CDX1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDX1
Entrez Gene ID	1044
Full Name	caudal type homeobox 1
General protein information	Preferred Names caudal type homeobox 1 Names homeobox protein CDX-1 caudal type homeo box transcription factor 1 caudal type homeobox transcription factor 1 caudal-type homeobox protein 1 caudal-type homeobox protein CDX1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q32
Summary	This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008].
Disorder MIM:	600746

mRNA and Protein(s)

mRNA	Protein	Name
NM_001804.2	NP_001795.2	homeobox protein CDX-1
NM_001804.3	NP_001795.2	homeobox protein CDX-1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CDX1	NP_001795.2
Canis lupus familiaris (dog)	CDX1	XP_855089.1
Bos taurus (cattle)	CDX1	NP_001095417.1
Mus musculus (house mouse)	Cdx1	NP_034010.3
	CDX1	XP_001108012.1
Rattus norvegicus (Norway rat)	Cdx1	XP_006254878.1
Pan troglodytes (chimpanzee)	CDX1	XP_527071.3

Gene Ontology
Bibliography

Related articles in PubMed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Sch?beler D, Vinson C, Taipale J
Science (New York, N.Y.)356(6337)(2017 05)

Combining omics data to identify genes associated with allergic rhinitis.
Morin A, Laviolette M, Pastinen T, Boulet LP, Laprise C
Clinical epigenetics93(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results identified CDX1 as cis methylation quantitative trait loci in allergic rhinitis.
Title: Combining omics data to identify genes associated with allergic rhinitis.

Downregulation of CDX1 is associated with recurrence in hepatocellular carcinoma.
Title: Low CDX1 expression predicts a poor prognosis for hepatocellular carcinoma patients after hepatectomy.

Changes in CDX1/CDX2 mRNA expression in gastric mucosa following H. pylori eradication showed only insignificant results
Title: Follow-Up Study on CDX1 and CDX2 mRNA Expression in Noncancerous Gastric Mucosae After Helicobacter pylori Eradication.

Data indicate an association between highly fucosylated glycans and caudal type homeobox 1 (CDX1) and/or villin mRNA expression that both correlate with cell differentiation.
Title: N-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and Caudal Type Homebox 1 (CDX1)/Villin mRNA Expression.

miR-215 is a link between CDX1 expression and BMI1 repression that governs differentiation in colorectal cancer
Title: The CDX1-microRNA-215 axis regulates colorectal cancer stem cell differentiation.

The following CDX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13389	NM_001804.3 Latest version!	Homo sapiens caudal type homeobox 1 (CDX1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
View Old Accession Versions >>
OHu13389	NM_001804.2	Homo sapiens caudal type homeobox 1 (CDX1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDX1 ( NM_001804.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001795.2 Homo sapiens caudal type homeobox 1 (CDX1), mRNA.

Price & Availability↑

CloneID	OHu13389
Clone ID Related Accession (Same CDS sequence)	NM_001804.2 , NM_001804.3
Accession Version	NM_001804.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 798bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	homeobox protein CDX-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005895.1 and AF239666.1. This sequence is a reference standard in the RefSeqGene project. On Jan 5, 2007 this sequence version replaced NM_001804.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279855.223.1, U51095.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTATGTGG GCTATGTGCT GGACAAGGAT TCGCCCGTGT ACCCCGGCCC AGCCAGGCCA 
GCCAGCCTCG GCCTGGGCCC GCAAGCCTAC GGCCCCCCGG CCCCGCCCCC GGCGCCCCCG 
CAGTACCCCG ACTTCTCCAG CTACTCTCAC GTGGAGCCGG CCCCCGCGCC CCCGACGGCC 
TGGGGGGCGC CCTTCCCTGC GCCCAAGGAC GACTGGGCCG CCGCCTACGG CCCGGGCCCC 
GCGGCCCCTG CCGCCAGCCC AGCTTCGCTG GCATTCGGGC CCCCTCCAGA CTTTAGCCCG 
GTGCCGGCGC CCCCTGGGCC CGGCCCGGGC CTCCTGGCGC AGCCCCTCGG GGGCCCGGGC 
ACACCGTCCT CGCCCGGAGC GCAGAGGCCG ACGCCCTACG AGTGGATGCG GCGCAGCGTG 
GCGGCCGGAG GCGGCGGTGG CAGCGGTAAG ACTCGGACCA AGGACAAGTA CCGCGTGGTC 
TACACCGACC ACCAACGCCT GGAGCTGGAG AAGGAGTTTC ATTACAGCCG TTACATCACA 
ATCCGGCGGA AATCAGAGCT GGCTGCCAAT CTGGGGCTCA CTGAACGGCA GGTGAAGATC 
TGGTTCCAAA ACCGGCGGGC AAAGGAGCGC AAAGTGAACA AGAAGAAACA GCAGCAGCAA 
CAGCCCCCAC AGCCGCCGAT GGCCCACGAC ATCACGGCCA CCCCAGCCGG GCCATCCCTG 
GGGGGCCTGT GTCCCAGCAA CACCAGCCTC CTGGCCACCT CCTCTCCAAT GCCTGTGAAA 
GAGGAGTTTC TGCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001795.2
CDS	97..894
Translation	MYVGYVLDKDSPVYPGPARPASLGLGPQAYGPPAPPPAPPQYPDFSSYSHVEPAPAPPTAWGAPFPAPKDDWAAAYGPGPAAPAASPASLAFGPPPDFSPVPAPPGPGPGLLAQPLGGPGTPSSPGAQRPTPYEWMRRSVAAGGGGGSGKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQPPQPPMAHDITATPAGPSLGGLCPSNTSLLATSSPMPVKEEFLP

