Selenop cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Selenop
Entrez Gene ID	20363
Full Name	selenoprotein P
Synonyms	AU018766,D15Ucla1,Se-P,Sepp1,selp
General protein information	Preferred Names selenoprotein P Names selenoprotein P plasma selenoprotein P seP selenoprotein P, plasma, 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15 A1\|15 1.84 cM
Summary	This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in mouse), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. Alternatively spliced transcript variants differing in 5' non-coding region have been described for this gene. Expression of these variants varies in different tissues and developmental stages (PMID:23064117). [provided by RefSeq, Feb 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001042614.2	NP_001036079.1	selenoprotein P precursor
NM_009155.4	NP_033181.3	selenoprotein P precursor
NM_001042613.2	NP_001036078.1	selenoprotein P precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Sepp1	NP_001036078.1
Rattus norvegicus (Norway rat)	Sepp1	NP_001077380.1
Homo sapiens (human)	SEPP1	NP_005401.3
Gallus gallus (chicken)	SEPP1	NP_001026780.2
Bos taurus (cattle)	SEPP1	NP_776884.2
	SEPP1	NP_001152962.1
Canis lupus familiaris (dog)	SEPP1	NP_001108590.1
Danio rerio (zebrafish)	sepp1a	NP_840082.2
Pan troglodytes (chimpanzee)	SEPP1	NP_001108587.1
Xenopus tropicalis (tropical clawed frog)	sepp1	NP_001186813.1

Gene Ontology
Bibliography

Related articles in PubMed

Multiple RNA structures affect translation initiation and UGA redefinition efficiency during synthesis of selenoprotein P.
Mariotti M, Shetty S, Baird L, Wu S, Loughran G, Copeland PR, Atkins JF, Howard MT
Nucleic acids research45(22)13004-13015(2017 Dec)

Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle.
Misu H, Takayama H, Saito Y, Mita Y, Kikuchi A, Ishii KA, Chikamoto K, Kanamori T, Tajima N, Lan F, Takeshita Y, Honda M, Tanaka M, Kato S, Matsuyama N, Yoshioka Y, Iwayama K, Tokuyama K, Akazawa N, Maeda S, Takekoshi K, Matsugo S, Noguchi N, Kaneko S, Takamura T
Nature medicine23(4)508-516(2017 Apr)

Expression and regulation of mouse selenoprotein P transcript variants differing in non-coding RNA.
Dewing AS, Rueli RH, Robles MJ, Nguyen-Wu ED, Zeyda T, Berry MJ, Bellinger FP
RNA biology9(11)1361-9(2012 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results indicate a diversity of RNA elements conducting multiple occurrences of UGA redefinition to control the synthesis of full-length and truncated selenoprotein P (SELENOP) isoforms.
Title: Multiple RNA structures affect translation initiation and UGA redefinition efficiency during synthesis of selenoprotein P.

SeP causes exercise resistance through its muscle receptor low-density lipoprotein receptor-related protein 1 (LRP1). SeP-deficient mice showed a 'super-endurance' phenotype after exercise training, as well as enhanced reactive oxygen species production, AMPK phosphorylation and Ppargc-1alpha expression in skeletal muscle.
Title: Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle.

Through correlational analysis, it was determined that the effects of Se-supplement were closely related to SelP expression, inflammatory cytokines, and apoptosis molecule production.
Title: Protective Action of Se-Supplement Against Acute Alcoholism Is Regulated by Selenoprotein P (SelP) in the Liver.

Study suggests the 3' UTR structural elements (SECIS) in Sepp1 functions with site specificity and further illustrates how mRNA processing may produce transcripts with altered coding potential to produce diversity in selenoprotein isoforms.
Title: Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements.

This study showed that Male mice lacking two key genes involved in Se metabolism (Scly(-/-)Sepp1(-/-) mice), selenoprotein P (Sepp1) and Sec lyase (Scly), develop severe neurological dysfunction, neurodegeneration, and audiogenic seizures.
Title: Competition between the Brain and Testes under Selenium-Compromised Conditions: Insight into Sex Differences in Selenium Metabolism and Risk of Neurodevelopmental Disease.

