SIRT4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SIRT4
Entrez Gene ID	23409
Full Name	sirtuin 4
Synonyms	SIR2L4
General protein information	Preferred Names sirtuin 4 Names NAD-dependent protein lipoamidase sirtuin-4, mitochondrial NAD-dependent ADP-ribosyltransferase sirtuin-4 NAD-dependent protein deacetylase sirtuin-4 SIR2-like protein 4 regulatory protein SIR2 homolog 4 sir2-like 4 sirtuin type 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q24.23-q24.31
Summary	This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008].
Disorder MIM:	604482

mRNA and Protein(s)

mRNA	Protein	Name
XM_005253865.4	XP_005253922.1	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X2
XM_006719309.4	XP_006719372.1	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1
XM_006719309.3	XP_006719372.1	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1
XM_006719309.2	XP_006719372.1	NAD-dependent protein deacetylase sirtuin-4 isoform X1
XM_006719308.2	XP_006719371.1	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1
NM_012240.2	NP_036372.1	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
XM_006719308.3	XP_006719371.1	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1
XM_024448907.1	XP_024304675.1	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X2

Pathways from BioSystems

Homologies

Homo sapiens (human)	SIRT4	NP_036372.1
Gallus gallus (chicken)	SIRT4	XP_004934452.1
Caenorhabditis elegans (roundworm)	sir-2.3	NP_510220.1
Caenorhabditis elegans (roundworm)	sir-2.2	NP_001257218.1
Oryza sativa (rice)	Os12g0179800	NP_001066310.1
Arabidopsis thaliana (thale cress)	SRT2	NP_001078550.1
Xenopus tropicalis (tropical clawed frog)	sirt4	NP_001039093.1
Bos taurus (cattle)	SIRT4	NP_001069253.1
	SIRT4	XP_001115744.2
Mus musculus (house mouse)	Sirt4	NP_001161163.1
Danio rerio (zebrafish)	sirt4	NP_001005988.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP013148	XP_003436605.1
Rattus norvegicus (Norway rat)	Sirt4	NP_001100617.1
Drosophila melanogaster (fruit fly)	Sirt4	NP_572241.2
Pan troglodytes (chimpanzee)	SIRT4	XP_001160214.1
Canis lupus familiaris (dog)	SIRT4	XP_005636355.1

Gene Ontology
Bibliography

Related articles in PubMed

SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy.
Lang A, Anand R, Altinoluk-Hamb?chen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L, Urbach J, B?hler P, H?nsel J, Franke M, St?hler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP
Aging9(10)2163-2189(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we found that knock-out of mitochondrial sirtuin sir-2.3, homologous to mammalian SIRT4, is protective in both chemical ischemia and hyperactive channel induced necrosis. This work suggests a deleterious role of SIRT4 during ischemic processes in mammals that must be further investigated
Title: Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans.

This is the first study to identify an association between SIRT4 expression and decreased mitochondrial fission, which was driven by Drp1. SIRT4 inhibited Drp1 phosphorylation and weakened Drp1 recruitment to the mitochondrial membrane via an interaction with Fis-1.
Title: SIRT4 inhibits malignancy progression of NSCLCs, through mitochondrial dynamics mediated by the ERK-Drp1 pathway.

Protein levels of SIRT 4 were significantly higher in HUVECs from HELLP pregnancies compared to control after 60 and 120 minutes of hypoxia.
Title: HELLP Syndrome.

The function of the three mitochondrial sirtuins (SIRT3, SIRT4, SIRT5) and their role in disease are reviewed.
Title: The role of mitochondrial sirtuins in health and disease.

SIRT4 overexpression inhibits the proliferation of colorectal cancer cells in vitro and in vivo.
Title: Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer.

The following SIRT4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SIRT4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26789	NM_012240.2 Latest version!	Homo sapiens sirtuin 4 (SIRT4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu26789	XM_006719308.3 Latest version!	Homo sapiens sirtuin 4 (SIRT4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu26789	XM_006719309.4 Latest version!	Homo sapiens sirtuin 4 (SIRT4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu46432	XM_005253865.4 Latest version!	Homo sapiens sirtuin 4 (SIRT4), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu46432	XM_024448907.1 Latest version!	Homo sapiens sirtuin 4 (SIRT4), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu26789	XM_006719309.3	Homo sapiens sirtuin 4 (SIRT4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu26789	XM_006719309.2	Homo sapiens sirtuin 4 (SIRT4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu26789	XM_006719308.2	Homo sapiens sirtuin 4 (SIRT4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SIRT4 ( NM_012240.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036372.1 Homo sapiens sirtuin 4 (SIRT4), mRNA.

