NXNL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NXNL1
Entrez Gene ID	115861
Full Name	nucleoredoxin like 1
Synonyms	RDCVF,TXNL6
General protein information	Preferred Names nucleoredoxin like 1 Names nucleoredoxin-like protein 1 rod-derived cone viability factor thioredoxin-like 6 thioredoxin-like protein 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.11
Summary	Retinitis pigmentosa (RP) is a disease that leads to blindness by degeneration of cone photoreceptors. Rods produce factors required for cone viability. The protein encoded by this gene is one of those factors and is similar to a truncated form of thioredoxin. This gene has been proposed to have therapeutic value against RP. [provided by RefSeq, Dec 2015].
Disorder MIM:	608791

mRNA and Protein(s)

mRNA	Protein	Name
NM_138454.2	NP_612463.1	nucleoredoxin-like protein 1
NM_138454.1	NP_612463.1	nucleoredoxin-like protein 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Nxnl1	NP_663573.1
Xenopus tropicalis (tropical clawed frog)	nxnl1	XP_002935469.1
Homo sapiens (human)	NXNL1	NP_612463.1
	LOC719125	XP_001113624.1
Bos taurus (cattle)	NXNL1	XP_002688620.1
Rattus norvegicus (Norway rat)	Nxnl1	NP_001258270.1
Canis lupus familiaris (dog)	NXNL1	XP_541952.2
Danio rerio (zebrafish)	nxnl1	NP_001104230.1
Pan troglodytes (chimpanzee)	NXNL1	XP_512493.3
Gallus gallus (chicken)	NXNL1	XP_423688.1
Danio rerio (zebrafish)	LOC100330884	XP_002664792.1

Gene Ontology
Bibliography

Related articles in PubMed

Cell Signaling with Extracellular Thioredoxin and Thioredoxin-Like Proteins: Insight into Their Mechanisms of Action.
L?veillard T, A?t-Ali N
Oxidative medicine and cellular longevity20178475125(2017)

Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis.
A?t-Ali N, Fridlich R, Millet-Puel G, Cl?rin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier-Bandini A, Bellalou J, Moyse E, Bouillaud F, Nicol X, Dalkara D, van Dorsselaer A, Sahel JA, L?veillard T
Cell161(4)817-32(2015 May)

TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of ?-crystallin and cytochrome C in the eye lens.
Brennan LA, Lee W, Kantorow M
PloS one5(11)e15421(2010 Nov)

Expression of rod-derived cone viability factor: dual role of CRX in regulating promoter activity and cell-type specificity.
Lambard S, Reichman S, Berlinicke C, Niepon ML, Goureau O, Sahel JA, L?veillard T, Zack DJ
PloS one5(10)e13075(2010 Oct)

The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina.
Reichman S, Kalathur RK, Lambard S, A?t-Ali N, Yang Y, Lardenois A, Ripp R, Poch O, Zack DJ, Sahel JA, L?veillard T
Human molecular genetics19(2)250-61(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study shows that RdCVF acts through binding to Basigin-1 (BSG1), a transmembrane protein expressed specifically by photoreceptors. BSG1 binds to the glucose transporter GLUT1, resulting in increased glucose entry into cones.
Title: Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis.

Data suggest a critical role for TXNL6 in MsrA repair of essential lens proteins under oxidative stress conditions and that TXNL6 is important for MsrA defense protection against cataract.
Title: TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of ?-crystallin and cytochrome C in the eye lens.

regulation of the Nucleoredoxin-like genes involves a CRX responsive element that can act as both as a positive regulator of promoter activity and as a modulator of cell-type specificity
Title: Expression of rod-derived cone viability factor: dual role of CRX in regulating promoter activity and cell-type specificity.

CHX10 regulates RdCVF promoter activity in the inner retina.
Title: The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina.

Observational study of gene-disease association. (HuGE Navigator)
Title: BBS7 and TTC8 (BBS8) mutations play a minor role in the mutational load of Bardet-Biedl syndrome in a multiethnic population.

The following NXNL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NXNL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06123	NM_138454.2 Latest version!	Homo sapiens nucleoredoxin like 1 (NXNL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu06123	NM_138454.1	Homo sapiens nucleoredoxin like 1 (NXNL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NXNL1 ( NM_138454.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_612463.1 Homo sapiens nucleoredoxin like 1 (NXNL1), mRNA.

