OTOL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OTOL1
Entrez Gene ID	131149
Full Name	otolin 1
Synonyms	C1QTNF15,C1QTNF16
General protein information	Preferred Names otolin 1 Names otolin-1 C1q and TNF related 16 C1q and tumor necrosis factor related protein 15
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q26.1
Summary	This gene encodes a secreted glycoprotein with a C-terminal complement Cq1-like globular domain that belongs to the C1q/tumor necrosis factor-related protein (CTRP) family. The encoded protein is expressed in the inner ear and forms a multimeric complex called the otoconia, together with cerebellin-1 and otoconin-90, as part of the otoconial membrane. It contains extensive posttranslational modifications including hydroxylated prolines and glycosylated lysines. Naturally occurring mutations in this gene are associated with abnormal otoconia formation and balance deficits resulting from vestibular dysfunction. [provided by RefSeq, Jul 2017].

mRNA and Protein(s)

mRNA	Protein	Name
XM_005247109.2	XP_005247166.1	otolin-1 isoform X1
NM_001080440.1	NP_001073909.1	otolin-1 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Otol1	XP_006232550.1
Xenopus tropicalis (tropical clawed frog)	LOC100495841	XP_002933297.2
Canis lupus familiaris (dog)	OTOL1	XP_003640182.1
Danio rerio (zebrafish)	otol1a	NP_001093211.1
Bos taurus (cattle)	OTOL1	NP_001179533.1
Gallus gallus (chicken)	OTOL1	XP_426716.3
Danio rerio (zebrafish)	LOC572364	XP_701165.5
Homo sapiens (human)	OTOL1	NP_001073909.1
Pan troglodytes (chimpanzee)	OTOL1	XP_526369.3
	LOC100426070	XP_002802984.1
Mus musculus (house mouse)	Otol1	NP_001018041.2

Gene Ontology
Bibliography

Related articles in PubMed

Effect of calcium ions on structure and stability of the C1q-like domain of otolin-1 from human and zebrafish.
Ho?ubowicz R, Wojtas M, Taube M, Kozak M, O?yhar A, Dobryszycki P
The FEBS journal284(24)4278-4297(2017 Dec)

Age-Related Increase in Blood Levels of Otolin-1 in Humans.
Tabtabai R, Haynes L, Kuchel GA, Parham K
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology38(6)865-869(2017 Jul)

In vitro calcite crystal morphology is modulated by otoconial proteins otolin-1 and otoconin-90.
Moreland KT, Hong M, Lu W, Rowley CW, Ornitz DM, De Yoreo JJ, Thalmann R
PloS one9(4)e95333(2014)

A genome-wide association study of aging.
Walter S, Atzmon G, Demerath EW, Garcia ME, Kaplan RC, Kumari M, Lunetta KL, Milaneschi Y, Tanaka T, Tranah GJ, V?lker U, Yu L, Arnold A, Benjamin EJ, Biffar R, Buchman AS, Boerwinkle E, Couper D, De Jager PL, Evans DA, Harris TB, Hoffmann W, Hofman A, Karasik D, Kiel DP, Kocher T, Kuningas M, Launer LJ, Lohman KK, Lutsey PL, Mackenbach J, Marciante K, Psaty BM, Reiman EM, Rotter JI, Seshadri S, Shardell MD, Smith AV, van Duijn C, Walston J, Zillikens MC, Bandinelli S, Baumeister SE, Bennett DA, Ferrucci L, Gudnason V, Kivimaki M, Liu Y, Murabito JM, Newman AB, Tiemeier H, Franceschini N
Neurobiology of aging32(11)2109.e15-28(2011 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

An expression and purification procedure for the C1q-like domain of human otolin-1 was developed. It forms stable trimers in solution in the presence of calcium ions. C1q-like domains were stabilized by the calcium ions.
Title: Effect of calcium ions on structure and stability of the C1q-like domain of otolin-1 from human and zebrafish.

calcium carbonate crystal growth data demonstrate that Otolin-1 and OC90 modulate in vitro calcite crystal morphology but neither protein is sufficient to produce the shape of otoconia
Title: In vitro calcite crystal morphology is modulated by otoconial proteins otolin-1 and otoconin-90.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.

