SELENOP cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	SELENOP
Entrez Gene ID	282066
Full Name	selenoprotein P
Synonyms	SELP,SEPP1
Gene Type	protein-coding
Organism	Bos taurus(cattle)
Summary	This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (12 in cow), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. [provided by RefSeq, Feb 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_174459.3	NP_776884.2	selenoprotein P precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Sepp1	NP_001036078.1
Rattus norvegicus (Norway rat)	Sepp1	NP_001077380.1
Homo sapiens (human)	SEPP1	NP_005401.3
Gallus gallus (chicken)	SEPP1	NP_001026780.2
Bos taurus (cattle)	SEPP1	NP_776884.2
	SEPP1	NP_001152962.1
Canis lupus familiaris (dog)	SEPP1	NP_001108590.1
Danio rerio (zebrafish)	sepp1a	NP_840082.2
Pan troglodytes (chimpanzee)	SEPP1	NP_001108587.1
Xenopus tropicalis (tropical clawed frog)	sepp1	NP_001186813.1

Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Composition and evolution of the vertebrate and mammalian selenoproteomes.
Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
PloS one7(3)e33066(2012)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Characterization of mammalian selenoproteomes.
Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guig? R, Gladyshev VN
Science (New York, N.Y.)300(5624)1439-43(2003 May)

Analysis of bovine selenoprotein P-like protein gene and availability of metal responsive element (MRE) located in its promoter.
Fujii M, Saijoh K, Kobayashi T, Fujii S, Lee MJ, Sumino K
Gene199(1-2)211-7(1997 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SELENOP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SELENOP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa43242	NM_174459.3 Latest version!	Bos taurus selenoprotein P (SELENOP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SELENOP ( NM_174459.3 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776884.2 Bos taurus selenoprotein P (SELENOP), mRNA.

Price & Availability↑

CloneID	OBa43242
Clone ID Related Accession (Same CDS sequence)	NM_174459.3
Accession Version	NM_174459.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1209bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Bos taurus(cattle)
Product	selenoprotein P precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB532844.1, EE223056.1, CN787575.1, DT819005.1 and AJ690193.1. On Aug 31, 2007 this sequence version replaced NM_174459.2. ##Evidence-Data-START## Transcript exon combination :: CB532844.1, DV884327.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 7637580 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGAGAG GCCTGGGGCT GGCTCTGGCT CTCTGCCTCC TCCTAACCGG AGGGACAGAG 
AGCCAGGGCC AAAGCTCCTA TTGTAAGCAA CCTCCACCCT GGAGCATAAA GGATCAAGAC 
CCTATGCTGA ACTCCTACGG TTCAGTGACT GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
CTGTGCATTC TGCAGGCATC TAGATTGGAG GACCTGCGAG TAAAACTGGA GAAAGAAGGA 
TATTCTAACA TCTCCTATGT TGTTGTTAAT CATCAAGGAA TCTCTTCTCG ATTAAAATAT 
GTGCATCTTA AAAATAAGGT TTCAGAACAT ATTCCTGTTT ACCAACAAGA AGAAAACCAA 
CCAGATGTCT GGACTCTCTT AAATGGAAAC AAAGATGACT TCCTCATATA TGACAGATGT 
GGCCGCCTTG TATATCATCT TGGTTTGCCT TATTCCTTCC TAACTTTCAC ATATGTAGAA 
GATTCCATTA AGACTGTTTA CTGTGAAGAT AAATGTGGAA ACTGCTCTCT CAAGGCACTG 
GAAGATGAAG ACGTCTGTAA AAATGTATTT CTGGCTACCA AGGAGAAAAC AGCTGAGGCT 
TCACAGCGAC ATCACCACCC CCACCCCCAC TCCCACCCCC ACCCCCACCC CCATCCCCAT 
CCCCACCCCC ACCCCCATCC CCATCATGGG CATCAGCTTC ATGAAAATGC TCATCTTTCA 
GAGTCTCCAA AACCAGACAC ACCAGATACC CCTGAGAATC CCCCTCCTTC AGGTCTTCAT 
CACCACCACC ACAGGCACAA GGGTCCCCAA AGACAGGGTC ACTCAGATAA CTGTGATACA 
CCAGTAGGAA GTGAAAGTTT ACAACCTTCT CTTCCACAAA AGAAGCTCTG ACGAAAGAGA 
TGCATAAATC AGTTACTCTG ACAGTTTCCC AAAGATTCAG AATCTGCTTT GAGTAGCTGC 
TGTTGCCACT GTCGACATCT GGTATTTGAA AAAACAGGGT CTGCAATCAC CTGACAGTGT 
ACAGAAAAGC TCCCCTCTTT GTGTAGCTGA CAGGGCCTTT TGGCGGAGGA GAATGTCATT 
GAATCTTGAC AGTGACGTTT GCCTCCAGCT GCCTGACAGG CAGCAGGTCA GCAGCTCAAC 
CCCACAGAAG CCAGCACCAA GTGAAGCTGA AAAAATAAGG CCAAAATGTG AAAATGACCT 
TCAAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776884.2
CDS	173..1381
Translation	MWRGLGLALALCLLLTGGTESQGQSSYCKQPPPWSIKDQDPMLNSYGSVTVVALLQASYLCILQASRLEDLRVKLEKEGYSNISYVVVNHQGISSRLKYVHLKNKVSEHIPVYQQEENQPDVWTLLNGNKDDFLIYDRCGRLVYHLGLPYSFLTFTYVEDSIKTVYCEDKCGNCSLKALEDEDVCKNVFLATKEKTAEASQRHHHPHPHSHPHPHPHPHPHPHPHPHHGHQLHENAHLSESPKPDTPDTPENPPPSGLHHHHHRHKGPQRQGHSDNCDTPVGSESLQPSLPQKKLRKRCINQLLQFPKDSESALSSCCCHCRHLVFEKTGSAITQCTEKLPSLCSQGLLAEENVIESQRLPPAAQAAGQQLNPTEASTKSKNKAKMKPSN