Price & Availability↑

CloneID	OHu06123
Clone ID Related Accession (Same CDS sequence)	NM_138454.2 , NM_138454.1
Accession Version	NM_138454.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 639bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	nucleoredoxin-like protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010319.10 and BC014127.1. On Jun 2, 2019 this sequence version replaced NM_138454.1. ##Evidence-Data-START## Transcript exon combination :: BC014127.1, BQ639327.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2145313 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCTCCC TGTTCTCTGG CCGCATCCTG ATCCGCAACA ATAGCGACCA GGACGAGCTG 
GATACGGAGG CTGAGGTCAG TCGCAGGCTG GAGAACCGGC TGGTGCTGCT GTTCTTTGGT 
GCTGGGGCTT GTCCACAGTG CCAGGCCTTC GTGCCCATCC TCAAGGACTT CTTCGTGCGG 
CTCACAGATG AGTTCTATGT ACTGCGGGCG GCTCAGCTGG CCCTGGTGTA CGTGTCCCAG 
GACTCCACGG AGGAGCAGCA GGACCTGTTC CTCAAGGACA TGCCAAAGAA ATGGCTTTTC 
CTGCCCTTTG AGGATGATCT GAGGAGGGAC CTCGGGCGCC AGTTCTCAGT GGAGCGCCTG 
CCGGCGGTCG TGGTGCTCAA GCCGGACGGG GACGTGCTCA CTCGCGACGG CGCCGACGAG 
ATCCAGCGCC TGGGCACCGC CTGCTTCGCC AACTGGCAGG AGGCGGCCGA GGTGCTGGAC 
CGCAACTTCC AGCTGCCAGA GGACCTGGAG GACCAGGAGC CACGGAGCCT CACCGAGTGC 
CTGCGCCGCC ACAAGTACCG CGTGGAAAAG GCGGCGCGAG GCGGGCGCGA CCCCGGGGGA 
GGGGGTGGGG AGGAGGGCGG GGCCGGGGGG CTGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612463.1
CDS	58..696
Translation	MASLFSGRILIRNNSDQDELDTEAEVSRRLENRLVLLFFGAGACPQCQAFVPILKDFFVRLTDEFYVLRAAQLALVYVSQDSTEEQQDLFLKDMPKKWLFLPFEDDLRRDLGRQFSVERLPAVVVLKPDGDVLTRDGADEIQRLGTACFANWQEAAEVLDRNFQLPEDLEDQEPRSLTECLRRHKYRVEKAARGGRDPGGGGGEEGGAGGLF

Target ORF information:

RefSeq Version	NM_138454.2
Organism	Homo sapiens(human)
Definition	Homo sapiens nucleoredoxin like 1 (NXNL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138454.2

ORF Insert Sequence:

ATGGCCTCCC TGTTCTCTGG CCGCATCCTG ATCCGCAACA ATAGCGACCA GGACGAGCTG 
GATACGGAGG CTGAGGTCAG TCGCAGGCTG GAGAACCGGC TGGTGCTGCT GTTCTTTGGT 
GCTGGGGCTT GTCCACAGTG CCAGGCCTTC GTGCCCATCC TCAAGGACTT CTTCGTGCGG 
CTCACAGATG AGTTCTATGT ACTGCGGGCG GCTCAGCTGG CCCTGGTGTA CGTGTCCCAG 
GACTCCACGG AGGAGCAGCA GGACCTGTTC CTCAAGGACA TGCCAAAGAA ATGGCTTTTC 
CTGCCCTTTG AGGATGATCT GAGGAGGGAC CTCGGGCGCC AGTTCTCAGT GGAGCGCCTG 
CCGGCGGTCG TGGTGCTCAA GCCGGACGGG GACGTGCTCA CTCGCGACGG CGCCGACGAG 
ATCCAGCGCC TGGGCACCGC CTGCTTCGCC AACTGGCAGG AGGCGGCCGA GGTGCTGGAC 
CGCAACTTCC AGCTGCCAGA GGACCTGGAG GACCAGGAGC CACGGAGCCT CACCGAGTGC 
CTGCGCCGCC ACAAGTACCG CGTGGAAAAG GCGGCGCGAG GCGGGCGCGA CCCCGGGGGA 
GGGGGTGGGG AGGAGGGCGG GGCCGGGGGG CTGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NXNL1 ( NM_138454.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_612463.1 Homo sapiens nucleoredoxin like 1 (NXNL1), mRNA.