The following Selenop gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Selenop cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu22667	NM_001042614.2 Latest version!	Mus musculus selenoprotein P (Selenop), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu22667	NM_001042613.2 Latest version!	Mus musculus selenoprotein P (Selenop), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu22667	NM_009155.4 Latest version!	Mus musculus selenoprotein P (Selenop), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Selenop ( NM_001042614.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001036079.1 Mus musculus selenoprotein P (Selenop), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu22667
Clone ID Related Accession (Same CDS sequence)	NM_001042614.2 , NM_009155.4 , NM_001042613.2
Accession Version	NM_001042614.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1143bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-11
Organism	Mus musculus(house mouse)
Product	selenoprotein P precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI892015.1, AK002450.1 and AA153204.1. On Feb 13, 2017 this sequence version replaced NM_001042614.1. Transcript Variant: This variant (3, also known as Sepp1c) uses an alternate 5' non-coding exon, hence has a different 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein containing 10 selenocysteine residues. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI452539.1, BE374601.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 9288402 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGAGAA GCCTAGGGCT TGCCCTGGCT CTCTGTCTCC TCCCCTATGG AGGAGCAGAG 
AGCCAAGGCC AAAGCTCTGC TTGTTACAAA GCCCCGGAGT GGTACATAGG AGATCAAAAT 
CCAATGCTAA ACTCAGAGGG CAAAGTGACA GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
TTGTGTCTTC TGCAGGCATC CAGATTGGAA GACCTGCGCA TAAAACTAGA AAGCCAAGGA 
TATTTTAACA TCTCTTACAT TGTTGTTAAC CATCAAGGAT CTCCTTCCCA ATTAAAACAC 
TCACATCTTA AAAAGCAGGT GTCAGAACAC ATCGCAGTGT ACAGACAAGA AGAAGATGGC 
ATAGATGTCT GGACTCTCTT AAATGGAAAC AAAGATGACT TCCTCATCTA TGACAGATGT 
GGCCGTCTTG TGTATCACCT TGGTTTGCCT TACTCCTTCC TCACATTCCC ATATGTTGAA 
GAAGCCATTA AGATCGCTTA CTGTGAGGAG AGGTGCGGAA ACTGCAATCT CACGAGTCTT 
GAAGATGAAG ACTTCTGTAA AACTGTGACC TCAGCTACTG CCAATAAAAC TGCGGAGCCC 
TCAGAGGCTC ATAGCCACCA CAAACACCAC AACAAACATG GGCAGGAGCA TCTTGGCAGC 
AGTAAGCCTT CAGAGAATCA GCAACCAGGG CCATCAGAGA CGACTCTGCC TCCTTCAGGC 
TTGCACCACC ACCACAGGCA TAGGGGCCAG CACAGGCAGG GTCACTTAGA GAGCTGAGAC 
ACCACAGCAA GTGAAGGCTT GCACCTTTCA CTTGCCCAGA GGAAGCTCTG ACGAAGGGGG 
TGCATCAACC AGCTCCTGTG TAAGTTGTCT AAGGAGTCCG AGGCAGCCCC CAGCAGCTGC 
TGCTGTCACT GCCGCCACCT CATATTTGAG AAGTCAGGGT CTGCAATTGC TTGACAGTGT 
GCGGAAAACC TCCCATCCTT ATGTAGCTGA CAGGGGCTTT TCGCGGAGGA GAAAGTCACT 
GAATCCTGTC AGTGTAGGTC ACCTCCAGCT GCCTGACAAA ATCAGCCCAT GAACCCCATG 
GAAGCCAACC CCAACTGAAG CTGAGATAAT CAGACCAGGA AGTGAAAATG ACATTCAAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001036079.1
CDS	156..1298
Translation	MWRSLGLALALCLLPYGGAESQGQSSACYKAPEWYIGDQNPMLNSEGKVTVVALLQASYLCLLQASRLEDLRIKLESQGYFNISYIVVNHQGSPSQLKHSHLKKQVSEHIAVYRQEEDGIDVWTLLNGNKDDFLIYDRCGRLVYHLGLPYSFLTFPYVEEAIKIAYCEERCGNCNLTSLEDEDFCKTVTSATANKTAEPSEAHSHHKHHNKHGQEHLGSSKPSENQQPGPSETTLPPSGLHHHHRHRGQHRQGHLESDTTASEGLHLSLAQRKLRRGCINQLLCKLSKESEAAPSSCCCHCRHLIFEKSGSAIAQCAENLPSLCSQGLFAEEKVTESCQCRSPPAAQNQPMNPMEANPNSDNQTRKKHSN

Target ORF information:

RefSeq Version	NM_001042614.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus selenoprotein P (Selenop), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001042614.2

ORF Insert Sequence:

