selenop1 cDNA ORF clone, Xenopus tropicalis(tropical clawed frog)

Gene
Clones
gRNAs

Summary

Gene Symbol	selenop1
Entrez Gene ID	100379942
Full Name	selenoprotein P1
Synonyms	selenop,sepp1
General protein information	Preferred Names selenoprotein P1 Names selenoprotein P
Gene Type	protein-coding
Organism	Xenopus tropicalis(tropical clawed frog)
Summary	This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma in mammals. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (18 in Xenopus tropicalis), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. [provided by RefSeq, Feb 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001199884.1	NP_001186813.1	selenoprotein P precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Sepp1	NP_001036078.1
Rattus norvegicus (Norway rat)	Sepp1	NP_001077380.1
Homo sapiens (human)	SEPP1	NP_005401.3
Gallus gallus (chicken)	SEPP1	NP_001026780.2
Bos taurus (cattle)	SEPP1	NP_776884.2
	SEPP1	NP_001152962.1
Canis lupus familiaris (dog)	SEPP1	NP_001108590.1
Danio rerio (zebrafish)	sepp1a	NP_840082.2
Pan troglodytes (chimpanzee)	SEPP1	NP_001108587.1
Xenopus tropicalis (tropical clawed frog)	sepp1	NP_001186813.1

Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Composition and evolution of the vertebrate and mammalian selenoproteomes.
Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
PloS one7(3)e33066(2012)

Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative.
Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW, Richardson P
Developmental dynamics : an official publication of the American Association of Anatomists225(4)384-91(2002 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following selenop1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the selenop1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OXa25545	NM_001199884.1 Latest version!	Xenopus tropicalis selenoprotein P1 (selenop1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

selenop1 ( NM_001199884.1 ) cDNA ORF clone, Xenopus tropicalis(tropical clawed frog) -> NP_001186813.1 Xenopus tropicalis selenoprotein P1 (selenop1), mRNA.

Price & Availability↑

CloneID	OXa25545
Clone ID Related Accession (Same CDS sequence)	NM_001199884.1
Accession Version	NM_001199884.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1209bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Xenopus tropicalis(tropical clawed frog)
Product	selenoprotein P precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DN069392.1 and BC161127.1. On Dec 27, 2010 this sequence version replaced XM_002933046.1. ##Evidence-Data-START## Transcript exon combination :: BC161127.1, EL653709.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00028290, SAMD00028291 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGAAGG GCTTTGCTCT TGCCCTGGCT CTTTGCCTTC TCCCTTGGGG AGGGGCAGAG 
AGCCAGGGCC ATCGAAAGCG GTGTAAAGAA CCGCCAGAAT GGAGCATCGG AGACCAGAAT 
CCAATGATGC AATCTGCTGG GAAAGTGACG GTGGTGGCCC TTCTTCAGGC TAGCTGATCT 
CTGTGCCTGC TGCAGGCTTC CAGGTTGGAG GATCTGCGGT TGAAACTGGA GAAGGAGAAA 
TTGGTGGGTA TTTCCTACGT TGTGGTTAAT CACCAAGGGA GACAATCTCG GGCAAAGTAT 
GATCTGCTGA AGTCTAAGGT CTCCGAGCAC ATTCCTGTGT ATCAGCAAGA GGAATACCAG 
CCTGATGTCT GGAGCCTACT GAAGGGAGAC AAGGATGATT TCTTCGTTTA TGACAGGTGC 
GGACGTTTGG TGCAACATCT CGAACTGCCG TACTCACTCT TACATTTCCC TTACGTTGAA 
GAAGCCATAA GAATTGCTTA TTGTGAAGAT AAATGTGGGG AATGTGAACA CAAGATACTA 
GATGCTGATG TTTGCAAGAA ACCAGAGGAG CAGCAAGAGC AAGACAAACC AGTTGAAGAG 
AAGGTGGAGA GACCCAGACA TCACAGGAAT CACCATAGAC ACCACCGCCC TAAGCACAGT 
GGGCACAGAC ACCGACATCA TCACAGTGAA GATGGCCAAG TGGCCGAACT TGATGTCCTT 
AGGTCTAGCG CTCAAGCTAA CAATAGGGCT GGCAGTCAAA ATGGGCAGGG TCAAAGTGTT 
GTGCAAGTTG TACCACAGAG TGAGGTTTTA TTTGTGCCAC AAAGGGAGGC AGACATTCCA 
GTATTAGCTC GACAGCCTTG AAAAAAGGCT AAAAGCTGAA AGAAACAGTA TTTATGAGAC 
TGGAGAGAGG AGGGAGGCAA GGCATTTAAC AGCTGATGCT GACACTGACG ACAGCTGTCA 
TTTGAAGTAA CAGAAAATGA AGTGGCTTGA CACTGACAGG AGGCTTTGCC ATCTTCCTGC 
AGTTGACAAG AGCTGCTGTC GGACAGCCTC CCTGAATCCT GACAGTGACG TCTGTCTGCC 
GCTGCATGAC ATTCAGAAAG CACAGGCCTG CCAGAGACAA AGCTAGAGTC AGAGCCCAAT 
GCCCCCTGAG CCTGACCTCA GGAGGCAGAA AACTGACAAT GAAAGGAACT CTGACGATTC 
CTAATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186813.1
CDS	158..1366
Translation	MWKGFALALALCLLPWGGAESQGHRKRCKEPPEWSIGDQNPMMQSAGKVTVVALLQASSLCLLQASRLEDLRLKLEKEKLVGISYVVVNHQGRQSRAKYDLLKSKVSEHIPVYQQEEYQPDVWSLLKGDKDDFFVYDRCGRLVQHLELPYSLLHFPYVEEAIRIAYCEDKCGECEHKILDADVCKKPEEQQEQDKPVEEKVERPRHHRNHHRHHRPKHSGHRHRHHHSEDGQVAELDVLRSSAQANNRAGSQNGQGQSVVQVVPQSEVLFVPQREADIPVLARQPKKAKSKKQYLDWREEGGKAFNSCHRQLSFEVTENEVAHQEALPSSCSQELLSDSLPESQRLSAAAHSESTGLPETKLESEPNAPAPQEAENQKELRFLM

