TCP10L cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TCP10L
Entrez Gene ID	140290
Full Name	t-complex 10 like
Synonyms	C21orf77,PRED77,TCP10A-2
General protein information	Preferred Names t-complex 10 like Names T-complex protein 10A homolog 2 T-complex protein 10A-2 TCP10-like
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q22.11
Disorder MIM:	608365

mRNA and Protein(s)

mRNA	Protein	Name
NM_144659.5	NP_653260.1	T-complex protein 10A homolog 2
NM_144659.7	NP_653260.1	T-complex protein 10A homolog 1
NM_144659.6	NP_653260.1	T-complex protein 10A homolog 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TCP10L	NP_001037842.1
	TCP10L	XP_001096096.1
Homo sapiens (human)	TCP10L	NP_653260.1

Gene Ontology
Bibliography

Related articles in PubMed

TCP10L synergizes with MAD1 in transcriptional suppression and cell cycle arrest through mutual interaction.
Shen S, Zuo J, Feng H, Bai M, Wang C, Wei Y, Li Y, Le Y, Wu J, Wu Y, Yu L
BMB reports49(6)325-30(2016 Jun)

TCP10L acts as a tumor suppressor by inhibiting cell proliferation in hepatocellular carcinoma.
Zuo J, Cai H, Wu Y, Ma H, Jiang W, Liu C, Han D, Ji G, Yu L
Biochemical and biophysical research communications446(1)61-7(2014 Mar)

Identification of TCP10L as primate-specific gene derived via segmental duplication and homodimerization of TCP10L through the leucine zipper motif.
Zhong Z, Qiu J, Chen X, Wan B, Ni J, Yang Y, Bai M, Zhang H, Yu L
Molecular biology reports35(2)171-8(2008 Jun)

Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions.
Denoeud F, Kapranov P, Ucla C, Frankish A, Castelo R, Drenkow J, Lagarde J, Alioto T, Manzano C, Chrast J, Dike S, Wyss C, Henrichsen CN, Holroyd N, Dickson MC, Taylor R, Hance Z, Foissac S, Myers RM, Rogers J, Hubbard T, Harrow J, Guig? R, Gingeras TR, Antonarakis SE, Reymond A
Genome research17(6)746-59(2007 Jun)

TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3.
Yu H, Jiang D, Guo Z, Saiyin H, Guo J, Wang X, Yu L
International journal of andrology28(3)163-70(2005 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TCP10L stabilizes MAD1 protein level through direct interaction, and they cooperatively regulate cell cycle progression.
Title: TCP10L synergizes with MAD1 in transcriptional suppression and cell cycle arrest through mutual interaction.

Overexpression of TCP10L in hepatocellular carcinoma cells suppressed colony formation, inhibited cell cycle progression through G0/G1 phase, and attenuated cell growth in vivo.
Title: TCP10L acts as a tumor suppressor by inhibiting cell proliferation in hepatocellular carcinoma.

The specific expression pattern of TCP10L and interaction with DAPK-3 implies that TCP10L might play crucially important roles in spermatogenesis through its interaction with DAPK-3.
Title: TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3.

Data suggest that the biological function of the interaction between T-complex protein 10-like and MAD4 may be to maintain the differentiation state in liver cells.
Title: Human liver specific transcriptional factor TCP10L binds to MAD4.

The result revealed that TCP10L expressed specifically in the human liver and testis
Title: Identification of a novel liver-specific expressed gene, TCP10L, encoding a human leucine zipper protein with transcription inhibition activity.

The following TCP10L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TCP10L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10362	NM_144659.7 Latest version!	Homo sapiens t-complex 10 like (TCP10L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu10362	NM_144659.5	Homo sapiens t-complex 10-like (TCP10L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu10362	NM_144659.6	Homo sapiens t-complex 10 like (TCP10L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TCP10L ( NM_144659.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_653260.1 Homo sapiens t-complex 10-like (TCP10L), mRNA.