Price & Availability↑

CloneID	OHu26789
Clone ID Related Accession (Same CDS sequence)	XM_006719309.4 , XM_006719309.3 , XM_006719309.2 , XM_006719308.2 , NM_012240.2 , XM_006719308.3
Accession Version	NM_012240.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Homo sapiens(human)
Product	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP232525.1 and AF083109.1. On Jul 17, 2010 this sequence version replaced NM_012240.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF083109.1, BC034736.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGATGA GCTTTGCGTT GACTTTCAGG TCAGCAAAAG GCCGTTGGAT CGCAAACCCC 
AGCCAGCCGT GCTCGAAAGC CTCCATTGGG TTATTTGTGC CAGCAAGTCC TCCTCTGGAC 
CCTGAGAAGG TCAAAGAGTT ACAGCGCTTC ATCACCCTTT CCAAGAGACT CCTTGTGATG 
ACTGGGGCAG GAATCTCCAC CGAATCGGGG ATACCAGACT ACAGGTCAGA AAAAGTGGGG 
CTTTATGCCC GCACTGACCG CAGGCCCATC CAGCATGGTG ATTTTGTCCG GAGTGCCCCA 
ATCCGCCAGC GGTACTGGGC GAGAAACTTC GTAGGCTGGC CTCAATTCTC CTCCCACCAG 
CCTAACCCTG CACACTGGGC TTTGAGCACC TGGGAGAAAC TCGGAAAGCT GTACTGGTTG 
GTGACCCAAA ATGTGGATGC TTTGCACACC AAGGCGGGGA GTCGGCGCCT GACAGAGCTC 
CACGGATGCA TGGACAGGGT CCTGTGCTTG GATTGTGGGG AACAGACTCC CCGGGGGGTG 
CTGCAAGAGC GTTTCCAAGT CCTGAACCCC ACCTGGAGTG CTGAGGCCCA TGGCCTGGCT 
CCTGATGGTG ACGTCTTTCT CTCAGAGGAG CAAGTCCGGA GCTTTCAGGT CCCAACCTGC 
GTTCAATGTG GAGGCCATCT GAAACCAGAT GTCGTTTTCT TCGGGGACAC AGTGAACCCT 
GACAAGGTTG ATTTTGTGCA CAAGCGTGTA AAAGAAGCCG ACTCCCTCTT GGTGGTGGGA 
TCATCCTTGC AGGTATACTC TGGTTACAGG TTTATCCTCA CTGCCTGGGA GAAGAAGCTC 
CCGATTGCAA TACTGAACAT TGGGCCCACA CGGTCGGATG ACTTGGCGTG TCTGAAACTG 
AATTCTCGTT GTGGAGAGTT GCTGCCTTTG ATAGACCCAT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036372.1
CDS	60..1004
Translation	MKMSFALTFRSAKGRWIANPSQPCSKASIGLFVPASPPLDPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKLNSRCGELLPLIDPC

Target ORF information:

RefSeq Version	NM_012240.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sirtuin 4 (SIRT4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012240.2

ORF Insert Sequence:

ATGAAGATGA GCTTTGCGTT GACTTTCAGG TCAGCAAAAG GCCGTTGGAT CGCAAACCCC 
AGCCAGCCGT GCTCGAAAGC CTCCATTGGG TTATTTGTGC CAGCAAGTCC TCCTCTGGAC 
CCTGAGAAGG TCAAAGAGTT ACAGCGCTTC ATCACCCTTT CCAAGAGACT CCTTGTGATG 
ACTGGGGCAG GAATCTCCAC CGAATCGGGG ATACCAGACT ACAGGTCAGA AAAAGTGGGG 
CTTTATGCCC GCACTGACCG CAGGCCCATC CAGCATGGTG ATTTTGTCCG GAGTGCCCCA 
ATCCGCCAGC GGTACTGGGC GAGAAACTTC GTAGGCTGGC CTCAATTCTC CTCCCACCAG 
CCTAACCCTG CACACTGGGC TTTGAGCACC TGGGAGAAAC TCGGAAAGCT GTACTGGTTG 
GTGACCCAAA ATGTGGATGC TTTGCACACC AAGGCGGGGA GTCGGCGCCT GACAGAGCTC 
CACGGATGCA TGGACAGGGT CCTGTGCTTG GATTGTGGGG AACAGACTCC CCGGGGGGTG 
CTGCAAGAGC GTTTCCAAGT CCTGAACCCC ACCTGGAGTG CTGAGGCCCA TGGCCTGGCT 
CCTGATGGTG ACGTCTTTCT CTCAGAGGAG CAAGTCCGGA GCTTTCAGGT CCCAACCTGC 
GTTCAATGTG GAGGCCATCT GAAACCAGAT GTCGTTTTCT TCGGGGACAC AGTGAACCCT 
GACAAGGTTG ATTTTGTGCA CAAGCGTGTA AAAGAAGCCG ACTCCCTCTT GGTGGTGGGA 
TCATCCTTGC AGGTATACTC TGGTTACAGG TTTATCCTCA CTGCCTGGGA GAAGAAGCTC 
CCGATTGCAA TACTGAACAT TGGGCCCACA CGGTCGGATG ACTTGGCGTG TCTGAAACTG 
AATTCTCGTT GTGGAGAGTT GCTGCCTTTG ATAGACCCAT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIRT4 ( XM_006719309.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_006719372.1 Homo sapiens sirtuin 4 (SIRT4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu26789
Clone ID Related Accession (Same CDS sequence)	XM_006719309.4 , XM_006719309.3 , XM_006719309.2 , XM_006719308.2 , NM_012240.2 , XM_006719308.3
Accession Version	XM_006719309.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006719309.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGATGA GCTTTGCGTT GACTTTCAGG TCAGCAAAAG GCCGTTGGAT CGCAAACCCC 
AGCCAGCCGT GCTCGAAAGC CTCCATTGGG TTATTTGTGC CAGCAAGTCC TCCTCTGGAC 
CCTGAGAAGG TCAAAGAGTT ACAGCGCTTC ATCACCCTTT CCAAGAGACT CCTTGTGATG 
ACTGGGGCAG GAATCTCCAC CGAATCGGGG ATACCAGACT ACAGGTCAGA AAAAGTGGGG 
CTTTATGCCC GCACTGACCG CAGGCCCATC CAGCATGGTG ATTTTGTCCG GAGTGCCCCA 
ATCCGCCAGC GGTACTGGGC GAGAAACTTC GTAGGCTGGC CTCAATTCTC CTCCCACCAG 
CCTAACCCTG CACACTGGGC TTTGAGCACC TGGGAGAAAC TCGGAAAGCT GTACTGGTTG 
GTGACCCAAA ATGTGGATGC TTTGCACACC AAGGCGGGGA GTCGGCGCCT GACAGAGCTC 
CACGGATGCA TGGACAGGGT CCTGTGCTTG GATTGTGGGG AACAGACTCC CCGGGGGGTG 
CTGCAAGAGC GTTTCCAAGT CCTGAACCCC ACCTGGAGTG CTGAGGCCCA TGGCCTGGCT 
CCTGATGGTG ACGTCTTTCT CTCAGAGGAG CAAGTCCGGA GCTTTCAGGT CCCAACCTGC 
GTTCAATGTG GAGGCCATCT GAAACCAGAT GTCGTTTTCT TCGGGGACAC AGTGAACCCT 
GACAAGGTTG ATTTTGTGCA CAAGCGTGTA AAAGAAGCCG ACTCCCTCTT GGTGGTGGGA 
TCATCCTTGC AGGTATACTC TGGTTACAGG TTTATCCTCA CTGCCTGGGA GAAGAAGCTC 
CCGATTGCAA TACTGAACAT TGGGCCCACA CGGTCGGATG ACTTGGCGTG TCTGAAACTG 
AATTCTCGTT GTGGAGAGTT GCTGCCTTTG ATAGACCCAT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006719372.1
CDS	742..1686
Translation	MKMSFALTFRSAKGRWIANPSQPCSKASIGLFVPASPPLDPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKLNSRCGELLPLIDPC

Target ORF information:

RefSeq Version	XM_006719309.4
Organism	Homo sapiens(human)
Definition	Homo sapiens sirtuin 4 (SIRT4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006719309.4

ORF Insert Sequence:

ATGAAGATGA GCTTTGCGTT GACTTTCAGG TCAGCAAAAG GCCGTTGGAT CGCAAACCCC 
AGCCAGCCGT GCTCGAAAGC CTCCATTGGG TTATTTGTGC CAGCAAGTCC TCCTCTGGAC 
CCTGAGAAGG TCAAAGAGTT ACAGCGCTTC ATCACCCTTT CCAAGAGACT CCTTGTGATG 
ACTGGGGCAG GAATCTCCAC CGAATCGGGG ATACCAGACT ACAGGTCAGA AAAAGTGGGG 
CTTTATGCCC GCACTGACCG CAGGCCCATC CAGCATGGTG ATTTTGTCCG GAGTGCCCCA 
ATCCGCCAGC GGTACTGGGC GAGAAACTTC GTAGGCTGGC CTCAATTCTC CTCCCACCAG 
CCTAACCCTG CACACTGGGC TTTGAGCACC TGGGAGAAAC TCGGAAAGCT GTACTGGTTG 
GTGACCCAAA ATGTGGATGC TTTGCACACC AAGGCGGGGA GTCGGCGCCT GACAGAGCTC 
CACGGATGCA TGGACAGGGT CCTGTGCTTG GATTGTGGGG AACAGACTCC CCGGGGGGTG 
CTGCAAGAGC GTTTCCAAGT CCTGAACCCC ACCTGGAGTG CTGAGGCCCA TGGCCTGGCT 
CCTGATGGTG ACGTCTTTCT CTCAGAGGAG CAAGTCCGGA GCTTTCAGGT CCCAACCTGC 
GTTCAATGTG GAGGCCATCT GAAACCAGAT GTCGTTTTCT TCGGGGACAC AGTGAACCCT 
GACAAGGTTG ATTTTGTGCA CAAGCGTGTA AAAGAAGCCG ACTCCCTCTT GGTGGTGGGA 
TCATCCTTGC AGGTATACTC TGGTTACAGG TTTATCCTCA CTGCCTGGGA GAAGAAGCTC 
CCGATTGCAA TACTGAACAT TGGGCCCACA CGGTCGGATG ACTTGGCGTG TCTGAAACTG 
AATTCTCGTT GTGGAGAGTT GCTGCCTTTG ATAGACCCAT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIRT4 ( XM_006719309.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006719372.1 Homo sapiens sirtuin 4 (SIRT4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu26789
Clone ID Related Accession (Same CDS sequence)	XM_006719309.4 , XM_006719309.3 , XM_006719309.2 , XM_006719308.2 , NM_012240.2 , XM_006719308.3
Accession Version	XM_006719309.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006719309.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGATGA GCTTTGCGTT GACTTTCAGG TCAGCAAAAG GCCGTTGGAT CGCAAACCCC 
AGCCAGCCGT GCTCGAAAGC CTCCATTGGG TTATTTGTGC CAGCAAGTCC TCCTCTGGAC 
CCTGAGAAGG TCAAAGAGTT ACAGCGCTTC ATCACCCTTT CCAAGAGACT CCTTGTGATG 
ACTGGGGCAG GAATCTCCAC CGAATCGGGG ATACCAGACT ACAGGTCAGA AAAAGTGGGG 
CTTTATGCCC GCACTGACCG CAGGCCCATC CAGCATGGTG ATTTTGTCCG GAGTGCCCCA 
ATCCGCCAGC GGTACTGGGC GAGAAACTTC GTAGGCTGGC CTCAATTCTC CTCCCACCAG 
CCTAACCCTG CACACTGGGC TTTGAGCACC TGGGAGAAAC TCGGAAAGCT GTACTGGTTG 
GTGACCCAAA ATGTGGATGC TTTGCACACC AAGGCGGGGA GTCGGCGCCT GACAGAGCTC 
CACGGATGCA TGGACAGGGT CCTGTGCTTG GATTGTGGGG AACAGACTCC CCGGGGGGTG 
CTGCAAGAGC GTTTCCAAGT CCTGAACCCC ACCTGGAGTG CTGAGGCCCA TGGCCTGGCT 
CCTGATGGTG ACGTCTTTCT CTCAGAGGAG CAAGTCCGGA GCTTTCAGGT CCCAACCTGC 
GTTCAATGTG GAGGCCATCT GAAACCAGAT GTCGTTTTCT TCGGGGACAC AGTGAACCCT 
GACAAGGTTG ATTTTGTGCA CAAGCGTGTA AAAGAAGCCG ACTCCCTCTT GGTGGTGGGA 
TCATCCTTGC AGGTATACTC TGGTTACAGG TTTATCCTCA CTGCCTGGGA GAAGAAGCTC 
CCGATTGCAA TACTGAACAT TGGGCCCACA CGGTCGGATG ACTTGGCGTG TCTGAAACTG 
AATTCTCGTT GTGGAGAGTT GCTGCCTTTG ATAGACCCAT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006719372.1
CDS	242..1186
Translation	MKMSFALTFRSAKGRWIANPSQPCSKASIGLFVPASPPLDPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKLNSRCGELLPLIDPC

Target ORF information:

RefSeq Version	XM_006719309.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sirtuin 4 (SIRT4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006719309.3

ORF Insert Sequence:

ATGAAGATGA GCTTTGCGTT GACTTTCAGG TCAGCAAAAG GCCGTTGGAT CGCAAACCCC 
AGCCAGCCGT GCTCGAAAGC CTCCATTGGG TTATTTGTGC CAGCAAGTCC TCCTCTGGAC 
CCTGAGAAGG TCAAAGAGTT ACAGCGCTTC ATCACCCTTT CCAAGAGACT CCTTGTGATG 
ACTGGGGCAG GAATCTCCAC CGAATCGGGG ATACCAGACT ACAGGTCAGA AAAAGTGGGG 
CTTTATGCCC GCACTGACCG CAGGCCCATC CAGCATGGTG ATTTTGTCCG GAGTGCCCCA 
ATCCGCCAGC GGTACTGGGC GAGAAACTTC GTAGGCTGGC CTCAATTCTC CTCCCACCAG 
CCTAACCCTG CACACTGGGC TTTGAGCACC TGGGAGAAAC TCGGAAAGCT GTACTGGTTG 
GTGACCCAAA ATGTGGATGC TTTGCACACC AAGGCGGGGA GTCGGCGCCT GACAGAGCTC 
CACGGATGCA TGGACAGGGT CCTGTGCTTG GATTGTGGGG AACAGACTCC CCGGGGGGTG 
CTGCAAGAGC GTTTCCAAGT CCTGAACCCC ACCTGGAGTG CTGAGGCCCA TGGCCTGGCT 
CCTGATGGTG ACGTCTTTCT CTCAGAGGAG CAAGTCCGGA GCTTTCAGGT CCCAACCTGC 
GTTCAATGTG GAGGCCATCT GAAACCAGAT GTCGTTTTCT TCGGGGACAC AGTGAACCCT 
GACAAGGTTG ATTTTGTGCA CAAGCGTGTA AAAGAAGCCG ACTCCCTCTT GGTGGTGGGA 
TCATCCTTGC AGGTATACTC TGGTTACAGG TTTATCCTCA CTGCCTGGGA GAAGAAGCTC 
CCGATTGCAA TACTGAACAT TGGGCCCACA CGGTCGGATG ACTTGGCGTG TCTGAAACTG 
AATTCTCGTT GTGGAGAGTT GCTGCCTTTG ATAGACCCAT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIRT4 ( XM_006719309.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006719372.1 Homo sapiens sirtuin 4 (SIRT4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu26789
Clone ID Related Accession (Same CDS sequence)	XM_006719309.4 , XM_006719309.3 , XM_006719309.2 , XM_006719308.2 , NM_012240.2 , XM_006719308.3
Accession Version	XM_006719309.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	NAD-dependent protein deacetylase sirtuin-4 isoform X1
Comment

ATGAAGATGA GCTTTGCGTT GACTTTCAGG TCAGCAAAAG GCCGTTGGAT CGCAAACCCC 
AGCCAGCCGT GCTCGAAAGC CTCCATTGGG TTATTTGTGC CAGCAAGTCC TCCTCTGGAC 
CCTGAGAAGG TCAAAGAGTT ACAGCGCTTC ATCACCCTTT CCAAGAGACT CCTTGTGATG 
ACTGGGGCAG GAATCTCCAC CGAATCGGGG ATACCAGACT ACAGGTCAGA AAAAGTGGGG 
CTTTATGCCC GCACTGACCG CAGGCCCATC CAGCATGGTG ATTTTGTCCG GAGTGCCCCA 
ATCCGCCAGC GGTACTGGGC GAGAAACTTC GTAGGCTGGC CTCAATTCTC CTCCCACCAG 
CCTAACCCTG CACACTGGGC TTTGAGCACC TGGGAGAAAC TCGGAAAGCT GTACTGGTTG 
GTGACCCAAA ATGTGGATGC TTTGCACACC AAGGCGGGGA GTCGGCGCCT GACAGAGCTC 
CACGGATGCA TGGACAGGGT CCTGTGCTTG GATTGTGGGG AACAGACTCC CCGGGGGGTG 
CTGCAAGAGC GTTTCCAAGT CCTGAACCCC ACCTGGAGTG CTGAGGCCCA TGGCCTGGCT 
CCTGATGGTG ACGTCTTTCT CTCAGAGGAG CAAGTCCGGA GCTTTCAGGT CCCAACCTGC 
GTTCAATGTG GAGGCCATCT GAAACCAGAT GTCGTTTTCT TCGGGGACAC AGTGAACCCT 
GACAAGGTTG ATTTTGTGCA CAAGCGTGTA AAAGAAGCCG ACTCCCTCTT GGTGGTGGGA 
TCATCCTTGC AGGTATACTC TGGTTACAGG TTTATCCTCA CTGCCTGGGA GAAGAAGCTC 
CCGATTGCAA TACTGAACAT TGGGCCCACA CGGTCGGATG ACTTGGCGTG TCTGAAACTG 
AATTCTCGTT GTGGAGAGTT GCTGCCTTTG ATAGACCCAT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006719372.1
Translation	MKMSFALTFRSAKGRWIANPSQPCSKASIGLFVPASPPLDPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKLNSRCGELLPLIDPC

Target ORF information:

RefSeq Version	XM_006719309.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens sirtuin 4 (SIRT4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006719309.2

ORF Insert Sequence:

ATGAAGATGA GCTTTGCGTT GACTTTCAGG TCAGCAAAAG GCCGTTGGAT CGCAAACCCC 
AGCCAGCCGT GCTCGAAAGC CTCCATTGGG TTATTTGTGC CAGCAAGTCC TCCTCTGGAC 
CCTGAGAAGG TCAAAGAGTT ACAGCGCTTC ATCACCCTTT CCAAGAGACT CCTTGTGATG 
ACTGGGGCAG GAATCTCCAC CGAATCGGGG ATACCAGACT ACAGGTCAGA AAAAGTGGGG 
CTTTATGCCC GCACTGACCG CAGGCCCATC CAGCATGGTG ATTTTGTCCG GAGTGCCCCA 
ATCCGCCAGC GGTACTGGGC GAGAAACTTC GTAGGCTGGC CTCAATTCTC CTCCCACCAG 
CCTAACCCTG CACACTGGGC TTTGAGCACC TGGGAGAAAC TCGGAAAGCT GTACTGGTTG 
GTGACCCAAA ATGTGGATGC TTTGCACACC AAGGCGGGGA GTCGGCGCCT GACAGAGCTC 
CACGGATGCA TGGACAGGGT CCTGTGCTTG GATTGTGGGG AACAGACTCC CCGGGGGGTG 
CTGCAAGAGC GTTTCCAAGT CCTGAACCCC ACCTGGAGTG CTGAGGCCCA TGGCCTGGCT 
CCTGATGGTG ACGTCTTTCT CTCAGAGGAG CAAGTCCGGA GCTTTCAGGT CCCAACCTGC 
GTTCAATGTG GAGGCCATCT GAAACCAGAT GTCGTTTTCT TCGGGGACAC AGTGAACCCT 
GACAAGGTTG ATTTTGTGCA CAAGCGTGTA AAAGAAGCCG ACTCCCTCTT GGTGGTGGGA 
TCATCCTTGC AGGTATACTC TGGTTACAGG TTTATCCTCA CTGCCTGGGA GAAGAAGCTC 
CCGATTGCAA TACTGAACAT TGGGCCCACA CGGTCGGATG ACTTGGCGTG TCTGAAACTG 
AATTCTCGTT GTGGAGAGTT GCTGCCTTTG ATAGACCCAT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIRT4 ( XM_006719308.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006719371.1 Homo sapiens sirtuin 4 (SIRT4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu26789
Clone ID Related Accession (Same CDS sequence)	XM_006719309.4 , XM_006719309.3 , XM_006719309.2 , XM_006719308.2 , NM_012240.2 , XM_006719308.3
Accession Version	XM_006719308.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_006719308.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGATGA GCTTTGCGTT GACTTTCAGG TCAGCAAAAG GCCGTTGGAT CGCAAACCCC 
AGCCAGCCGT GCTCGAAAGC CTCCATTGGG TTATTTGTGC CAGCAAGTCC TCCTCTGGAC 
CCTGAGAAGG TCAAAGAGTT ACAGCGCTTC ATCACCCTTT CCAAGAGACT CCTTGTGATG 
ACTGGGGCAG GAATCTCCAC CGAATCGGGG ATACCAGACT ACAGGTCAGA AAAAGTGGGG 
CTTTATGCCC GCACTGACCG CAGGCCCATC CAGCATGGTG ATTTTGTCCG GAGTGCCCCA 
ATCCGCCAGC GGTACTGGGC GAGAAACTTC GTAGGCTGGC CTCAATTCTC CTCCCACCAG 
CCTAACCCTG CACACTGGGC TTTGAGCACC TGGGAGAAAC TCGGAAAGCT GTACTGGTTG 
GTGACCCAAA ATGTGGATGC TTTGCACACC AAGGCGGGGA GTCGGCGCCT GACAGAGCTC 
CACGGATGCA TGGACAGGGT CCTGTGCTTG GATTGTGGGG AACAGACTCC CCGGGGGGTG 
CTGCAAGAGC GTTTCCAAGT CCTGAACCCC ACCTGGAGTG CTGAGGCCCA TGGCCTGGCT 
CCTGATGGTG ACGTCTTTCT CTCAGAGGAG CAAGTCCGGA GCTTTCAGGT CCCAACCTGC 
GTTCAATGTG GAGGCCATCT GAAACCAGAT GTCGTTTTCT TCGGGGACAC AGTGAACCCT 
GACAAGGTTG ATTTTGTGCA CAAGCGTGTA AAAGAAGCCG ACTCCCTCTT GGTGGTGGGA 
TCATCCTTGC AGGTATACTC TGGTTACAGG TTTATCCTCA CTGCCTGGGA GAAGAAGCTC 
CCGATTGCAA TACTGAACAT TGGGCCCACA CGGTCGGATG ACTTGGCGTG TCTGAAACTG 
AATTCTCGTT GTGGAGAGTT GCTGCCTTTG ATAGACCCAT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006719371.1
CDS	746..1690
Translation	MKMSFALTFRSAKGRWIANPSQPCSKASIGLFVPASPPLDPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKLNSRCGELLPLIDPC

Target ORF information:

RefSeq Version	XM_006719308.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sirtuin 4 (SIRT4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006719308.2

ORF Insert Sequence:

ATGAAGATGA GCTTTGCGTT GACTTTCAGG TCAGCAAAAG GCCGTTGGAT CGCAAACCCC 
AGCCAGCCGT GCTCGAAAGC CTCCATTGGG TTATTTGTGC CAGCAAGTCC TCCTCTGGAC 
CCTGAGAAGG TCAAAGAGTT ACAGCGCTTC ATCACCCTTT CCAAGAGACT CCTTGTGATG 
ACTGGGGCAG GAATCTCCAC CGAATCGGGG ATACCAGACT ACAGGTCAGA AAAAGTGGGG 
CTTTATGCCC GCACTGACCG CAGGCCCATC CAGCATGGTG ATTTTGTCCG GAGTGCCCCA 
ATCCGCCAGC GGTACTGGGC GAGAAACTTC GTAGGCTGGC CTCAATTCTC CTCCCACCAG 
CCTAACCCTG CACACTGGGC TTTGAGCACC TGGGAGAAAC TCGGAAAGCT GTACTGGTTG 
GTGACCCAAA ATGTGGATGC TTTGCACACC AAGGCGGGGA GTCGGCGCCT GACAGAGCTC 
CACGGATGCA TGGACAGGGT CCTGTGCTTG GATTGTGGGG AACAGACTCC CCGGGGGGTG 
CTGCAAGAGC GTTTCCAAGT CCTGAACCCC ACCTGGAGTG CTGAGGCCCA TGGCCTGGCT 
CCTGATGGTG ACGTCTTTCT CTCAGAGGAG CAAGTCCGGA GCTTTCAGGT CCCAACCTGC 
GTTCAATGTG GAGGCCATCT GAAACCAGAT GTCGTTTTCT TCGGGGACAC AGTGAACCCT 
GACAAGGTTG ATTTTGTGCA CAAGCGTGTA AAAGAAGCCG ACTCCCTCTT GGTGGTGGGA 
TCATCCTTGC AGGTATACTC TGGTTACAGG TTTATCCTCA CTGCCTGGGA GAAGAAGCTC 
CCGATTGCAA TACTGAACAT TGGGCCCACA CGGTCGGATG ACTTGGCGTG TCTGAAACTG 
AATTCTCGTT GTGGAGAGTT GCTGCCTTTG ATAGACCCAT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIRT4 ( XM_006719308.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006719371.1 Homo sapiens sirtuin 4 (SIRT4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu26789
Clone ID Related Accession (Same CDS sequence)	XM_006719309.4 , XM_006719309.3 , XM_006719309.2 , XM_006719308.2 , NM_012240.2 , XM_006719308.3
Accession Version	XM_006719308.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006719308.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGATGA GCTTTGCGTT GACTTTCAGG TCAGCAAAAG GCCGTTGGAT CGCAAACCCC 
AGCCAGCCGT GCTCGAAAGC CTCCATTGGG TTATTTGTGC CAGCAAGTCC TCCTCTGGAC 
CCTGAGAAGG TCAAAGAGTT ACAGCGCTTC ATCACCCTTT CCAAGAGACT CCTTGTGATG 
ACTGGGGCAG GAATCTCCAC CGAATCGGGG ATACCAGACT ACAGGTCAGA AAAAGTGGGG 
CTTTATGCCC GCACTGACCG CAGGCCCATC CAGCATGGTG ATTTTGTCCG GAGTGCCCCA 
ATCCGCCAGC GGTACTGGGC GAGAAACTTC GTAGGCTGGC CTCAATTCTC CTCCCACCAG 
CCTAACCCTG CACACTGGGC TTTGAGCACC TGGGAGAAAC TCGGAAAGCT GTACTGGTTG 
GTGACCCAAA ATGTGGATGC TTTGCACACC AAGGCGGGGA GTCGGCGCCT GACAGAGCTC 
CACGGATGCA TGGACAGGGT CCTGTGCTTG GATTGTGGGG AACAGACTCC CCGGGGGGTG 
CTGCAAGAGC GTTTCCAAGT CCTGAACCCC ACCTGGAGTG CTGAGGCCCA TGGCCTGGCT 
CCTGATGGTG ACGTCTTTCT CTCAGAGGAG CAAGTCCGGA GCTTTCAGGT CCCAACCTGC 
GTTCAATGTG GAGGCCATCT GAAACCAGAT GTCGTTTTCT TCGGGGACAC AGTGAACCCT 
GACAAGGTTG ATTTTGTGCA CAAGCGTGTA AAAGAAGCCG ACTCCCTCTT GGTGGTGGGA 
TCATCCTTGC AGGTATACTC TGGTTACAGG TTTATCCTCA CTGCCTGGGA GAAGAAGCTC 
CCGATTGCAA TACTGAACAT TGGGCCCACA CGGTCGGATG ACTTGGCGTG TCTGAAACTG 
AATTCTCGTT GTGGAGAGTT GCTGCCTTTG ATAGACCCAT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006719371.1
CDS	2306..3250
Translation	MKMSFALTFRSAKGRWIANPSQPCSKASIGLFVPASPPLDPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKLNSRCGELLPLIDPC

Target ORF information:

RefSeq Version	XM_006719308.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sirtuin 4 (SIRT4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006719308.3

ORF Insert Sequence:

ATGAAGATGA GCTTTGCGTT GACTTTCAGG TCAGCAAAAG GCCGTTGGAT CGCAAACCCC 
AGCCAGCCGT GCTCGAAAGC CTCCATTGGG TTATTTGTGC CAGCAAGTCC TCCTCTGGAC 
CCTGAGAAGG TCAAAGAGTT ACAGCGCTTC ATCACCCTTT CCAAGAGACT CCTTGTGATG 
ACTGGGGCAG GAATCTCCAC CGAATCGGGG ATACCAGACT ACAGGTCAGA AAAAGTGGGG 
CTTTATGCCC GCACTGACCG CAGGCCCATC CAGCATGGTG ATTTTGTCCG GAGTGCCCCA 
ATCCGCCAGC GGTACTGGGC GAGAAACTTC GTAGGCTGGC CTCAATTCTC CTCCCACCAG 
CCTAACCCTG CACACTGGGC TTTGAGCACC TGGGAGAAAC TCGGAAAGCT GTACTGGTTG 
GTGACCCAAA ATGTGGATGC TTTGCACACC AAGGCGGGGA GTCGGCGCCT GACAGAGCTC 
CACGGATGCA TGGACAGGGT CCTGTGCTTG GATTGTGGGG AACAGACTCC CCGGGGGGTG 
CTGCAAGAGC GTTTCCAAGT CCTGAACCCC ACCTGGAGTG CTGAGGCCCA TGGCCTGGCT 
CCTGATGGTG ACGTCTTTCT CTCAGAGGAG CAAGTCCGGA GCTTTCAGGT CCCAACCTGC 
GTTCAATGTG GAGGCCATCT GAAACCAGAT GTCGTTTTCT TCGGGGACAC AGTGAACCCT 
GACAAGGTTG ATTTTGTGCA CAAGCGTGTA AAAGAAGCCG ACTCCCTCTT GGTGGTGGGA 
TCATCCTTGC AGGTATACTC TGGTTACAGG TTTATCCTCA CTGCCTGGGA GAAGAAGCTC 
CCGATTGCAA TACTGAACAT TGGGCCCACA CGGTCGGATG ACTTGGCGTG TCTGAAACTG 
AATTCTCGTT GTGGAGAGTT GCTGCCTTTG ATAGACCCAT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIRT4 ( XM_005253865.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005253922.1 Homo sapiens sirtuin 4 (SIRT4), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu46432
Clone ID Related Accession (Same CDS sequence)	XM_005253865.4 , XM_024448907.1
Accession Version	XM_005253865.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 672bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005253865.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGATGA GCTTTGCGTT GACTTTCAGG TCAGCAAAAG GCCGTTGGAT CGCAAACCCC 
AGCCAGCCGT GCTCGAAAGC CTCCATTGGG TTATTTGTGC CAGCAAGTCC TCCTCTGGAC 
CCTGAGAAGG TCAAAGAGTT ACAGCGCTTC ATCACCCTTT CCAAGAGACT CCTTGTGATG 
ACTGGGGCAG GAATCTCCAC CGAATCGGGG ATACCAGACT ACAGGGTCCT GTGCTTGGAT 
TGTGGGGAAC AGACTCCCCG GGGGGTGCTG CAAGAGCGTT TCCAAGTCCT GAACCCCACC 
TGGAGTGCTG AGGCCCATGG CCTGGCTCCT GATGGTGACG TCTTTCTCTC AGAGGAGCAA 
GTCCGGAGCT TTCAGGTCCC AACCTGCGTT CAATGTGGAG GCCATCTGAA ACCAGATGTC 
GTTTTCTTCG GGGACACAGT GAACCCTGAC AAGGTTGATT TTGTGCACAA GCGTGTAAAA 
GAAGCCGACT CCCTCTTGGT GGTGGGATCA TCCTTGCAGG TATACTCTGG TTACAGGTTT 
ATCCTCACTG CCTGGGAGAA GAAGCTCCCG ATTGCAATAC TGAACATTGG GCCCACACGG 
TCGGATGACT TGGCGTGTCT GAAACTGAAT TCTCGTTGTG GAGAGTTGCT GCCTTTGATA 
GACCCATGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005253922.1
CDS	61..732
Translation	MKMSFALTFRSAKGRWIANPSQPCSKASIGLFVPASPPLDPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKLNSRCGELLPLIDPC

Target ORF information:

RefSeq Version	XM_005253865.4
Organism	Homo sapiens(human)
Definition	Homo sapiens sirtuin 4 (SIRT4), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005253865.4

ORF Insert Sequence:

