RAD51AP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RAD51AP1
Entrez Gene ID	10635
Full Name	RAD51 associated protein 1
Synonyms	PIR51
General protein information	Preferred Names RAD51 associated protein 1 Names RAD51-associated protein 1 RAD51-interacting protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.32
Disorder MIM:	603070

mRNA and Protein(s)

mRNA	Protein	Name
NM_001130862.1	NP_001124334.1	RAD51-associated protein 1 isoform a
NM_001130862.2	NP_001124334.1	RAD51-associated protein 1 isoform a
NM_006479.5	NP_006470.1	RAD51-associated protein 1 isoform b
NM_006479.4	NP_006470.1	RAD51-associated protein 1 isoform b

Pathways from BioSystems

Homologies

	RAD51AP1	XP_001100737.1
Bos taurus (cattle)	LOC100336690	XP_005207265.1
Rattus norvegicus (Norway rat)	Rad51ap1	NP_001073179.1
Homo sapiens (human)	RAD51AP1	NP_001124334.1
Bos taurus (cattle)	RAD51AP1	NP_001069871.1
Mus musculus (house mouse)	Rad51ap1	NP_033039.2
Gallus gallus (chicken)	RAD51AP1	XP_417234.4
Danio rerio (zebrafish)	rad51ap1	NP_001037803.2
Xenopus tropicalis (tropical clawed frog)	rad51ap1	XP_004912814.1
Pan troglodytes (chimpanzee)	RAD51AP1	XP_001157782.1
Canis lupus familiaris (dog)	RAD51AP1	XP_005637322.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of novel cancer biomarkers of prognostic value using specific gene regulatory networks (GRN): a novel role of RAD51AP1 for ovarian and lung cancers.
Chudasama D, Bo V, Hall M, Anikin V, Jeyaneethi J, Gregory J, Pados G, Tucker A, Harvey A, Pink R, Karteris E
Carcinogenesis(2017 Nov)

Role of RAD51AP1 in homologous recombination DNA repair and carcinogenesis.
Pires E, Sung P, Wiese C
DNA repair5976-81(2017 Nov)

The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair.
Cukras S, Lee E, Palumbo E, Benavidez P, Moldovan GL, Kee Y
Cell cycle (Georgetown, Tex.)15(19)2636-2646(2016 Oct)

NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
Parplys AC, Zhao W, Sharma N, Groesser T, Liang F, Maranon DG, Leung SG, Grundt K, Dray E, Idate R, ?stvold AC, Schild D, Sung P, Wiese C
Nucleic acids research43(20)9817-34(2015 Nov)

RAD51AP1-deficiency in vertebrate cells impairs DNA replication.
Parplys AC, Kratz K, Speed MC, Leung SG, Schild D, Wiese C
DNA repair2487-97(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The current understanding of the biochemical and biological functions of RAD51AP1 as HR factor is reviewed. It is also discussed how RAD51AP1 may help to promote cancer development and potentially be a promising new target for therapeutic intervention. [REVIEW]
Title: Role of RAD51AP1 in homologous recombination DNA repair and carcinogenesis.

USP1-UAF1 complex promotes homologous recombination repair via multiple mechanisms: through FANCD2 deubiquitination, as well as by interacting with RAD51AP1.
Title: The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair.

RAD51AP1 is required for the maintenance of DNA replication fork progression.
Title: RAD51AP1-deficiency in vertebrate cells impairs DNA replication.

We have finely mapped the two DNA binding domains in RAD51AP1 and using mutant variants, reveal that both domains are indispensable for RAD51AP1 function in cells.
Title: Mechanistic insights into RAD51-associated protein 1 (RAD51AP1) action in homologous DNA repair.

Data suggest that microRNA/mRNA pairs in hsa-miR-140-3p/RAD51AP1/, hsa-miR-145/E2F3, hsa-miR-139-5p/TOP2A, and hsa-miR-133a/GCLC were correlated with ovarian tumorigenesis.
Title: Identifying microRNA/mRNA dysregulations in ovarian cancer.

The following RAD51AP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAD51AP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24391	NM_006479.5 Latest version!	Homo sapiens RAD51 associated protein 1 (RAD51AP1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu30607	NM_001130862.2 Latest version!	Homo sapiens RAD51 associated protein 1 (RAD51AP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu30607	NM_001130862.1	Homo sapiens RAD51 associated protein 1 (RAD51AP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu24391	NM_006479.4	Homo sapiens RAD51 associated protein 1 (RAD51AP1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RAD51AP1 ( NM_006479.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_006470.1 Homo sapiens RAD51 associated protein 1 (RAD51AP1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu24391
Clone ID Related Accession (Same CDS sequence)	NM_006479.5 , NM_006479.4
Accession Version	NM_006479.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1008bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-08
Organism	Homo sapiens(human)
Product	RAD51-associated protein 1 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK291948.1, BU689445.1 and AC005832.1. On Jun 2, 2019 this sequence version replaced NM_006479.4. Transcript Variant: This variant lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC006992.1, SRR7346977.989663.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGCGGC CTGTGAGACA TAAGAAACCA GTCAATTACT CACAGTTTGA CCACTCTGAC 
AGTGATGATG ATTTTGTTTC TGCAACTGTA CCTTTAAACA AGAAATCCAG AACAGCACCA 
AAGGAGTTAA AACAAGATAA ACCAAAACCT AACTTGAACA ATCTCCGGAA AGAAGAAATC 
CCAGTACAAG AGAAAACCCC TAAAAAAAGG ATGGCTTTAG ATGACAAGCT CTACCAGAGA 
GACTTAGAAG TTGCACTAGC TTTATCAGTG AAGGAACTTC CAACAGTCAC CACTAATGTG 
CAGAACTCTC AAGATAAAAG CATTGAAAAA CATGGCAGTA GTAAAATAGA AACAATGAAT 
AAGTCTCCTC ATATCTCTAA TTGCAGTGTA GCCAGTGATT ATTTAGATTT GGATAAGATT 
ACTGTGGAAG ATGATGTTGG TGGTGTTCAA GGGAAAAGAA AAGCAGCATC TAAAGCTGCA 
GCACAGCAGA GGAAGATTCT TCTGGAAGGC AGTGATGGTG ATAGTGCTAA TGACACTGAA 
CCAGACTTTG CACCTGGTGA AGATTCTGAG GATGATTCTG ATTTTTGTGA GAGTGAGGAT 
AATGACGAAG ACTTCTCTAT GAGAAAAAGT AAAGTTAAAG AAATTAAAAA GAAAGAAGTG 
AAGGTAAAAT CCCCAGTAGA AAAGAAAGAG AAGAAATCTA AATCCAAATG TAATGCTTTG 
GTGACTTCGG TGGACTCTGC TCCAGCTGCC GTCAAATCAG AATCTCAGTC CTTGCCAAAA 
AAGGTTTCTC TGTCTTCAGA TACCACTAGG AAACCATTAG AAATACGCAG TCCTTCAGCT 
GAAAGCAAGA AACCTAAATG GGTCCCACCA GCGGCATCTG GAGGTAGCAG AAGTAGCAGC 
AGCCCACTGG TGGTAGTGTC TGTGAAGTCT CCCAATCAGA GTCTCCGCCT TGGCTTGTCC 
AGATTAGCAC GAGTTAAACC TTTGCATCCA AATGCCACTA GCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006470.1
CDS	51..1058
Translation	MVRPVRHKKPVNYSQFDHSDSDDDFVSATVPLNKKSRTAPKELKQDKPKPNLNNLRKEEIPVQEKTPKKRMALDDKLYQRDLEVALALSVKELPTVTTNVQNSQDKSIEKHGSSKIETMNKSPHISNCSVASDYLDLDKITVEDDVGGVQGKRKAASKAAAQQRKILLEGSDGDSANDTEPDFAPGEDSEDDSDFCESEDNDEDFSMRKSKVKEIKKKEVKVKSPVEKKEKKSKSKCNALVTSVDSAPAAVKSESQSLPKKVSLSSDTTRKPLEIRSPSAESKKPKWVPPAASGGSRSSSSPLVVVSVKSPNQSLRLGLSRLARVKPLHPNATST