Price & Availability↑

CloneID	OHu10362
Clone ID Related Accession (Same CDS sequence)	NM_144659.5 , NM_144659.7 , NM_144659.6
Accession Version	NM_144659.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	T-complex protein 10A homolog 2
Comment

ATGCTGGCAG GTCAACTCGA GGCCAGGGAC CCCAAAGAGG GCACCCACCC AGAGGACCCG 
TGCCCAGGAG CTGGGGCTGT CATGGAGAAG ACAGCTGTGG CAGCCGAGGT TCTCACGGAG 
GACTGCAACA CTGGGGAGAT GCCACCATTA CAGCAGCAGA TCATCAGACT CCACCAAGAG 
CTTGGGAGAC AGAAGTCTCT GTGGGCTGAT GTTCATGGAA AACTCCGGAG TCATATAGAT 
GCTTTGAGGG AGCAGAACAT GGAGCTCCGA GAAAAGCTGA GAGCTCTGCA GCTGCAGCGG 
TGGAAAGCCA GGAAGAAATC TGCAGCGTCC CCACACGCGG GGCAAGAATC GCACACTCTG 
GCATTGGAAC CTGCTTTTGG AAAAATTTCA CCTCTGTCAG CTGATGAAGA GACAATACCC 
AAATACGCTG GCCACAAGAA TCAGAGTGCC ACTCTCCTGG GACAAAGATC GTCATCTAAC 
AATTCAGCTC CTCCAAAGCC AATGAGTTTA AAGATAGAAA GAATTAGCTC GTGGAAAACA 
CCACCACAGG AAAATAGAGA TAAAAATCTT TCCAGGAGAC GTCAAGACAG AAGAGCAACA 
CCTACTGGAA GGCCAACTCC CTGTGCAGAG AGACGGGGGG GTGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_653260.1
Translation	MLAGQLEARDPKEGTHPEDPCPGAGAVMEKTAVAAEVLTEDCNTGEMPPLQQQIIRLHQELGRQKSLWADVHGKLRSHIDALREQNMELREKLRALQLQRWKARKKSAASPHAGQESHTLALEPAFGKISPLSADEETIPKYAGHKNQSATLLGQRSSSNNSAPPKPMSLKIERISSWKTPPQENRDKNLSRRRQDRRATPTGRPTPCAERRGGV

Target ORF information:

RefSeq Version	NM_144659.5
Organism	Homo sapiens(Human)
Definition	Homo sapiens t-complex 10-like (TCP10L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144659.5

ORF Insert Sequence:

ATGCTGGCAG GTCAACTCGA GGCCAGGGAC CCCAAAGAGG GCACCCACCC AGAGGACCCG 
TGCCCAGGAG CTGGGGCTGT CATGGAGAAG ACAGCTGTGG CAGCCGAGGT TCTCACGGAG 
GACTGCAACA CTGGGGAGAT GCCACCATTA CAGCAGCAGA TCATCAGACT CCACCAAGAG 
CTTGGGAGAC AGAAGTCTCT GTGGGCTGAT GTTCATGGAA AACTCCGGAG TCATATAGAT 
GCTTTGAGGG AGCAGAACAT GGAGCTCCGA GAAAAGCTGA GAGCTCTGCA GCTGCAGCGG 
TGGAAAGCCA GGAAGAAATC TGCAGCGTCC CCACACGCGG GGCAAGAATC GCACACTCTG 
GCATTGGAAC CTGCTTTTGG AAAAATTTCA CCTCTGTCAG CTGATGAAGA GACAATACCC 
AAATACGCTG GCCACAAGAA TCAGAGTGCC ACTCTCCTGG GACAAAGATC GTCATCTAAC 
AATTCAGCTC CTCCAAAGCC AATGAGTTTA AAGATAGAAA GAATTAGCTC GTGGAAAACA 
CCACCACAGG AAAATAGAGA TAAAAATCTT TCCAGGAGAC GTCAAGACAG AAGAGCAACA 
CCTACTGGAA GGCCAACTCC CTGTGCAGAG AGACGGGGGG GTGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TCP10L ( NM_144659.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_653260.1 Homo sapiens t-complex 10 like (TCP10L), mRNA.

