ADRB2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ADRB2
Entrez Gene ID	154
Full Name	adrenoceptor beta 2
Synonyms	ADRB2R,ADRBR,B2AR,BAR,BETA2AR
General protein information	Preferred Names adrenoceptor beta 2 Names beta-2 adrenergic receptor adrenergic, beta-2-, receptor, surface adrenoceptor beta 2 surface beta-2 adrenoceptor beta-2 adrenoreceptor catecholamine receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q32
Summary	This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008].
Disorder MIM:	109690
Disorder Html:	{Asthma, nocturnal, susceptibility to}, 600807 (3); {Obesity, susceptibility to}, 601665 (3); Beta-2-adrenoreceptor agonist, reduced response to (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000024.5	NP_000015.1	beta-2 adrenergic receptor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Adrb2	NP_031446.2
Danio rerio (zebrafish)	adrb2b	NP_001082940.1
Pan troglodytes (chimpanzee)	ADRB2	NP_001182193.1
Canis lupus familiaris (dog)	ADRB2	NP_001003234.1
Bos taurus (cattle)	ADRB2	NP_776656.1
Rattus norvegicus (Norway rat)	Adrb2	NP_036624.2
Anopheles gambiae (African malaria mosquito)	GPRNNA2	XP_003436280.1
Xenopus tropicalis (tropical clawed frog)	adrb2	NP_001116897.2
Drosophila melanogaster (fruit fly)	Octbeta2R	NP_001247076.1
Homo sapiens (human)	ADRB2	NP_000015.1
	ADRB2	NP_001036239.1
Gallus gallus (chicken)	ADRB2	XP_004950644.1
Danio rerio (zebrafish)	adrb2a	NP_001096122.1

Gene Ontology
Bibliography

Related articles in PubMed

The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor mRNA inhibits receptor synthesis.
Parola AL, Kobilka BK
The Journal of biological chemistry269(6)4497-505(1994 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The data suggested that Arg/Arg homozygosity at codon 16 of the ADRB2 gene predisposes patients to a clinically more severe course of chronic obstructive pulmonary disease
Title: Beta-2-adrenoreceptor polymorphism at position 16 determines the clinical severity of chronic obstructive pulmonary disease.

Gln27Glu polymorphism of ADRB2 influences exercise-induced vascular adaptation in patients with acute coronary syndrome.
Title: Neurovascular control during exercise in acute coronary syndrome patients with Gln27Glu polymorphism of ?2-adrenergic receptor.

beta2-adrenoceptor gly16gly genotype is associated with the elevated resting cardiac output during anesthesia for abdominal aortic aneurysm surgery.
Title: ADRB2 gly16gly Genotype, Cardiac Output, and Cerebral Oxygenation in Patients Undergoing Anesthesia for Abdominal Aortic Aneurysm Surgery.

ARRDC3 functions as a switch to modulate the endosomal residence time and subsequent intracellular signaling of the beta2AR
Title: The ?-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the ?2-Adrenergic Receptor.

Low ADRB2 level may promote development of castration resistant prostate cancer.
Title: Low ??-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism.

The following ADRB2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADRB2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu19730	NM_000024.5 Latest version!	Homo sapiens adrenoceptor beta 2 (ADRB2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ADRB2 ( NM_000024.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000015.1 Homo sapiens adrenoceptor beta 2 (ADRB2), mRNA.

Price & Availability↑

CloneID	OHu19730
Clone ID Related Accession (Same CDS sequence)	NM_000024.5
Accession Version	NM_000024.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1242bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	beta-2 adrenergic receptor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA705141.1, BC073856.1, M15169.1, BC012481.2 and AA886615.1. This sequence is a reference standard in the RefSeqGene project. On Jan 8, 2010 this sequence version replaced NM_000024.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript regulatory uORF :: PMID: 8308019 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGCAAC CCGGGAACGG CAGCGCCTTC TTGCTGGCAC CCAATAGAAG CCATGCGCCG 
GACCACGACG TCACGCAGCA AAGGGACGAG GTGTGGGTGG TGGGCATGGG CATCGTCATG 
TCTCTCATCG TCCTGGCCAT CGTGTTTGGC AATGTGCTGG TCATCACAGC CATTGCCAAG 
TTCGAGCGTC TGCAGACGGT CACCAACTAC TTCATCACTT CACTGGCCTG TGCTGATCTG 
GTCATGGGCC TGGCAGTGGT GCCCTTTGGG GCCGCCCATA TTCTTATGAA AATGTGGACT 
TTTGGCAACT TCTGGTGCGA GTTTTGGACT TCCATTGATG TGCTGTGCGT CACGGCCAGC 
ATTGAGACCC TGTGCGTGAT CGCAGTGGAT CGCTACTTTG CCATTACTTC ACCTTTCAAG 
TACCAGAGCC TGCTGACCAA GAATAAGGCC CGGGTGATCA TTCTGATGGT GTGGATTGTG 
TCAGGCCTTA CCTCCTTCTT GCCCATTCAG ATGCACTGGT ACCGGGCCAC CCACCAGGAA 
GCCATCAACT GCTATGCCAA TGAGACCTGC TGTGACTTCT TCACGAACCA AGCCTATGCC 
ATTGCCTCTT CCATCGTGTC CTTCTACGTT CCCCTGGTGA TCATGGTCTT CGTCTACTCC 
AGGGTCTTTC AGGAGGCCAA AAGGCAGCTC CAGAAGATTG ACAAATCTGA GGGCCGCTTC 
CATGTCCAGA ACCTTAGCCA GGTGGAGCAG GATGGGCGGA CGGGGCATGG ACTCCGCAGA 
TCTTCCAAGT TCTGCTTGAA GGAGCACAAA GCCCTCAAGA CGTTAGGCAT CATCATGGGC 
ACTTTCACCC TCTGCTGGCT GCCCTTCTTC ATCGTTAACA TTGTGCATGT GATCCAGGAT 
AACCTCATCC GTAAGGAAGT TTACATCCTC CTAAATTGGA TAGGCTATGT CAATTCTGGT 
TTCAATCCCC TTATCTACTG CCGGAGCCCA GATTTCAGGA TTGCCTTCCA GGAGCTTCTG 
TGCCTGCGCA GGTCTTCTTT GAAGGCCTAT GGGAATGGCT ACTCCAGCAA CGGCAACACA 
GGGGAGCAGA GTGGATATCA CGTGGAACAG GAGAAAGAAA ATAAACTGCT GTGTGAAGAC 
CTCCCAGGCA CGGAAGACTT TGTGGGCCAT CAAGGTACTG TGCCTAGCGA TAACATTGAT 
TCACAAGGGA GGAATTGTAG TACAAATGAC TCACTGCTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000015.1
CDS	240..1481
Translation	MGQPGNGSAFLLAPNRSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL

Target ORF information:

RefSeq Version	NM_000024.5
Organism	Homo sapiens(human)
Definition	Homo sapiens adrenoceptor beta 2 (ADRB2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000024.5

ORF Insert Sequence:

ATGGGGCAAC CCGGGAACGG CAGCGCCTTC TTGCTGGCAC CCAATAGAAG CCATGCGCCG 
GACCACGACG TCACGCAGCA AAGGGACGAG GTGTGGGTGG TGGGCATGGG CATCGTCATG 
TCTCTCATCG TCCTGGCCAT CGTGTTTGGC AATGTGCTGG TCATCACAGC CATTGCCAAG 
TTCGAGCGTC TGCAGACGGT CACCAACTAC TTCATCACTT CACTGGCCTG TGCTGATCTG 
GTCATGGGCC TGGCAGTGGT GCCCTTTGGG GCCGCCCATA TTCTTATGAA AATGTGGACT 
TTTGGCAACT TCTGGTGCGA GTTTTGGACT TCCATTGATG TGCTGTGCGT CACGGCCAGC 
ATTGAGACCC TGTGCGTGAT CGCAGTGGAT CGCTACTTTG CCATTACTTC ACCTTTCAAG 
TACCAGAGCC TGCTGACCAA GAATAAGGCC CGGGTGATCA TTCTGATGGT GTGGATTGTG 
TCAGGCCTTA CCTCCTTCTT GCCCATTCAG ATGCACTGGT ACCGGGCCAC CCACCAGGAA 
GCCATCAACT GCTATGCCAA TGAGACCTGC TGTGACTTCT TCACGAACCA AGCCTATGCC 
ATTGCCTCTT CCATCGTGTC CTTCTACGTT CCCCTGGTGA TCATGGTCTT CGTCTACTCC 
AGGGTCTTTC AGGAGGCCAA AAGGCAGCTC CAGAAGATTG ACAAATCTGA GGGCCGCTTC 
CATGTCCAGA ACCTTAGCCA GGTGGAGCAG GATGGGCGGA CGGGGCATGG ACTCCGCAGA 
TCTTCCAAGT TCTGCTTGAA GGAGCACAAA GCCCTCAAGA CGTTAGGCAT CATCATGGGC 
ACTTTCACCC TCTGCTGGCT GCCCTTCTTC ATCGTTAACA TTGTGCATGT GATCCAGGAT 
AACCTCATCC GTAAGGAAGT TTACATCCTC CTAAATTGGA TAGGCTATGT CAATTCTGGT 
TTCAATCCCC TTATCTACTG CCGGAGCCCA GATTTCAGGA TTGCCTTCCA GGAGCTTCTG 
TGCCTGCGCA GGTCTTCTTT GAAGGCCTAT GGGAATGGCT ACTCCAGCAA CGGCAACACA 
GGGGAGCAGA GTGGATATCA CGTGGAACAG GAGAAAGAAA ATAAACTGCT GTGTGAAGAC 
CTCCCAGGCA CGGAAGACTT TGTGGGCCAT CAAGGTACTG TGCCTAGCGA TAACATTGAT 
TCACAAGGGA GGAATTGTAG TACAAATGAC TCACTGCTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor mRNA inhibits receptor synthesis.
The Journal of biological chemistry269(6)4497-505(1994 Feb)
Parola AL,Kobilka BK

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ADRB2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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