Selenop cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Selenop
Entrez Gene ID	29360
Full Name	selenoprotein P
Synonyms	Sepp1
General protein information	Preferred Names selenoprotein P Names selenoprotein P seP selenoprotein P, plasma, 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q16
Summary	This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in rat), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001083911.1	NP_001077380.1	selenoprotein P precursor
NM_019192.2	NP_062065.2	selenoprotein P precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Sepp1	NP_001036078.1
Rattus norvegicus (Norway rat)	Sepp1	NP_001077380.1
Homo sapiens (human)	SEPP1	NP_005401.3
Gallus gallus (chicken)	SEPP1	NP_001026780.2
Bos taurus (cattle)	SEPP1	NP_776884.2
	SEPP1	NP_001152962.1
Canis lupus familiaris (dog)	SEPP1	NP_001108590.1
Danio rerio (zebrafish)	sepp1a	NP_840082.2
Pan troglodytes (chimpanzee)	SEPP1	NP_001108587.1
Xenopus tropicalis (tropical clawed frog)	sepp1	NP_001186813.1

Gene Ontology
Bibliography

Related articles in PubMed

Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes.
Tajima-Shirasaki N, Ishii KA, Takayama H, Shirasaki T, Iwama H, Chikamoto K, Saito Y, Iwasaki Y, Teraguchi A, Lan F, Kikuchi A, Takeshita Y, Murao K, Matsugo S, Kaneko S, Misu H, Takamura T
The Journal of biological chemistry292(26)10791-10800(2017 06)

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Regulation of selenocysteine incorporation into the selenium transport protein, selenoprotein P.
Shetty SP, Shah R, Copeland PR
The Journal of biological chemistry289(36)25317-26(2014 Sep)

Secisbp2 is essential for embryonic development and enhances selenoprotein expression.
Seeher S, Atassi T, Mahdi Y, Carlson BA, Braun D, Wirth EK, Klein MO, Reix N, Miniard AC, Schomburg L, Hatfield DL, Driscoll DM, Schweizer U
Antioxidants & redox signaling21(6)835-49(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A chromatin immunoprecipitation (ChIP) assay revealed that EPA decreases binding of SREBP-1c to the SELENOP promoter. Knockdown of Srebf1 resulted in a significant down-regulation of Selenop expression.
Title: Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes.

Data indicate that Selenoprotein P SEPP1 processivity is intrinsic, but efficiency is governed by selenium levels.
Title: Regulation of selenocysteine incorporation into the selenium transport protein, selenoprotein P.

metformin decreases binding of FoxO3a, a direct target of AMPK, to the SEPP1 promoter.
Title: Metformin suppresses expression of the selenoprotein P gene via an AMP-activated kinase (AMPK)/FoxO3a pathway in H4IIEC3 hepatocytes.

Sepp1 secreted from epithelial cells may support the intestinal immune system by providing immune cells (including plasma cells) with selenium
Title: Intestinal selenoprotein P in epithelial cells and in plasma cells.

apoER2-mediated uptake of long isoform Sepp1 is responsible for selenium distribution to tissues throughout the body.
Title: Long isoform mouse selenoprotein P (Sepp1) supplies rat myoblast L8 cells with selenium via endocytosis mediated by heparin binding properties and apolipoprotein E receptor-2 (ApoER2).