Target ORF information:

RefSeq Version	NM_001199884.1
Organism	Xenopus tropicalis(tropical clawed frog)
Definition	Xenopus tropicalis selenoprotein P1 (selenop1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199884.1

ORF Insert Sequence:

ATGTGGAAGG GCTTTGCTCT TGCCCTGGCT CTTTGCCTTC TCCCTTGGGG AGGGGCAGAG 
AGCCAGGGCC ATCGAAAGCG GTGTAAAGAA CCGCCAGAAT GGAGCATCGG AGACCAGAAT 
CCAATGATGC AATCTGCTGG GAAAGTGACG GTGGTGGCCC TTCTTCAGGC TAGCTGATCT 
CTGTGCCTGC TGCAGGCTTC CAGGTTGGAG GATCTGCGGT TGAAACTGGA GAAGGAGAAA 
TTGGTGGGTA TTTCCTACGT TGTGGTTAAT CACCAAGGGA GACAATCTCG GGCAAAGTAT 
GATCTGCTGA AGTCTAAGGT CTCCGAGCAC ATTCCTGTGT ATCAGCAAGA GGAATACCAG 
CCTGATGTCT GGAGCCTACT GAAGGGAGAC AAGGATGATT TCTTCGTTTA TGACAGGTGC 
GGACGTTTGG TGCAACATCT CGAACTGCCG TACTCACTCT TACATTTCCC TTACGTTGAA 
GAAGCCATAA GAATTGCTTA TTGTGAAGAT AAATGTGGGG AATGTGAACA CAAGATACTA 
GATGCTGATG TTTGCAAGAA ACCAGAGGAG CAGCAAGAGC AAGACAAACC AGTTGAAGAG 
AAGGTGGAGA GACCCAGACA TCACAGGAAT CACCATAGAC ACCACCGCCC TAAGCACAGT 
GGGCACAGAC ACCGACATCA TCACAGTGAA GATGGCCAAG TGGCCGAACT TGATGTCCTT 
AGGTCTAGCG CTCAAGCTAA CAATAGGGCT GGCAGTCAAA ATGGGCAGGG TCAAAGTGTT 
GTGCAAGTTG TACCACAGAG TGAGGTTTTA TTTGTGCCAC AAAGGGAGGC AGACATTCCA 
GTATTAGCTC GACAGCCTTG AAAAAAGGCT AAAAGCTGAA AGAAACAGTA TTTATGAGAC 
TGGAGAGAGG AGGGAGGCAA GGCATTTAAC AGCTGATGCT GACACTGACG ACAGCTGTCA 
TTTGAAGTAA CAGAAAATGA AGTGGCTTGA CACTGACAGG AGGCTTTGCC ATCTTCCTGC 
AGTTGACAAG AGCTGCTGTC GGACAGCCTC CCTGAATCCT GACAGTGACG TCTGTCTGCC 
GCTGCATGAC ATTCAGAAAG CACAGGCCTG CCAGAGACAA AGCTAGAGTC AGAGCCCAAT 
GCCCCCTGAG CCTGACCTCA GGAGGCAGAA AACTGACAAT GAAAGGAACT CTGACGATTC 
CTAATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Composition and evolution of the vertebrate and mammalian selenoproteomes.
PloS one7(3)e33066(2012)
Mariotti M,Ridge PG,Zhang Y,Lobanov AV,Pringle TH,Guigo R,Hatfield DL,Gladyshev VN

Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative.
Developmental dynamics : an official publication of the American Association of Anatomists225(4)384-91(2002 Dec)
Klein SL,Strausberg RL,Wagner L,Pontius J,Clifton SW,Richardson P

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selenop1 cDNA ORF clone, Xenopus tropicalis(tropical clawed frog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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