NLRP8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NLRP8
Entrez Gene ID	126205
Full Name	NLR family pyrin domain containing 8
Synonyms	CLR19.2,NALP8,NOD16,PAN4
General protein information	Preferred Names NLR family pyrin domain containing 8 Names NACHT, LRR and PYD domains-containing protein 8 NACHT, leucine rich repeat and PYD containing 8 PYRIN and NACHT-containing protein 4 nucleotide-binding oligomerization domain protein 16 nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.43
Summary	This gene encodes a member of the nucleotide-binding oligomerization domain/ leucine rich repeat/ pyrin domain containing (NLRP) subfamily, which belongs to the Nod-like receptor family of proteins. NLRP genes play roles in the mammalian innate immune system through inflammasome formation and activation of caspases. In addition, NLRP genes have been found to function during mammalian reproduction. Consistent with a function during human preimplantation development, this gene is expressed at high levels in oocytes with decreased levels in embryos. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
Disorder MIM:	609659

mRNA and Protein(s)

mRNA	Protein	Name
NM_001317000.1	NP_001303929.1	NACHT, LRR and PYD domains-containing protein 8 isoform 2
NM_176811.2	NP_789781.2	NACHT, LRR and PYD domains-containing protein 8 isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NLRP8	XP_853947.1
Bos taurus (cattle)	NLRP8	XP_002695513.2
Pan troglodytes (chimpanzee)	NLRP8	XP_512922.2
Homo sapiens (human)	NLRP8	NP_789781.2
	NLRP8	NP_001107587.1

Gene Ontology
Bibliography

Related articles in PubMed

A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease.
Rovelet-Lecrux A, Legallic S, Wallon D, Flaman JM, Martinaud O, Bombois S, Rollin-Sillaire A, Michon A, Le Ber I, Pariente J, Puel M, Paquet C, Croisile B, Thomas-Ant?rion C, Vercelletto M, L?vy R, Fr?bourg T, Hannequin D, Campion D,
European journal of human genetics : EJHG20(6)613-7(2012 Jun)

The genetics of NOD-like receptors in Crohn's disease.
Cummings JR, Cooney RM, Clarke G, Beckly J, Geremia A, Pathan S, Hancock L, Guo C, Cardon LR, Jewell DP
Tissue antigens76(1)48-56(2010 Jul)

Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Enjuanes A, Benavente Y, Bosch F, Mart?n-Guerrero I, Colomer D, P?rez-Alvarez S, Reina O, Ardanaz MT, Jares P, Garc?a-Orad A, Pujana MA, Montserrat E, de Sanjos? S, Campo E
Cancer research68(24)10178-86(2008 Dec)

Expression analysis of the NLRP gene family suggests a role in human preimplantation development.
Zhang P, Dixon M, Zucchelli M, Hambiliki F, Levkov L, Hovatta O, Kere J
PloS one3(7)e2755(2008 Jul)

NODs: intracellular proteins involved in inflammation and apoptosis.
Inohara N, Nu?ez G
Nature reviews. Immunology3(5)371-82(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: The genetics of NOD-like receptors in Crohn's disease.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.