Target ORF information:

RefSeq Version	NM_006479.5
Organism	Homo sapiens(human)
Definition	Homo sapiens RAD51 associated protein 1 (RAD51AP1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006479.5

ORF Insert Sequence:

ATGGTGCGGC CTGTGAGACA TAAGAAACCA GTCAATTACT CACAGTTTGA CCACTCTGAC 
AGTGATGATG ATTTTGTTTC TGCAACTGTA CCTTTAAACA AGAAATCCAG AACAGCACCA 
AAGGAGTTAA AACAAGATAA ACCAAAACCT AACTTGAACA ATCTCCGGAA AGAAGAAATC 
CCAGTACAAG AGAAAACCCC TAAAAAAAGG ATGGCTTTAG ATGACAAGCT CTACCAGAGA 
GACTTAGAAG TTGCACTAGC TTTATCAGTG AAGGAACTTC CAACAGTCAC CACTAATGTG 
CAGAACTCTC AAGATAAAAG CATTGAAAAA CATGGCAGTA GTAAAATAGA AACAATGAAT 
AAGTCTCCTC ATATCTCTAA TTGCAGTGTA GCCAGTGATT ATTTAGATTT GGATAAGATT 
ACTGTGGAAG ATGATGTTGG TGGTGTTCAA GGGAAAAGAA AAGCAGCATC TAAAGCTGCA 
GCACAGCAGA GGAAGATTCT TCTGGAAGGC AGTGATGGTG ATAGTGCTAA TGACACTGAA 
CCAGACTTTG CACCTGGTGA AGATTCTGAG GATGATTCTG ATTTTTGTGA GAGTGAGGAT 
AATGACGAAG ACTTCTCTAT GAGAAAAAGT AAAGTTAAAG AAATTAAAAA GAAAGAAGTG 
AAGGTAAAAT CCCCAGTAGA AAAGAAAGAG AAGAAATCTA AATCCAAATG TAATGCTTTG 
GTGACTTCGG TGGACTCTGC TCCAGCTGCC GTCAAATCAG AATCTCAGTC CTTGCCAAAA 
AAGGTTTCTC TGTCTTCAGA TACCACTAGG AAACCATTAG AAATACGCAG TCCTTCAGCT 
GAAAGCAAGA AACCTAAATG GGTCCCACCA GCGGCATCTG GAGGTAGCAG AAGTAGCAGC 
AGCCCACTGG TGGTAGTGTC TGTGAAGTCT CCCAATCAGA GTCTCCGCCT TGGCTTGTCC 
AGATTAGCAC GAGTTAAACC TTTGCATCCA AATGCCACTA GCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAD51AP1 ( NM_006479.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006470.1 Homo sapiens RAD51 associated protein 1 (RAD51AP1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu24391
Clone ID Related Accession (Same CDS sequence)	NM_006479.5 , NM_006479.4
Accession Version	NM_006479.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1008bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-03
Organism	Homo sapiens(human)