Price & Availability↑

CloneID	OHu10362
Clone ID Related Accession (Same CDS sequence)	NM_144659.5 , NM_144659.7 , NM_144659.6
Accession Version	NM_144659.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	T-complex protein 10A homolog 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY036551.1, AF115967.1, BG721020.1, AP000274.2 and BC027970.1. On Nov 23, 2018 this sequence version replaced NM_144659.6. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AF115967.1, SRR5189667.33764.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151119 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000300258.8/ ENSP00000300258.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGGCAG GTCAACTCGA GGCCAGGGAC CCCAAAGAGG GCACCCACCC AGAGGACCCG 
TGCCCAGGAG CTGGGGCTGT CATGGAGAAG ACAGCTGTGG CAGCCGAGGT TCTCACGGAG 
GACTGCAACA CTGGGGAGAT GCCACCATTA CAGCAGCAGA TCATCAGACT CCACCAAGAG 
CTTGGGAGAC AGAAGTCTCT GTGGGCTGAT GTTCATGGAA AACTCCGGAG TCATATAGAT 
GCTTTGAGGG AGCAGAACAT GGAGCTCCGA GAAAAGCTGA GAGCTCTGCA GCTGCAGCGG 
TGGAAAGCCA GGAAGAAATC TGCAGCGTCC CCACACGCGG GGCAAGAATC GCACACTCTG 
GCATTGGAAC CTGCTTTTGG AAAAATTTCA CCTCTGTCAG CTGATGAAGA GACAATACCC 
AAATACGCTG GCCACAAGAA TCAGAGTGCC ACTCTCCTGG GACAAAGATC GTCATCTAAC 
AATTCAGCTC CTCCAAAGCC AATGAGTTTA AAGATAGAAA GAATTAGCTC GTGGAAAACA 
CCACCACAGG AAAATAGAGA TAAAAATCTT TCCAGGAGAC GTCAAGACAG AAGAGCAACA 
CCTACTGGAA GGCCAACTCC CTGTGCAGAG AGACGGGGGG GTGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_653260.1
CDS	105..752
Translation	MLAGQLEARDPKEGTHPEDPCPGAGAVMEKTAVAAEVLTEDCNTGEMPPLQQQIIRLHQELGRQKSLWADVHGKLRSHIDALREQNMELREKLRALQLQRWKARKKSAASPHAGQESHTLALEPAFGKISPLSADEETIPKYAGHKNQSATLLGQRSSSNNSAPPKPMSLKIERISSWKTPPQENRDKNLSRRRQDRRATPTGRPTPCAERRGGV

Target ORF information:

RefSeq Version	NM_144659.7
Organism	Homo sapiens(human)
Definition	Homo sapiens t-complex 10 like (TCP10L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144659.7

ORF Insert Sequence:

ATGCTGGCAG GTCAACTCGA GGCCAGGGAC CCCAAAGAGG GCACCCACCC AGAGGACCCG 
TGCCCAGGAG CTGGGGCTGT CATGGAGAAG ACAGCTGTGG CAGCCGAGGT TCTCACGGAG 
GACTGCAACA CTGGGGAGAT GCCACCATTA CAGCAGCAGA TCATCAGACT CCACCAAGAG 
CTTGGGAGAC AGAAGTCTCT GTGGGCTGAT GTTCATGGAA AACTCCGGAG TCATATAGAT 
GCTTTGAGGG AGCAGAACAT GGAGCTCCGA GAAAAGCTGA GAGCTCTGCA GCTGCAGCGG 
TGGAAAGCCA GGAAGAAATC TGCAGCGTCC CCACACGCGG GGCAAGAATC GCACACTCTG 
GCATTGGAAC CTGCTTTTGG AAAAATTTCA CCTCTGTCAG CTGATGAAGA GACAATACCC 
AAATACGCTG GCCACAAGAA TCAGAGTGCC ACTCTCCTGG GACAAAGATC GTCATCTAAC 
AATTCAGCTC CTCCAAAGCC AATGAGTTTA AAGATAGAAA GAATTAGCTC GTGGAAAACA 
CCACCACAGG AAAATAGAGA TAAAAATCTT TCCAGGAGAC GTCAAGACAG AAGAGCAACA 
CCTACTGGAA GGCCAACTCC CTGTGCAGAG AGACGGGGGG GTGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TCP10L ( NM_144659.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_653260.1 Homo sapiens t-complex 10 like (TCP10L), mRNA.