The following NLRP8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NLRP8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu29401	NM_176811.2 Latest version!	Homo sapiens NLR family pyrin domain containing 8 (NLRP8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$529.50-$741.30 $1059.00
OHu52016	NM_001317000.1 Latest version!	Homo sapiens NLR family pyrin domain containing 8 (NLRP8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NLRP8 ( NM_176811.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_789781.2 Homo sapiens NLR family pyrin domain containing 8 (NLRP8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29401
Clone ID Related Accession (Same CDS sequence)	NM_176811.2
Accession Version	NM_176811.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3147bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	NACHT, LRR and PYD domains-containing protein 8 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BK001109.1. This sequence is a reference standard in the RefSeqGene project. On Aug 15, 2003 this sequence version replaced NM_176811.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: BK001109.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2148874 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000291971.7/ ENSP00000291971.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGAGTGACG TGAATCCACC CTCTGACACC CCCATTCCCT TTTCATCCTC CTCCACTCAC 
AGTTCTCATA TTCCGCCCTG GACATTCTCT TGCTACCCCG GCTCCCCATG TGAAAATGGG 
GTCATGCTGT ACATGAGAAA CGTGAGCCAT GAGGAGCTAC AACGGTTCAA GCAGCTCTTA 
CTGACTGAGC TCAGTACTGG CACCATGCCC ATCACCTGGG ACCAGGTCGA GACAGCCAGC 
TGGGCAGAGG TGGTTCATCT CTTGATAGAG CGTTTCCCTG GACGACGCGC TTGGGATGTG 
ACTTCGAACA TCTTTGCCAT TATGAACTGT GATAAAATGT GTGTTGTAGT CCGCAGAGAG 
ATAAATGCCA TTCTGCCTAC CTTGGAACCA GAGGACTTGA ATGTGGGAGA AACACAGGTG 
AATCTGGAGG AAGGAGAATC TGGTAAAATA CGGCGGTATA AATCGAATGT GATGGAAAAG 
TTTTTCCCCA TATGGGACAT TACGACTTGG CCTGGAAACC AGAGGGACTT CTTCTACCAA 
GGTGTACACA GGCACGAGGA GTACTTACCA TGTCTGCTTC TGCCCAAAAG ACCCCAGGGT 
AGACAGCCCA AGACCGTGGC CATACAGGGA GCTCCTGGGA TCGGAAAAAC AATCCTGGCC 
AAAAAGGTGA TGTTTGAGTG GGCCAGAAAC AAGTTCTACG CCCACAAGCG CTGGTGTGCT 
TTCTACTTCC ATTGCCAAGA GGTGAACCAG ACGACAGACC AGAGCTTCTC CGAGCTGATT 
GAGCAAAAGT GGCCTGGATC TCAGGACCTC GTGTCAAAGA TTATGTCCAA ACCCGACCAA 
CTTCTGCTGC TCTTGGATGG CTTTGAGGAG CTCACATCTA CCCTCATTGA CAGACTGGAG 
GACCTGAGTG AAGACTGGAG GCAGAAATTG CCTGGGTCTG TCCTACTGAG CAGTTTGCTG 
AGCAAAACGA TGCTTCCAGA GGCCACGCTA CTGATCATGA TAAGATTTAC CTCTTGGCAG 
ACATGCAAGC CCTTGCTGAA ATGTCCCTCT CTCGTAACCC TTCCGGGGTT TAATACGATG 
GAAAAAATCA AGTATTTCCA GATGTATTTT GGACACACAG AGGAGGGAGA CCAAGTCTTG 
AGTTTCGCCA TGGAAAACAC CATTCTCTTC TCCATGTGCC GGGTCCCTGT GGTTTGCTGG 