ATGTGGAGAA GCCTAGGGCT TGCCCTGGCT CTCTGTCTCC TCCCCTATGG AGGAGCAGAG 
AGCCAAGGCC AAAGCTCTGC TTGTTACAAA GCCCCGGAGT GGTACATAGG AGATCAAAAT 
CCAATGCTAA ACTCAGAGGG CAAAGTGACA GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
TTGTGTCTTC TGCAGGCATC CAGATTGGAA GACCTGCGCA TAAAACTAGA AAGCCAAGGA 
TATTTTAACA TCTCTTACAT TGTTGTTAAC CATCAAGGAT CTCCTTCCCA ATTAAAACAC 
TCACATCTTA AAAAGCAGGT GTCAGAACAC ATCGCAGTGT ACAGACAAGA AGAAGATGGC 
ATAGATGTCT GGACTCTCTT AAATGGAAAC AAAGATGACT TCCTCATCTA TGACAGATGT 
GGCCGTCTTG TGTATCACCT TGGTTTGCCT TACTCCTTCC TCACATTCCC ATATGTTGAA 
GAAGCCATTA AGATCGCTTA CTGTGAGGAG AGGTGCGGAA ACTGCAATCT CACGAGTCTT 
GAAGATGAAG ACTTCTGTAA AACTGTGACC TCAGCTACTG CCAATAAAAC TGCGGAGCCC 
TCAGAGGCTC ATAGCCACCA CAAACACCAC AACAAACATG GGCAGGAGCA TCTTGGCAGC 
AGTAAGCCTT CAGAGAATCA GCAACCAGGG CCATCAGAGA CGACTCTGCC TCCTTCAGGC 
TTGCACCACC ACCACAGGCA TAGGGGCCAG CACAGGCAGG GTCACTTAGA GAGCTGAGAC 
ACCACAGCAA GTGAAGGCTT GCACCTTTCA CTTGCCCAGA GGAAGCTCTG ACGAAGGGGG 
TGCATCAACC AGCTCCTGTG TAAGTTGTCT AAGGAGTCCG AGGCAGCCCC CAGCAGCTGC 
TGCTGTCACT GCCGCCACCT CATATTTGAG AAGTCAGGGT CTGCAATTGC TTGACAGTGT 
GCGGAAAACC TCCCATCCTT ATGTAGCTGA CAGGGGCTTT TCGCGGAGGA GAAAGTCACT 
GAATCCTGTC AGTGTAGGTC ACCTCCAGCT GCCTGACAAA ATCAGCCCAT GAACCCCATG 
GAAGCCAACC CCAACTGAAG CTGAGATAAT CAGACCAGGA AGTGAAAATG ACATTCAAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Selenop ( NM_009155.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033181.3 Mus musculus selenoprotein P (Selenop), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu22667
Clone ID Related Accession (Same CDS sequence)	NM_001042614.2 , NM_009155.4 , NM_001042613.2
Accession Version	NM_009155.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1143bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-11
Organism	Mus musculus(house mouse)
Product	selenoprotein P precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB231357.1, AK002450.1 and AA153204.1. On Feb 13, 2017 this sequence version replaced NM_009155.3. Transcript Variant: This variant (1, also known as Sepp1a) represents the predominant transcript. Variants 1, 2 and 3 encode the same protein containing 10 selenocysteine residues. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001991.1, AK002450.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 9288402 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGAGAA GCCTAGGGCT TGCCCTGGCT CTCTGTCTCC TCCCCTATGG AGGAGCAGAG 
AGCCAAGGCC AAAGCTCTGC TTGTTACAAA GCCCCGGAGT GGTACATAGG AGATCAAAAT 
CCAATGCTAA ACTCAGAGGG CAAAGTGACA GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
TTGTGTCTTC TGCAGGCATC CAGATTGGAA GACCTGCGCA TAAAACTAGA AAGCCAAGGA 
TATTTTAACA TCTCTTACAT TGTTGTTAAC CATCAAGGAT CTCCTTCCCA ATTAAAACAC 
TCACATCTTA AAAAGCAGGT GTCAGAACAC ATCGCAGTGT ACAGACAAGA AGAAGATGGC 
ATAGATGTCT GGACTCTCTT AAATGGAAAC AAAGATGACT TCCTCATCTA TGACAGATGT 
GGCCGTCTTG TGTATCACCT TGGTTTGCCT TACTCCTTCC TCACATTCCC ATATGTTGAA 
GAAGCCATTA AGATCGCTTA CTGTGAGGAG AGGTGCGGAA ACTGCAATCT CACGAGTCTT 
GAAGATGAAG ACTTCTGTAA AACTGTGACC TCAGCTACTG CCAATAAAAC TGCGGAGCCC 
TCAGAGGCTC ATAGCCACCA CAAACACCAC AACAAACATG GGCAGGAGCA TCTTGGCAGC 
AGTAAGCCTT CAGAGAATCA GCAACCAGGG CCATCAGAGA CGACTCTGCC TCCTTCAGGC 
TTGCACCACC ACCACAGGCA TAGGGGCCAG CACAGGCAGG GTCACTTAGA GAGCTGAGAC 
ACCACAGCAA GTGAAGGCTT GCACCTTTCA CTTGCCCAGA GGAAGCTCTG ACGAAGGGGG 
TGCATCAACC AGCTCCTGTG TAAGTTGTCT AAGGAGTCCG AGGCAGCCCC CAGCAGCTGC 
TGCTGTCACT GCCGCCACCT CATATTTGAG AAGTCAGGGT CTGCAATTGC TTGACAGTGT 
GCGGAAAACC TCCCATCCTT ATGTAGCTGA CAGGGGCTTT TCGCGGAGGA GAAAGTCACT 
GAATCCTGTC AGTGTAGGTC ACCTCCAGCT GCCTGACAAA ATCAGCCCAT GAACCCCATG 
GAAGCCAACC CCAACTGAAG CTGAGATAAT CAGACCAGGA AGTGAAAATG ACATTCAAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033181.3
CDS	90..1232
Translation	MWRSLGLALALCLLPYGGAESQGQSSACYKAPEWYIGDQNPMLNSEGKVTVVALLQASYLCLLQASRLEDLRIKLESQGYFNISYIVVNHQGSPSQLKHSHLKKQVSEHIAVYRQEEDGIDVWTLLNGNKDDFLIYDRCGRLVYHLGLPYSFLTFPYVEEAIKIAYCEERCGNCNLTSLEDEDFCKTVTSATANKTAEPSEAHSHHKHHNKHGQEHLGSSKPSENQQPGPSETTLPPSGLHHHHRHRGQHRQGHLESDTTASEGLHLSLAQRKLRRGCINQLLCKLSKESEAAPSSCCCHCRHLIFEKSGSAIAQCAENLPSLCSQGLFAEEKVTESCQCRSPPAAQNQPMNPMEANPNSDNQTRKKHSN

Target ORF information:

RefSeq Version	NM_009155.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus selenoprotein P (Selenop), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009155.4

ORF Insert Sequence:

ATGTGGAGAA GCCTAGGGCT TGCCCTGGCT CTCTGTCTCC TCCCCTATGG AGGAGCAGAG 
AGCCAAGGCC AAAGCTCTGC TTGTTACAAA GCCCCGGAGT GGTACATAGG AGATCAAAAT 
CCAATGCTAA ACTCAGAGGG CAAAGTGACA GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
TTGTGTCTTC TGCAGGCATC CAGATTGGAA GACCTGCGCA TAAAACTAGA AAGCCAAGGA 
TATTTTAACA TCTCTTACAT TGTTGTTAAC CATCAAGGAT CTCCTTCCCA ATTAAAACAC 
TCACATCTTA AAAAGCAGGT GTCAGAACAC ATCGCAGTGT ACAGACAAGA AGAAGATGGC 
ATAGATGTCT GGACTCTCTT AAATGGAAAC AAAGATGACT TCCTCATCTA TGACAGATGT 
GGCCGTCTTG TGTATCACCT TGGTTTGCCT TACTCCTTCC TCACATTCCC ATATGTTGAA 
GAAGCCATTA AGATCGCTTA CTGTGAGGAG AGGTGCGGAA ACTGCAATCT CACGAGTCTT 
GAAGATGAAG ACTTCTGTAA AACTGTGACC TCAGCTACTG CCAATAAAAC TGCGGAGCCC 
TCAGAGGCTC ATAGCCACCA CAAACACCAC AACAAACATG GGCAGGAGCA TCTTGGCAGC 
AGTAAGCCTT CAGAGAATCA GCAACCAGGG CCATCAGAGA CGACTCTGCC TCCTTCAGGC 
TTGCACCACC ACCACAGGCA TAGGGGCCAG CACAGGCAGG GTCACTTAGA GAGCTGAGAC 
ACCACAGCAA GTGAAGGCTT GCACCTTTCA CTTGCCCAGA GGAAGCTCTG ACGAAGGGGG 
TGCATCAACC AGCTCCTGTG TAAGTTGTCT AAGGAGTCCG AGGCAGCCCC CAGCAGCTGC 
TGCTGTCACT GCCGCCACCT CATATTTGAG AAGTCAGGGT CTGCAATTGC TTGACAGTGT 
GCGGAAAACC TCCCATCCTT ATGTAGCTGA CAGGGGCTTT TCGCGGAGGA GAAAGTCACT 
GAATCCTGTC AGTGTAGGTC ACCTCCAGCT GCCTGACAAA ATCAGCCCAT GAACCCCATG 
GAAGCCAACC CCAACTGAAG CTGAGATAAT CAGACCAGGA AGTGAAAATG ACATTCAAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Selenop ( NM_001042613.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001036078.1 Mus musculus selenoprotein P (Selenop), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu22667
Clone ID Related Accession (Same CDS sequence)	NM_001042614.2 , NM_009155.4 , NM_001042613.2
Accession Version	NM_001042613.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1143bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-11
Organism	Mus musculus(house mouse)