Identification and functional characterization of a similar protein in zebrafish.
Title: Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculae.

The following OTOL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OTOL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu30383	NM_001080440.1 Latest version!	Homo sapiens otolin 1 (OTOL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu30383	XM_005247109.2 Latest version!	Homo sapiens otolin 1 (OTOL1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OTOL1 ( NM_001080440.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001073909.1 Homo sapiens otolin 1 (OTOL1), mRNA.

Price & Availability↑

CloneID	OHu30383
Clone ID Related Accession (Same CDS sequence)	XM_005247109.2 , NM_001080440.1
Accession Version	NM_001080440.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1434bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Homo sapiens(human)
Product	otolin-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC104471.6. On Jan 18, 2007 this sequence version replaced XM_067228.8. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: DW009679.1, DW009680.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2145544, SAMEA2154361 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000327928.4/ ENSP00000330808.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTGGATGT TTTCTTGGCT TTGTGCTATT TTAATTATTT TGGCTATTGC TGGTATGAAC 
ACAATAGCAA AGACCACACC ACATACCAAA TTTACGAAGA AATCTGAGGA AAGAGAGATG 
CCAAAGGGTC TAAAGCCATC CAGTGGCCCA CCTCCAGAAG AAGAAGAAAC CCTCTTCACA 
GAAATGGCTG AAATGGCAGA ACCAATTACC AAACCCTCGG CCTTGGATTC TGTCTTTGGC 
ACTGCCACTC TCTCTCCCTT TGAAAACTTC ACTCTTGACC CAGCTGATTT CTTTTTGAAT 
TGTTGTGATT GTTGTTCACC TGTACCCGGG CAGAAAGGAG AACCTGGAGA GACTGGACAG 
CCAGGTCCTA AAGGAGAGGC TGGAAATTTG GGGATCCCAG GGCCACCAGG AGTTGTTGGG 
CCCCAAGGCC CTAGAGGCTA CAAAGGAGAG AAAGGACTCA AAGGAGAACG TGGGGACCAA 
GGAGTTCCAG GATACCCAGG AAAACCGGGA GCACAAGGTG AACCTGGCCC TAAGGGAGAT 
AAAGGAAACA TTGGTTTGGG AGGAGTGAAA GGACAAAAAG GCTCCAAGGG AGACACATGT 
GGGAATTGTA CCAAAGGAGA AAAAGGAGAC CAAGGGGCTA TGGGCTCACC TGGCCTGCAC 
GGAGGGCCTG GCGCCAAGGG AGAGAAGGGG GAGATGGGGG AGAAGGGGGA GATGGGGGAT 
AAGGGCTGCT GTGGAGATTC TGGGGAGAGG GGAGGAAAAG GACAGAAAGG TGAGGGGGGT 
ATGAAAGGGG AAAAAGGTAG CAAAGGAGAC AGTGGAATGG AAGGCAAAAG CGGCCGTAAT 
GGTCTGCCTG GGGCCAAAGG TGATCCAGGG ATTAAAGGAG AAAAAGGAGA GTTAGGTCCT 
CCTGGTCTCC TGGGACCTAC TGGGCCGAAG GGTGACATTG GCAACAAAGG GGTCCGAGGC 
CCCACTGGGA AGAAGGGCTC TCGGGGCTTT AAAGGCTCCA AGGGTGAGTT GGCTAGAGTG 
CCCCGGTCGG CTTTCAGCGC TGGTTTGTCA AAGCCATTTC CTCCTCCTAA CATCCCCATC 
AAATTTGAAA AGATTCTCTA TAATGACCAA GGGAATTACA GTCCTGTCAC TGGGAAGTTT 
AACTGCTCTA TTCCTGGGAC ATATGTTTTT TCCTACCATA TTACGGTGAG GGGGCGACCT 
GCTCGAATCA GTCTGGTGGC CCAGAATAAG AAGCAGTTCA AGTCCAGAGA AACTCTCTAT 
GGTCAGGAAA TAGACCAGGC CTCTCTCCTC GTCATCTTGA AATTAAGTGC AGGAGACCAA 
GTCTGGCTTG AGGTGTCAAA AGATTGGAAT GGGGTGTATG TCAGTGCTGA GGATGACAGC 
ATTTTTACTG GGTTCCTTTT GTACCCAGAG GAAACTTCTG GAATTTCACC ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001073909.1
CDS	1..1434
Translation	MWMFSWLCAILIILAIAGMNTIAKTTPHTKFTKKSEEREMPKGLKPSSGPPPEEEETLFTEMAEMAEPITKPSALDSVFGTATLSPFENFTLDPADFFLNCCDCCSPVPGQKGEPGETGQPGPKGEAGNLGIPGPPGVVGPQGPRGYKGEKGLKGERGDQGVPGYPGKPGAQGEPGPKGDKGNIGLGGVKGQKGSKGDTCGNCTKGEKGDQGAMGSPGLHGGPGAKGEKGEMGEKGEMGDKGCCGDSGERGGKGQKGEGGMKGEKGSKGDSGMEGKSGRNGLPGAKGDPGIKGEKGELGPPGLLGPTGPKGDIGNKGVRGPTGKKGSRGFKGSKGELARVPRSAFSAGLSKPFPPPNIPIKFEKILYNDQGNYSPVTGKFNCSIPGTYVFSYHITVRGRPARISLVAQNKKQFKSRETLYGQEIDQASLLVILKLSAGDQVWLEVSKDWNGVYVSAEDDSIFTGFLLYPEETSGISP