ATGGTCTGCT CTGGTCTGAA ACAGCAAATG GAGAGAGGAA ACAATCTCAC ACAGTCATGT 
CCAAATGCCA CCTCTGTGTT CGTCCGGTAT ATTTCTAGCT TGTTTCCCAC CAGAGCTGAG 
AACTTTTCCA GAAAGATCCA CCAAGCACAA CTGGAAGGTC TGTGTCACTT GGCCGCAGAC 
AGCATGTGGC ACAGGAAATG GGTGTTAGGT AAAGAAGATC TTGAGGAAGC CAAGCTGGAT 
CAGACGGGAG TCACCGCCTT CCTTGGCATG AGTATTCTTC GGAGAATTGC AGGTGAGGAA 
GACCACTATG TCTTTACCCT CGTGACTTTT CAGGAATTTT TTGCGGCCTT GTTTTATGTT 
CTCTGTTTCC CACAAAGACT CAAAAATTTT CATGTGTTGA GCCACGTGAA TATCCAGCGC 
CTGATAGCGA GTCCCAGAGG AAGCAAAAGC TATCTCTCTC ACATGGGACT TTTCTTATTC 
GGTTTTCTGA ACGAGGCCTG CGCTTCGGCC GTGGAACAGT CATTCCAATG CAAGGTGTCT 
TTCGGTAATA AGAGGAAACT GCTGAAAGTC ATACCTCTGT TGCATAAATG TGACCCACCT 
TCTCCGGGCA GTGGGGTCCC GCAGTTATTC TACTGTCTGC ATGAAATCCG GGAGGAAGCC 
TTTGTAAGCC AAGCCCTAAA TGATTATCAT AAAGTTGTCT TGAGAATTGG CAACAACAAA 
GAAGTTCAAG TGTCTGCTTT TTGCCTGAAG CGGTGTCAAT ATTTGCATGA GGTGGAACTG 
ACCGTCACCC TGAACTTCAT GAACGTGTGG AAGCTCAGCT CCAGCTCCCA TCCTGGCTCT 
GAAGCGCCAG AGAGCAATGG GCTGCATCGT TGGTGGCAAG ACTTATGCTC TGTGTTTGCA 
ACGAATGATA AGCTGGAAGT CCTGACTATG ACCAACAGTG TTTTGGGGCC TCCTTTTTTG 
AAGGCTCTCG CGGCCGCACT GAGGCACCCT CAGTGCAAAC TGCAAAAGCT ACTCCTAAGG 
CGTGTGAATA GCACCATGTT GAACCAGGAC TTAATCGGTG TTTTGACGGG GAACCAGCAT 
CTGAGATACT TGGAAATACA ACATGTGGAA GTGGAGTCCA AAGCTGTGAA GCTTCTATGC 
AGGGTGCTGA GATCCCCCCG GTGCCGTCTG CAGTGTCTCA GGTTGGAAGA CTGCTTGGCC 
ACCCCTAGAA TTTGGACTGA TCTTGGCAAT AATCTTCAAG GTAACGGGCA TCTAAAGACT 
CTCATACTAA GAAAAAACTC CCTGGAGAAC TGTGGGGCGT ATTACCTGTC TGTGGCCCAG 
CTGGAGAGGC TGTCGATAGA GAACTGCAAC CTTACACAGC TTACTTGTGA AAGCCTTGCC 
TCCTGTCTCA GGCAGAGTAA GATGCTGACC CACCTGAGCT TGGCAGAAAA CGCCTTGAAA 
GATGAAGGGG CCAAGCATAT TTGGAATGCC CTGCCACACC TGAGATGTCC TCTGCAGAGG 
CTGGTACTGA GAAAGTGTGA CTTGACCTTT AATTGCTGTC AGGATATGAT CTCTGCGCTC 
TGTAAAAATA AAACCCTGAA AAGTCTTGAC CTAAGTTTTA ATAGCCTGAA GGATGATGGG 
GTGATCCTGC TGTGTGAGGC CCTGAAGAAC CCTGACTGTA CATTACAGAT CCTGGAGCTG 
GAAAACTGCC TGTTCACCTC CATCTGCTGC CAGGCCATGG CTTCCATGCT CCGCAAAAAC 
CAACATCTGA GACATCTGGA CTTGAGCAAG AATGCGATTG GAGTCTATGG TATTCTGACC 
TTGTGCGAGG CCTTCTCAAG CCAAAAGAAG AGAGAAGAGG TCATTTTCTG TATTCCTGCC 
TGGACTCGAA TAACTAGCTT CTCCCCAACT CCTCACCCAC CCGACTTCAC GGGAAAAAGT 
GACTGCCTAT CCCAGATTAA TCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_789781.2
CDS	72..3218
Translation	MSDVNPPSDTPIPFSSSSTHSSHIPPWTFSCYPGSPCENGVMLYMRNVSHEELQRFKQLLLTELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTSNIFAIMNCDKMCVVVRREINAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVMEKFFPIWDITTWPGNQRDFFYQGVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHMGLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQKKREEVIFCIPAWTRITSFSPTPHPPDFTGKSDCLSQINP