The following Selenop gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Selenop cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12521	NM_001083911.1 Latest version!	Rattus norvegicus selenoprotein P (Selenop), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa12521	NM_019192.2 Latest version!	Rattus norvegicus selenoprotein P (Selenop), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Selenop ( NM_001083911.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001077380.1 Rattus norvegicus selenoprotein P (Selenop), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa12521
Clone ID Related Accession (Same CDS sequence)	NM_001083911.1 , NM_019192.2
Accession Version	NM_001083911.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1158bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-30
Organism	Rattus norvegicus(Norway rat)
Product	selenoprotein P precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB699091.1, CB745388.1, BC072539.1 and BF389559.1. Transcript Variant: This variant (2, also known as Sepp1b) uses an alternate 5' non-coding exon, hence has a different 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein containing 10 selenocysteine residues. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ241495.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 2037562 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGAGAA GCCTAGGGCT TGCCCTGGCT CTCTGTCTCC TCCCCTATGG AGGAGCAGAG 
AGCCAAGGCC AAAGCCCTGC TTGTAAGCAA GCTCCACCCT GGAACATAGG AGATCAAAAT 
CCAATGCTAA ACTCCGAGGG CACAGTGACA GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
CTGTGCCTTC TGCAGGCATC CAGATTGGAA GACCTGCGAA TAAAACTAGA GAACCAAGGA 
TATTTTAACA TCTCCTATAT TGTTGTTAAT CATCAAGGAT CTCCTTCCCA ATTAAAACAT 
GCACATCTTA AAAAGCAGGT GTCAGATCAC ATTGCTGTTT ACAGACAAGA TGAACATCAA 
ACAGATGTCT GGACACTCTT AAATGGAAAC AAAGATGACT TCCTCATATA TGACAGATGT 
GGCCGTCTTG TGTATCACCT TGGTTTGCCC TACTCCTTCC TCACTTTCCC GTATGTTGAA 
GAAGCCATCA AGATCGCTTA CTGTGAGAAG AGGTGTGGAA ACTGCTCTTT CACGAGTCTT 
GAAGATGAAG CCTTCTGTAA AAACGTGTCC TCGGCTACTG CAAGTAAAAC CACAGAGCCC 
TCAGAGGAGC ATAACCACCA CAAGCACCAT GACAAACATG GGCATGAGCA TCTTGGGAGC 
AGTAAGCCTT CAGAGAATCA GCAACCAGGG GCATTAGATG TTGAGACAAG TCTTCCTCCT 
TCAGGCTTGC ACCACCACCA CCACCACCAT AAGCACAAGG GCCAGCACAG GCAGGGTCAC 
TTAGAGAGCT GAGACATGGG GGCAAGTGAA GGCTTGCAAC TTTCACTTGC CCAGAGGAAG 
CTCTGACGAA GGGGATGCAT AAACCAGCTC CTGTGTAAGT TATCTGAGGA GTCTGGGGCA 
GCTACCAGTA GCTGCTGCTG CCACTGCCGA CACCTCATAT TTGAGAAGTC AGGATCTGCA 
ATCACTTGAC AGTGTGCCGA AAACCTCCCA TCCTTGTGTA GCTGACAGGG GCTTTTCGCG 
GAGGAGAAAG TCATTGAATC CTGTCAATGT AGATCACCTC CAGCTGCCTG ACACAGTCAG 
CATGTAAGCC CCACAGAAGC CAGCCCCAAC TGAAGCTGAA ATAATAAGAC CAAGAAGTGA 
AAATGAAATT TGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001077380.1
CDS	147..1304
Translation	MWRSLGLALALCLLPYGGAESQGQSPACKQAPPWNIGDQNPMLNSEGTVTVVALLQASYLCLLQASRLEDLRIKLENQGYFNISYIVVNHQGSPSQLKHAHLKKQVSDHIAVYRQDEHQTDVWTLLNGNKDDFLIYDRCGRLVYHLGLPYSFLTFPYVEEAIKIAYCEKRCGNCSFTSLEDEAFCKNVSSATASKTTEPSEEHNHHKHHDKHGHEHLGSSKPSENQQPGALDVETSLPPSGLHHHHHHHKHKGQHRQGHLESDMGASEGLQLSLAQRKLRRGCINQLLCKLSEESGAATSSCCCHCRHLIFEKSGSAITQCAENLPSLCSQGLFAEEKVIESCQCRSPPAAHSQHVSPTEASPNSNNKTKKKNLN

Target ORF information:

RefSeq Version	NM_001083911.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus selenoprotein P (Selenop), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001083911.1

ORF Insert Sequence:

ATGTGGAGAA GCCTAGGGCT TGCCCTGGCT CTCTGTCTCC TCCCCTATGG AGGAGCAGAG 
AGCCAAGGCC AAAGCCCTGC TTGTAAGCAA GCTCCACCCT GGAACATAGG AGATCAAAAT 
CCAATGCTAA ACTCCGAGGG CACAGTGACA GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
CTGTGCCTTC TGCAGGCATC CAGATTGGAA GACCTGCGAA TAAAACTAGA GAACCAAGGA 
TATTTTAACA TCTCCTATAT TGTTGTTAAT CATCAAGGAT CTCCTTCCCA ATTAAAACAT 
GCACATCTTA AAAAGCAGGT GTCAGATCAC ATTGCTGTTT ACAGACAAGA TGAACATCAA 
ACAGATGTCT GGACACTCTT AAATGGAAAC AAAGATGACT TCCTCATATA TGACAGATGT 
GGCCGTCTTG TGTATCACCT TGGTTTGCCC TACTCCTTCC TCACTTTCCC GTATGTTGAA 
GAAGCCATCA AGATCGCTTA CTGTGAGAAG AGGTGTGGAA ACTGCTCTTT CACGAGTCTT 
GAAGATGAAG CCTTCTGTAA AAACGTGTCC TCGGCTACTG CAAGTAAAAC CACAGAGCCC 
TCAGAGGAGC ATAACCACCA CAAGCACCAT GACAAACATG GGCATGAGCA TCTTGGGAGC 
AGTAAGCCTT CAGAGAATCA GCAACCAGGG GCATTAGATG TTGAGACAAG TCTTCCTCCT 
TCAGGCTTGC ACCACCACCA CCACCACCAT AAGCACAAGG GCCAGCACAG GCAGGGTCAC 
TTAGAGAGCT GAGACATGGG GGCAAGTGAA GGCTTGCAAC TTTCACTTGC CCAGAGGAAG 
CTCTGACGAA GGGGATGCAT AAACCAGCTC CTGTGTAAGT TATCTGAGGA GTCTGGGGCA 
GCTACCAGTA GCTGCTGCTG CCACTGCCGA CACCTCATAT TTGAGAAGTC AGGATCTGCA 
ATCACTTGAC AGTGTGCCGA AAACCTCCCA TCCTTGTGTA GCTGACAGGG GCTTTTCGCG 
GAGGAGAAAG TCATTGAATC CTGTCAATGT AGATCACCTC CAGCTGCCTG ACACAGTCAG 
CATGTAAGCC CCACAGAAGC CAGCCCCAAC TGAAGCTGAA ATAATAAGAC CAAGAAGTGA 
AAATGAAATT TGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Selenop ( NM_019192.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062065.2 Rattus norvegicus selenoprotein P (Selenop), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa12521
Clone ID Related Accession (Same CDS sequence)	NM_001083911.1 , NM_019192.2
Accession Version	NM_019192.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1158bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-30
Organism	Rattus norvegicus(Norway rat)
Product	selenoprotein P precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DN933732.1, BC072539.1 and BF389559.1. On Apr 11, 2007 this sequence version replaced NM_019192.1. Transcript Variant: This variant (1, also known as Sepp1a) represents the predominant transcript. Variants 1 and 2 encode the same protein containing 10 selenocysteine residues. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ110608.1, BC072539.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 2037562 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGAGAA GCCTAGGGCT TGCCCTGGCT CTCTGTCTCC TCCCCTATGG AGGAGCAGAG 
AGCCAAGGCC AAAGCCCTGC TTGTAAGCAA GCTCCACCCT GGAACATAGG AGATCAAAAT 
CCAATGCTAA ACTCCGAGGG CACAGTGACA GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
CTGTGCCTTC TGCAGGCATC CAGATTGGAA GACCTGCGAA TAAAACTAGA GAACCAAGGA 
TATTTTAACA TCTCCTATAT TGTTGTTAAT CATCAAGGAT CTCCTTCCCA ATTAAAACAT 
GCACATCTTA AAAAGCAGGT GTCAGATCAC ATTGCTGTTT ACAGACAAGA TGAACATCAA 
ACAGATGTCT GGACACTCTT AAATGGAAAC AAAGATGACT TCCTCATATA TGACAGATGT 
GGCCGTCTTG TGTATCACCT TGGTTTGCCC TACTCCTTCC TCACTTTCCC GTATGTTGAA 
GAAGCCATCA AGATCGCTTA CTGTGAGAAG AGGTGTGGAA ACTGCTCTTT CACGAGTCTT 
GAAGATGAAG CCTTCTGTAA AAACGTGTCC TCGGCTACTG CAAGTAAAAC CACAGAGCCC 
TCAGAGGAGC ATAACCACCA CAAGCACCAT GACAAACATG GGCATGAGCA TCTTGGGAGC 
AGTAAGCCTT CAGAGAATCA GCAACCAGGG GCATTAGATG TTGAGACAAG TCTTCCTCCT 
TCAGGCTTGC ACCACCACCA CCACCACCAT AAGCACAAGG GCCAGCACAG GCAGGGTCAC 
TTAGAGAGCT GAGACATGGG GGCAAGTGAA GGCTTGCAAC TTTCACTTGC CCAGAGGAAG 
CTCTGACGAA GGGGATGCAT AAACCAGCTC CTGTGTAAGT TATCTGAGGA GTCTGGGGCA 
GCTACCAGTA GCTGCTGCTG CCACTGCCGA CACCTCATAT TTGAGAAGTC AGGATCTGCA 
ATCACTTGAC AGTGTGCCGA AAACCTCCCA TCCTTGTGTA GCTGACAGGG GCTTTTCGCG 
GAGGAGAAAG TCATTGAATC CTGTCAATGT AGATCACCTC CAGCTGCCTG ACACAGTCAG 
CATGTAAGCC CCACAGAAGC CAGCCCCAAC TGAAGCTGAA ATAATAAGAC CAAGAAGTGA 
AAATGAAATT TGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062065.2
CDS	75..1232
Translation	MWRSLGLALALCLLPYGGAESQGQSPACKQAPPWNIGDQNPMLNSEGTVTVVALLQASYLCLLQASRLEDLRIKLENQGYFNISYIVVNHQGSPSQLKHAHLKKQVSDHIAVYRQDEHQTDVWTLLNGNKDDFLIYDRCGRLVYHLGLPYSFLTFPYVEEAIKIAYCEKRCGNCSFTSLEDEAFCKNVSSATASKTTEPSEEHNHHKHHDKHGHEHLGSSKPSENQQPGALDVETSLPPSGLHHHHHHHKHKGQHRQGHLESDMGASEGLQLSLAQRKLRRGCINQLLCKLSEESGAATSSCCCHCRHLIFEKSGSAITQCAENLPSLCSQGLFAEEKVIESCQCRSPPAAHSQHVSPTEASPNSNNKTKKKNLN

