NEURL2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NEURL2
Entrez Gene ID	140825
Full Name	neuralized E3 ubiquitin protein ligase 2
Synonyms	C20orf163,OZZ,OZZ-E3
General protein information	Preferred Names neuralized E3 ubiquitin protein ligase 2 Names neuralized-like protein 2 neuralized homolog 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.12
Summary	This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013].
Disorder MIM:	608597

mRNA and Protein(s)

mRNA	Protein	Name
NM_080749.3	NP_542787.1	neuralized-like protein 2 isoform 1
NM_001278535.1	NP_001265464.1	neuralized-like protein 2 isoform 2

Pathways from BioSystems

Homologies

	NEURL2	XP_001106359.1
Mus musculus (house mouse)	Neurl2	NP_001076443.1
Homo sapiens (human)	NEURL2	NP_542787.1
Danio rerio (zebrafish)	zgc:162187	NP_001077300.1
Drosophila melanogaster (fruit fly)	CG3894	NP_611963.5
Bos taurus (cattle)	NEURL2	NP_001179565.1
Rattus norvegicus (Norway rat)	Neurl2	NP_001101272.1
Xenopus tropicalis (tropical clawed frog)	LOC100494896	XP_002932555.2
Pan troglodytes (chimpanzee)	NEURL2	XP_525342.1
Canis lupus familiaris (dog)	NEURL2	XP_534441.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009070	XP_319819.4

Gene Ontology
Bibliography

Related articles in PubMed

Neuralized-2: expression in human and rodents and interaction with Delta-like ligands.
Rullinkov G, Tamme R, Sarapuu A, Laur?n J, Sepp M, Palm K, Timmusk T
Biochemical and biophysical research communications389(3)420-5(2009 Nov)

Candidate-gene testing for orphan limb-girdle muscular dystrophies.
Aurino S, Piluso G, Saccone V, Cacciottolo M, D'Amico F, Dionisi M, Totaro A, Belsito A, Di Vicino U, Nigro V
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology2790-7(2008 Dec)

Ozz; a new name on the long list of beta-catenin's nemeses.
Wu G, Liu C, He X
Molecular cell13(4)451-3(2004 Feb)

Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis.
Nastasi T, Bongiovanni A, Campos Y, Mann L, Toy JN, Bostrom J, Rottier R, Hahn C, Conaway JW, Harris AJ, D'Azzo A
Developmental cell6(2)269-82(2004 Feb)

The SOCS box: a tale of destruction and degradation.
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ
Trends in biochemical sciences27(5)235-41(2002 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Candidate-gene testing for orphan limb-girdle muscular dystrophies.

The following NEURL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NEURL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu20711	NM_080749.3 Latest version!	Homo sapiens neuralized E3 ubiquitin protein ligase 2 (NEURL2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu04556	NM_001278535.1 Latest version!	Homo sapiens neuralized E3 ubiquitin protein ligase 2 (NEURL2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NEURL2 ( NM_080749.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_542787.1 Homo sapiens neuralized E3 ubiquitin protein ligase 2 (NEURL2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20711
Clone ID Related Accession (Same CDS sequence)	NM_080749.3
Accession Version	NM_080749.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 858bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	neuralized-like protein 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK054821.1 and HY058356.1. This sequence is a reference standard in the RefSeqGene project. On Jun 18, 2013 this sequence version replaced NM_080749.2. Transcript Variant: This variant (1) encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AK054821.1, BC105935.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCTG CCTCCGAGCC CGTGGATTCG GGTGCACTCT GGGGACTCGA GCGCCCGGAG 
CCCCCTCCCA CCCGCTTCCA TCGGGTGCAC GGTGCCAACA TCCGCGTGGA CCCCTCTGGG 
ACGCGGGCCA CACGCGTGGA GAGCTTCGCC CACGGCGTGT GCTTCAGCCG CGAGCCGCTG 
GCCCCGGGCC AGGTCTTCCT GGTCGAGATC GAGGAGAAAG AGCTGGGCTG GTGCGGACAT 
CTGCGTCTCG GTCTGACCGC GCTGGACCCC GCCAGTCTGG CCCCCGTTCC CGAGTTTTCT 
CTGCCCGATC TGGTCAACCT GGGCCACACC TGGGTCTTCG CCATCACGCG CCACCACAAC 
CGCGTGCCCC GGGAGGGCCG CCCGGAGGCG GAGGCAGCGG CCCCCAGCCG ACCTCCAACC 
CTCCTCGTGG AACCATATCT GCGCATTGAG CAGTTTCGCA TTCCCCGGGA CCGCCTGGTG 
GGCCGCAGCC GGCCAGGGCT CTACAGCCAT CTCTTGGACC AGCTCTATGA GCTGAACGTG 
CTGCCTCCGA CCGCGCGCCG TAGCCGCCTG GGTGTCCTCT TTTGCCCGCG CCCCGATGGC 
ACGGCCGACA TGCACATCAT CATCAACGGC GAGGACATGG GCCCGAGCGC CCGGGGACTG 
CCAGCTGCGC AGCCCCTCTA CGCGGTGGTG GACGTGTTTG CTTCCACAAA GAGCGTGCGC 
CTTGTCCAGC TCGAGTATGG CTTGCCATCC CTGCAGACTC TGTGCCGCCT AGTGATACAA 
AGGAGCATGG TGCACCGGCT GGCCATTGAT GGGCTCCACC TGCCCAAAGA ACTTAAGGAT 
TTCTGCAAGT ATGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542787.1
CDS	297..1154
Translation	MAAASEPVDSGALWGLERPEPPPTRFHRVHGANIRVDPSGTRATRVESFAHGVCFSREPLAPGQVFLVEIEEKELGWCGHLRLGLTALDPASLAPVPEFSLPDLVNLGHTWVFAITRHHNRVPREGRPEAEAAAPSRPPTLLVEPYLRIEQFRIPRDRLVGRSRPGLYSHLLDQLYELNVLPPTARRSRLGVLFCPRPDGTADMHIIINGEDMGPSARGLPAAQPLYAVVDVFASTKSVRLVQLEYGLPSLQTLCRLVIQRSMVHRLAIDGLHLPKELKDFCKYE