Target ORF information:

RefSeq Version	NM_176811.2
Organism	Homo sapiens(human)
Definition	Homo sapiens NLR family pyrin domain containing 8 (NLRP8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_176811.2

ORF Insert Sequence:

ATGAGTGACG TGAATCCACC CTCTGACACC CCCATTCCCT TTTCATCCTC CTCCACTCAC 
AGTTCTCATA TTCCGCCCTG GACATTCTCT TGCTACCCCG GCTCCCCATG TGAAAATGGG 
GTCATGCTGT ACATGAGAAA CGTGAGCCAT GAGGAGCTAC AACGGTTCAA GCAGCTCTTA 
CTGACTGAGC TCAGTACTGG CACCATGCCC ATCACCTGGG ACCAGGTCGA GACAGCCAGC 
TGGGCAGAGG TGGTTCATCT CTTGATAGAG CGTTTCCCTG GACGACGCGC TTGGGATGTG 
ACTTCGAACA TCTTTGCCAT TATGAACTGT GATAAAATGT GTGTTGTAGT CCGCAGAGAG 
ATAAATGCCA TTCTGCCTAC CTTGGAACCA GAGGACTTGA ATGTGGGAGA AACACAGGTG 
AATCTGGAGG AAGGAGAATC TGGTAAAATA CGGCGGTATA AATCGAATGT GATGGAAAAG 
TTTTTCCCCA TATGGGACAT TACGACTTGG CCTGGAAACC AGAGGGACTT CTTCTACCAA 
GGTGTACACA GGCACGAGGA GTACTTACCA TGTCTGCTTC TGCCCAAAAG ACCCCAGGGT 
AGACAGCCCA AGACCGTGGC CATACAGGGA GCTCCTGGGA TCGGAAAAAC AATCCTGGCC 
AAAAAGGTGA TGTTTGAGTG GGCCAGAAAC AAGTTCTACG CCCACAAGCG CTGGTGTGCT 
TTCTACTTCC ATTGCCAAGA GGTGAACCAG ACGACAGACC AGAGCTTCTC CGAGCTGATT 
GAGCAAAAGT GGCCTGGATC TCAGGACCTC GTGTCAAAGA TTATGTCCAA ACCCGACCAA 
CTTCTGCTGC TCTTGGATGG CTTTGAGGAG CTCACATCTA CCCTCATTGA CAGACTGGAG 
GACCTGAGTG AAGACTGGAG GCAGAAATTG CCTGGGTCTG TCCTACTGAG CAGTTTGCTG 
AGCAAAACGA TGCTTCCAGA GGCCACGCTA CTGATCATGA TAAGATTTAC CTCTTGGCAG 
ACATGCAAGC CCTTGCTGAA ATGTCCCTCT CTCGTAACCC TTCCGGGGTT TAATACGATG 
GAAAAAATCA AGTATTTCCA GATGTATTTT GGACACACAG AGGAGGGAGA CCAAGTCTTG 
AGTTTCGCCA TGGAAAACAC CATTCTCTTC TCCATGTGCC GGGTCCCTGT GGTTTGCTGG 
ATGGTCTGCT CTGGTCTGAA ACAGCAAATG GAGAGAGGAA ACAATCTCAC ACAGTCATGT 
CCAAATGCCA CCTCTGTGTT CGTCCGGTAT ATTTCTAGCT TGTTTCCCAC CAGAGCTGAG 
AACTTTTCCA GAAAGATCCA CCAAGCACAA CTGGAAGGTC TGTGTCACTT GGCCGCAGAC 
AGCATGTGGC ACAGGAAATG GGTGTTAGGT AAAGAAGATC TTGAGGAAGC CAAGCTGGAT 
CAGACGGGAG TCACCGCCTT CCTTGGCATG AGTATTCTTC GGAGAATTGC AGGTGAGGAA 
GACCACTATG TCTTTACCCT CGTGACTTTT CAGGAATTTT TTGCGGCCTT GTTTTATGTT 
CTCTGTTTCC CACAAAGACT CAAAAATTTT CATGTGTTGA GCCACGTGAA TATCCAGCGC 
CTGATAGCGA GTCCCAGAGG AAGCAAAAGC TATCTCTCTC ACATGGGACT TTTCTTATTC 
GGTTTTCTGA ACGAGGCCTG CGCTTCGGCC GTGGAACAGT CATTCCAATG CAAGGTGTCT 
TTCGGTAATA AGAGGAAACT GCTGAAAGTC ATACCTCTGT TGCATAAATG TGACCCACCT 