Target ORF information:

RefSeq Version	NM_001804.2
Organism	Homo sapiens(human)
Definition	Homo sapiens caudal type homeobox 1 (CDX1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001804.2

ORF Insert Sequence:

ATGTATGTGG GCTATGTGCT GGACAAGGAT TCGCCCGTGT ACCCCGGCCC AGCCAGGCCA 
GCCAGCCTCG GCCTGGGCCC GCAAGCCTAC GGCCCCCCGG CCCCGCCCCC GGCGCCCCCG 
CAGTACCCCG ACTTCTCCAG CTACTCTCAC GTGGAGCCGG CCCCCGCGCC CCCGACGGCC 
TGGGGGGCGC CCTTCCCTGC GCCCAAGGAC GACTGGGCCG CCGCCTACGG CCCGGGCCCC 
GCGGCCCCTG CCGCCAGCCC AGCTTCGCTG GCATTCGGGC CCCCTCCAGA CTTTAGCCCG 
GTGCCGGCGC CCCCTGGGCC CGGCCCGGGC CTCCTGGCGC AGCCCCTCGG GGGCCCGGGC 
ACACCGTCCT CGCCCGGAGC GCAGAGGCCG ACGCCCTACG AGTGGATGCG GCGCAGCGTG 
GCGGCCGGAG GCGGCGGTGG CAGCGGTAAG ACTCGGACCA AGGACAAGTA CCGCGTGGTC 
TACACCGACC ACCAACGCCT GGAGCTGGAG AAGGAGTTTC ATTACAGCCG TTACATCACA 
ATCCGGCGGA AATCAGAGCT GGCTGCCAAT CTGGGGCTCA CTGAACGGCA GGTGAAGATC 
TGGTTCCAAA ACCGGCGGGC AAAGGAGCGC AAAGTGAACA AGAAGAAACA GCAGCAGCAA 
CAGCCCCCAC AGCCGCCGAT GGCCCACGAC ATCACGGCCA CCCCAGCCGG GCCATCCCTG 
GGGGGCCTGT GTCCCAGCAA CACCAGCCTC CTGGCCACCT CCTCTCCAAT GCCTGTGAAA 
GAGGAGTTTC TGCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDX1 ( NM_001804.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001795.2 Homo sapiens caudal type homeobox 1 (CDX1), mRNA.