Product	selenoprotein P precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CK627189.1, AK002450.1 and AA153204.1. On Feb 13, 2017 this sequence version replaced NM_001042613.1. Transcript Variant: This variant (2, also known as Sepp1b) uses an alternate 5' non-coding exon, hence has a different 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein containing 10 selenocysteine residues. Variant Sepp1b is specifically localized to the hippocampus in the brain, and is a specific target for regulation by miR-7 microRNA (PMID:23064117). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CK627189.1, SRR1660815.130375.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 9288402 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGAGAA GCCTAGGGCT TGCCCTGGCT CTCTGTCTCC TCCCCTATGG AGGAGCAGAG 
AGCCAAGGCC AAAGCTCTGC TTGTTACAAA GCCCCGGAGT GGTACATAGG AGATCAAAAT 
CCAATGCTAA ACTCAGAGGG CAAAGTGACA GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
TTGTGTCTTC TGCAGGCATC CAGATTGGAA GACCTGCGCA TAAAACTAGA AAGCCAAGGA 
TATTTTAACA TCTCTTACAT TGTTGTTAAC CATCAAGGAT CTCCTTCCCA ATTAAAACAC 
TCACATCTTA AAAAGCAGGT GTCAGAACAC ATCGCAGTGT ACAGACAAGA AGAAGATGGC 
ATAGATGTCT GGACTCTCTT AAATGGAAAC AAAGATGACT TCCTCATCTA TGACAGATGT 
GGCCGTCTTG TGTATCACCT TGGTTTGCCT TACTCCTTCC TCACATTCCC ATATGTTGAA 
GAAGCCATTA AGATCGCTTA CTGTGAGGAG AGGTGCGGAA ACTGCAATCT CACGAGTCTT 
GAAGATGAAG ACTTCTGTAA AACTGTGACC TCAGCTACTG CCAATAAAAC TGCGGAGCCC 
TCAGAGGCTC ATAGCCACCA CAAACACCAC AACAAACATG GGCAGGAGCA TCTTGGCAGC 
AGTAAGCCTT CAGAGAATCA GCAACCAGGG CCATCAGAGA CGACTCTGCC TCCTTCAGGC 
TTGCACCACC ACCACAGGCA TAGGGGCCAG CACAGGCAGG GTCACTTAGA GAGCTGAGAC 
ACCACAGCAA GTGAAGGCTT GCACCTTTCA CTTGCCCAGA GGAAGCTCTG ACGAAGGGGG 
TGCATCAACC AGCTCCTGTG TAAGTTGTCT AAGGAGTCCG AGGCAGCCCC CAGCAGCTGC 
TGCTGTCACT GCCGCCACCT CATATTTGAG AAGTCAGGGT CTGCAATTGC TTGACAGTGT 
GCGGAAAACC TCCCATCCTT ATGTAGCTGA CAGGGGCTTT TCGCGGAGGA GAAAGTCACT 
GAATCCTGTC AGTGTAGGTC ACCTCCAGCT GCCTGACAAA ATCAGCCCAT GAACCCCATG 
GAAGCCAACC CCAACTGAAG CTGAGATAAT CAGACCAGGA AGTGAAAATG ACATTCAAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001036078.1
CDS	73..1215
Translation	MWRSLGLALALCLLPYGGAESQGQSSACYKAPEWYIGDQNPMLNSEGKVTVVALLQASYLCLLQASRLEDLRIKLESQGYFNISYIVVNHQGSPSQLKHSHLKKQVSEHIAVYRQEEDGIDVWTLLNGNKDDFLIYDRCGRLVYHLGLPYSFLTFPYVEEAIKIAYCEERCGNCNLTSLEDEDFCKTVTSATANKTAEPSEAHSHHKHHNKHGQEHLGSSKPSENQQPGPSETTLPPSGLHHHHRHRGQHRQGHLESDTTASEGLHLSLAQRKLRRGCINQLLCKLSKESEAAPSSCCCHCRHLIFEKSGSAIAQCAENLPSLCSQGLFAEEKVTESCQCRSPPAAQNQPMNPMEANPNSDNQTRKKHSN