Target ORF information:

RefSeq Version	NM_001080440.1
Organism	Homo sapiens(human)
Definition	Homo sapiens otolin 1 (OTOL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001080440.1

ORF Insert Sequence:

ATGTGGATGT TTTCTTGGCT TTGTGCTATT TTAATTATTT TGGCTATTGC TGGTATGAAC 
ACAATAGCAA AGACCACACC ACATACCAAA TTTACGAAGA AATCTGAGGA AAGAGAGATG 
CCAAAGGGTC TAAAGCCATC CAGTGGCCCA CCTCCAGAAG AAGAAGAAAC CCTCTTCACA 
GAAATGGCTG AAATGGCAGA ACCAATTACC AAACCCTCGG CCTTGGATTC TGTCTTTGGC 
ACTGCCACTC TCTCTCCCTT TGAAAACTTC ACTCTTGACC CAGCTGATTT CTTTTTGAAT 
TGTTGTGATT GTTGTTCACC TGTACCCGGG CAGAAAGGAG AACCTGGAGA GACTGGACAG 
CCAGGTCCTA AAGGAGAGGC TGGAAATTTG GGGATCCCAG GGCCACCAGG AGTTGTTGGG 
CCCCAAGGCC CTAGAGGCTA CAAAGGAGAG AAAGGACTCA AAGGAGAACG TGGGGACCAA 
GGAGTTCCAG GATACCCAGG AAAACCGGGA GCACAAGGTG AACCTGGCCC TAAGGGAGAT 
AAAGGAAACA TTGGTTTGGG AGGAGTGAAA GGACAAAAAG GCTCCAAGGG AGACACATGT 
GGGAATTGTA CCAAAGGAGA AAAAGGAGAC CAAGGGGCTA TGGGCTCACC TGGCCTGCAC 
GGAGGGCCTG GCGCCAAGGG AGAGAAGGGG GAGATGGGGG AGAAGGGGGA GATGGGGGAT 
AAGGGCTGCT GTGGAGATTC TGGGGAGAGG GGAGGAAAAG GACAGAAAGG TGAGGGGGGT 
ATGAAAGGGG AAAAAGGTAG CAAAGGAGAC AGTGGAATGG AAGGCAAAAG CGGCCGTAAT 
GGTCTGCCTG GGGCCAAAGG TGATCCAGGG ATTAAAGGAG AAAAAGGAGA GTTAGGTCCT 
CCTGGTCTCC TGGGACCTAC TGGGCCGAAG GGTGACATTG GCAACAAAGG GGTCCGAGGC 
CCCACTGGGA AGAAGGGCTC TCGGGGCTTT AAAGGCTCCA AGGGTGAGTT GGCTAGAGTG 
CCCCGGTCGG CTTTCAGCGC TGGTTTGTCA AAGCCATTTC CTCCTCCTAA CATCCCCATC 
AAATTTGAAA AGATTCTCTA TAATGACCAA GGGAATTACA GTCCTGTCAC TGGGAAGTTT 
AACTGCTCTA TTCCTGGGAC ATATGTTTTT TCCTACCATA TTACGGTGAG GGGGCGACCT 
GCTCGAATCA GTCTGGTGGC CCAGAATAAG AAGCAGTTCA AGTCCAGAGA AACTCTCTAT 
GGTCAGGAAA TAGACCAGGC CTCTCTCCTC GTCATCTTGA AATTAAGTGC AGGAGACCAA 
GTCTGGCTTG AGGTGTCAAA AGATTGGAAT GGGGTGTATG TCAGTGCTGA GGATGACAGC 
ATTTTTACTG GGTTCCTTTT GTACCCAGAG GAAACTTCTG GAATTTCACC ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OTOL1 ( XM_005247109.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005247166.1 Homo sapiens otolin 1 (OTOL1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu30383
Clone ID Related Accession (Same CDS sequence)	XM_005247109.2 , NM_001080440.1
Accession Version	XM_005247109.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1434bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	otolin-1 isoform X1
Comment