Product	RAD51-associated protein 1 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC397655.1, AK291948.1, BU689445.1 and AC005832.1. On Aug 7, 2008 this sequence version replaced NM_006479.3. Transcript Variant: This variant lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC006992.1, SRR1163657.127670.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGCGGC CTGTGAGACA TAAGAAACCA GTCAATTACT CACAGTTTGA CCACTCTGAC 
AGTGATGATG ATTTTGTTTC TGCAACTGTA CCTTTAAACA AGAAATCCAG AACAGCACCA 
AAGGAGTTAA AACAAGATAA ACCAAAACCT AACTTGAACA ATCTCCGGAA AGAAGAAATC 
CCAGTACAAG AGAAAACCCC TAAAAAAAGG ATGGCTTTAG ATGACAAGCT CTACCAGAGA 
GACTTAGAAG TTGCACTAGC TTTATCAGTG AAGGAACTTC CAACAGTCAC CACTAATGTG 
CAGAACTCTC AAGATAAAAG CATTGAAAAA CATGGCAGTA GTAAAATAGA AACAATGAAT 
AAGTCTCCTC ATATCTCTAA TTGCAGTGTA GCCAGTGATT ATTTAGATTT GGATAAGATT 
ACTGTGGAAG ATGATGTTGG TGGTGTTCAA GGGAAAAGAA AAGCAGCATC TAAAGCTGCA 
GCACAGCAGA GGAAGATTCT TCTGGAAGGC AGTGATGGTG ATAGTGCTAA TGACACTGAA 
CCAGACTTTG CACCTGGTGA AGATTCTGAG GATGATTCTG ATTTTTGTGA GAGTGAGGAT 
AATGACGAAG ACTTCTCTAT GAGAAAAAGT AAAGTTAAAG AAATTAAAAA GAAAGAAGTG 
AAGGTAAAAT CCCCAGTAGA AAAGAAAGAG AAGAAATCTA AATCCAAATG TAATGCTTTG 
GTGACTTCGG TGGACTCTGC TCCAGCTGCC GTCAAATCAG AATCTCAGTC CTTGCCAAAA 
AAGGTTTCTC TGTCTTCAGA TACCACTAGG AAACCATTAG AAATACGCAG TCCTTCAGCT 
GAAAGCAAGA AACCTAAATG GGTCCCACCA GCGGCATCTG GAGGTAGCAG AAGTAGCAGC 
AGCCCACTGG TGGTAGTGTC TGTGAAGTCT CCCAATCAGA GTCTCCGCCT TGGCTTGTCC 
AGATTAGCAC GAGTTAAACC TTTGCATCCA AATGCCACTA GCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006470.1
CDS	157..1164
Translation	MVRPVRHKKPVNYSQFDHSDSDDDFVSATVPLNKKSRTAPKELKQDKPKPNLNNLRKEEIPVQEKTPKKRMALDDKLYQRDLEVALALSVKELPTVTTNVQNSQDKSIEKHGSSKIETMNKSPHISNCSVASDYLDLDKITVEDDVGGVQGKRKAASKAAAQQRKILLEGSDGDSANDTEPDFAPGEDSEDDSDFCESEDNDEDFSMRKSKVKEIKKKEVKVKSPVEKKEKKSKSKCNALVTSVDSAPAAVKSESQSLPKKVSLSSDTTRKPLEIRSPSAESKKPKWVPPAASGGSRSSSSPLVVVSVKSPNQSLRLGLSRLARVKPLHPNATST

