Otol1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Otol1
Entrez Gene ID	229389
Full Name	otolin 1
Synonyms	Gm414
General protein information	Preferred Names otolin 1 Names otolin-1 otolin 1 homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 E2

mRNA and Protein(s)

mRNA	Protein	Name
NM_001018031.2	NP_001018041.2	otolin-1 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Otol1	XP_006232550.1
Xenopus tropicalis (tropical clawed frog)	LOC100495841	XP_002933297.2
Canis lupus familiaris (dog)	OTOL1	XP_003640182.1
Danio rerio (zebrafish)	otol1a	NP_001093211.1
Bos taurus (cattle)	OTOL1	NP_001179533.1
Gallus gallus (chicken)	OTOL1	XP_426716.3
Danio rerio (zebrafish)	LOC572364	XP_701165.5
Homo sapiens (human)	OTOL1	NP_001073909.1
Pan troglodytes (chimpanzee)	OTOL1	XP_526369.3
	LOC100426070	XP_002802984.1
Mus musculus (house mouse)	Otol1	NP_001018041.2

Gene Ontology
Bibliography

Related articles in PubMed

Effect of calcium ions on structure and stability of the C1q-like domain of otolin-1 from human and zebrafish.
Ho?ubowicz R, Wojtas M, Taube M, Kozak M, O?yhar A, Dobryszycki P
The FEBS journal284(24)4278-4297(2017 Dec)

Spatiotemporal differences in otoconial gene expression.
Xu Y, Zhang Y, Lundberg YW
Genesis (New York, N.Y. : 2000)54(12)613-625(2016 Dec)

In vitro calcite crystal morphology is modulated by otoconial proteins otolin-1 and otoconin-90.
Moreland KT, Hong M, Lu W, Rowley CW, Ornitz DM, De Yoreo JJ, Thalmann R
PloS one9(4)e95333(2014)

Immunogold TEM of otoconin 90 and otolin - relevance to mineralization of?otoconia, and pathogenesis of benign positional vertigo.
Andrade LR, Lins U, Farina M, Kachar B, Thalmann R
Hearing research292(1-2)14-25(2012 Oct)

Matrix recruitment and calcium sequestration for spatial specific otoconia development.
Yang H, Zhao X, Xu Y, Wang L, He Q, Lundberg YW
PloS one6(5)e20498(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Report otoconin 90 is attached to a scaffold consisting of the hexagonal fibrillar meshwork, characteristic of otolin, in the otoconia.
Title: Immunogold TEM of otoconin 90 and otolin - relevance to mineralization of?otoconia, and pathogenesis of benign positional vertigo.

Otolin 1 interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1 in the inner ear.
Title: Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.

Identification and functional characterization of a similar protein in zebrafish.
Title: Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculae.

The following Otol1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Otol1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11789	NM_001018031.2 Latest version!	Mus musculus otolin 1 (Otol1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$286.30 $409.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Otol1 ( NM_001018031.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001018041.2 Mus musculus otolin 1 (Otol1), mRNA.

Price & Availability↑

CloneID	OMu11789
Clone ID Related Accession (Same CDS sequence)	NM_001018031.2
Accession Version	NM_001018031.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1449bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Mus musculus(house mouse)
Product	otolin-1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC140315.3, BC150904.1 and AK158454.1. On Oct 1, 2009 this sequence version replaced NM_001018031.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: DQ002405.2, BC150904.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138 [ECO:0000348] ##Evidence-Data-END##

