ADRB2 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	ADRB2
Entrez Gene ID	281605
Full Name	adrenoceptor beta 2
General protein information	Preferred Names adrenoceptor beta 2 Names beta-2 adrenergic receptor adrenergic receptor beta 2 adrenergic, beta-2, receptor, surface adrenergic, beta-2-, receptor, surface adrenoceptor beta 2, surface beta-2 adrenoceptor beta-2 adrenoreceptor
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174231.1	NP_776656.1	beta-2 adrenergic receptor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Adrb2	NP_031446.2
Danio rerio (zebrafish)	adrb2b	NP_001082940.1
Pan troglodytes (chimpanzee)	ADRB2	NP_001182193.1
Canis lupus familiaris (dog)	ADRB2	NP_001003234.1
Bos taurus (cattle)	ADRB2	NP_776656.1
Rattus norvegicus (Norway rat)	Adrb2	NP_036624.2
Anopheles gambiae (African malaria mosquito)	GPRNNA2	XP_003436280.1
Xenopus tropicalis (tropical clawed frog)	adrb2	NP_001116897.2
Drosophila melanogaster (fruit fly)	Octbeta2R	NP_001247076.1
Homo sapiens (human)	ADRB2	NP_000015.1
	ADRB2	NP_001036239.1
Gallus gallus (chicken)	ADRB2	XP_004950644.1
Danio rerio (zebrafish)	adrb2a	NP_001096122.1

Gene Ontology
Bibliography

Related articles in PubMed

Hepatic glucocorticoid and ?1- and ?2-adrenergic receptors in calves change during neonatal maturation and are related to energy regulation.
Sch?ff CT, Rohrbeck D, Steinhoff-Wagner J, Kanitz E, Sauerwein H, Bruckmaier RM, Hammon HM
Journal of dairy science98(2)1046-56(2015 Feb)

Constitutive phospholipid scramblase activity of a G protein-coupled receptor.
Goren MA, Morizumi T, Menon I, Joseph JS, Dittman JS, Cherezov V, Stevens RC, Ernst OP, Menon AK
Nature communications55115(2014 Oct)

Relationship between concentrations of progesterone, oxytocin, noradrenaline, gene expression and protein level for their receptors in corpus luteum during estrous cycle in the cow.
Rekawiecki R, Nowocin A, Kotwica J
Prostaglandins & other lipid mediators92(1-4)13-8(2010 Jun)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Ontogenetic development of mRNA levels and binding sites of hepatic beta-adrenergic receptors in cattle.
Carron J, Morel C, Hammon HM, Blum JW
Domestic animal endocrinology28(3)320-30(2005 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results indicate dependence of hepatic glucocorticoid and adrenergic receptors on stage of maturation in neonatal calves and emphasize the association of alpha1-adrenergic receptor and glucocorticoid receptor with neonatal glucose and lipid metabolism.
Title: Hepatic glucocorticoid and ?1- and ?2-adrenergic receptors in calves change during neonatal maturation and are related to energy regulation.

ADRb2 shows lipid scrambling activity.
Title: Constitutive phospholipid scramblase activity of a G protein-coupled receptor.

relationship between luteal concentrations of oxytocin (OT), noradrenaline (NA), progesterone (P4), oxytocin receptors (OT-R) and beta(2)-adrenoreceptors (beta(2)-R) gene expression and their protein level throughout the estrous cycle
Title: Relationship between concentrations of progesterone, oxytocin, noradrenaline, gene expression and protein level for their receptors in corpus luteum during estrous cycle in the cow.

beta 1,2 and 3-adrenergic receptors in cattle were positively associated with hepatic activities of gluconeogenetic enzymes and with plasma glucose levels, suggesting functional importance
Title: Ontogenetic development of mRNA levels and binding sites of hepatic beta-adrenergic receptors in cattle.

of the beta-adrenergic receptors, adrenergic beta(2)-receptor type was most highly expressed in the mammary gland of dairy cows followed by beta(1) and beta(3)
Title: Detection and quantification of mRNA expression of alpha- and beta-adrenergic receptor subtypes in the mammary gland of dairy cows.

The following ADRB2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADRB2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa43409	NM_174231.1 Latest version!	Bos taurus adrenoceptor beta 2 (ADRB2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ADRB2 ( NM_174231.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776656.1 Bos taurus adrenoceptor beta 2 (ADRB2), mRNA.