Target ORF information:

RefSeq Version	NM_006479.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RAD51 associated protein 1 (RAD51AP1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006479.4

ORF Insert Sequence:

ATGGTGCGGC CTGTGAGACA TAAGAAACCA GTCAATTACT CACAGTTTGA CCACTCTGAC 
AGTGATGATG ATTTTGTTTC TGCAACTGTA CCTTTAAACA AGAAATCCAG AACAGCACCA 
AAGGAGTTAA AACAAGATAA ACCAAAACCT AACTTGAACA ATCTCCGGAA AGAAGAAATC 
CCAGTACAAG AGAAAACCCC TAAAAAAAGG ATGGCTTTAG ATGACAAGCT CTACCAGAGA 
GACTTAGAAG TTGCACTAGC TTTATCAGTG AAGGAACTTC CAACAGTCAC CACTAATGTG 
CAGAACTCTC AAGATAAAAG CATTGAAAAA CATGGCAGTA GTAAAATAGA AACAATGAAT 
AAGTCTCCTC ATATCTCTAA TTGCAGTGTA GCCAGTGATT ATTTAGATTT GGATAAGATT 
ACTGTGGAAG ATGATGTTGG TGGTGTTCAA GGGAAAAGAA AAGCAGCATC TAAAGCTGCA 
GCACAGCAGA GGAAGATTCT TCTGGAAGGC AGTGATGGTG ATAGTGCTAA TGACACTGAA 
CCAGACTTTG CACCTGGTGA AGATTCTGAG GATGATTCTG ATTTTTGTGA GAGTGAGGAT 
AATGACGAAG ACTTCTCTAT GAGAAAAAGT AAAGTTAAAG AAATTAAAAA GAAAGAAGTG 
AAGGTAAAAT CCCCAGTAGA AAAGAAAGAG AAGAAATCTA AATCCAAATG TAATGCTTTG 
GTGACTTCGG TGGACTCTGC TCCAGCTGCC GTCAAATCAG AATCTCAGTC CTTGCCAAAA 
AAGGTTTCTC TGTCTTCAGA TACCACTAGG AAACCATTAG AAATACGCAG TCCTTCAGCT 
GAAAGCAAGA AACCTAAATG GGTCCCACCA GCGGCATCTG GAGGTAGCAG AAGTAGCAGC 
AGCCCACTGG TGGTAGTGTC TGTGAAGTCT CCCAATCAGA GTCTCCGCCT TGGCTTGTCC 
AGATTAGCAC GAGTTAAACC TTTGCATCCA AATGCCACTA GCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAD51AP1 ( NM_001130862.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001124334.1 Homo sapiens RAD51 associated protein 1 (RAD51AP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30607
Clone ID Related Accession (Same CDS sequence)	NM_001130862.1 , NM_001130862.2
Accession Version	NM_001130862.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	RAD51-associated protein 1 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC397655.1, BC016330.1 and AC005832.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016330.1, AL832243.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGCGGC CTGTGAGACA TAAGAAACCA GTCAATTACT CACAGTTTGA CCACTCTGAC 
AGTGATGATG ATTTTGTTTC TGCAACTGTA CCTTTAAACA AGAAATCCAG AACAGCACCA 
AAGGAGTTAA AACAAGATAA ACCAAAACCT AACTTGAACA ATCTCCGGAA AGAAGAAATC 
CCAGTACAAG AGAAAACCCC TAAAAAAAGA CTCCCTGAAG GTACTTTTAG TATTCCAGCT 
AGTGCAGTGC CTTGTACAAA GATGGCTTTA GATGACAAGC TCTACCAGAG AGACTTAGAA 
GTTGCACTAG CTTTATCAGT GAAGGAACTT CCAACAGTCA CCACTAATGT GCAGAACTCT 
CAAGATAAAA GCATTGAAAA ACATGGCAGT AGTAAAATAG AAACAATGAA TAAGTCTCCT 
CATATCTCTA ATTGCAGTGT AGCCAGTGAT TATTTAGATT TGGATAAGAT TACTGTGGAA 
GATGATGTTG GTGGTGTTCA AGGGAAAAGA AAAGCAGCAT CTAAAGCTGC AGCACAGCAG 
AGGAAGATTC TTCTGGAAGG CAGTGATGGT GATAGTGCTA ATGACACTGA ACCAGACTTT 
GCACCTGGTG AAGATTCTGA GGATGATTCT GATTTTTGTG AGAGTGAGGA TAATGACGAA 
GACTTCTCTA TGAGAAAAAG TAAAGTTAAA GAAATTAAAA AGAAAGAAGT GAAGGTAAAA 
TCCCCAGTAG AAAAGAAAGA GAAGAAATCT AAATCCAAAT GTAATGCTTT GGTGACTTCG 
GTGGACTCTG CTCCAGCTGC CGTCAAATCA GAATCTCAGT CCTTGCCAAA AAAGGTTTCT 
CTGTCTTCAG ATACCACTAG GAAACCATTA GAAATACGCA GTCCTTCAGC TGAAAGCAAG 
AAACCTAAAT GGGTCCCACC AGCGGCATCT GGAGGTAGCA GAAGTAGCAG CAGCCCACTG 
GTGGTAGTGT CTGTGAAGTC TCCCAATCAG AGTCTCCGCC TTGGCTTGTC CAGATTAGCA 
CGAGTTAAAC CTTTGCATCC AAATGCCACT AGCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001124334.1
CDS	157..1215
Translation	MVRPVRHKKPVNYSQFDHSDSDDDFVSATVPLNKKSRTAPKELKQDKPKPNLNNLRKEEIPVQEKTPKKRLPEGTFSIPASAVPCTKMALDDKLYQRDLEVALALSVKELPTVTTNVQNSQDKSIEKHGSSKIETMNKSPHISNCSVASDYLDLDKITVEDDVGGVQGKRKAASKAAAQQRKILLEGSDGDSANDTEPDFAPGEDSEDDSDFCESEDNDEDFSMRKSKVKEIKKKEVKVKSPVEKKEKKSKSKCNALVTSVDSAPAAVKSESQSLPKKVSLSSDTTRKPLEIRSPSAESKKPKWVPPAASGGSRSSSSPLVVVSVKSPNQSLRLGLSRLARVKPLHPNATST

