Gene Symbol | CDKN1C |
Entrez Gene ID | 1028 |
Full Name | cyclin dependent kinase inhibitor 1C |
Synonyms | BWCR,BWS,KIP2,WBS,p57,p57Kip2 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]. |
Disorder MIM: | |
Disorder Html: | Beckwith-Wiedemann syndrome, 130650 (3); IMAGE syndrome, 614732 (3) |