Price & Availability↑

CloneID	OBa43409
Clone ID Related Accession (Same CDS sequence)	NM_174231.1
Accession Version	NM_174231.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1257bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Bos taurus(cattle)
Product	beta-2 adrenergic receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Z86037.1. ##Evidence-Data-START## Transcript exon combination :: Z86037.1 [ECO:0000332] ##Evidence-Data-END##

ATGGGGCAGC CCGGGAACCG CAGCGTCTTT TTGCTGGCGC CCAACGCAAG CCACGCGCCG 
GACCAAAACG TCACGCTGGA ACGGGACGAG GCCTGGGTTG TGGGCATGGG CATCCTCATG 
TCGCTTATTG TCCTGGCCAT CGTGTTTGGA AACGTGCTAG TCATCACAGC CATTGCCAAG 
TTTGAGCGTC TCCAGACGGT CACCAACTAC TTCATCACCT CCCTGGCCTG TGCTGACCTG 
GTCATGGGCC TGGCAGTGGT GCCCTTTGGG GCCTGCCACA TCCTCATGAA AATGTGGACT 
TTTGGCAACT TCTGGTGTGA GTTTTGGACT TCCATTGACG TGTTATGCGT CACGGCCAGC 
ATTGAGACCT TGTGCGTGAT CGCTGTGGAT CGCTACTTAG CCATCACGTC ACCCTTCAAG 
TATCAGTGCC TGCTGACCAA GAATAAGGCC CGGGTGGTCA TTTTGATGGT GTGGATCGTG 
TCTGGCCTTA CCTCCTTCTT ACCCATTCAG ATGCACTGGT ACCGGGCCAG CCACAAGGAA 
GCCATCAACT GCTATGCTAA GGAAACCTGC TGTGACTTCT TCACGAACCA ACCCTATGCC 
ATTGCCTCCT CCATTGTGTC CTTCTACCTT CCCCTGGTGG TCATGGTCTT CGTCTACTCC 
AGGGTGTTCC AGGTGGCCAA AAGGCAGCTC CAGAAGATCG ACAAATCTGA GGGCCGCTTC 
CATGCCCAAA ACGTCAGTCA AGTGGAGCAG GATGGGCGGA GCGGTCTAGG ACAACGCAGG 
ACCTCCAAGT TCTACTTGAA GGAACACAAA GCCCTCAAGA CTTTAGGCAT TATCATGGGC 
ACTTTCACCC TGTGCTGGCT GCCCTTCTTC ATTGTCAACA TTGTGCACGT GATCAAGGAT 
AACCTCATCC GTAAGGAAAT ATACATCCTT CTAAACTGGT TGGGCTACAT CAACTCCGCT 
TTCAATCCCC TTATCTACTG CCGGAGCCCA GATTTCAGGA TTGCCTTCCA GGAGCTTCTC 
TGCCTGCGCA GGTCTTCATT GAAGGCCTAT GGGAATGGCT GCTCCAGCAA CAGCAATGAC 
AGGACTGACT ACACAGGGGA ACAGAGTGGA TATCACCTGG GGGAGGAGAA AGACAGTGAA 
CTTCTGTGTG AAGACCCCCC AGGCACCGAA AACTTTGTGA ACCAGCAAGG TACTGTGCCC 
AGTGATAGCA TTGATTCACA AGGGAGGAAT TGTAGTACAA ATGACTCACT GCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776656.1
CDS	224..1480
Translation	MGQPGNRSVFLLAPNASHAPDQNVTLERDEAWVVGMGILMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGACHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYLAITSPFKYQCLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRASHKEAINCYAKETCCDFFTNQPYAIASSIVSFYLPLVVMVFVYSRVFQVAKRQLQKIDKSEGRFHAQNVSQVEQDGRSGLGQRRTSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIKDNLIRKEIYILLNWLGYINSAFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGCSSNSNDRTDYTGEQSGYHLGEEKDSELLCEDPPGTENFVNQQGTVPSDSIDSQGRNCSTNDSLL

Target ORF information:

RefSeq Version	NM_174231.1
Organism	Bos taurus(cattle)
Definition	Bos taurus adrenoceptor beta 2 (ADRB2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174231.1