Target ORF information:

RefSeq Version	NM_019192.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus selenoprotein P (Selenop), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019192.2

ORF Insert Sequence:

ATGTGGAGAA GCCTAGGGCT TGCCCTGGCT CTCTGTCTCC TCCCCTATGG AGGAGCAGAG 
AGCCAAGGCC AAAGCCCTGC TTGTAAGCAA GCTCCACCCT GGAACATAGG AGATCAAAAT 
CCAATGCTAA ACTCCGAGGG CACAGTGACA GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
CTGTGCCTTC TGCAGGCATC CAGATTGGAA GACCTGCGAA TAAAACTAGA GAACCAAGGA 
TATTTTAACA TCTCCTATAT TGTTGTTAAT CATCAAGGAT CTCCTTCCCA ATTAAAACAT 
GCACATCTTA AAAAGCAGGT GTCAGATCAC ATTGCTGTTT ACAGACAAGA TGAACATCAA 
ACAGATGTCT GGACACTCTT AAATGGAAAC AAAGATGACT TCCTCATATA TGACAGATGT 
GGCCGTCTTG TGTATCACCT TGGTTTGCCC TACTCCTTCC TCACTTTCCC GTATGTTGAA 
GAAGCCATCA AGATCGCTTA CTGTGAGAAG AGGTGTGGAA ACTGCTCTTT CACGAGTCTT 
GAAGATGAAG CCTTCTGTAA AAACGTGTCC TCGGCTACTG CAAGTAAAAC CACAGAGCCC 
TCAGAGGAGC ATAACCACCA CAAGCACCAT GACAAACATG GGCATGAGCA TCTTGGGAGC 
AGTAAGCCTT CAGAGAATCA GCAACCAGGG GCATTAGATG TTGAGACAAG TCTTCCTCCT 
TCAGGCTTGC ACCACCACCA CCACCACCAT AAGCACAAGG GCCAGCACAG GCAGGGTCAC 
TTAGAGAGCT GAGACATGGG GGCAAGTGAA GGCTTGCAAC TTTCACTTGC CCAGAGGAAG 
CTCTGACGAA GGGGATGCAT AAACCAGCTC CTGTGTAAGT TATCTGAGGA GTCTGGGGCA 
GCTACCAGTA GCTGCTGCTG CCACTGCCGA CACCTCATAT TTGAGAAGTC AGGATCTGCA 
ATCACTTGAC AGTGTGCCGA AAACCTCCCA TCCTTGTGTA GCTGACAGGG GCTTTTCGCG 
GAGGAGAAAG TCATTGAATC CTGTCAATGT AGATCACCTC CAGCTGCCTG ACACAGTCAG 
CATGTAAGCC CCACAGAAGC CAGCCCCAAC TGAAGCTGAA ATAATAAGAC CAAGAAGTGA 
AAATGAAATT TGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes.
The Journal of biological chemistry292(26)10791-10800(2017 06)
Tajima-Shirasaki N,Ishii KA,Takayama H,Shirasaki T,Iwama H,Chikamoto K,Saito Y,Iwasaki Y,Teraguchi A,Lan F,Kikuchi A,Takeshita Y,Murao K,Matsugo S,Kaneko S,Misu H,Takamura T

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Regulation of selenocysteine incorporation into the selenium transport protein, selenoprotein P.
The Journal of biological chemistry289(36)25317-26(2014 Sep)
Shetty SP,Shah R,Copeland PR

Secisbp2 is essential for embryonic development and enhances selenoprotein expression.
Antioxidants & redox signaling21(6)835-49(2014 Aug)
Seeher S,Atassi T,Mahdi Y,Carlson BA,Braun D,Wirth EK,Klein MO,Reix N,Miniard AC,Schomburg L,Hatfield DL,Driscoll DM,Schweizer U

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Selenop cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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