Price & Availability↑

CloneID	OHu13389
Clone ID Related Accession (Same CDS sequence)	NM_001804.2 , NM_001804.3
Accession Version	NM_001804.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 798bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	homeobox protein CDX-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005895.1 and AF239666.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_001804.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U51095.1, U15212.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000231656.13/ ENSP00000231656.7 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTATGTGG GCTATGTGCT GGACAAGGAT TCGCCCGTGT ACCCCGGCCC AGCCAGGCCA 
GCCAGCCTCG GCCTGGGCCC GCAAGCCTAC GGCCCCCCGG CCCCGCCCCC GGCGCCCCCG 
CAGTACCCCG ACTTCTCCAG CTACTCTCAC GTGGAGCCGG CCCCCGCGCC CCCGACGGCC 
TGGGGGGCGC CCTTCCCTGC GCCCAAGGAC GACTGGGCCG CCGCCTACGG CCCGGGCCCC 
GCGGCCCCTG CCGCCAGCCC AGCTTCGCTG GCATTCGGGC CCCCTCCAGA CTTTAGCCCG 
GTGCCGGCGC CCCCTGGGCC CGGCCCGGGC CTCCTGGCGC AGCCCCTCGG GGGCCCGGGC 
ACACCGTCCT CGCCCGGAGC GCAGAGGCCG ACGCCCTACG AGTGGATGCG GCGCAGCGTG 
GCGGCCGGAG GCGGCGGTGG CAGCGGTAAG ACTCGGACCA AGGACAAGTA CCGCGTGGTC 
TACACCGACC ACCAACGCCT GGAGCTGGAG AAGGAGTTTC ATTACAGCCG TTACATCACA 
ATCCGGCGGA AATCAGAGCT GGCTGCCAAT CTGGGGCTCA CTGAACGGCA GGTGAAGATC 
TGGTTCCAAA ACCGGCGGGC AAAGGAGCGC AAAGTGAACA AGAAGAAACA GCAGCAGCAA 
CAGCCCCCAC AGCCGCCGAT GGCCCACGAC ATCACGGCCA CCCCAGCCGG GCCATCCCTG 
GGGGGCCTGT GTCCCAGCAA CACCAGCCTC CTGGCCACCT CCTCTCCAAT GCCTGTGAAA 
GAGGAGTTTC TGCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001795.2
CDS	100..897
Translation	MYVGYVLDKDSPVYPGPARPASLGLGPQAYGPPAPPPAPPQYPDFSSYSHVEPAPAPPTAWGAPFPAPKDDWAAAYGPGPAAPAASPASLAFGPPPDFSPVPAPPGPGPGLLAQPLGGPGTPSSPGAQRPTPYEWMRRSVAAGGGGGSGKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQPPQPPMAHDITATPAGPSLGGLCPSNTSLLATSSPMPVKEEFLP

Target ORF information:

RefSeq Version	NM_001804.3
Organism	Homo sapiens(human)
Definition	Homo sapiens caudal type homeobox 1 (CDX1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001804.3

ORF Insert Sequence:

ATGTATGTGG GCTATGTGCT GGACAAGGAT TCGCCCGTGT ACCCCGGCCC AGCCAGGCCA 
GCCAGCCTCG GCCTGGGCCC GCAAGCCTAC GGCCCCCCGG CCCCGCCCCC GGCGCCCCCG 
CAGTACCCCG ACTTCTCCAG CTACTCTCAC GTGGAGCCGG CCCCCGCGCC CCCGACGGCC 
TGGGGGGCGC CCTTCCCTGC GCCCAAGGAC GACTGGGCCG CCGCCTACGG CCCGGGCCCC 
GCGGCCCCTG CCGCCAGCCC AGCTTCGCTG GCATTCGGGC CCCCTCCAGA CTTTAGCCCG 
GTGCCGGCGC CCCCTGGGCC CGGCCCGGGC CTCCTGGCGC AGCCCCTCGG GGGCCCGGGC 
ACACCGTCCT CGCCCGGAGC GCAGAGGCCG ACGCCCTACG AGTGGATGCG GCGCAGCGTG 
GCGGCCGGAG GCGGCGGTGG CAGCGGTAAG ACTCGGACCA AGGACAAGTA CCGCGTGGTC 
TACACCGACC ACCAACGCCT GGAGCTGGAG AAGGAGTTTC ATTACAGCCG TTACATCACA 
ATCCGGCGGA AATCAGAGCT GGCTGCCAAT CTGGGGCTCA CTGAACGGCA GGTGAAGATC 
TGGTTCCAAA ACCGGCGGGC AAAGGAGCGC AAAGTGAACA AGAAGAAACA GCAGCAGCAA 
CAGCCCCCAC AGCCGCCGAT GGCCCACGAC ATCACGGCCA CCCCAGCCGG GCCATCCCTG 
GGGGGCCTGT GTCCCAGCAA CACCAGCCTC CTGGCCACCT CCTCTCCAAT GCCTGTGAAA 
GAGGAGTTTC TGCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Science (New York, N.Y.)356(6337)(2017 05)
Yin Y,Morgunova E,Jolma A,Kaasinen E,Sahu B,Khund-Sayeed S,Das PK,Kivioja T,Dave K,Zhong F,Nitta KR,Taipale M,Popov A,Ginno PA,Domcke S,Yan J,Sch?beler D,Vinson C,Taipale J

Combining omics data to identify genes associated with allergic rhinitis.
Clinical epigenetics93(2017)
Morin A,Laviolette M,Pastinen T,Boulet LP,Laprise C

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CDX1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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