Target ORF information:

RefSeq Version	NM_080749.3
Organism	Homo sapiens(human)
Definition	Homo sapiens neuralized E3 ubiquitin protein ligase 2 (NEURL2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080749.3

ORF Insert Sequence:

ATGGCTGCTG CCTCCGAGCC CGTGGATTCG GGTGCACTCT GGGGACTCGA GCGCCCGGAG 
CCCCCTCCCA CCCGCTTCCA TCGGGTGCAC GGTGCCAACA TCCGCGTGGA CCCCTCTGGG 
ACGCGGGCCA CACGCGTGGA GAGCTTCGCC CACGGCGTGT GCTTCAGCCG CGAGCCGCTG 
GCCCCGGGCC AGGTCTTCCT GGTCGAGATC GAGGAGAAAG AGCTGGGCTG GTGCGGACAT 
CTGCGTCTCG GTCTGACCGC GCTGGACCCC GCCAGTCTGG CCCCCGTTCC CGAGTTTTCT 
CTGCCCGATC TGGTCAACCT GGGCCACACC TGGGTCTTCG CCATCACGCG CCACCACAAC 
CGCGTGCCCC GGGAGGGCCG CCCGGAGGCG GAGGCAGCGG CCCCCAGCCG ACCTCCAACC 
CTCCTCGTGG AACCATATCT GCGCATTGAG CAGTTTCGCA TTCCCCGGGA CCGCCTGGTG 
GGCCGCAGCC GGCCAGGGCT CTACAGCCAT CTCTTGGACC AGCTCTATGA GCTGAACGTG 
CTGCCTCCGA CCGCGCGCCG TAGCCGCCTG GGTGTCCTCT TTTGCCCGCG CCCCGATGGC 
ACGGCCGACA TGCACATCAT CATCAACGGC GAGGACATGG GCCCGAGCGC CCGGGGACTG 
CCAGCTGCGC AGCCCCTCTA CGCGGTGGTG GACGTGTTTG CTTCCACAAA GAGCGTGCGC 
CTTGTCCAGC TCGAGTATGG CTTGCCATCC CTGCAGACTC TGTGCCGCCT AGTGATACAA 
AGGAGCATGG TGCACCGGCT GGCCATTGAT GGGCTCCACC TGCCCAAAGA ACTTAAGGAT 
TTCTGCAAGT ATGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NEURL2 ( NM_001278535.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265464.1 Homo sapiens neuralized E3 ubiquitin protein ligase 2 (NEURL2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04556
Clone ID Related Accession (Same CDS sequence)	NM_001278535.1
Accession Version	NM_001278535.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	neuralized-like protein 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK054821.1, AW298115.1 and HY058356.1. Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.579870.1, ERR279836.5557.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCTG CCTCCGAGCC CGTGGATTCG GGTGCACTCT GGGGACTCGA GCGCCCGGAG 
CCCCCTCCCA CCCGCTTCCA TCGGGTGCAC GGTGCCAACA TCCGCGTGGA CCCCTCTGGG 
ACGCGGGCCA CACGCGTGGA GAGCTTCGCC CACGGCGTGT GCTTCAGCCG CGAGCCGCTG 
GCCCCGGGCC AGGTCTTCCT GGTCGAGATC GAGGAGAAAG AGCTGGGCTG GTGCGGACAT 
CTGCGTCTCG GTCTGACCGC GCTGGACCCC GCCAGTCTGG CCCCCGTTCC CGAGTTTTCT 
CTGCCCGATC TGGTCAACCT GGGCCACACC TGGGTCTTCG CCATCACGCG CCACCACAAC 
CGCGTGCCCC GGGAGGGCCG CCCGGAGGCG GAGGCAGCGG CCCCCAGCCG ACCTCCAACC 
CTCCTCGTGG AACCATATCT GCGCATTGAG CAGTTTCGCA TTCCCCGGGA CCGCCTGGTG 
GGCCGCAGCC GGCCAGGGCT CTACAGCCAT CTCTTGGACC AGCTCTATGA GCTGAACGTG 
CTGCCTCCGA CCGCGCGCCG TAGCCGCCTG GGTGTCCTCT TTTGCCCGCG CCCCGATGGC 
ACGGCCGACA TGCACATCAT CATCAACGGC GAGGACATGG GCCCGAGCGC CCGGGGACTG 
CCAGCTGCGC AGCCCCTCTA CGCGGTGGTG GACGTGTTTG CTTCCACAAA GAGCGTGCGC 
CTTGTCCAGC TCGAGTATGG CTTCTTCTTC CCACAGTGCC ATCCCTGCAG ACTCTGTGCC 
GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265464.1
CDS	297..1082
Translation	MAAASEPVDSGALWGLERPEPPPTRFHRVHGANIRVDPSGTRATRVESFAHGVCFSREPLAPGQVFLVEIEEKELGWCGHLRLGLTALDPASLAPVPEFSLPDLVNLGHTWVFAITRHHNRVPREGRPEAEAAAPSRPPTLLVEPYLRIEQFRIPRDRLVGRSRPGLYSHLLDQLYELNVLPPTARRSRLGVLFCPRPDGTADMHIIINGEDMGPSARGLPAAQPLYAVVDVFASTKSVRLVQLEYGFFFPQCHPCRLCAA