Price & Availability↑

CloneID	OHu06123
Clone ID Related Accession (Same CDS sequence)	NM_138454.2 , NM_138454.1
Accession Version	NM_138454.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 639bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-14
Organism	Homo sapiens(human)
Product	nucleoredoxin-like protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC014127.1. ##Evidence-Data-START## Transcript exon combination :: BC014127.1, BG395178.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2145313 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTCCC TGTTCTCTGG CCGCATCCTG ATCCGCAACA ATAGCGACCA GGACGAGCTG 
GATACGGAGG CTGAGGTCAG TCGCAGGCTG GAGAACCGGC TGGTGCTGCT GTTCTTTGGT 
GCTGGGGCTT GTCCACAGTG CCAGGCCTTC GTGCCCATCC TCAAGGACTT CTTCGTGCGG 
CTCACAGATG AGTTCTATGT ACTGCGGGCG GCTCAGCTGG CCCTGGTGTA CGTGTCCCAG 
GACTCCACGG AGGAGCAGCA GGACCTGTTC CTCAAGGACA TGCCAAAGAA ATGGCTTTTC 
CTGCCCTTTG AGGATGATCT GAGGAGGGAC CTCGGGCGCC AGTTCTCAGT GGAGCGCCTG 
CCGGCGGTCG TGGTGCTCAA GCCGGACGGG GACGTGCTCA CTCGCGACGG CGCCGACGAG 
ATCCAGCGCC TGGGCACCGC CTGCTTCGCC AACTGGCAGG AGGCGGCCGA GGTGCTGGAC 
CGCAACTTCC AGCTGCCAGA GGACCTGGAG GACCAGGAGC CACGGAGCCT CACCGAGTGC 
CTGCGCCGCC ACAAGTACCG CGTGGAAAAG GCGGCGCGAG GCGGGCGCGA CCCCGGGGGA 
GGGGGTGGGG AGGAGGGCGG GGCCGGGGGG CTGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612463.1
CDS	48..686
Translation	MASLFSGRILIRNNSDQDELDTEAEVSRRLENRLVLLFFGAGACPQCQAFVPILKDFFVRLTDEFYVLRAAQLALVYVSQDSTEEQQDLFLKDMPKKWLFLPFEDDLRRDLGRQFSVERLPAVVVLKPDGDVLTRDGADEIQRLGTACFANWQEAAEVLDRNFQLPEDLEDQEPRSLTECLRRHKYRVEKAARGGRDPGGGGGEEGGAGGLF

Target ORF information:

RefSeq Version	NM_138454.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nucleoredoxin like 1 (NXNL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138454.1

ORF Insert Sequence:

ATGGCCTCCC TGTTCTCTGG CCGCATCCTG ATCCGCAACA ATAGCGACCA GGACGAGCTG 
GATACGGAGG CTGAGGTCAG TCGCAGGCTG GAGAACCGGC TGGTGCTGCT GTTCTTTGGT 
GCTGGGGCTT GTCCACAGTG CCAGGCCTTC GTGCCCATCC TCAAGGACTT CTTCGTGCGG 
CTCACAGATG AGTTCTATGT ACTGCGGGCG GCTCAGCTGG CCCTGGTGTA CGTGTCCCAG 
GACTCCACGG AGGAGCAGCA GGACCTGTTC CTCAAGGACA TGCCAAAGAA ATGGCTTTTC 
CTGCCCTTTG AGGATGATCT GAGGAGGGAC CTCGGGCGCC AGTTCTCAGT GGAGCGCCTG 
CCGGCGGTCG TGGTGCTCAA GCCGGACGGG GACGTGCTCA CTCGCGACGG CGCCGACGAG 
ATCCAGCGCC TGGGCACCGC CTGCTTCGCC AACTGGCAGG AGGCGGCCGA GGTGCTGGAC 
CGCAACTTCC AGCTGCCAGA GGACCTGGAG GACCAGGAGC CACGGAGCCT CACCGAGTGC 
CTGCGCCGCC ACAAGTACCG CGTGGAAAAG GCGGCGCGAG GCGGGCGCGA CCCCGGGGGA 
GGGGGTGGGG AGGAGGGCGG GGCCGGGGGG CTGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cell Signaling with Extracellular Thioredoxin and Thioredoxin-Like Proteins: Insight into Their Mechanisms of Action.
Oxidative medicine and cellular longevity20178475125(2017)
L?veillard T,A?t-Ali N

Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis.
Cell161(4)817-32(2015 May)
A?t-Ali N,Fridlich R,Millet-Puel G,Cl?rin E,Delalande F,Jaillard C,Blond F,Perrocheau L,Reichman S,Byrne LC,Olivier-Bandini A,Bellalou J,Moyse E,Bouillaud F,Nicol X,Dalkara D,van Dorsselaer A,Sahel JA,L?veillard T

TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of ?-crystallin and cytochrome C in the eye lens.
PloS one5(11)e15421(2010 Nov)
Brennan LA,Lee W,Kantorow M

Expression of rod-derived cone viability factor: dual role of CRX in regulating promoter activity and cell-type specificity.
PloS one5(10)e13075(2010 Oct)
Lambard S,Reichman S,Berlinicke C,Niepon ML,Goureau O,Sahel JA,L?veillard T,Zack DJ

The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina.
Human molecular genetics19(2)250-61(2010 Jan)
Reichman S,Kalathur RK,Lambard S,A?t-Ali N,Yang Y,Lardenois A,Ripp R,Poch O,Zack DJ,Sahel JA,L?veillard T

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NXNL1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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