Gene Symbol | IL2RA |
Entrez Gene ID | 281861 |
Full Name | interleukin 2 receptor subunit alpha |
Synonyms | CD25 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
Genome |
ORF » Species Summary » Bos taurus » IL2RA cDNA ORF clone
Gene Symbol | IL2RA |
Entrez Gene ID | 281861 |
Full Name | interleukin 2 receptor subunit alpha |
Synonyms | CD25 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_025000304.1 | XP_024856072.1 | interleukin-2 receptor subunit alpha isoform X1 |
NM_174358.2 | NP_776783.1 | interleukin-2 receptor subunit alpha precursor |
XM_005214133.4 | XP_005214190.1 | interleukin-2 receptor subunit alpha isoform X2 |
XM_005214133.3 | XP_005214190.1 | interleukin-2 receptor subunit alpha isoform X1 |
Increase of CD25 expression on bovine neutrophils correlates with disease severity in post-partum and early lactating dairy cows.
Zoldan K, Moellmer T, Schneider J, Fueldner C, Knauer J, Lehmann J
Developmental and comparative immunology47(2)254-63(2014 Dec)
Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves.
Palomares RA, Hurley DJ, Woolums AR, Parrish JE, Brock KV
Comparative immunology, microbiology and infectious diseases37(5-6)331-8(2014 Dec)
Prostaglandin E? down-regulates the expression of CD25 on bovine T cells, and this effect is mediated through the EP4 receptor.
Ma?lanka T, Spodniewska A, Barski D, Jasiecka A, Zu?ka-Prot M, Zi??kowski H, Markiewicz W, Jaroszewski JJ
Veterinary immunology and immunopathology160(3-4)192-200(2014 Aug)
Foxp3 expression in bovine CD8+ T cells is associated with the intensity of CD25 expression.
Ma?lanka T, Jaroszewski JJ
The Journal of veterinary medical science75(2)241-4(2013 Feb)
A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Increase of CD25 expression on bovine neutrophils correlates with mastitis severity in post-partum and early lactating dairy cows.
Title: Increase of CD25 expression on bovine neutrophils correlates with disease severity in post-partum and early lactating dairy cows.
Differential expression of CD25 and IDO mRNA with high and low virulence bovine viral diarrhea virus might reflect temporal differences in transcription during the immune response elicited by these viral strains.
Title: Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves.
The PGE2-mediated down-regulation of CD25 expression on T cells is mediated via the EP4 receptor, although selective activation of the EP2 receptor up-regulates the CD25 expression on these cells.
Title: Prostaglandin E? down-regulates the expression of CD25 on bovine T cells, and this effect is mediated through the EP4 receptor.
There is a positive correlation between the intensity of CD25 expression and the expression of the transcription Foxp3 factor in bovine CD8(+) cells.
Title: Foxp3 expression in bovine CD8+ T cells is associated with the intensity of CD25 expression.
These findings revealed that despite the existence of a distinct bovine CD4(+)CD25(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population
Title: Subpopulations of bovine WC1(+) gammadelta T cells rather than CD4(+)CD25(high) Foxp3(+) T cells act as immune regulatory cells ex vivo.
The following IL2RA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL2RA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa41514 | |
Clone ID Related Accession (Same CDS sequence) | NM_174358.2 | |
Accession Version | NM_174358.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 828bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Bos taurus(cattle) | |
Product | interleukin-2 receptor subunit alpha precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M20818.1. On Jun 3, 2003 this sequence version replaced NM_174358.1. ##Evidence-Data-START## Transcript exon combination :: M20818.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145415, SAMN03145420 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGAGCCAA GCTTGCTGAT GTGGAGGTTC TTCGTATTCA TCGTGGTACC TGGCTGCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_776783.1 |
CDS | 196..1023 |
Translation |
Target ORF information:
Target ORF information:
|
NM_174358.2 |
1 | ATGGAGCCAA GCTTGCTGAT GTGGAGGTTC TTCGTATTCA TCGTGGTACC TGGCTGCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa25020 | |
Clone ID Related Accession (Same CDS sequence) | XM_005214133.4 , XM_005214133.3 | |
Accession Version | XM_005214133.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 828bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | interleukin-2 receptor subunit alpha isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037340.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 7, 2018 this sequence version replaced XM_005214133.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGCCAA GCTTGCTGAT GTGGAGGTTC TTCGTATTCA TCGTGGTACC TGGCTGCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005214190.1 |
CDS | 258..1085 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005214133.4 |
1 | ATGGAGCCAA GCTTGCTGAT GTGGAGGTTC TTCGTATTCA TCGTGGTACC TGGCTGCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa25020 | |
Clone ID Related Accession (Same CDS sequence) | XM_005214133.4 , XM_005214133.3 | |
Accession Version | XM_005214133.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 828bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-01-25 | |
Organism | Bos taurus(cattle) | |
Product | interleukin-2 receptor subunit alpha isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003104364.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 26, 2016 this sequence version replaced XM_005214133.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGCCAA GCTTGCTGAT GTGGAGGTTC TTCGTATTCA TCGTGGTACC TGGCTGCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005214190.1 |
CDS | 401..1228 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005214133.3 |
1 | ATGGAGCCAA GCTTGCTGAT GTGGAGGTTC TTCGTATTCA TCGTGGTACC TGGCTGCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa221433 | |
Clone ID Related Accession (Same CDS sequence) | XM_025000304.1 | |
Accession Version | XM_025000304.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | interleukin-2 receptor subunit alpha isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037340.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGCCAA GCTTGCTGAT GTGGAGGTTC TTCGTATTCA TCGTGGTACC TGGCTGCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024856072.1 |
CDS | 262..1149 |
Translation |
Target ORF information:
Target ORF information:
|
XM_025000304.1 |
1 | ATGGAGCCAA GCTTGCTGAT GTGGAGGTTC TTCGTATTCA TCGTGGTACC TGGCTGCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Increase of CD25 expression on bovine neutrophils correlates with disease severity in post-partum and early lactating dairy cows. |
Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves. |
Prostaglandin E? down-regulates the expression of CD25 on bovine T cells, and this effect is mediated through the EP4 receptor. |
Foxp3 expression in bovine CD8+ T cells is associated with the intensity of CD25 expression. |
A whole-genome assembly of the domestic cow, Bos taurus. |