Target ORF information:

RefSeq Version	NM_001278535.1
Organism	Homo sapiens(human)
Definition	Homo sapiens neuralized E3 ubiquitin protein ligase 2 (NEURL2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278535.1

ORF Insert Sequence:

ATGGCTGCTG CCTCCGAGCC CGTGGATTCG GGTGCACTCT GGGGACTCGA GCGCCCGGAG 
CCCCCTCCCA CCCGCTTCCA TCGGGTGCAC GGTGCCAACA TCCGCGTGGA CCCCTCTGGG 
ACGCGGGCCA CACGCGTGGA GAGCTTCGCC CACGGCGTGT GCTTCAGCCG CGAGCCGCTG 
GCCCCGGGCC AGGTCTTCCT GGTCGAGATC GAGGAGAAAG AGCTGGGCTG GTGCGGACAT 
CTGCGTCTCG GTCTGACCGC GCTGGACCCC GCCAGTCTGG CCCCCGTTCC CGAGTTTTCT 
CTGCCCGATC TGGTCAACCT GGGCCACACC TGGGTCTTCG CCATCACGCG CCACCACAAC 
CGCGTGCCCC GGGAGGGCCG CCCGGAGGCG GAGGCAGCGG CCCCCAGCCG ACCTCCAACC 
CTCCTCGTGG AACCATATCT GCGCATTGAG CAGTTTCGCA TTCCCCGGGA CCGCCTGGTG 
GGCCGCAGCC GGCCAGGGCT CTACAGCCAT CTCTTGGACC AGCTCTATGA GCTGAACGTG 
CTGCCTCCGA CCGCGCGCCG TAGCCGCCTG GGTGTCCTCT TTTGCCCGCG CCCCGATGGC 
ACGGCCGACA TGCACATCAT CATCAACGGC GAGGACATGG GCCCGAGCGC CCGGGGACTG 
CCAGCTGCGC AGCCCCTCTA CGCGGTGGTG GACGTGTTTG CTTCCACAAA GAGCGTGCGC 
CTTGTCCAGC TCGAGTATGG CTTCTTCTTC CCACAGTGCC ATCCCTGCAG ACTCTGTGCC 
GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neuralized-2: expression in human and rodents and interaction with Delta-like ligands.
Biochemical and biophysical research communications389(3)420-5(2009 Nov)
Rullinkov G,Tamme R,Sarapuu A,Laur?n J,Sepp M,Palm K,Timmusk T

Candidate-gene testing for orphan limb-girdle muscular dystrophies.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology2790-7(2008 Dec)
Aurino S,Piluso G,Saccone V,Cacciottolo M,D'Amico F,Dionisi M,Totaro A,Belsito A,Di Vicino U,Nigro V

Ozz; a new name on the long list of beta-catenin's nemeses.
Molecular cell13(4)451-3(2004 Feb)
Wu G,Liu C,He X

Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis.
Developmental cell6(2)269-82(2004 Feb)
Nastasi T,Bongiovanni A,Campos Y,Mann L,Toy JN,Bostrom J,Rottier R,Hahn C,Conaway JW,Harris AJ,D'Azzo A

The SOCS box: a tale of destruction and degradation.
Trends in biochemical sciences27(5)235-41(2002 May)
Kile BT,Schulman BA,Alexander WS,Nicola NA,Martin HM,Hilton DJ

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NEURL2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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