TCTCCGGGCA GTGGGGTCCC GCAGTTATTC TACTGTCTGC ATGAAATCCG GGAGGAAGCC 
TTTGTAAGCC AAGCCCTAAA TGATTATCAT AAAGTTGTCT TGAGAATTGG CAACAACAAA 
GAAGTTCAAG TGTCTGCTTT TTGCCTGAAG CGGTGTCAAT ATTTGCATGA GGTGGAACTG 
ACCGTCACCC TGAACTTCAT GAACGTGTGG AAGCTCAGCT CCAGCTCCCA TCCTGGCTCT 
GAAGCGCCAG AGAGCAATGG GCTGCATCGT TGGTGGCAAG ACTTATGCTC TGTGTTTGCA 
ACGAATGATA AGCTGGAAGT CCTGACTATG ACCAACAGTG TTTTGGGGCC TCCTTTTTTG 
AAGGCTCTCG CGGCCGCACT GAGGCACCCT CAGTGCAAAC TGCAAAAGCT ACTCCTAAGG 
CGTGTGAATA GCACCATGTT GAACCAGGAC TTAATCGGTG TTTTGACGGG GAACCAGCAT 
CTGAGATACT TGGAAATACA ACATGTGGAA GTGGAGTCCA AAGCTGTGAA GCTTCTATGC 
AGGGTGCTGA GATCCCCCCG GTGCCGTCTG CAGTGTCTCA GGTTGGAAGA CTGCTTGGCC 
ACCCCTAGAA TTTGGACTGA TCTTGGCAAT AATCTTCAAG GTAACGGGCA TCTAAAGACT 
CTCATACTAA GAAAAAACTC CCTGGAGAAC TGTGGGGCGT ATTACCTGTC TGTGGCCCAG 
CTGGAGAGGC TGTCGATAGA GAACTGCAAC CTTACACAGC TTACTTGTGA AAGCCTTGCC 
TCCTGTCTCA GGCAGAGTAA GATGCTGACC CACCTGAGCT TGGCAGAAAA CGCCTTGAAA 
GATGAAGGGG CCAAGCATAT TTGGAATGCC CTGCCACACC TGAGATGTCC TCTGCAGAGG 
CTGGTACTGA GAAAGTGTGA CTTGACCTTT AATTGCTGTC AGGATATGAT CTCTGCGCTC 
TGTAAAAATA AAACCCTGAA AAGTCTTGAC CTAAGTTTTA ATAGCCTGAA GGATGATGGG 
GTGATCCTGC TGTGTGAGGC CCTGAAGAAC CCTGACTGTA CATTACAGAT CCTGGAGCTG 
GAAAACTGCC TGTTCACCTC CATCTGCTGC CAGGCCATGG CTTCCATGCT CCGCAAAAAC 
CAACATCTGA GACATCTGGA CTTGAGCAAG AATGCGATTG GAGTCTATGG TATTCTGACC 
TTGTGCGAGG CCTTCTCAAG CCAAAAGAAG AGAGAAGAGG TCATTTTCTG TATTCCTGCC 
TGGACTCGAA TAACTAGCTT CTCCCCAACT CCTCACCCAC CCGACTTCAC GGGAAAAAGT 
GACTGCCTAT CCCAGATTAA TCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NLRP8 ( NM_001317000.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001303929.1 Homo sapiens NLR family pyrin domain containing 8 (NLRP8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu52016
Clone ID Related Accession (Same CDS sequence)	NM_001317000.1
Accession Version	NM_001317000.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3090bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	NACHT, LRR and PYD domains-containing protein 8 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BK001109.1 and AY154463.1. On Nov 6, 2015 this sequence version replaced XM_005258511.1. Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AY154463.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2148874 [ECO:0000350] ##Evidence-Data-END##