Target ORF information:

RefSeq Version	NM_001042613.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus selenoprotein P (Selenop), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001042613.2

ORF Insert Sequence:

ATGTGGAGAA GCCTAGGGCT TGCCCTGGCT CTCTGTCTCC TCCCCTATGG AGGAGCAGAG 
AGCCAAGGCC AAAGCTCTGC TTGTTACAAA GCCCCGGAGT GGTACATAGG AGATCAAAAT 
CCAATGCTAA ACTCAGAGGG CAAAGTGACA GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
TTGTGTCTTC TGCAGGCATC CAGATTGGAA GACCTGCGCA TAAAACTAGA AAGCCAAGGA 
TATTTTAACA TCTCTTACAT TGTTGTTAAC CATCAAGGAT CTCCTTCCCA ATTAAAACAC 
TCACATCTTA AAAAGCAGGT GTCAGAACAC ATCGCAGTGT ACAGACAAGA AGAAGATGGC 
ATAGATGTCT GGACTCTCTT AAATGGAAAC AAAGATGACT TCCTCATCTA TGACAGATGT 
GGCCGTCTTG TGTATCACCT TGGTTTGCCT TACTCCTTCC TCACATTCCC ATATGTTGAA 
GAAGCCATTA AGATCGCTTA CTGTGAGGAG AGGTGCGGAA ACTGCAATCT CACGAGTCTT 
GAAGATGAAG ACTTCTGTAA AACTGTGACC TCAGCTACTG CCAATAAAAC TGCGGAGCCC 
TCAGAGGCTC ATAGCCACCA CAAACACCAC AACAAACATG GGCAGGAGCA TCTTGGCAGC 
AGTAAGCCTT CAGAGAATCA GCAACCAGGG CCATCAGAGA CGACTCTGCC TCCTTCAGGC 
TTGCACCACC ACCACAGGCA TAGGGGCCAG CACAGGCAGG GTCACTTAGA GAGCTGAGAC 
ACCACAGCAA GTGAAGGCTT GCACCTTTCA CTTGCCCAGA GGAAGCTCTG ACGAAGGGGG 
TGCATCAACC AGCTCCTGTG TAAGTTGTCT AAGGAGTCCG AGGCAGCCCC CAGCAGCTGC 
TGCTGTCACT GCCGCCACCT CATATTTGAG AAGTCAGGGT CTGCAATTGC TTGACAGTGT 
GCGGAAAACC TCCCATCCTT ATGTAGCTGA CAGGGGCTTT TCGCGGAGGA GAAAGTCACT 
GAATCCTGTC AGTGTAGGTC ACCTCCAGCT GCCTGACAAA ATCAGCCCAT GAACCCCATG 
GAAGCCAACC CCAACTGAAG CTGAGATAAT CAGACCAGGA AGTGAAAATG ACATTCAAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Multiple RNA structures affect translation initiation and UGA redefinition efficiency during synthesis of selenoprotein P.
Nucleic acids research45(22)13004-13015(2017 Dec)
Mariotti M,Shetty S,Baird L,Wu S,Loughran G,Copeland PR,Atkins JF,Howard MT

Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle.
Nature medicine23(4)508-516(2017 Apr)
Misu H,Takayama H,Saito Y,Mita Y,Kikuchi A,Ishii KA,Chikamoto K,Kanamori T,Tajima N,Lan F,Takeshita Y,Honda M,Tanaka M,Kato S,Matsuyama N,Yoshioka Y,Iwayama K,Tokuyama K,Akazawa N,Maeda S,Takekoshi K,Matsugo S,Noguchi N,Kaneko S,Takamura T

Expression and regulation of mouse selenoprotein P transcript variants differing in non-coding RNA.
RNA biology9(11)1361-9(2012 Nov)
Dewing AS,Rueli RH,Robles MJ,Nguyen-Wu ED,Zeyda T,Berry MJ,Bellinger FP

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Selenop cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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