ORF Insert Sequence:

ATGGGGCAGC CCGGGAACCG CAGCGTCTTT TTGCTGGCGC CCAACGCAAG CCACGCGCCG 
GACCAAAACG TCACGCTGGA ACGGGACGAG GCCTGGGTTG TGGGCATGGG CATCCTCATG 
TCGCTTATTG TCCTGGCCAT CGTGTTTGGA AACGTGCTAG TCATCACAGC CATTGCCAAG 
TTTGAGCGTC TCCAGACGGT CACCAACTAC TTCATCACCT CCCTGGCCTG TGCTGACCTG 
GTCATGGGCC TGGCAGTGGT GCCCTTTGGG GCCTGCCACA TCCTCATGAA AATGTGGACT 
TTTGGCAACT TCTGGTGTGA GTTTTGGACT TCCATTGACG TGTTATGCGT CACGGCCAGC 
ATTGAGACCT TGTGCGTGAT CGCTGTGGAT CGCTACTTAG CCATCACGTC ACCCTTCAAG 
TATCAGTGCC TGCTGACCAA GAATAAGGCC CGGGTGGTCA TTTTGATGGT GTGGATCGTG 
TCTGGCCTTA CCTCCTTCTT ACCCATTCAG ATGCACTGGT ACCGGGCCAG CCACAAGGAA 
GCCATCAACT GCTATGCTAA GGAAACCTGC TGTGACTTCT TCACGAACCA ACCCTATGCC 
ATTGCCTCCT CCATTGTGTC CTTCTACCTT CCCCTGGTGG TCATGGTCTT CGTCTACTCC 
AGGGTGTTCC AGGTGGCCAA AAGGCAGCTC CAGAAGATCG ACAAATCTGA GGGCCGCTTC 
CATGCCCAAA ACGTCAGTCA AGTGGAGCAG GATGGGCGGA GCGGTCTAGG ACAACGCAGG 
ACCTCCAAGT TCTACTTGAA GGAACACAAA GCCCTCAAGA CTTTAGGCAT TATCATGGGC 
ACTTTCACCC TGTGCTGGCT GCCCTTCTTC ATTGTCAACA TTGTGCACGT GATCAAGGAT 
AACCTCATCC GTAAGGAAAT ATACATCCTT CTAAACTGGT TGGGCTACAT CAACTCCGCT 
TTCAATCCCC TTATCTACTG CCGGAGCCCA GATTTCAGGA TTGCCTTCCA GGAGCTTCTC 
TGCCTGCGCA GGTCTTCATT GAAGGCCTAT GGGAATGGCT GCTCCAGCAA CAGCAATGAC 
AGGACTGACT ACACAGGGGA ACAGAGTGGA TATCACCTGG GGGAGGAGAA AGACAGTGAA 
CTTCTGTGTG AAGACCCCCC AGGCACCGAA AACTTTGTGA ACCAGCAAGG TACTGTGCCC 
AGTGATAGCA TTGATTCACA AGGGAGGAAT TGTAGTACAA ATGACTCACT GCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hepatic glucocorticoid and ?1- and ?2-adrenergic receptors in calves change during neonatal maturation and are related to energy regulation.
Journal of dairy science98(2)1046-56(2015 Feb)
Sch?ff CT,Rohrbeck D,Steinhoff-Wagner J,Kanitz E,Sauerwein H,Bruckmaier RM,Hammon HM

Constitutive phospholipid scramblase activity of a G protein-coupled receptor.
Nature communications55115(2014 Oct)
Goren MA,Morizumi T,Menon I,Joseph JS,Dittman JS,Cherezov V,Stevens RC,Ernst OP,Menon AK

Relationship between concentrations of progesterone, oxytocin, noradrenaline, gene expression and protein level for their receptors in corpus luteum during estrous cycle in the cow.
Prostaglandins & other lipid mediators92(1-4)13-8(2010 Jun)
Rekawiecki R,Nowocin A,Kotwica J

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Ontogenetic development of mRNA levels and binding sites of hepatic beta-adrenergic receptors in cattle.
Domestic animal endocrinology28(3)320-30(2005 Apr)
Carron J,Morel C,Hammon HM,Blum JW

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ADRB2 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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