Price & Availability↑

CloneID	OHu10362
Clone ID Related Accession (Same CDS sequence)	NM_144659.5 , NM_144659.7 , NM_144659.6
Accession Version	NM_144659.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	T-complex protein 10A homolog 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY036551.1, AF115967.1, BG721020.1, AP000274.2 and BC027970.1. On Apr 13, 2017 this sequence version replaced NM_144659.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AF115967.1, AK058078.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151119 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGGCAG GTCAACTCGA GGCCAGGGAC CCCAAAGAGG GCACCCACCC AGAGGACCCG 
TGCCCAGGAG CTGGGGCTGT CATGGAGAAG ACAGCTGTGG CAGCCGAGGT TCTCACGGAG 
GACTGCAACA CTGGGGAGAT GCCACCATTA CAGCAGCAGA TCATCAGACT CCACCAAGAG 
CTTGGGAGAC AGAAGTCTCT GTGGGCTGAT GTTCATGGAA AACTCCGGAG TCATATAGAT 
GCTTTGAGGG AGCAGAACAT GGAGCTCCGA GAAAAGCTGA GAGCTCTGCA GCTGCAGCGG 
TGGAAAGCCA GGAAGAAATC TGCAGCGTCC CCACACGCGG GGCAAGAATC GCACACTCTG 
GCATTGGAAC CTGCTTTTGG AAAAATTTCA CCTCTGTCAG CTGATGAAGA GACAATACCC 
AAATACGCTG GCCACAAGAA TCAGAGTGCC ACTCTCCTGG GACAAAGATC GTCATCTAAC 
AATTCAGCTC CTCCAAAGCC AATGAGTTTA AAGATAGAAA GAATTAGCTC GTGGAAAACA 
CCACCACAGG AAAATAGAGA TAAAAATCTT TCCAGGAGAC GTCAAGACAG AAGAGCAACA 
CCTACTGGAA GGCCAACTCC CTGTGCAGAG AGACGGGGGG GTGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_653260.1
CDS	127..774
Translation	MLAGQLEARDPKEGTHPEDPCPGAGAVMEKTAVAAEVLTEDCNTGEMPPLQQQIIRLHQELGRQKSLWADVHGKLRSHIDALREQNMELREKLRALQLQRWKARKKSAASPHAGQESHTLALEPAFGKISPLSADEETIPKYAGHKNQSATLLGQRSSSNNSAPPKPMSLKIERISSWKTPPQENRDKNLSRRRQDRRATPTGRPTPCAERRGGV

Target ORF information:

RefSeq Version	NM_144659.6
Organism	Homo sapiens(human)
Definition	Homo sapiens t-complex 10 like (TCP10L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144659.6

ORF Insert Sequence:

ATGCTGGCAG GTCAACTCGA GGCCAGGGAC CCCAAAGAGG GCACCCACCC AGAGGACCCG 
TGCCCAGGAG CTGGGGCTGT CATGGAGAAG ACAGCTGTGG CAGCCGAGGT TCTCACGGAG 
GACTGCAACA CTGGGGAGAT GCCACCATTA CAGCAGCAGA TCATCAGACT CCACCAAGAG 
CTTGGGAGAC AGAAGTCTCT GTGGGCTGAT GTTCATGGAA AACTCCGGAG TCATATAGAT 
GCTTTGAGGG AGCAGAACAT GGAGCTCCGA GAAAAGCTGA GAGCTCTGCA GCTGCAGCGG 
TGGAAAGCCA GGAAGAAATC TGCAGCGTCC CCACACGCGG GGCAAGAATC GCACACTCTG 
GCATTGGAAC CTGCTTTTGG AAAAATTTCA CCTCTGTCAG CTGATGAAGA GACAATACCC 
AAATACGCTG GCCACAAGAA TCAGAGTGCC ACTCTCCTGG GACAAAGATC GTCATCTAAC 
AATTCAGCTC CTCCAAAGCC AATGAGTTTA AAGATAGAAA GAATTAGCTC GTGGAAAACA 
CCACCACAGG AAAATAGAGA TAAAAATCTT TCCAGGAGAC GTCAAGACAG AAGAGCAACA 
CCTACTGGAA GGCCAACTCC CTGTGCAGAG AGACGGGGGG GTGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TCP10L synergizes with MAD1 in transcriptional suppression and cell cycle arrest through mutual interaction.
BMB reports49(6)325-30(2016 Jun)
Shen S,Zuo J,Feng H,Bai M,Wang C,Wei Y,Li Y,Le Y,Wu J,Wu Y,Yu L

TCP10L acts as a tumor suppressor by inhibiting cell proliferation in hepatocellular carcinoma.
Biochemical and biophysical research communications446(1)61-7(2014 Mar)
Zuo J,Cai H,Wu Y,Ma H,Jiang W,Liu C,Han D,Ji G,Yu L

Identification of TCP10L as primate-specific gene derived via segmental duplication and homodimerization of TCP10L through the leucine zipper motif.
Molecular biology reports35(2)171-8(2008 Jun)
Zhong Z,Qiu J,Chen X,Wan B,Ni J,Yang Y,Bai M,Zhang H,Yu L

Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions.
Genome research17(6)746-59(2007 Jun)
Denoeud F,Kapranov P,Ucla C,Frankish A,Castelo R,Drenkow J,Lagarde J,Alioto T,Manzano C,Chrast J,Dike S,Wyss C,Henrichsen CN,Holroyd N,Dickson MC,Taylor R,Hance Z,Foissac S,Myers RM,Rogers J,Hubbard T,Harrow J,Guig? R,Gingeras TR,Antonarakis SE,Reymond A

TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3.
International journal of andrology28(3)163-70(2005 Jun)
Yu H,Jiang D,Guo Z,Saiyin H,Guo J,Wang X,Yu L

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TCP10L cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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