Gene Symbol | sir-2.3 |
Entrez Gene ID | 185876 |
Full Name | NAD-dependent protein deacylase sir-2.3 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » sir-2.3 cDNA ORF clone
Gene Symbol | sir-2.3 |
Entrez Gene ID | 185876 |
Full Name | NAD-dependent protein deacylase sir-2.3 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_077819.3 | NP_510220.1 | NAD-dependent protein deacylase sir-2.3 |
NM_077819.1 | NP_510220.1 | NAD-dependent protein deacylase sir-2.3 |
Homo sapiens (human) | SIRT4 | NP_036372.1 |
Gallus gallus (chicken) | SIRT4 | XP_004934452.1 |
Caenorhabditis elegans (roundworm) | sir-2.3 | NP_510220.1 |
Caenorhabditis elegans (roundworm) | sir-2.2 | NP_001257218.1 |
Oryza sativa (rice) | Os12g0179800 | NP_001066310.1 |
Arabidopsis thaliana (thale cress) | SRT2 | NP_001078550.1 |
Xenopus tropicalis (tropical clawed frog) | sirt4 | NP_001039093.1 |
Bos taurus (cattle) | SIRT4 | NP_001069253.1 |
SIRT4 | XP_001115744.2 | |
Mus musculus (house mouse) | Sirt4 | NP_001161163.1 |
Danio rerio (zebrafish) | sirt4 | NP_001005988.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP013148 | XP_003436605.1 |
Rattus norvegicus (Norway rat) | Sirt4 | NP_001100617.1 |
Drosophila melanogaster (fruit fly) | Sirt4 | NP_572241.2 |
Pan troglodytes (chimpanzee) | SIRT4 | XP_001160214.1 |
Canis lupus familiaris (dog) | SIRT4 | XP_005636355.1 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
we found that knock-out of mitochondrial sirtuin sir-2.3, homologous to mammalian SIRT4, is protective in both chemical ischemia and hyperactive channel induced necrosis. Furthermore, the protective effect of sir-2.3 knock-out is enhanced by block of glycolysis and eliminated by a null mutation in daf-16/FOXO transcription factor, supporting the involvement of the insulin/IGF pathway
Title: Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans.
The following sir-2.3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the sir-2.3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa350131 | |
Clone ID Related Accession (Same CDS sequence) | NM_077819.3 , NM_077819.1 | |
Accession Version | NM_077819.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 864bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | NAD-dependent protein deacylase sir-2.3 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003284). On Oct 18, 2019 this sequence version replaced NM_077819.2. |
1 | ATGGCACGAA AGTATGTACC ACATACGACA GAGCTTTGTG AAAACTCCCT AAAAAAGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_510220.1 |
CDS | 3..866 |
Translation |
Target ORF information:
Target ORF information:
|
NM_077819.3 |
1 | ATGGCACGAA AGTATGTACC ACATACGACA GAGCTTTGTG AAAACTCCCT AAAAAAGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa350131 | |
Clone ID Related Accession (Same CDS sequence) | NM_077819.3 , NM_077819.1 | |
Accession Version | NM_077819.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 864bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | NAD-dependent protein deacylase sir-2.3 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003284). COMPLETENESS: incomplete on both ends. |
1 | ATGGCACGAA AGTATGTACC ACATACGACA GAGCTTTGTG AAAACTCCCT AAAAAAGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_510220.1 |
CDS | 1..864 |
Translation |
Target ORF information:
Target ORF information:
|
NM_077819.1 |
1 | ATGGCACGAA AGTATGTACC ACATACGACA GAGCTTTGTG AAAACTCCCT AAAAAAGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |