| Gene Symbol | selenop |
| Entrez Gene ID | 352931 |
| Full Name | selenoprotein P |
| Synonyms | SePPa,SelPa,cb688,sepp1a,wu:fa55a04,wu:fb38a09,wu:fj79f04 |
| General protein information |
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| Gene Type | protein-coding |
| Organism | Danio rerio(zebrafish) |
| Summary | This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma in mammals. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (17 in zebrafish), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. A paralog of this gene exists on chromosome 2 (GeneID:791479). [provided by RefSeq, Aug 2017]. |
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