IL2RA cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL2RA
Entrez Gene ID	281861
Full Name	interleukin 2 receptor subunit alpha
Synonyms	CD25
Gene Type	protein-coding
Organism	Bos taurus(cattle)
Genome	Chromosome: 13 Map Location: 13q13-q14

mRNA and Protein(s)

mRNA	Protein	Name
XM_025000304.1	XP_024856072.1	interleukin-2 receptor subunit alpha isoform X1
NM_174358.2	NP_776783.1	interleukin-2 receptor subunit alpha precursor
XM_005214133.4	XP_005214190.1	interleukin-2 receptor subunit alpha isoform X2
XM_005214133.3	XP_005214190.1	interleukin-2 receptor subunit alpha isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Il2ra	NP_037295.1
Homo sapiens (human)	IL2RA	NP_000408.1
Pan troglodytes (chimpanzee)	IL2RA	NP_001030597.1
	IL2RA	NP_001028089.1
Bos taurus (cattle)	IL2RA	NP_776783.1
Mus musculus (house mouse)	Il2ra	NP_032393.3
Canis lupus familiaris (dog)	IL2RA	NP_001003211.1

Gene Ontology
Bibliography

Related articles in PubMed

Increase of CD25 expression on bovine neutrophils correlates with disease severity in post-partum and early lactating dairy cows.
Zoldan K, Moellmer T, Schneider J, Fueldner C, Knauer J, Lehmann J
Developmental and comparative immunology47(2)254-63(2014 Dec)

Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves.
Palomares RA, Hurley DJ, Woolums AR, Parrish JE, Brock KV
Comparative immunology, microbiology and infectious diseases37(5-6)331-8(2014 Dec)

Prostaglandin E? down-regulates the expression of CD25 on bovine T cells, and this effect is mediated through the EP4 receptor.
Ma?lanka T, Spodniewska A, Barski D, Jasiecka A, Zu?ka-Prot M, Zi??kowski H, Markiewicz W, Jaroszewski JJ
Veterinary immunology and immunopathology160(3-4)192-200(2014 Aug)

Foxp3 expression in bovine CD8+ T cells is associated with the intensity of CD25 expression.
Ma?lanka T, Jaroszewski JJ
The Journal of veterinary medical science75(2)241-4(2013 Feb)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Increase of CD25 expression on bovine neutrophils correlates with mastitis severity in post-partum and early lactating dairy cows.
Title: Increase of CD25 expression on bovine neutrophils correlates with disease severity in post-partum and early lactating dairy cows.

Differential expression of CD25 and IDO mRNA with high and low virulence bovine viral diarrhea virus might reflect temporal differences in transcription during the immune response elicited by these viral strains.
Title: Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves.

The PGE2-mediated down-regulation of CD25 expression on T cells is mediated via the EP4 receptor, although selective activation of the EP2 receptor up-regulates the CD25 expression on these cells.
Title: Prostaglandin E? down-regulates the expression of CD25 on bovine T cells, and this effect is mediated through the EP4 receptor.

There is a positive correlation between the intensity of CD25 expression and the expression of the transcription Foxp3 factor in bovine CD8(+) cells.
Title: Foxp3 expression in bovine CD8+ T cells is associated with the intensity of CD25 expression.

These findings revealed that despite the existence of a distinct bovine CD4(+)CD25(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population
Title: Subpopulations of bovine WC1(+) gammadelta T cells rather than CD4(+)CD25(high) Foxp3(+) T cells act as immune regulatory cells ex vivo.

The following IL2RA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL2RA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OBa41514	NM_174358.2 Latest version!	Bos taurus interleukin 2 receptor subunit alpha (IL2RA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OBa25020	XM_005214133.4 Latest version!	Bos taurus interleukin 2 receptor subunit alpha (IL2RA), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OBa221433	XM_025000304.1 Latest version!	Bos taurus interleukin 2 receptor subunit alpha (IL2RA), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OBa25020	XM_005214133.3	Bos taurus interleukin 2 receptor subunit alpha (IL2RA), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL2RA ( NM_174358.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776783.1 Bos taurus interleukin 2 receptor subunit alpha (IL2RA), mRNA.

Price & Availability↑

CloneID	OBa41514
Clone ID Related Accession (Same CDS sequence)	NM_174358.2
Accession Version	NM_174358.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 828bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Bos taurus(cattle)
Product	interleukin-2 receptor subunit alpha precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M20818.1. On Jun 3, 2003 this sequence version replaced NM_174358.1. ##Evidence-Data-START## Transcript exon combination :: M20818.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145415, SAMN03145420 [ECO:0000350] ##Evidence-Data-END##

ATGGAGCCAA GCTTGCTGAT GTGGAGGTTC TTCGTATTCA TCGTGGTACC TGGCTGCGTG 
ACAGAGGCTT GTCATGATGA CCCTCCGAGT CTCAGAAACG CCATGTTCAA GGTCTTCAGG 
TACGAGGTGG GCACCATGAT AAACTGCGAC TGCAAGACAG GCTTCCGCAG AGTGTCGGCC 
GTCATGCGCT GCGTGGGGGA CTCCAGCCAC TCTGCCTGGG AAAACAGATG CTTCTGTAAC 
AGCACCTCCC CTGCTAAGAA CCAAGTAAAA CAAGTCACTC CTGCACCCGA AGAACATAGG 
GAGAAAAAAC ACACAGATGC GCAGAACCAA ACGCAGCCTC CGGAGGAAGC GGACCTTCCA 
GGTCACTGTG AGGAACCGCC TCCATGGGAA CACGAACGTG AACCTTTAAA GAGAGTCTAC 
CATTTCACGC TGGGGCAGAC GGTTCATTAC CAGTGCGCCC AGGGATTCAG GGCCCTACAG 
ACCAGTCCTG CTGAAAGCAC CTGCATGATG ATCAACGGGG AGCTGAGGTG GACCAGGCCC 
AGGCTCAAGT GCATACGTGA AGGGGAGCAC GGTCAGGCTT CAGATGACGC AGAGCCTCAG 
GAGAGCACGG AAGCTCCCCC TGGGAGTGGA ACTTTCTTAC CAACCAGGAT GGCAGGGACC 
ACAAATTTCC AGAAGCCCAC AGATGAGATT GCAACGCTGG ATACGTTCAT ATTTACCACT 
GAGTACCAGA TTGCAGTGGC CGGCTGCACC CTCCTGCTCG CCAGCATCCT CCTCCTTAGC 
TGCCTCACCT GGCAGCGGAA ATGGAAGAAG AACAGAAGGA CAATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776783.1
CDS	196..1023
Translation	MEPSLLMWRFFVFIVVPGCVTEACHDDPPSLRNAMFKVFRYEVGTMINCDCKTGFRRVSAVMRCVGDSSHSAWENRCFCNSTSPAKNQVKQVTPAPEEHREKKHTDAQNQTQPPEEADLPGHCEEPPPWEHEREPLKRVYHFTLGQTVHYQCAQGFRALQTSPAESTCMMINGELRWTRPRLKCIREGEHGQASDDAEPQESTEAPPGSGTFLPTRMAGTTNFQKPTDEIATLDTFIFTTEYQIAVAGCTLLLASILLLSCLTWQRKWKKNRRTI

Target ORF information:

RefSeq Version	NM_174358.2
Organism	Bos taurus(cattle)
Definition	Bos taurus interleukin 2 receptor subunit alpha (IL2RA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174358.2

ORF Insert Sequence:

ATGGAGCCAA GCTTGCTGAT GTGGAGGTTC TTCGTATTCA TCGTGGTACC TGGCTGCGTG 
ACAGAGGCTT GTCATGATGA CCCTCCGAGT CTCAGAAACG CCATGTTCAA GGTCTTCAGG 
TACGAGGTGG GCACCATGAT AAACTGCGAC TGCAAGACAG GCTTCCGCAG AGTGTCGGCC 
GTCATGCGCT GCGTGGGGGA CTCCAGCCAC TCTGCCTGGG AAAACAGATG CTTCTGTAAC 
AGCACCTCCC CTGCTAAGAA CCAAGTAAAA CAAGTCACTC CTGCACCCGA AGAACATAGG 
GAGAAAAAAC ACACAGATGC GCAGAACCAA ACGCAGCCTC CGGAGGAAGC GGACCTTCCA 
GGTCACTGTG AGGAACCGCC TCCATGGGAA CACGAACGTG AACCTTTAAA GAGAGTCTAC 
CATTTCACGC TGGGGCAGAC GGTTCATTAC CAGTGCGCCC AGGGATTCAG GGCCCTACAG 
ACCAGTCCTG CTGAAAGCAC CTGCATGATG ATCAACGGGG AGCTGAGGTG GACCAGGCCC 
AGGCTCAAGT GCATACGTGA AGGGGAGCAC GGTCAGGCTT CAGATGACGC AGAGCCTCAG 
GAGAGCACGG AAGCTCCCCC TGGGAGTGGA ACTTTCTTAC CAACCAGGAT GGCAGGGACC 
ACAAATTTCC AGAAGCCCAC AGATGAGATT GCAACGCTGG ATACGTTCAT ATTTACCACT 
GAGTACCAGA TTGCAGTGGC CGGCTGCACC CTCCTGCTCG CCAGCATCCT CCTCCTTAGC 
TGCCTCACCT GGCAGCGGAA ATGGAAGAAG AACAGAAGGA CAATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL2RA ( XM_005214133.4 ) cDNA ORF clone, Bos taurus(cattle) -> XP_005214190.1 Bos taurus interleukin 2 receptor subunit alpha (IL2RA), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OBa25020
Clone ID Related Accession (Same CDS sequence)	XM_005214133.4 , XM_005214133.3
Accession Version	XM_005214133.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 828bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-06
Organism	Bos taurus(cattle)
Product	interleukin-2 receptor subunit alpha isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037340.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 7, 2018 this sequence version replaced XM_005214133.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCAA GCTTGCTGAT GTGGAGGTTC TTCGTATTCA TCGTGGTACC TGGCTGCGTG 
ACAGAGGCTT GTCATGATGA CCCTCCGAGT CTCAGAAACG CCATGTTCAA GGTCTTCAGG 
TACGAGGTGG GCACCATGAT AAACTGCGAC TGCAAGACAG GCTTCCGCAG AGTGTCGGCC 
GTCATGCGCT GCGTGGGGGA CTCCAGCCAC TCTGCCTGGG AAAACAGATG CTTCTGCAAC 
AGCACCTCCC CTGCTAAGAA CCCAGTAAAA CAAGTCACTC CTGCACCCGA AGAACAGAGG 
GAGAAAAAAC CCACAGATGC GCAGAACCAA ACGCAGCCTC CGGAGGAAGC TGACCTTCCA 
GGTCACTGTG AGGAACCGCC ACCATGGGAA CACGAACGTG AACCTTTAAA GAGAGTCTAC 
CATTTCACGC TGGGGCAGAC GGTTCATTAC CAGTGCGCCC AGGGATTCAG GGCCCTACAG 
ACCAGTCCTG CTGAAAGCAC CTGCATGATG ATCAACGGGG AGCTGAGGTG GACCAGGCCC 
AGGCTCAAGT GCATACGTGA AGGGGAGCAC GGTCAGGCTT CAGATGACGC AGAGCCTCAG 
GAGAGCACGG AAGCTCCCCC TGGGAGTGGA ACTTTCTTAC CAACCAGGAT GGCAGGGACC 
ACAGATTTCC AGAAGCCCAC AGATGAGATT GCAACGCTGG ATACGTTCAT ATTTACCACT 
GAGTACCAGA TTGCAGTGGC CGGCTGCACC CTCCTGCTCG CCAGCATCCT CCTCCTGAGC 
TGCCTCACCT GGCAGCGGAA ATGGAAGAAG AACAGAAGGA CAATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005214190.1
CDS	258..1085
Translation	MEPSLLMWRFFVFIVVPGCVTEACHDDPPSLRNAMFKVFRYEVGTMINCDCKTGFRRVSAVMRCVGDSSHSAWENRCFCNSTSPAKNPVKQVTPAPEEQREKKPTDAQNQTQPPEEADLPGHCEEPPPWEHEREPLKRVYHFTLGQTVHYQCAQGFRALQTSPAESTCMMINGELRWTRPRLKCIREGEHGQASDDAEPQESTEAPPGSGTFLPTRMAGTTDFQKPTDEIATLDTFIFTTEYQIAVAGCTLLLASILLLSCLTWQRKWKKNRRTI

Target ORF information:

RefSeq Version	XM_005214133.4
Organism	Bos taurus(cattle)
Definition	Bos taurus interleukin 2 receptor subunit alpha (IL2RA), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005214133.4

ORF Insert Sequence:

ATGGAGCCAA GCTTGCTGAT GTGGAGGTTC TTCGTATTCA TCGTGGTACC TGGCTGCGTG 
ACAGAGGCTT GTCATGATGA CCCTCCGAGT CTCAGAAACG CCATGTTCAA GGTCTTCAGG 
TACGAGGTGG GCACCATGAT AAACTGCGAC TGCAAGACAG GCTTCCGCAG AGTGTCGGCC 
GTCATGCGCT GCGTGGGGGA CTCCAGCCAC TCTGCCTGGG AAAACAGATG CTTCTGCAAC 
AGCACCTCCC CTGCTAAGAA CCCAGTAAAA CAAGTCACTC CTGCACCCGA AGAACAGAGG 
GAGAAAAAAC CCACAGATGC GCAGAACCAA ACGCAGCCTC CGGAGGAAGC TGACCTTCCA 
GGTCACTGTG AGGAACCGCC ACCATGGGAA CACGAACGTG AACCTTTAAA GAGAGTCTAC 
CATTTCACGC TGGGGCAGAC GGTTCATTAC CAGTGCGCCC AGGGATTCAG GGCCCTACAG 
ACCAGTCCTG CTGAAAGCAC CTGCATGATG ATCAACGGGG AGCTGAGGTG GACCAGGCCC 
AGGCTCAAGT GCATACGTGA AGGGGAGCAC GGTCAGGCTT CAGATGACGC AGAGCCTCAG 
GAGAGCACGG AAGCTCCCCC TGGGAGTGGA ACTTTCTTAC CAACCAGGAT GGCAGGGACC 
ACAGATTTCC AGAAGCCCAC AGATGAGATT GCAACGCTGG ATACGTTCAT ATTTACCACT 
GAGTACCAGA TTGCAGTGGC CGGCTGCACC CTCCTGCTCG CCAGCATCCT CCTCCTGAGC 
TGCCTCACCT GGCAGCGGAA ATGGAAGAAG AACAGAAGGA CAATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL2RA ( XM_005214133.3 ) cDNA ORF clone, Bos taurus(cattle) -> XP_005214190.1 Bos taurus interleukin 2 receptor subunit alpha (IL2RA), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa25020
Clone ID Related Accession (Same CDS sequence)	XM_005214133.4 , XM_005214133.3
Accession Version	XM_005214133.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 828bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-01-25
Organism	Bos taurus(cattle)
Product	interleukin-2 receptor subunit alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003104364.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 26, 2016 this sequence version replaced XM_005214133.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCAA GCTTGCTGAT GTGGAGGTTC TTCGTATTCA TCGTGGTACC TGGCTGCGTG 
ACAGAGGCTT GTCATGATGA CCCTCCGAGT CTCAGAAACG CCATGTTCAA GGTCTTCAGG 
TACGAGGTGG GCACCATGAT AAACTGCGAC TGCAAGACAG GCTTCCGCAG AGTGTCGGCC 
GTCATGCGCT GCGTGGGGGA CTCCAGCCAC TCTGCCTGGG AAAACAGATG CTTCTGCAAC 
AGCACCTCCC CTGCTAAGAA CCCAGTAAAA CAAGTCACTC CTGCACCCGA AGAACAGAGG 
GAGAAAAAAC CCACAGATGC GCAGAACCAA ACGCAGCCTC CGGAGGAAGC TGACCTTCCA 
GGTCACTGTG AGGAACCGCC ACCATGGGAA CACGAACGTG AACCTTTAAA GAGAGTCTAC 
CATTTCACGC TGGGGCAGAC GGTTCATTAC CAGTGCGCCC AGGGATTCAG GGCCCTACAG 
ACCAGTCCTG CTGAAAGCAC CTGCATGATG ATCAACGGGG AGCTGAGGTG GACCAGGCCC 
AGGCTCAAGT GCATACGTGA AGGGGAGCAC GGTCAGGCTT CAGATGACGC AGAGCCTCAG 
GAGAGCACGG AAGCTCCCCC TGGGAGTGGA ACTTTCTTAC CAACCAGGAT GGCAGGGACC 
ACAGATTTCC AGAAGCCCAC AGATGAGATT GCAACGCTGG ATACGTTCAT ATTTACCACT 
GAGTACCAGA TTGCAGTGGC CGGCTGCACC CTCCTGCTCG CCAGCATCCT CCTCCTGAGC 
TGCCTCACCT GGCAGCGGAA ATGGAAGAAG AACAGAAGGA CAATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005214190.1
CDS	401..1228
Translation	MEPSLLMWRFFVFIVVPGCVTEACHDDPPSLRNAMFKVFRYEVGTMINCDCKTGFRRVSAVMRCVGDSSHSAWENRCFCNSTSPAKNPVKQVTPAPEEQREKKPTDAQNQTQPPEEADLPGHCEEPPPWEHEREPLKRVYHFTLGQTVHYQCAQGFRALQTSPAESTCMMINGELRWTRPRLKCIREGEHGQASDDAEPQESTEAPPGSGTFLPTRMAGTTDFQKPTDEIATLDTFIFTTEYQIAVAGCTLLLASILLLSCLTWQRKWKKNRRTI

Target ORF information:

RefSeq Version	XM_005214133.3
Organism	Bos taurus(cattle)
Definition	Bos taurus interleukin 2 receptor subunit alpha (IL2RA), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005214133.3

ORF Insert Sequence:

ATGGAGCCAA GCTTGCTGAT GTGGAGGTTC TTCGTATTCA TCGTGGTACC TGGCTGCGTG 
ACAGAGGCTT GTCATGATGA CCCTCCGAGT CTCAGAAACG CCATGTTCAA GGTCTTCAGG 
TACGAGGTGG GCACCATGAT AAACTGCGAC TGCAAGACAG GCTTCCGCAG AGTGTCGGCC 
GTCATGCGCT GCGTGGGGGA CTCCAGCCAC TCTGCCTGGG AAAACAGATG CTTCTGCAAC 
AGCACCTCCC CTGCTAAGAA CCCAGTAAAA CAAGTCACTC CTGCACCCGA AGAACAGAGG 
GAGAAAAAAC CCACAGATGC GCAGAACCAA ACGCAGCCTC CGGAGGAAGC TGACCTTCCA 
GGTCACTGTG AGGAACCGCC ACCATGGGAA CACGAACGTG AACCTTTAAA GAGAGTCTAC 
CATTTCACGC TGGGGCAGAC GGTTCATTAC CAGTGCGCCC AGGGATTCAG GGCCCTACAG 
ACCAGTCCTG CTGAAAGCAC CTGCATGATG ATCAACGGGG AGCTGAGGTG GACCAGGCCC 
AGGCTCAAGT GCATACGTGA AGGGGAGCAC GGTCAGGCTT CAGATGACGC AGAGCCTCAG 
GAGAGCACGG AAGCTCCCCC TGGGAGTGGA ACTTTCTTAC CAACCAGGAT GGCAGGGACC 
ACAGATTTCC AGAAGCCCAC AGATGAGATT GCAACGCTGG ATACGTTCAT ATTTACCACT 
GAGTACCAGA TTGCAGTGGC CGGCTGCACC CTCCTGCTCG CCAGCATCCT CCTCCTGAGC 
TGCCTCACCT GGCAGCGGAA ATGGAAGAAG AACAGAAGGA CAATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL2RA ( XM_025000304.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_024856072.1 Bos taurus interleukin 2 receptor subunit alpha (IL2RA), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa221433
Clone ID Related Accession (Same CDS sequence)	XM_025000304.1
Accession Version	XM_025000304.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-06
Organism	Bos taurus(cattle)
Product	interleukin-2 receptor subunit alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037340.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCAA GCTTGCTGAT GTGGAGGTTC TTCGTATTCA TCGTGGTACC TGGCTGCGTG 
ACAGAGGCTT GTCATGATGA CCCTCCGAGT CTCAGAAACG CCATGTTCAA GGTCTTCAGG 
TACGAGGTGG GCACCATGAT AAACTGCGAC TGCAAGACAG GCTTCCGCAG AGTGTCGGCC 
GTCATGCGCT GCGTGGGGGA CTCCAGCCAC TCTGCCTGGG AAAACAGATG CTTCTGCAAC 
AGCACCTCCC CTGCTAAGAA CCCAGTAAAA CAAGTCACTC CTGCACCCGA AGAACAGAGG 
GAGAAAAAAC CCACAGATGC GCAGAACCAA ACGCAGCCTC CGGAGGAAGC TGACCTTCCA 
GGTCACTGTG AGGAACCGCC ACCATGGGAA CACGAACGTG AACCTTTAAA GAGAGTCTAC 
CATTTCACGC TGGGGCAGAC GGTTCATTAC CAGTGCGCCC AGGGATTCAG GGCCCTACAG 
ACCAGTCCTG CTGAAAGCAC CTGCATGATG ATCAACGGGG AGCTGAGGTG GACCAGGCCC 
AGGCTCAAGT GCATACGTGA AGGGGAGCAC GGTCAGGCTT CAGATGACGC AGAGCCTCAG 
GAGAGCACGG AAGCTCCCCC TGGGAGTGGA ACTTTCTTAC CAACCAGGAT GGCAGGGACC 
ACAGATTTCC AGAAGCCCAC AGATGAGATT GCAACGCTGG ATACGTTCAT ATTTACCACT 
GAGTACCAGA TTGCAGTGGC CGGCTGCACC CTCCTGCTCG CCAGCATCCT CCTCCTGAGC 
TGCCTCACCT GGCAGCGGAA ATGGGGACGA GGAGAGGCTG GACCAGGTTG GGGGCATCAG 
CTAAACCAGA GGAAAAGAAT GGAGAGACAC ATAAAGGAGT CAGGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024856072.1
CDS	262..1149
Translation	MEPSLLMWRFFVFIVVPGCVTEACHDDPPSLRNAMFKVFRYEVGTMINCDCKTGFRRVSAVMRCVGDSSHSAWENRCFCNSTSPAKNPVKQVTPAPEEQREKKPTDAQNQTQPPEEADLPGHCEEPPPWEHEREPLKRVYHFTLGQTVHYQCAQGFRALQTSPAESTCMMINGELRWTRPRLKCIREGEHGQASDDAEPQESTEAPPGSGTFLPTRMAGTTDFQKPTDEIATLDTFIFTTEYQIAVAGCTLLLASILLLSCLTWQRKWGRGEAGPGWGHQLNQRKRMERHIKESG

Target ORF information:

RefSeq Version	XM_025000304.1
Organism	Bos taurus(cattle)
Definition	Bos taurus interleukin 2 receptor subunit alpha (IL2RA), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_025000304.1

ORF Insert Sequence:

ATGGAGCCAA GCTTGCTGAT GTGGAGGTTC TTCGTATTCA TCGTGGTACC TGGCTGCGTG 
ACAGAGGCTT GTCATGATGA CCCTCCGAGT CTCAGAAACG CCATGTTCAA GGTCTTCAGG 
TACGAGGTGG GCACCATGAT AAACTGCGAC TGCAAGACAG GCTTCCGCAG AGTGTCGGCC 
GTCATGCGCT GCGTGGGGGA CTCCAGCCAC TCTGCCTGGG AAAACAGATG CTTCTGCAAC 
AGCACCTCCC CTGCTAAGAA CCCAGTAAAA CAAGTCACTC CTGCACCCGA AGAACAGAGG 
GAGAAAAAAC CCACAGATGC GCAGAACCAA ACGCAGCCTC CGGAGGAAGC TGACCTTCCA 
GGTCACTGTG AGGAACCGCC ACCATGGGAA CACGAACGTG AACCTTTAAA GAGAGTCTAC 
CATTTCACGC TGGGGCAGAC GGTTCATTAC CAGTGCGCCC AGGGATTCAG GGCCCTACAG 
ACCAGTCCTG CTGAAAGCAC CTGCATGATG ATCAACGGGG AGCTGAGGTG GACCAGGCCC 
AGGCTCAAGT GCATACGTGA AGGGGAGCAC GGTCAGGCTT CAGATGACGC AGAGCCTCAG 
GAGAGCACGG AAGCTCCCCC TGGGAGTGGA ACTTTCTTAC CAACCAGGAT GGCAGGGACC 
ACAGATTTCC AGAAGCCCAC AGATGAGATT GCAACGCTGG ATACGTTCAT ATTTACCACT 
GAGTACCAGA TTGCAGTGGC CGGCTGCACC CTCCTGCTCG CCAGCATCCT CCTCCTGAGC 
TGCCTCACCT GGCAGCGGAA ATGGGGACGA GGAGAGGCTG GACCAGGTTG GGGGCATCAG 
CTAAACCAGA GGAAAAGAAT GGAGAGACAC ATAAAGGAGT CAGGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increase of CD25 expression on bovine neutrophils correlates with disease severity in post-partum and early lactating dairy cows.
Developmental and comparative immunology47(2)254-63(2014 Dec)
Zoldan K,Moellmer T,Schneider J,Fueldner C,Knauer J,Lehmann J

Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves.
Comparative immunology, microbiology and infectious diseases37(5-6)331-8(2014 Dec)
Palomares RA,Hurley DJ,Woolums AR,Parrish JE,Brock KV

Prostaglandin E? down-regulates the expression of CD25 on bovine T cells, and this effect is mediated through the EP4 receptor.
Veterinary immunology and immunopathology160(3-4)192-200(2014 Aug)
Ma?lanka T,Spodniewska A,Barski D,Jasiecka A,Zu?ka-Prot M,Zi??kowski H,Markiewicz W,Jaroszewski JJ

Foxp3 expression in bovine CD8+ T cells is associated with the intensity of CD25 expression.
The Journal of veterinary medical science75(2)241-4(2013 Feb)
Ma?lanka T,Jaroszewski JJ

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

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IL2RA cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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