ATGTGGATGT TTTCTTGGCT TTGTGCTATT TTAATTATTT TGGCTATTGC TGGTATGAAC 
ACAATAGCAA AGACCACACC ACATACCAAA TTTACGAAGA AATCTGAGGA AAGAGAGATG 
CCAAAGGGTC TAAAGCCATC CAGTGGCCCA CCTCCAGAAG AAGAAGAAAC CCTCTTCACA 
GAAATGGCTG AAATGGCAGA ACCAATTACC AAACCCTCGG CCTTGGATTC TGTCTTTGGC 
ACTGCCACTC TCTCTCCCTT TGAAAACTTC ACTCTTGACC CAGCTGATTT CTTTTTGAAT 
TGTTGTGATT GTTGTTCACC TGTACCCGGG CAGAAAGGAG AACCTGGAGA GACTGGACAG 
CCAGGTCCTA AAGGAGAGGC TGGAAATTTG GGGATCCCAG GGCCACCAGG AGTTGTTGGG 
CCCCAAGGCC CTAGAGGCTA CAAAGGAGAG AAAGGACTCA AAGGAGAACG TGGGGACCAA 
GGAGTTCCAG GATACCCAGG AAAACCGGGA GCACAAGGTG AACCTGGCCC TAAGGGAGAT 
AAAGGAAACA TTGGTTTGGG AGGAGTGAAA GGACAAAAAG GCTCCAAGGG AGACACATGT 
GGGAATTGTA CCAAAGGAGA AAAAGGAGAC CAAGGGGCTA TGGGCTCACC TGGCCTGCAC 
GGAGGGCCTG GCGCCAAGGG AGAGAAGGGG GAGATGGGGG AGAAGGGGGA GATGGGGGAT 
AAGGGCTGCT GTGGAGATTC TGGGGAGAGG GGAGGAAAAG GACAGAAAGG TGAGGGGGGT 
ATGAAAGGGG AAAAAGGTAG CAAAGGAGAC AGTGGAATGG AAGGCAAAAG CGGCCGTAAT 
GGTCTGCCTG GGGCCAAAGG TGATCCAGGG ATTAAAGGAG AAAAAGGAGA GTTAGGTCCT 
CCTGGTCTCC TGGGACCTAC TGGGCCGAAG GGTGACATTG GCAACAAAGG GGTCCGAGGC 
CCCACTGGGA AGAAGGGCTC TCGGGGCTTT AAAGGCTCCA AGGGTGAGTT GGCTAGAGTG 
CCCCGGTCGG CTTTCAGCGC TGGTTTGTCA AAGCCATTTC CTCCTCCTAA CATCCCCATC 
AAATTTGAAA AGATTCTCTA TAATGACCAA GGGAATTACA GTCCTGTCAC TGGGAAGTTT 
AACTGCTCTA TTCCTGGGAC ATATGTTTTT TCCTACCATA TTACGGTGAG GGGGCGACCT 
GCTCGAATCA GTCTGGTGGC CCAGAATAAG AAGCAGTTCA AGTCCAGAGA AACTCTCTAT 
GGTCAGGAAA TAGACCAGGC CTCTCTCCTC GTCATCTTGA AATTAAGTGC AGGAGACCAA 
GTCTGGCTTG AGGTGTCAAA AGATTGGAAT GGGGTGTATG TCAGTGCTGA GGATGACAGC 
ATTTTTACTG GGTTCCTTTT GTACCCAGAG GAAACTTCTG GAATTTCACC ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_005247166.1