ATGAGTGACG TGAATCCACC CTCTGACACC CCCATTCCCT TTTCATCCTC CTCCACTCAC 
AGTTCTCATA TTCCGCCCTG GACATTCTCT TGCTACCCCG GCTCCCCATG TGAAAATGGG 
GTCATGCTGT ACATGAGAAA CGTGAGCCAT GAGGAGCTAC AACGGTTCAA GCAGCTCTTA 
CTGACTGAGC TCAGTACTGG CACCATGCCC ATCACCTGGG ACCAGGTCGA GACAGCCAGC 
TGGGCAGAGG TGGTTCATCT CTTGATAGAG CGTTTCCCTG GACGACGCGC TTGGGATGTG 
ACTTCGAACA TCTTTGCCAT TATGAACTGT GATAAAATGT GTGTTGTAGT CCGCAGAGAG 
ATAAATGCCA TTCTGCCTAC CTTGGAACCA GAGGACTTGA ATGTGGGAGA AACACAGGTG 
AATCTGGAGG AAGGAGAATC TGGTAAAATA CGGCGGTATA AATCGAATGT GATGGAAAAG 
TTTTTCCCCA TATGGGACAT TACGACTTGG CCTGGAAACC AGAGGGACTT CTTCTACCAA 
GGTGTACACA GGCACGAGGA GTACTTACCA TGTCTGCTTC TGCCCAAAAG ACCCCAGGGT 
AGACAGCCCA AGACCGTGGC CATACAGGGA GCTCCTGGGA TCGGAAAAAC AATCCTGGCC 
AAAAAGGTGA TGTTTGAGTG GGCCAGAAAC AAGTTCTACG CCCACAAGCG CTGGTGTGCT 
TTCTACTTCC ATTGCCAAGA GGTGAACCAG ACGACAGACC AGAGCTTCTC CGAGCTGATT 
GAGCAAAAGT GGCCTGGATC TCAGGACCTC GTGTCAAAGA TTATGTCCAA ACCCGACCAA 
CTTCTGCTGC TCTTGGATGG CTTTGAGGAG CTCACATCTA CCCTCATTGA CAGACTGGAG 
GACCTGAGTG AAGACTGGAG GCAGAAATTG CCTGGGTCTG TCCTACTGAG CAGTTTGCTG 
AGCAAAACGA TGCTTCCAGA GGCCACGCTA CTGATCATGA TAAGATTTAC CTCTTGGCAG 
ACATGCAAGC CCTTGCTGAA ATGTCCCTCT CTCGTAACCC TTCCGGGGTT TAATACGATG 
GAAAAAATCA AGTATTTCCA GATGTATTTT GGACACACAG AGGAGGGAGA CCAAGTCTTG 
AGTTTCGCCA TGGAAAACAC CATTCTCTTC TCCATGTGCC GGGTCCCTGT GGTTTGCTGG 
ATGGTCTGCT CTGGTCTGAA ACAGCAAATG GAGAGAGGAA ACAATCTCAC ACAGTCATGT 
CCAAATGCCA CCTCTGTGTT CGTCCGGTAT ATTTCTAGCT TGTTTCCCAC CAGAGCTGAG 
AACTTTTCCA GAAAGATCCA CCAAGCACAA CTGGAAGGTC TGTGTCACTT GGCCGCAGAC 
AGCATGTGGC ACAGGAAATG GGTGTTAGGT AAAGAAGATC TTGAGGAAGC CAAGCTGGAT 
CAGACGGGAG TCACCGCCTT CCTTGGCATG AGTATTCTTC GGAGAATTGC AGGTGAGGAA 
GACCACTATG TCTTTACCCT CGTGACTTTT CAGGAATTTT TTGCGGCCTT GTTTTATGTT 
CTCTGTTTCC CACAAAGACT CAAAAATTTT CATGTGTTGA GCCACGTGAA TATCCAGCGC 
CTGATAGCGA GTCCCAGAGG AAGCAAAAGC TATCTCTCTC ACATGGGACT TTTCTTATTC 
GGTTTTCTGA ACGAGGCCTG CGCTTCGGCC GTGGAACAGT CATTCCAATG CAAGGTGTCT 
TTCGGTAATA AGAGGAAACT GCTGAAAGTC ATACCTCTGT TGCATAAATG TGACCCACCT 
TCTCCGGGCA GTGGGGTCCC GCAGTTATTC TACTGTCTGC ATGAAATCCG GGAGGAAGCC 
TTTGTAAGCC AAGCCCTAAA TGATTATCAT AAAGTTGTCT TGAGAATTGG CAACAACAAA 
GAAGTTCAAG TGTCTGCTTT TTGCCTGAAG CGGTGTCAAT ATTTGCATGA GGTGGAACTG 
ACCGTCACCC TGAACTTCAT GAACGTGTGG AAGCTCAGCT CCAGCTCCCA TCCTGGCTCT 
GAAGCGCCAG AGAGCAATGG GCTGCATCGT TGGTGGCAAG ACTTATGCTC TGTGTTTGCA 
ACGAATGATA AGCTGGAAGT CCTGACTATG ACCAACAGTG TTTTGGGGCC TCCTTTTTTG 
AAGGCTCTCG CGGCCGCACT GAGGCACCCT CAGTGCAAAC TGCAAAAGCT ACTCCTAAGG 
CGTGTGAATA GCACCATGTT GAACCAGGAC TTAATCGGTG TTTTGACGGG GAACCAGCAT 
CTGAGATACT TGGAAATACA ACATGTGGAA GTGGAGTCCA AAGCTGTGAA GCTTCTATGC 
AGGGTGCTGA GATCCCCCCG GTGCCGTCTG CAGTGTCTCA GGTTGGAAGA CTGCTTGGCC 
ACCCCTAGAA TTTGGACTGA TCTTGGCAAT AATCTTCAAG GTAACGGGCA TCTAAAGACT 
CTCATACTAA GAAAAAACTC CCTGGAGAAC TGTGGGGCGT ATTACCTGTC TGTGGCCCAG 
CTGGAGAGGC TGTCGCAGAG TAAGATGCTG ACCCACCTGA GCTTGGCAGA AAACGCCTTG 
AAAGATGAAG GGGCCAAGCA TATTTGGAAT GCCCTGCCAC ACCTGAGATG TCCTCTGCAG 
AGGCTGGTAC TGAGAAAGTG TGACTTGACC TTTAATTGCT GTCAGGATAT GATCTCTGCG 
CTCTGTAAAA ATAAAACCCT GAAAAGTCTT GACCTAAGTT TTAATAGCCT GAAGGATGAT 
GGGGTGATCC TGCTGTGTGA GGCCCTGAAG AACCCTGACT GTACATTACA GATCCTGGAG 
CTGGAAAACT GCCTGTTCAC CTCCATCTGC TGCCAGGCCA TGGCTTCCAT GCTCCGCAAA 
AACCAACATC TGAGACATCT GGACTTGAGC AAGAATGCGA TTGGAGTCTA TGGTATTCTG 
ACCTTGTGCG AGGCCTTCTC AAGCCAAAAG AAGAGAGAAG AGGTCATTTT CTGTATTCCT 
GCCTGGACTC GAATAACTAG CTTCTCCCCA ACTCCTCACC CACCCGACTT CACGGGAAAA 
AGTGACTGCC TATCCCAGAT TAATCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001303929.1
CDS	72..3161
Translation	MSDVNPPSDTPIPFSSSSTHSSHIPPWTFSCYPGSPCENGVMLYMRNVSHEELQRFKQLLLTELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTSNIFAIMNCDKMCVVVRREINAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVMEKFFPIWDITTWPGNQRDFFYQGVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHMGLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYLSVAQLERLSQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQKKREEVIFCIPAWTRITSFSPTPHPPDFTGKSDCLSQINP

