Cdx1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdx1
Entrez Gene ID	12590
Full Name	caudal type homeobox 1
Synonyms	Cdx,Cdx-1
General protein information	Preferred Names caudal type homeobox 1 Names homeobox protein CDX-1 caudal type homeo box 1 caudal type homeobox transcription factor 1 caudal-type homeobox protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18 E1\|18 34.41 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009880.3	NP_034010.3	homeobox protein CDX-1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CDX1	NP_001795.2
Canis lupus familiaris (dog)	CDX1	XP_855089.1
Bos taurus (cattle)	CDX1	NP_001095417.1
Mus musculus (house mouse)	Cdx1	NP_034010.3
	CDX1	XP_001108012.1
Rattus norvegicus (Norway rat)	Cdx1	XP_006254878.1
Pan troglodytes (chimpanzee)	CDX1	XP_527071.3

Gene Ontology
Bibliography

Related articles in PubMed

New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.
Naruse C, Shibata S, Tamura M, Kawaguchi T, Abe K, Sugihara K, Kato T, Nishiuchi T, Wakana S, Ikawa M, Asano M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(6)2252-2266(2017 06)

Cdx is crucial for the timing mechanism driving colinear Hox activation and defines a trunk segment in the Hox cluster topology.
Neijts R, Amin S, van Rooijen C, Deschamps J
Developmental biology422(2)146-154(2017 02)

Essential roles for Cdx in murine primitive hematopoiesis.
Brooke-Bisschop T, Savory JGA, Foley T, Ringuette R, Lohnes D
Developmental biology422(2)115-124(2017 02)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cdx1-Cdx2 double null mutants exhibited loss of primitive erythroblasts, aberrant vascular remodelling of the yolk sac and a block in hematopoietic differentiation from yolk sac-derived cells in culture.
Title: Essential roles for Cdx in murine primitive hematopoiesis.

These findings underscore previously unrecognized roles for Cdx members in intestinal tumorigenesis
Title: Cdx1 and Cdx2 function as tumor suppressors.

transient expression of CDX1 promotes epicardial EMT, whereas subsequent down-regulation of CDX1 after 11.5 dpc in mice is necessary for further subepicardial invasion of EPDCs and contribution to coronary vascular endothelium or smooth muscle cells.
Title: A novel role of CDX1 in embryonic epicardial development.

we found that relative to Cdx1, Cdx2 was significantly less potent at effecting a transcriptional response from the Cdx1 promoter, a known Cdx target gene.
Title: Cdx1 and Cdx2 exhibit transcriptional specificity in the intestine.

study is the first example of Cdx-Hox protein interactions and suggests that such complexes may modulate Hox and/or Cdx function
Title: Cdx1 interacts physically with a subset of Hox proteins.

The following Cdx1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdx1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19401	NM_009880.3 Latest version!	Mus musculus caudal type homeobox 1 (Cdx1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdx1 ( NM_009880.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034010.3 Mus musculus caudal type homeobox 1 (Cdx1), mRNA.

Price & Availability↑

CloneID	OMu19401
Clone ID Related Accession (Same CDS sequence)	NM_009880.3
Accession Version	NM_009880.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 807bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	homeobox protein CDX-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC124448.4 and AC124431.4. On Jun 13, 2009 this sequence version replaced NM_009880.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC019986.1, M37163.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END##