ATGTGGATAT TTTCTTCGCT TTGTGCTGTT TTAACTATTT TGGCTATGGA TGATGTGGCC 
ACAGAAGCAA AGACCACACC ATACACCAAA TTTACGAAGA AATCTGAAGG AAAAGAGATG 
TTGAAGGGCT TAAAGCCGTC CAGTGGCTTC TTTCTGGATG GAGAAGAAAC CGTCCATACG 
GAAACGGCTG CCATGGCAGA GCCCACCACC GGCTCCCCTG CCTTGGCAAT GGCTGAGTCC 
ACCGCAGGCC CCTCGGCCTC TGCCACAACC CGTCTCCTTC CCTTCGAGAG CTTCTCTCTG 
GACACAACTG GTTTCGTTTT GAATTGCTGC CATTGTTGTT CATTTGTCAC TGGGCAGAAA 
GGAGAACCCG GAAAGATGGG AAAACAAGGC CCTAAAGGAG AGACTGGTGA CACTGGCAGC 
CCAGGACACC CAGGAACCAC TGGACCTCAA GGTCCCAAAG GCCAGAAAGG AGAGAAAGGA 
CTAAAGGGAG ACCGGGGGGA CCAAGGAGCA GGTGGCATTC CGGGGTACCC AGGAAAACCA 
GGAGAGCAAG GTGCACTTGG TCCCAAGGGA GATAAAGGAA CCATCGGCCC GGCAGGAACG 
AAAGGACAAA AAGGCTCTAA GGGAGAACTG TGTGGGAATG GCACTAAAGG AGAGAAAGGG 
GACCCTGGGG CCTCTGGGGC CCATGGCTTC ATTGGAGAGC CTGGGGCCAA GGGCGAGAAG 
GGTGGTGTTG GGGAGAAAGG CTACCGAGGA GATTTGGGGG AAAGGGGAGA AAAGGGGCAG 
AAAGGCGAGA AAGGGATGGA GGGAGAGAAA GGTAGCAGAG GAGATGTTGG GTCAGAAGGC 
AAAAGGGGTT CAGATGGTCT ACCAGGGCTC AGAGGCGATT CTGGTCCTAA AGGAGAAAAA 
GGAGAGATAG GTTCTCCTGG TTTCACCGGA CCTGCGGGAC CAAAGGGTGA GCTTGGAAGC 
AAAGGTGTTC GAGGGCCAAC AGGGAAGAAG GGCTCTCGGG GTGTCAAGGG TTCCAAAGGC 
GAGGCCACAC AAGTCCCACA GTCGGCTTTC AGTGCCCTTT TATCCAAGCC CTTCCCTCCC 
CCCAACGTTC CCATCAAGTT TGACAAGATT CTCTCTAATG ACCAAGGGGA TTACAGCCCC 
GTCACTGGGA AATTTAACTG TAGTGTTCCT GGGACATACA TATTTTCCTA TCATGTCACT 
GTCAGGGGTC GACCTGCTCG GATCAGCCTC GTGGCCCGCA ACAGGAAGCA GTTCAAATCC 
AGAGAGACGC TCTATGGTCA GCAAGTAGAT CAGGCCTCCC TCCTCCTCAT TCTGAAATTG 
AGTGCAGGAG ATCAAGTGTG GCTGGAAGTG TCAAAGGACT GGAATGGGCT GTATGTCGGC 
CCCGAGGATG ACAGCATCTT TAGTGGGTTC CTTCTGTACC CAGAGGAAAC TTTTAGTAAG 
TCACCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001018041.2
CDS	130..1578
Translation	MWIFSSLCAVLTILAMDDVATEAKTTPYTKFTKKSEGKEMLKGLKPSSGFFLDGEETVHTETAAMAEPTTGSPALAMAESTAGPSASATTRLLPFESFSLDTTGFVLNCCHCCSFVTGQKGEPGKMGKQGPKGETGDTGSPGHPGTTGPQGPKGQKGEKGLKGDRGDQGAGGIPGYPGKPGEQGALGPKGDKGTIGPAGTKGQKGSKGELCGNGTKGEKGDPGASGAHGFIGEPGAKGEKGGVGEKGYRGDLGERGEKGQKGEKGMEGEKGSRGDVGSEGKRGSDGLPGLRGDSGPKGEKGEIGSPGFTGPAGPKGELGSKGVRGPTGKKGSRGVKGSKGEATQVPQSAFSALLSKPFPPPNVPIKFDKILSNDQGDYSPVTGKFNCSVPGTYIFSYHVTVRGRPARISLVARNRKQFKSRETLYGQQVDQASLLLILKLSAGDQVWLEVSKDWNGLYVGPEDDSIFSGFLLYPEETFSKSP

Target ORF information:

RefSeq Version	NM_001018031.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus otolin 1 (Otol1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001018031.2

ORF Insert Sequence:

ATGTGGATAT TTTCTTCGCT TTGTGCTGTT TTAACTATTT TGGCTATGGA TGATGTGGCC 
ACAGAAGCAA AGACCACACC ATACACCAAA TTTACGAAGA AATCTGAAGG AAAAGAGATG 
TTGAAGGGCT TAAAGCCGTC CAGTGGCTTC TTTCTGGATG GAGAAGAAAC CGTCCATACG 
GAAACGGCTG CCATGGCAGA GCCCACCACC GGCTCCCCTG CCTTGGCAAT GGCTGAGTCC 
ACCGCAGGCC CCTCGGCCTC TGCCACAACC CGTCTCCTTC CCTTCGAGAG CTTCTCTCTG 
GACACAACTG GTTTCGTTTT GAATTGCTGC CATTGTTGTT CATTTGTCAC TGGGCAGAAA 
GGAGAACCCG GAAAGATGGG AAAACAAGGC CCTAAAGGAG AGACTGGTGA CACTGGCAGC 
CCAGGACACC CAGGAACCAC TGGACCTCAA GGTCCCAAAG GCCAGAAAGG AGAGAAAGGA 
CTAAAGGGAG ACCGGGGGGA CCAAGGAGCA GGTGGCATTC CGGGGTACCC AGGAAAACCA 
GGAGAGCAAG GTGCACTTGG TCCCAAGGGA GATAAAGGAA CCATCGGCCC GGCAGGAACG 
AAAGGACAAA AAGGCTCTAA GGGAGAACTG TGTGGGAATG GCACTAAAGG AGAGAAAGGG 
GACCCTGGGG CCTCTGGGGC CCATGGCTTC ATTGGAGAGC CTGGGGCCAA GGGCGAGAAG 
GGTGGTGTTG GGGAGAAAGG CTACCGAGGA GATTTGGGGG AAAGGGGAGA AAAGGGGCAG 
AAAGGCGAGA AAGGGATGGA GGGAGAGAAA GGTAGCAGAG GAGATGTTGG GTCAGAAGGC 
AAAAGGGGTT CAGATGGTCT ACCAGGGCTC AGAGGCGATT CTGGTCCTAA AGGAGAAAAA 
GGAGAGATAG GTTCTCCTGG TTTCACCGGA CCTGCGGGAC CAAAGGGTGA GCTTGGAAGC 
AAAGGTGTTC GAGGGCCAAC AGGGAAGAAG GGCTCTCGGG GTGTCAAGGG TTCCAAAGGC 
GAGGCCACAC AAGTCCCACA GTCGGCTTTC AGTGCCCTTT TATCCAAGCC CTTCCCTCCC 
CCCAACGTTC CCATCAAGTT TGACAAGATT CTCTCTAATG ACCAAGGGGA TTACAGCCCC 
GTCACTGGGA AATTTAACTG TAGTGTTCCT GGGACATACA TATTTTCCTA TCATGTCACT 
GTCAGGGGTC GACCTGCTCG GATCAGCCTC GTGGCCCGCA ACAGGAAGCA GTTCAAATCC 
AGAGAGACGC TCTATGGTCA GCAAGTAGAT CAGGCCTCCC TCCTCCTCAT TCTGAAATTG 
AGTGCAGGAG ATCAAGTGTG GCTGGAAGTG TCAAAGGACT GGAATGGGCT GTATGTCGGC 
CCCGAGGATG ACAGCATCTT TAGTGGGTTC CTTCTGTACC CAGAGGAAAC TTTTAGTAAG 
TCACCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effect of calcium ions on structure and stability of the C1q-like domain of otolin-1 from human and zebrafish.
The FEBS journal284(24)4278-4297(2017 Dec)
Ho?ubowicz R,Wojtas M,Taube M,Kozak M,O?yhar A,Dobryszycki P

Spatiotemporal differences in otoconial gene expression.
Genesis (New York, N.Y. : 2000)54(12)613-625(2016 Dec)
Xu Y,Zhang Y,Lundberg YW

In vitro calcite crystal morphology is modulated by otoconial proteins otolin-1 and otoconin-90.
PloS one9(4)e95333(2014)
Moreland KT,Hong M,Lu W,Rowley CW,Ornitz DM,De Yoreo JJ,Thalmann R

Immunogold TEM of otoconin 90 and otolin - relevance to mineralization of?otoconia, and pathogenesis of benign positional vertigo.
Hearing research292(1-2)14-25(2012 Oct)
Andrade LR,Lins U,Farina M,Kachar B,Thalmann R

Matrix recruitment and calcium sequestration for spatial specific otoconia development.
PloS one6(5)e20498(2011)
Yang H,Zhao X,Xu Y,Wang L,He Q,Lundberg YW

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Otol1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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