Target ORF information:

RefSeq Version	NM_001317000.1
Organism	Homo sapiens(human)
Definition	Homo sapiens NLR family pyrin domain containing 8 (NLRP8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317000.1

ORF Insert Sequence:

ATGAGTGACG TGAATCCACC CTCTGACACC CCCATTCCCT TTTCATCCTC CTCCACTCAC 
AGTTCTCATA TTCCGCCCTG GACATTCTCT TGCTACCCCG GCTCCCCATG TGAAAATGGG 
GTCATGCTGT ACATGAGAAA CGTGAGCCAT GAGGAGCTAC AACGGTTCAA GCAGCTCTTA 
CTGACTGAGC TCAGTACTGG CACCATGCCC ATCACCTGGG ACCAGGTCGA GACAGCCAGC 
TGGGCAGAGG TGGTTCATCT CTTGATAGAG CGTTTCCCTG GACGACGCGC TTGGGATGTG 
ACTTCGAACA TCTTTGCCAT TATGAACTGT GATAAAATGT GTGTTGTAGT CCGCAGAGAG 
ATAAATGCCA TTCTGCCTAC CTTGGAACCA GAGGACTTGA ATGTGGGAGA AACACAGGTG 
AATCTGGAGG AAGGAGAATC TGGTAAAATA CGGCGGTATA AATCGAATGT GATGGAAAAG 
TTTTTCCCCA TATGGGACAT TACGACTTGG CCTGGAAACC AGAGGGACTT CTTCTACCAA 
GGTGTACACA GGCACGAGGA GTACTTACCA TGTCTGCTTC TGCCCAAAAG ACCCCAGGGT 
AGACAGCCCA AGACCGTGGC CATACAGGGA GCTCCTGGGA TCGGAAAAAC AATCCTGGCC 
AAAAAGGTGA TGTTTGAGTG GGCCAGAAAC AAGTTCTACG CCCACAAGCG CTGGTGTGCT 
TTCTACTTCC ATTGCCAAGA GGTGAACCAG ACGACAGACC AGAGCTTCTC CGAGCTGATT 
GAGCAAAAGT GGCCTGGATC TCAGGACCTC GTGTCAAAGA TTATGTCCAA ACCCGACCAA 
CTTCTGCTGC TCTTGGATGG CTTTGAGGAG CTCACATCTA CCCTCATTGA CAGACTGGAG 
GACCTGAGTG AAGACTGGAG GCAGAAATTG CCTGGGTCTG TCCTACTGAG CAGTTTGCTG 
AGCAAAACGA TGCTTCCAGA GGCCACGCTA CTGATCATGA TAAGATTTAC CTCTTGGCAG 
ACATGCAAGC CCTTGCTGAA ATGTCCCTCT CTCGTAACCC TTCCGGGGTT TAATACGATG 
GAAAAAATCA AGTATTTCCA GATGTATTTT GGACACACAG AGGAGGGAGA CCAAGTCTTG 
AGTTTCGCCA TGGAAAACAC CATTCTCTTC TCCATGTGCC GGGTCCCTGT GGTTTGCTGG 
ATGGTCTGCT CTGGTCTGAA ACAGCAAATG GAGAGAGGAA ACAATCTCAC ACAGTCATGT 
CCAAATGCCA CCTCTGTGTT CGTCCGGTAT ATTTCTAGCT TGTTTCCCAC CAGAGCTGAG 
AACTTTTCCA GAAAGATCCA CCAAGCACAA CTGGAAGGTC TGTGTCACTT GGCCGCAGAC 
AGCATGTGGC ACAGGAAATG GGTGTTAGGT AAAGAAGATC TTGAGGAAGC CAAGCTGGAT 
CAGACGGGAG TCACCGCCTT CCTTGGCATG AGTATTCTTC GGAGAATTGC AGGTGAGGAA 
GACCACTATG TCTTTACCCT CGTGACTTTT CAGGAATTTT TTGCGGCCTT GTTTTATGTT 
CTCTGTTTCC CACAAAGACT CAAAAATTTT CATGTGTTGA GCCACGTGAA TATCCAGCGC 
CTGATAGCGA GTCCCAGAGG AAGCAAAAGC TATCTCTCTC ACATGGGACT TTTCTTATTC 
GGTTTTCTGA ACGAGGCCTG CGCTTCGGCC GTGGAACAGT CATTCCAATG CAAGGTGTCT 
TTCGGTAATA AGAGGAAACT GCTGAAAGTC ATACCTCTGT TGCATAAATG TGACCCACCT 
TCTCCGGGCA GTGGGGTCCC GCAGTTATTC TACTGTCTGC ATGAAATCCG GGAGGAAGCC 
TTTGTAAGCC AAGCCCTAAA TGATTATCAT AAAGTTGTCT TGAGAATTGG CAACAACAAA 
GAAGTTCAAG TGTCTGCTTT TTGCCTGAAG CGGTGTCAAT ATTTGCATGA GGTGGAACTG 