ATGTACGTGG GCTATGTGCT GGACAAGGAC TCCCCCGTGT ACCCAGGCCC CGCCAGACCC 
TCCAGCCTCG GCCTGGGCCC TCCGACCTAT GCGCCCCCTG GCCCGGCGCC CGCGCCCCCG 
CAGTACCCCG ACTTCGCGGG TTACACGCAC GTGGAGCCGG CGCCCGCGCC CCCTCCGACC 
TGGGCTGCGC CCTTCCCTGC GCCCAAGGAC GACTGGGCAG CTGCCTATGG CCCGGGCCCC 
ACGGCCTCAG CCGCCAGCCC GGCCCCGCTG GCCTTCGGGC CCCCTCCGGA CTTTAGCCCG 
GTGCCCGCGC CTCCCGGGCC TGGTCCCGGC ATCCTGGCGC AGTCCCTCGG GGCTCCGGGC 
GCACCGTCCT CGCCAGGAGC GCCAAGGCGG ACGCCCTACG AATGGATGCG GCGCAGCGTG 
GCGGCTGCAG GCGGCGGTGG CAGCGGTAAG ACCCGAACCA AGGACAAGTA CCGTGTGGTC 
TACACAGACC ACCAACGCCT AGAGCTGGAA AAGGAGTTTC ACTACAGCCG GTACATCACT 
ATCCGGCGCA AGTCCGAGCT GGCTGCTAAC CTGGGGCTCA CAGAGCGGCA GGTAAAGATC 
TGGTTCCAGA ACCGCCGGGC CAAGGAGCGC AAAGTAAACA AGAAGAAACA GCAGCAGCAG 
CAGCCCCTGC CTCCCACACA GCTGCCCCTG CCCCTGGATG GCACTCCCAC ACCATCAGGG 
CCACCCCTAG GAAGTCTATG CCCTACTAAT GCTGGCCTTC TGGGCACCCC CTCCCCAGTG 
CCCGTCAAGG AGGAGTTTCT ACCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034010.3
CDS	80..886
Translation	MYVGYVLDKDSPVYPGPARPSSLGLGPPTYAPPGPAPAPPQYPDFAGYTHVEPAPAPPPTWAAPFPAPKDDWAAAYGPGPTASAASPAPLAFGPPPDFSPVPAPPGPGPGILAQSLGAPGAPSSPGAPRRTPYEWMRRSVAAAGGGGSGKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQPLPPTQLPLPLDGTPTPSGPPLGSLCPTNAGLLGTPSPVPVKEEFLP

Target ORF information:

RefSeq Version	NM_009880.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus caudal type homeobox 1 (Cdx1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009880.3

ORF Insert Sequence:

ATGTACGTGG GCTATGTGCT GGACAAGGAC TCCCCCGTGT ACCCAGGCCC CGCCAGACCC 
TCCAGCCTCG GCCTGGGCCC TCCGACCTAT GCGCCCCCTG GCCCGGCGCC CGCGCCCCCG 
CAGTACCCCG ACTTCGCGGG TTACACGCAC GTGGAGCCGG CGCCCGCGCC CCCTCCGACC 
TGGGCTGCGC CCTTCCCTGC GCCCAAGGAC GACTGGGCAG CTGCCTATGG CCCGGGCCCC 
ACGGCCTCAG CCGCCAGCCC GGCCCCGCTG GCCTTCGGGC CCCCTCCGGA CTTTAGCCCG 
GTGCCCGCGC CTCCCGGGCC TGGTCCCGGC ATCCTGGCGC AGTCCCTCGG GGCTCCGGGC 
GCACCGTCCT CGCCAGGAGC GCCAAGGCGG ACGCCCTACG AATGGATGCG GCGCAGCGTG 
GCGGCTGCAG GCGGCGGTGG CAGCGGTAAG ACCCGAACCA AGGACAAGTA CCGTGTGGTC 
TACACAGACC ACCAACGCCT AGAGCTGGAA AAGGAGTTTC ACTACAGCCG GTACATCACT 
ATCCGGCGCA AGTCCGAGCT GGCTGCTAAC CTGGGGCTCA CAGAGCGGCA GGTAAAGATC 
TGGTTCCAGA ACCGCCGGGC CAAGGAGCGC AAAGTAAACA AGAAGAAACA GCAGCAGCAG 
CAGCCCCTGC CTCCCACACA GCTGCCCCTG CCCCTGGATG GCACTCCCAC ACCATCAGGG 
CCACCCCTAG GAAGTCTATG CCCTACTAAT GCTGGCCTTC TGGGCACCCC CTCCCCAGTG 
CCCGTCAAGG AGGAGTTTCT ACCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(6)2252-2266(2017 06)
Naruse C,Shibata S,Tamura M,Kawaguchi T,Abe K,Sugihara K,Kato T,Nishiuchi T,Wakana S,Ikawa M,Asano M

Cdx is crucial for the timing mechanism driving colinear Hox activation and defines a trunk segment in the Hox cluster topology.
Developmental biology422(2)146-154(2017 02)
Neijts R,Amin S,van Rooijen C,Deschamps J

Essential roles for Cdx in murine primitive hematopoiesis.
Developmental biology422(2)115-124(2017 02)
Brooke-Bisschop T,Savory JGA,Foley T,Ringuette R,Lohnes D

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Cdx1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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