CGB2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CGB2
Entrez Gene ID	114336
Full Name	chorionic gonadotropin beta subunit 2
General protein information	Preferred Names chorionic gonadotropin beta subunit 2 Names choriogonadotropin subunit beta variant 2 chorionic gonadotropin, beta polypeptide 2 product of CGB2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.33
Summary	The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 163 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008].
Disorder MIM:	608824

mRNA and Protein(s)

mRNA	Protein	Name
XM_005258479.3	XP_005258536.1	choriogonadotropin subunit beta variant 2 isoform X1
NM_001319065.1	NP_001305994.1	choriogonadotropin subunit beta variant 2 isoform 2
NM_033378.1	NP_203696.2	choriogonadotropin subunit beta variant 2 isoform 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CGB2	NP_203696.2
Homo sapiens (human)	CGB1	NP_203695.2

Gene Ontology
Bibliography

Related articles in PubMed

Novel insights into the expression of CGB1 & 2 genes by epithelial cancer cell lines secreting ectopic free hCG?.
Burczynska BB, Kobrouly L, Butler SA, Naase M, Iles RK
Anticancer research34(5)2239-48(2014 May)

Human chorionic gonadotropin beta subunit genes CGB1 and CGB2 are transcriptionally active in ovarian cancer.
Kubiczak M, Walkowiak GP, Nowak-Markwitz E, Jankowska A
International journal of molecular sciences14(6)12650-60(2013 Jun)

Molecular cloning, characterization and expression of thyroid-stimulating hormone receptor in channel catfish.
Goto-Kazeto R, Kazeto Y, Trant JM
General and comparative endocrinology161(3)313-9(2009 May)

Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues.
Rull K, Hallast P, Uusk?la L, Jackson J, Punab M, Salumets A, Campbell RK, Laan M
Molecular human reproduction14(1)23-31(2008 Jan)

The evolution and genomic landscape of CGB1 and CGB2 genes.
Hallast P, Rull K, Laan M
Molecular and cellular endocrinology260-2622-11(2007 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The presence of CGB1 and CGB2 transcripts in 41% of analyzed ovarian cancer cases, is reported.
Title: Human chorionic gonadotropin beta subunit genes CGB1 and CGB2 are transcriptionally active in ovarian cancer.

In silico prediction of putative transcription factor binding sites supports the hypothesis that CGB1 and CGB2 gene products are expressed in, and may contribute to, implantation and placental development.
Title: The evolution and genomic landscape of CGB1 and CGB2 genes.

The following CGB2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CGB2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25820	NM_033378.1 Latest version!	Homo sapiens chorionic gonadotropin subunit beta 2 (CGB2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu51988	NM_001319065.1 Latest version!	Homo sapiens chorionic gonadotropin subunit beta 2 (CGB2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu51987	XM_005258479.3 Latest version!	Homo sapiens chorionic gonadotropin subunit beta 2 (CGB2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CGB2 ( NM_033378.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_203696.2 Homo sapiens chorionic gonadotropin subunit beta 2 (CGB2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25820
Clone ID Related Accession (Same CDS sequence)	NM_033378.1
Accession Version	NM_033378.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 492bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	choriogonadotropin subunit beta variant 2 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008687.5. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AA393716.1, BC069367.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCAAAGG GGCTGCTGCT GTTGCTGCTG CTGAGCATGG GCGGGACATG GGCATCCAAG 
GAGCCGCTTC GGCCACGGTG CCGCCCCATC AATGCCACCC TGGCTGTGGA GAAGGAGGGC 
TGCCCCGTGT GCATCACCGT CAACACCACC ATCTGTGCCG GCTACTGCCC CACCATGACC 
CGCGTGCTGC AGGGGGTCCT GCCGGCCCTG CCTCAGGTGG TGTGCAACTA CCGCGATGTG 
CGCTTCGAGT CCATCCGGCT CCCTGGCTGC CCGCGCGGCG TGAACCCCGT GGTCTCCTAC 
GCCGTGGCTC TCAGCTGTCA ATGTGCACTC TGCCGCCGCA GCACCACTGA CTGCGGGGGT 
CCCAAGGACC ACCCCTTGAC CTGTGATGAC CCCCGCTTCC AGGCCTCCTC TTCCTCAAAG 
GCCCCTCCCC CCAGCCTTCC AAGCCCATCC CGACTCCCGG GGCCCTCAGA CACCCCGATC 
CTCCCACAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_203696.2
CDS	224..715
Translation	MSKGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQASSSSKAPPPSLPSPSRLPGPSDTPILPQ

