCC CTCCTCCTCT CTGCAAAACA GTACTCTTCA GCCAGATGCC 
TTTCCACCAG GACTTCTCCA CTCAGGGAAC AACCAAATAA CAGCGGAACG GAAAGTCTGT 
AACTGCTGCA GCCAGGAATT AGAAACTTCT TTTACCTATG TGGACAAAAA CATCAACTTG 
GAGCAGCGGA ACCGGAGCTC GCCATCAGCA AAAGGGCATA ATCACCCTGG GGAGCTTGGC 
TGGGAAAATC CAAATGAGTG GTCCCAAGAG GCTGCCATAT CTTTGATATC TGAAGAGGAG 
GATGATACAA GTTCAGAAGC CACGTCTTCA GGGAAGTCTA TAGACTATGG TTTCATCAGC 
GCCATCTTGT TCTTGGTCAC TGGGATCCTG CTCGTGATCA TCTCTTACAT CGTCCCACGG 
GAAGTGACTG TGGACCCCAA CACTGTGGCA GCCCGGGAGA TGGAGCGCCT GGAGAAGGAG 
AGTGCGAGGC TGGGGGCTCA CCTGGACCGC TGTGTGATTG CGGGGCTCTG CCTCCTCACG 
CTGGGGGGCG TCATCCTGTC CTGCTTGTTA ATGATGTCCA TGTGGAAGGG GGAGCTCTAT 
CGTCGAAACA GATTTGCCTC TTCCAAAGAG TCTGCAAAAC TCTATGGTTC TTTCAACTTC 
AGGATGAAAA CCAGCACGAA TGAAAACACT CTGGAACTGT CCTTGGTAGA GGAAGATGCG 
CTTGCTGTAC AGAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TMEM74 promotes tumor cell survival by inducing autophagy via interactions with ATG16L1 and ATG9A.
Cell death & disease8(8)e3031(2017 Aug)
Sun Y,Chen Y,Zhang J,Cao L,He M,Liu X,Zhao N,Yin A,Huang H,Wang L

Autophagy regulatory molecule, TMEM74, interacts with BIK and inhibits BIK-induced apoptosis.
Cellular signalling3634-41(2017 Aug)
Sun Y,Li Q,Zhang J,Chen Z,He Q,Liu X,Zhao N,Yin A,Huang H,He M,Cao L,Wang L

TMEM74, a lysosome and autophagosome protein, regulates autophagy.
Biochemical and biophysical research communications369(2)622-9(2008 May)
Yu C,Wang L,Lv B,Lu Y,Zeng L,Chen Y,Ma D,Shi T,Wang L

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TMEM74 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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