Translation

MWMFSWLCAILIILAIAGMNTIAKTTPHTKFTKKSEEREMPKGLKPSSGPPPEEEETLFTEMAEMAEPITKPSALDSVFGTATLSPFENFTLDPADFFLNCCDCCSPVPGQKGEPGETGQPGPKGEAGNLGIPGPPGVVGPQGPRGYKGEKGLKGERGDQGVPGYPGKPGAQGEPGPKGDKGNIGLGGVKGQKGSKGDTCGNCTKGEKGDQGAMGSPGLHGGPGAKGEKGEMGEKGEMGDKGCCGDSGERGGKGQKGEGGMKGEKGSKGDSGMEGKSGRNGLPGAKGDPGIKGEKGELGPPGLLGPTGPKGDIGNKGVRGPTGKKGSRGFKGSKGELARVPRSAFSAGLSKPFPPPNIPIKFEKILYNDQGNYSPVTGKFNCSIPGTYVFSYHITVRGRPARISLVAQNKKQFKSRETLYGQEIDQASLLVILKLSAGDQVWLEVSKDWNGVYVSAEDDSIFTGFLLYPEETSGISP

Target ORF information:

RefSeq Version	XM_005247109.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens otolin 1 (OTOL1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005247109.2

ORF Insert Sequence:

ATGTGGATGT TTTCTTGGCT TTGTGCTATT TTAATTATTT TGGCTATTGC TGGTATGAAC 
ACAATAGCAA AGACCACACC ACATACCAAA TTTACGAAGA AATCTGAGGA AAGAGAGATG 
CCAAAGGGTC TAAAGCCATC CAGTGGCCCA CCTCCAGAAG AAGAAGAAAC CCTCTTCACA 
GAAATGGCTG AAATGGCAGA ACCAATTACC AAACCCTCGG CCTTGGATTC TGTCTTTGGC 
ACTGCCACTC TCTCTCCCTT TGAAAACTTC ACTCTTGACC CAGCTGATTT CTTTTTGAAT 
TGTTGTGATT GTTGTTCACC TGTACCCGGG CAGAAAGGAG AACCTGGAGA GACTGGACAG 
CCAGGTCCTA AAGGAGAGGC TGGAAATTTG GGGATCCCAG GGCCACCAGG AGTTGTTGGG 
CCCCAAGGCC CTAGAGGCTA CAAAGGAGAG AAAGGACTCA AAGGAGAACG TGGGGACCAA 
GGAGTTCCAG GATACCCAGG AAAACCGGGA GCACAAGGTG AACCTGGCCC TAAGGGAGAT 
AAAGGAAACA TTGGTTTGGG AGGAGTGAAA GGACAAAAAG GCTCCAAGGG AGACACATGT 
GGGAATTGTA CCAAAGGAGA AAAAGGAGAC CAAGGGGCTA TGGGCTCACC TGGCCTGCAC 
GGAGGGCCTG GCGCCAAGGG AGAGAAGGGG GAGATGGGGG AGAAGGGGGA GATGGGGGAT 
AAGGGCTGCT GTGGAGATTC TGGGGAGAGG GGAGGAAAAG GACAGAAAGG TGAGGGGGGT 
ATGAAAGGGG AAAAAGGTAG CAAAGGAGAC AGTGGAATGG AAGGCAAAAG CGGCCGTAAT 
GGTCTGCCTG GGGCCAAAGG TGATCCAGGG ATTAAAGGAG AAAAAGGAGA GTTAGGTCCT 
CCTGGTCTCC TGGGACCTAC TGGGCCGAAG GGTGACATTG GCAACAAAGG GGTCCGAGGC 
CCCACTGGGA AGAAGGGCTC TCGGGGCTTT AAAGGCTCCA AGGGTGAGTT GGCTAGAGTG 
CCCCGGTCGG CTTTCAGCGC TGGTTTGTCA AAGCCATTTC CTCCTCCTAA CATCCCCATC 
AAATTTGAAA AGATTCTCTA TAATGACCAA GGGAATTACA GTCCTGTCAC TGGGAAGTTT 
AACTGCTCTA TTCCTGGGAC ATATGTTTTT TCCTACCATA TTACGGTGAG GGGGCGACCT 
GCTCGAATCA GTCTGGTGGC CCAGAATAAG AAGCAGTTCA AGTCCAGAGA AACTCTCTAT 
GGTCAGGAAA TAGACCAGGC CTCTCTCCTC GTCATCTTGA AATTAAGTGC AGGAGACCAA 
GTCTGGCTTG AGGTGTCAAA AGATTGGAAT GGGGTGTATG TCAGTGCTGA GGATGACAGC 
ATTTTTACTG GGTTCCTTTT GTACCCAGAG GAAACTTCTG GAATTTCACC ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effect of calcium ions on structure and stability of the C1q-like domain of otolin-1 from human and zebrafish.
The FEBS journal284(24)4278-4297(2017 Dec)
Ho?ubowicz R,Wojtas M,Taube M,Kozak M,O?yhar A,Dobryszycki P

Age-Related Increase in Blood Levels of Otolin-1 in Humans.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology38(6)865-869(2017 Jul)
Tabtabai R,Haynes L,Kuchel GA,Parham K

In vitro calcite crystal morphology is modulated by otoconial proteins otolin-1 and otoconin-90.
PloS one9(4)e95333(2014)
Moreland KT,Hong M,Lu W,Rowley CW,Ornitz DM,De Yoreo JJ,Thalmann R

A genome-wide association study of aging.
Neurobiology of aging32(11)2109.e15-28(2011 Nov)
Walter S,Atzmon G,Demerath EW,Garcia ME,Kaplan RC,Kumari M,Lunetta KL,Milaneschi Y,Tanaka T,Tranah GJ,V?lker U,Yu L,Arnold A,Benjamin EJ,Biffar R,Buchman AS,Boerwinkle E,Couper D,De Jager PL,Evans DA,Harris TB,Hoffmann W,Hofman A,Karasik D,Kiel DP,Kocher T,Kuningas M,Launer LJ,Lohman KK,Lutsey PL,Mackenbach J,Marciante K,Psaty BM,Reiman EM,Rotter JI,Seshadri S,Shardell MD,Smith AV,van Duijn C,Walston J,Zillikens MC,Bandinelli S,Baumeister SE,Bennett DA,Ferrucci L,Gudnason V,Kivimaki M,Liu Y,Murabito JM,Newman AB,Tiemeier H,Franceschini N

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OTOL1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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