Target ORF information:

RefSeq Version	NM_001130862.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RAD51 associated protein 1 (RAD51AP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001130862.1

ORF Insert Sequence:

ATGGTGCGGC CTGTGAGACA TAAGAAACCA GTCAATTACT CACAGTTTGA CCACTCTGAC 
AGTGATGATG ATTTTGTTTC TGCAACTGTA CCTTTAAACA AGAAATCCAG AACAGCACCA 
AAGGAGTTAA AACAAGATAA ACCAAAACCT AACTTGAACA ATCTCCGGAA AGAAGAAATC 
CCAGTACAAG AGAAAACCCC TAAAAAAAGA CTCCCTGAAG GTACTTTTAG TATTCCAGCT 
AGTGCAGTGC CTTGTACAAA GATGGCTTTA GATGACAAGC TCTACCAGAG AGACTTAGAA 
GTTGCACTAG CTTTATCAGT GAAGGAACTT CCAACAGTCA CCACTAATGT GCAGAACTCT 
CAAGATAAAA GCATTGAAAA ACATGGCAGT AGTAAAATAG AAACAATGAA TAAGTCTCCT 
CATATCTCTA ATTGCAGTGT AGCCAGTGAT TATTTAGATT TGGATAAGAT TACTGTGGAA 
GATGATGTTG GTGGTGTTCA AGGGAAAAGA AAAGCAGCAT CTAAAGCTGC AGCACAGCAG 
AGGAAGATTC TTCTGGAAGG CAGTGATGGT GATAGTGCTA ATGACACTGA ACCAGACTTT 
GCACCTGGTG AAGATTCTGA GGATGATTCT GATTTTTGTG AGAGTGAGGA TAATGACGAA 
GACTTCTCTA TGAGAAAAAG TAAAGTTAAA GAAATTAAAA AGAAAGAAGT GAAGGTAAAA 
TCCCCAGTAG AAAAGAAAGA GAAGAAATCT AAATCCAAAT GTAATGCTTT GGTGACTTCG 
GTGGACTCTG CTCCAGCTGC CGTCAAATCA GAATCTCAGT CCTTGCCAAA AAAGGTTTCT 
CTGTCTTCAG ATACCACTAG GAAACCATTA GAAATACGCA GTCCTTCAGC TGAAAGCAAG 
AAACCTAAAT GGGTCCCACC AGCGGCATCT GGAGGTAGCA GAAGTAGCAG CAGCCCACTG 
GTGGTAGTGT CTGTGAAGTC TCCCAATCAG AGTCTCCGCC TTGGCTTGTC CAGATTAGCA 
CGAGTTAAAC CTTTGCATCC AAATGCCACT AGCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAD51AP1 ( NM_001130862.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001124334.1 Homo sapiens RAD51 associated protein 1 (RAD51AP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30607
Clone ID Related Accession (Same CDS sequence)	NM_001130862.1 , NM_001130862.2
Accession Version	NM_001130862.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-01
Organism	Homo sapiens(human)