ACCGTCACCC TGAACTTCAT GAACGTGTGG AAGCTCAGCT CCAGCTCCCA TCCTGGCTCT 
GAAGCGCCAG AGAGCAATGG GCTGCATCGT TGGTGGCAAG ACTTATGCTC TGTGTTTGCA 
ACGAATGATA AGCTGGAAGT CCTGACTATG ACCAACAGTG TTTTGGGGCC TCCTTTTTTG 
AAGGCTCTCG CGGCCGCACT GAGGCACCCT CAGTGCAAAC TGCAAAAGCT ACTCCTAAGG 
CGTGTGAATA GCACCATGTT GAACCAGGAC TTAATCGGTG TTTTGACGGG GAACCAGCAT 
CTGAGATACT TGGAAATACA ACATGTGGAA GTGGAGTCCA AAGCTGTGAA GCTTCTATGC 
AGGGTGCTGA GATCCCCCCG GTGCCGTCTG CAGTGTCTCA GGTTGGAAGA CTGCTTGGCC 
ACCCCTAGAA TTTGGACTGA TCTTGGCAAT AATCTTCAAG GTAACGGGCA TCTAAAGACT 
CTCATACTAA GAAAAAACTC CCTGGAGAAC TGTGGGGCGT ATTACCTGTC TGTGGCCCAG 
CTGGAGAGGC TGTCGCAGAG TAAGATGCTG ACCCACCTGA GCTTGGCAGA AAACGCCTTG 
AAAGATGAAG GGGCCAAGCA TATTTGGAAT GCCCTGCCAC ACCTGAGATG TCCTCTGCAG 
AGGCTGGTAC TGAGAAAGTG TGACTTGACC TTTAATTGCT GTCAGGATAT GATCTCTGCG 
CTCTGTAAAA ATAAAACCCT GAAAAGTCTT GACCTAAGTT TTAATAGCCT GAAGGATGAT 
GGGGTGATCC TGCTGTGTGA GGCCCTGAAG AACCCTGACT GTACATTACA GATCCTGGAG 
CTGGAAAACT GCCTGTTCAC CTCCATCTGC TGCCAGGCCA TGGCTTCCAT GCTCCGCAAA 
AACCAACATC TGAGACATCT GGACTTGAGC AAGAATGCGA TTGGAGTCTA TGGTATTCTG 
ACCTTGTGCG AGGCCTTCTC AAGCCAAAAG AAGAGAGAAG AGGTCATTTT CTGTATTCCT 
GCCTGGACTC GAATAACTAG CTTCTCCCCA ACTCCTCACC CACCCGACTT CACGGGAAAA 
AGTGACTGCC TATCCCAGAT TAATCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease.
European journal of human genetics : EJHG20(6)613-7(2012 Jun)
Rovelet-Lecrux A,Legallic S,Wallon D,Flaman JM,Martinaud O,Bombois S,Rollin-Sillaire A,Michon A,Le Ber I,Pariente J,Puel M,Paquet C,Croisile B,Thomas-Ant?rion C,Vercelletto M,L?vy R,Fr?bourg T,Hannequin D,Campion D,

The genetics of NOD-like receptors in Crohn's disease.
Tissue antigens76(1)48-56(2010 Jul)
Cummings JR,Cooney RM,Clarke G,Beckly J,Geremia A,Pathan S,Hancock L,Guo C,Cardon LR,Jewell DP

Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Cancer research68(24)10178-86(2008 Dec)
Enjuanes A,Benavente Y,Bosch F,Mart?n-Guerrero I,Colomer D,P?rez-Alvarez S,Reina O,Ardanaz MT,Jares P,Garc?a-Orad A,Pujana MA,Montserrat E,de Sanjos? S,Campo E

Expression analysis of the NLRP gene family suggests a role in human preimplantation development.
PloS one3(7)e2755(2008 Jul)
Zhang P,Dixon M,Zucchelli M,Hambiliki F,Levkov L,Hovatta O,Kere J

NODs: intracellular proteins involved in inflammation and apoptosis.
Nature reviews. Immunology3(5)371-82(2003 May)
Inohara N,Nu?ez G

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NLRP8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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