ATGAAGATGA GCTTTGCGTT GACTTTCAGG TCAGCAAAAG GCCGTTGGAT CGCAAACCCC 
AGCCAGCCGT GCTCGAAAGC CTCCATTGGG TTATTTGTGC CAGCAAGTCC TCCTCTGGAC 
CCTGAGAAGG TCAAAGAGTT ACAGCGCTTC ATCACCCTTT CCAAGAGACT CCTTGTGATG 
ACTGGGGCAG GAATCTCCAC CGAATCGGGG ATACCAGACT ACAGGGTCCT GTGCTTGGAT 
TGTGGGGAAC AGACTCCCCG GGGGGTGCTG CAAGAGCGTT TCCAAGTCCT GAACCCCACC 
TGGAGTGCTG AGGCCCATGG CCTGGCTCCT GATGGTGACG TCTTTCTCTC AGAGGAGCAA 
GTCCGGAGCT TTCAGGTCCC AACCTGCGTT CAATGTGGAG GCCATCTGAA ACCAGATGTC 
GTTTTCTTCG GGGACACAGT GAACCCTGAC AAGGTTGATT TTGTGCACAA GCGTGTAAAA 
GAAGCCGACT CCCTCTTGGT GGTGGGATCA TCCTTGCAGG TATACTCTGG TTACAGGTTT 
ATCCTCACTG CCTGGGAGAA GAAGCTCCCG ATTGCAATAC TGAACATTGG GCCCACACGG 
TCGGATGACT TGGCGTGTCT GAAACTGAAT TCTCGTTGTG GAGAGTTGCT GCCTTTGATA 
GACCCATGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIRT4 ( XM_024448907.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024304675.1 Homo sapiens sirtuin 4 (SIRT4), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu46432
Clone ID Related Accession (Same CDS sequence)	XM_005253865.4 , XM_024448907.1
Accession Version	XM_024448907.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 672bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGATGA GCTTTGCGTT GACTTTCAGG TCAGCAAAAG GCCGTTGGAT CGCAAACCCC 
AGCCAGCCGT GCTCGAAAGC CTCCATTGGG TTATTTGTGC CAGCAAGTCC TCCTCTGGAC 
CCTGAGAAGG TCAAAGAGTT ACAGCGCTTC ATCACCCTTT CCAAGAGACT CCTTGTGATG 
ACTGGGGCAG GAATCTCCAC CGAATCGGGG ATACCAGACT ACAGGGTCCT GTGCTTGGAT 
TGTGGGGAAC AGACTCCCCG GGGGGTGCTG CAAGAGCGTT TCCAAGTCCT GAACCCCACC 
TGGAGTGCTG AGGCCCATGG CCTGGCTCCT GATGGTGACG TCTTTCTCTC AGAGGAGCAA 
GTCCGGAGCT TTCAGGTCCC AACCTGCGTT CAATGTGGAG GCCATCTGAA ACCAGATGTC 
GTTTTCTTCG GGGACACAGT GAACCCTGAC AAGGTTGATT TTGTGCACAA GCGTGTAAAA 
GAAGCCGACT CCCTCTTGGT GGTGGGATCA TCCTTGCAGG TATACTCTGG TTACAGGTTT 
ATCCTCACTG CCTGGGAGAA GAAGCTCCCG ATTGCAATAC TGAACATTGG GCCCACACGG 
TCGGATGACT TGGCGTGTCT GAAACTGAAT TCTCGTTGTG GAGAGTTGCT GCCTTTGATA 
GACCCATGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024304675.1
CDS	390..1061
Translation	MKMSFALTFRSAKGRWIANPSQPCSKASIGLFVPASPPLDPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKLNSRCGELLPLIDPC

Target ORF information:

RefSeq Version	XM_024448907.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sirtuin 4 (SIRT4), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024448907.1

ORF Insert Sequence:

ATGAAGATGA GCTTTGCGTT GACTTTCAGG TCAGCAAAAG GCCGTTGGAT CGCAAACCCC 
AGCCAGCCGT GCTCGAAAGC CTCCATTGGG TTATTTGTGC CAGCAAGTCC TCCTCTGGAC 
CCTGAGAAGG TCAAAGAGTT ACAGCGCTTC ATCACCCTTT CCAAGAGACT CCTTGTGATG 
ACTGGGGCAG GAATCTCCAC CGAATCGGGG ATACCAGACT ACAGGGTCCT GTGCTTGGAT 
TGTGGGGAAC AGACTCCCCG GGGGGTGCTG CAAGAGCGTT TCCAAGTCCT GAACCCCACC 
TGGAGTGCTG AGGCCCATGG CCTGGCTCCT GATGGTGACG TCTTTCTCTC AGAGGAGCAA 
GTCCGGAGCT TTCAGGTCCC AACCTGCGTT CAATGTGGAG GCCATCTGAA ACCAGATGTC 
GTTTTCTTCG GGGACACAGT GAACCCTGAC AAGGTTGATT TTGTGCACAA GCGTGTAAAA 
GAAGCCGACT CCCTCTTGGT GGTGGGATCA TCCTTGCAGG TATACTCTGG TTACAGGTTT 
ATCCTCACTG CCTGGGAGAA GAAGCTCCCG ATTGCAATAC TGAACATTGG GCCCACACGG 
TCGGATGACT TGGCGTGTCT GAAACTGAAT TCTCGTTGTG GAGAGTTGCT GCCTTTGATA 
GACCCATGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy.
Aging9(10)2163-2189(2017 Oct)
Lang A,Anand R,Altinoluk-Hamb?chen S,Ezzahoini H,Stefanski A,Iram A,Bergmann L,Urbach J,B?hler P,H?nsel J,Franke M,St?hler K,Krutmann J,Scheller J,Stork B,Reichert AS,Piekorz RP

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SIRT4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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