Target ORF information:

RefSeq Version	NM_033378.1
Organism	Homo sapiens(human)
Definition	Homo sapiens chorionic gonadotropin subunit beta 2 (CGB2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033378.1

ORF Insert Sequence:

ATGTCAAAGG GGCTGCTGCT GTTGCTGCTG CTGAGCATGG GCGGGACATG GGCATCCAAG 
GAGCCGCTTC GGCCACGGTG CCGCCCCATC AATGCCACCC TGGCTGTGGA GAAGGAGGGC 
TGCCCCGTGT GCATCACCGT CAACACCACC ATCTGTGCCG GCTACTGCCC CACCATGACC 
CGCGTGCTGC AGGGGGTCCT GCCGGCCCTG CCTCAGGTGG TGTGCAACTA CCGCGATGTG 
CGCTTCGAGT CCATCCGGCT CCCTGGCTGC CCGCGCGGCG TGAACCCCGT GGTCTCCTAC 
GCCGTGGCTC TCAGCTGTCA ATGTGCACTC TGCCGCCGCA GCACCACTGA CTGCGGGGGT 
CCCAAGGACC ACCCCTTGAC CTGTGATGAC CCCCGCTTCC AGGCCTCCTC TTCCTCAAAG 
GCCCCTCCCC CCAGCCTTCC AAGCCCATCC CGACTCCCGG GGCCCTCAGA CACCCCGATC 
CTCCCACAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CGB2 ( NM_001319065.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001305994.1 Homo sapiens chorionic gonadotropin subunit beta 2 (CGB2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu51988
Clone ID Related Accession (Same CDS sequence)	NM_001319065.1
Accession Version	NM_001319065.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	choriogonadotropin subunit beta variant 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC107143.1, AC008687.5 and AA400910.1. On Jan 21, 2016 this sequence version replaced XM_005258480.1. Transcript Variant: This variant (2) uses an alternate splice site in the 5'-terminal exon and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC107143.1, GE745565.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2150585 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCGGGA CATGGGCATC CAAGGAGCCG CTTCGGCCAC GGTGCCGCCC CATCAATGCC 
ACCCTGGCTG TGGAGAAGGA GGGCTGCCCC GTGTGCATCA CCGTCAACAC CACCATCTGT 
GCCGGCTACT GCCCCACCAT GACCCGCGTG CTGCAGGGGG TCCTGCCGGC CCTGCCTCAG 
GTGGTGTGCA ACTACCGCGA TGTGCGCTTC GAGTCCATCC GGCTCCCTGG CTGCCCGCGC 
GGCGTGAACC CCGTGGTCTC CTACGCCGTG GCTCTCAGCT GTCAATGTGC ACTCTGCCGC 
CGCAGCACCA CTGACTGCGG GGGTCCCAAG GACCACCCCT TGACCTGTGA TGACCCCCGC 
TTCCAGGCCT CCTCTTCCTC AAAGGCCCCT CCCCCCAGCC TTCCAAGCCC ATCCCGACTC 
CCGGGGCCCT CAGACACCCC GATCCTCCCA CAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001305994.1
CDS	387..842
Translation	MGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQASSSSKAPPPSLPSPSRLPGPSDTPILPQ

Target ORF information:

RefSeq Version	NM_001319065.1
Organism	Homo sapiens(human)
Definition	Homo sapiens chorionic gonadotropin subunit beta 2 (CGB2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001319065.1

ORF Insert Sequence:

ATGGGCGGGA CATGGGCATC CAAGGAGCCG CTTCGGCCAC GGTGCCGCCC CATCAATGCC 
ACCCTGGCTG TGGAGAAGGA GGGCTGCCCC GTGTGCATCA CCGTCAACAC CACCATCTGT 
GCCGGCTACT GCCCCACCAT GACCCGCGTG CTGCAGGGGG TCCTGCCGGC CCTGCCTCAG 
GTGGTGTGCA ACTACCGCGA TGTGCGCTTC GAGTCCATCC GGCTCCCTGG CTGCCCGCGC 
GGCGTGAACC CCGTGGTCTC CTACGCCGTG GCTCTCAGCT GTCAATGTGC ACTCTGCCGC 
CGCAGCACCA CTGACTGCGG GGGTCCCAAG GACCACCCCT TGACCTGTGA TGACCCCCGC 
TTCCAGGCCT CCTCTTCCTC AAAGGCCCCT CCCCCCAGCC TTCCAAGCCC ATCCCGACTC 
CCGGGGCCCT CAGACACCCC GATCCTCCCA CAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CGB2 ( XM_005258479.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005258536.1 Homo sapiens chorionic gonadotropin subunit beta 2 (CGB2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu51987
Clone ID Related Accession (Same CDS sequence)	XM_005258479.3
Accession Version	XM_005258479.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	choriogonadotropin subunit beta variant 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005258479.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAAGGC CAGGACTCGG GGCTGCGGTC TCAGACCCGG GTGAAGCAGT GTCCTTGTCC 
CAGGGGCTGC TGCTGTTGCT GCTGCTGAGC ATGGGCGGGA CATGGGCATC CAAGGAGCCG 
CTTCGGCCAC GGTGCCGCCC CATCAATGCC ACCCTGGCTG TGGAGAAGGA GGGCTGCCCC 
GTGTGCATCA CCGTCAACAC CACCATCTGT GCCGGCTACT GCCCCACCAT GACCCGCGTG 
CTGCAGGGGG TCCTGCCGGC CCTGCCTCAG GTGGTGTGCA ACTACCGCGA TGTGCGCTTC 
GAGTCCATCC GGCTCCCTGG CTGCCCGCGC GGCGTGAACC CCGTGGTCTC CTACGCCGTG 
GCTCTCAGCT GTCAATGTGC ACTCTGCCGC CGCAGCACCA CTGACTGCGG GGGTCCCAAG 
GACCACCCCT TGACCTGTGA TGACCCCCGC TTCCAGGCCT CCTCTTCCTC AAAGGCCCCT 
CCCCCCAGCC TTCCAAGCCC ATCCCGACTC CCGGGGCCCT CAGACACCCC GATCCTCCCA 
CAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005258536.1
CDS	103..648
Translation	MGRPGLGAAVSDPGEAVSLSQGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQASSSSKAPPPSLPSPSRLPGPSDTPILPQ

Target ORF information:

RefSeq Version	XM_005258479.3
Organism	Homo sapiens(human)
Definition	Homo sapiens chorionic gonadotropin subunit beta 2 (CGB2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005258479.3

ORF Insert Sequence:

ATGGGAAGGC CAGGACTCGG GGCTGCGGTC TCAGACCCGG GTGAAGCAGT GTCCTTGTCC 
CAGGGGCTGC TGCTGTTGCT GCTGCTGAGC ATGGGCGGGA CATGGGCATC CAAGGAGCCG 
CTTCGGCCAC GGTGCCGCCC CATCAATGCC ACCCTGGCTG TGGAGAAGGA GGGCTGCCCC 
GTGTGCATCA CCGTCAACAC CACCATCTGT GCCGGCTACT GCCCCACCAT GACCCGCGTG 
CTGCAGGGGG TCCTGCCGGC CCTGCCTCAG GTGGTGTGCA ACTACCGCGA TGTGCGCTTC 
GAGTCCATCC GGCTCCCTGG CTGCCCGCGC GGCGTGAACC CCGTGGTCTC CTACGCCGTG 
GCTCTCAGCT GTCAATGTGC ACTCTGCCGC CGCAGCACCA CTGACTGCGG GGGTCCCAAG 
GACCACCCCT TGACCTGTGA TGACCCCCGC TTCCAGGCCT CCTCTTCCTC AAAGGCCCCT 
CCCCCCAGCC TTCCAAGCCC ATCCCGACTC CCGGGGCCCT CAGACACCCC GATCCTCCCA 
CAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel insights into the expression of CGB1 & 2 genes by epithelial cancer cell lines secreting ectopic free hCG?.
Anticancer research34(5)2239-48(2014 May)
Burczynska BB,Kobrouly L,Butler SA,Naase M,Iles RK

Human chorionic gonadotropin beta subunit genes CGB1 and CGB2 are transcriptionally active in ovarian cancer.
International journal of molecular sciences14(6)12650-60(2013 Jun)
Kubiczak M,Walkowiak GP,Nowak-Markwitz E,Jankowska A

Molecular cloning, characterization and expression of thyroid-stimulating hormone receptor in channel catfish.
General and comparative endocrinology161(3)313-9(2009 May)
Goto-Kazeto R,Kazeto Y,Trant JM

Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues.
Molecular human reproduction14(1)23-31(2008 Jan)
Rull K,Hallast P,Uusk?la L,Jackson J,Punab M,Salumets A,Campbell RK,Laan M

The evolution and genomic landscape of CGB1 and CGB2 genes.
Molecular and cellular endocrinology260-2622-11(2007 Jan)
Hallast P,Rull K,Laan M

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CGB2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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