Product	RAD51-associated protein 1 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC397655.1, BC016330.1 and AC005832.1. On Jun 2, 2019 this sequence version replaced NM_001130862.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016330.1, AK290428.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGCGGC CTGTGAGACA TAAGAAACCA GTCAATTACT CACAGTTTGA CCACTCTGAC 
AGTGATGATG ATTTTGTTTC TGCAACTGTA CCTTTAAACA AGAAATCCAG AACAGCACCA 
AAGGAGTTAA AACAAGATAA ACCAAAACCT AACTTGAACA ATCTCCGGAA AGAAGAAATC 
CCAGTACAAG AGAAAACCCC TAAAAAAAGA CTCCCTGAAG GTACTTTTAG TATTCCAGCT 
AGTGCAGTGC CTTGTACAAA GATGGCTTTA GATGACAAGC TCTACCAGAG AGACTTAGAA 
GTTGCACTAG CTTTATCAGT GAAGGAACTT CCAACAGTCA CCACTAATGT GCAGAACTCT 
CAAGATAAAA GCATTGAAAA ACATGGCAGT AGTAAAATAG AAACAATGAA TAAGTCTCCT 
CATATCTCTA ATTGCAGTGT AGCCAGTGAT TATTTAGATT TGGATAAGAT TACTGTGGAA 
GATGATGTTG GTGGTGTTCA AGGGAAAAGA AAAGCAGCAT CTAAAGCTGC AGCACAGCAG 
AGGAAGATTC TTCTGGAAGG CAGTGATGGT GATAGTGCTA ATGACACTGA ACCAGACTTT 
GCACCTGGTG AAGATTCTGA GGATGATTCT GATTTTTGTG AGAGTGAGGA TAATGACGAA 
GACTTCTCTA TGAGAAAAAG TAAAGTTAAA GAAATTAAAA AGAAAGAAGT GAAGGTAAAA 
TCCCCAGTAG AAAAGAAAGA GAAGAAATCT AAATCCAAAT GTAATGCTTT GGTGACTTCG 
GTGGACTCTG CTCCAGCTGC CGTCAAATCA GAATCTCAGT CCTTGCCAAA AAAGGTTTCT 
CTGTCTTCAG ATACCACTAG GAAACCATTA GAAATACGCA GTCCTTCAGC TGAAAGCAAG 
AAACCTAAAT GGGTCCCACC AGCGGCATCT GGAGGTAGCA GAAGTAGCAG CAGCCCACTG 
GTGGTAGTGT CTGTGAAGTC TCCCAATCAG AGTCTCCGCC TTGGCTTGTC CAGATTAGCA 
CGAGTTAAAC CTTTGCATCC AAATGCCACT AGCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001124334.1
CDS	51..1109
Translation	MVRPVRHKKPVNYSQFDHSDSDDDFVSATVPLNKKSRTAPKELKQDKPKPNLNNLRKEEIPVQEKTPKKRLPEGTFSIPASAVPCTKMALDDKLYQRDLEVALALSVKELPTVTTNVQNSQDKSIEKHGSSKIETMNKSPHISNCSVASDYLDLDKITVEDDVGGVQGKRKAASKAAAQQRKILLEGSDGDSANDTEPDFAPGEDSEDDSDFCESEDNDEDFSMRKSKVKEIKKKEVKVKSPVEKKEKKSKSKCNALVTSVDSAPAAVKSESQSLPKKVSLSSDTTRKPLEIRSPSAESKKPKWVPPAASGGSRSSSSPLVVVSVKSPNQSLRLGLSRLARVKPLHPNATST

Target ORF information:

RefSeq Version	NM_001130862.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RAD51 associated protein 1 (RAD51AP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001130862.2

ORF Insert Sequence:

ATGGTGCGGC CTGTGAGACA TAAGAAACCA GTCAATTACT CACAGTTTGA CCACTCTGAC 
AGTGATGATG ATTTTGTTTC TGCAACTGTA CCTTTAAACA AGAAATCCAG AACAGCACCA 
AAGGAGTTAA AACAAGATAA ACCAAAACCT AACTTGAACA ATCTCCGGAA AGAAGAAATC 
CCAGTACAAG AGAAAACCCC TAAAAAAAGA CTCCCTGAAG GTACTTTTAG TATTCCAGCT 
AGTGCAGTGC CTTGTACAAA GATGGCTTTA GATGACAAGC TCTACCAGAG AGACTTAGAA 
GTTGCACTAG CTTTATCAGT GAAGGAACTT CCAACAGTCA CCACTAATGT GCAGAACTCT 
CAAGATAAAA GCATTGAAAA ACATGGCAGT AGTAAAATAG AAACAATGAA TAAGTCTCCT 
CATATCTCTA ATTGCAGTGT AGCCAGTGAT TATTTAGATT TGGATAAGAT TACTGTGGAA 
GATGATGTTG GTGGTGTTCA AGGGAAAAGA AAAGCAGCAT CTAAAGCTGC AGCACAGCAG 
AGGAAGATTC TTCTGGAAGG CAGTGATGGT GATAGTGCTA ATGACACTGA ACCAGACTTT 
GCACCTGGTG AAGATTCTGA GGATGATTCT GATTTTTGTG AGAGTGAGGA TAATGACGAA 
GACTTCTCTA TGAGAAAAAG TAAAGTTAAA GAAATTAAAA AGAAAGAAGT GAAGGTAAAA 
TCCCCAGTAG AAAAGAAAGA GAAGAAATCT AAATCCAAAT GTAATGCTTT GGTGACTTCG 
GTGGACTCTG CTCCAGCTGC CGTCAAATCA GAATCTCAGT CCTTGCCAAA AAAGGTTTCT 
CTGTCTTCAG ATACCACTAG GAAACCATTA GAAATACGCA GTCCTTCAGC TGAAAGCAAG 
AAACCTAAAT GGGTCCCACC AGCGGCATCT GGAGGTAGCA GAAGTAGCAG CAGCCCACTG 
GTGGTAGTGT CTGTGAAGTC TCCCAATCAG AGTCTCCGCC TTGGCTTGTC CAGATTAGCA 
CGAGTTAAAC CTTTGCATCC AAATGCCACT AGCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of novel cancer biomarkers of prognostic value using specific gene regulatory networks (GRN): a novel role of RAD51AP1 for ovarian and lung cancers.
Carcinogenesis(2017 Nov)
Chudasama D,Bo V,Hall M,Anikin V,Jeyaneethi J,Gregory J,Pados G,Tucker A,Harvey A,Pink R,Karteris E

Role of RAD51AP1 in homologous recombination DNA repair and carcinogenesis.
DNA repair5976-81(2017 Nov)
Pires E,Sung P,Wiese C

The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair.
Cell cycle (Georgetown, Tex.)15(19)2636-2646(2016 Oct)
Cukras S,Lee E,Palumbo E,Benavidez P,Moldovan GL,Kee Y

NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
Nucleic acids research43(20)9817-34(2015 Nov)
Parplys AC,Zhao W,Sharma N,Groesser T,Liang F,Maranon DG,Leung SG,Grundt K,Dray E,Idate R,?stvold AC,Schild D,Sung P,Wiese C

RAD51AP1-deficiency in vertebrate cells impairs DNA replication.
DNA repair2487-97(2014 Dec)
Parplys AC,Kratz K,Speed MC,Leung SG,Schild D,Wiese C

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RAD51AP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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