Target ORF information:

RefSeq Version	NM_174459.3
Organism	Bos taurus(cattle)
Definition	Bos taurus selenoprotein P (SELENOP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174459.3

ORF Insert Sequence:

ATGTGGAGAG GCCTGGGGCT GGCTCTGGCT CTCTGCCTCC TCCTAACCGG AGGGACAGAG 
AGCCAGGGCC AAAGCTCCTA TTGTAAGCAA CCTCCACCCT GGAGCATAAA GGATCAAGAC 
CCTATGCTGA ACTCCTACGG TTCAGTGACT GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
CTGTGCATTC TGCAGGCATC TAGATTGGAG GACCTGCGAG TAAAACTGGA GAAAGAAGGA 
TATTCTAACA TCTCCTATGT TGTTGTTAAT CATCAAGGAA TCTCTTCTCG ATTAAAATAT 
GTGCATCTTA AAAATAAGGT TTCAGAACAT ATTCCTGTTT ACCAACAAGA AGAAAACCAA 
CCAGATGTCT GGACTCTCTT AAATGGAAAC AAAGATGACT TCCTCATATA TGACAGATGT 
GGCCGCCTTG TATATCATCT TGGTTTGCCT TATTCCTTCC TAACTTTCAC ATATGTAGAA 
GATTCCATTA AGACTGTTTA CTGTGAAGAT AAATGTGGAA ACTGCTCTCT CAAGGCACTG 
GAAGATGAAG ACGTCTGTAA AAATGTATTT CTGGCTACCA AGGAGAAAAC AGCTGAGGCT 
TCACAGCGAC ATCACCACCC CCACCCCCAC TCCCACCCCC ACCCCCACCC CCATCCCCAT 
CCCCACCCCC ACCCCCATCC CCATCATGGG CATCAGCTTC ATGAAAATGC TCATCTTTCA 
GAGTCTCCAA AACCAGACAC ACCAGATACC CCTGAGAATC CCCCTCCTTC AGGTCTTCAT 
CACCACCACC ACAGGCACAA GGGTCCCCAA AGACAGGGTC ACTCAGATAA CTGTGATACA 
CCAGTAGGAA GTGAAAGTTT ACAACCTTCT CTTCCACAAA AGAAGCTCTG ACGAAAGAGA 
TGCATAAATC AGTTACTCTG ACAGTTTCCC AAAGATTCAG AATCTGCTTT GAGTAGCTGC 
TGTTGCCACT GTCGACATCT GGTATTTGAA AAAACAGGGT CTGCAATCAC CTGACAGTGT 
ACAGAAAAGC TCCCCTCTTT GTGTAGCTGA CAGGGCCTTT TGGCGGAGGA GAATGTCATT 
GAATCTTGAC AGTGACGTTT GCCTCCAGCT GCCTGACAGG CAGCAGGTCA GCAGCTCAAC 
CCCACAGAAG CCAGCACCAA GTGAAGCTGA AAAAATAAGG CCAAAATGTG AAAATGACCT 
TCAAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Composition and evolution of the vertebrate and mammalian selenoproteomes.
PloS one7(3)e33066(2012)
Mariotti M,Ridge PG,Zhang Y,Lobanov AV,Pringle TH,Guigo R,Hatfield DL,Gladyshev VN

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Characterization of mammalian selenoproteomes.
Science (New York, N.Y.)300(5624)1439-43(2003 May)
Kryukov GV,Castellano S,Novoselov SV,Lobanov AV,Zehtab O,Guig? R,Gladyshev VN

Analysis of bovine selenoprotein P-like protein gene and availability of metal responsive element (MRE) located in its promoter.
Gene199(1-2)211-7(1997 Oct)
Fujii M,Saijoh K,Kobayashi T,Fujii S,Lee MJ,Sumino K

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SELENOP cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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