oaz1a cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	oaz1a
Entrez Gene ID	259192
Full Name	ornithine decarboxylase antizyme 1a
Synonyms	AZS,oaz1
General protein information	Preferred Names ornithine decarboxylase antizyme 1a Names ornithine decarboxylase antizyme 1a ODC antizyme ODC-Az-S ornithine decarboxylase antizyme 1
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)
Summary	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. Several antizyme paralogs have been described in zebrafish. The mRNA for this antizyme is ubiquitously expressed in the embryo and differentially expressed during development from embryo to adult fish. This antizyme shares features in common with mammalian antizyme 1: it negatively regulates intracellular polyamine levels by inhibiting ODC activity and accelerating ODC degradation in vitro; like mammalian antizyme 1 mRNA, this antizyme mRNA contains two potential in-frame translation initiation sites. [provided by RefSeq, Jan 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_194264.2	NP_919240.2	ornithine decarboxylase antizyme 1a

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	OAZ1	NP_001120840.1
	OAZ1	NP_001128372.1
Canis lupus familiaris (dog)	OAZ1	NP_001120706.1
Rattus norvegicus (Norway rat)	Oaz1	NP_620781.1
Bos taurus (cattle)	OAZ1	NP_001120715.1
Homo sapiens (human)	OAZ1	NP_004143.1
Mus musculus (house mouse)	Oaz1	NP_032779.2
Gallus gallus (chicken)	OAZ1	NP_990247.1
Danio rerio (zebrafish)	oaz1a	NP_919240.2
Xenopus tropicalis (tropical clawed frog)	oaz1	NP_988880.2

Gene Ontology
Bibliography

Related articles in PubMed

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

Molecular dissection of the migrating posterior lateral line primordium during early development in zebrafish.
Gallardo VE, Liang J, Behra M, Elkahloun A, Villablanca EJ, Russo V, Allende ML, Burgess SM
BMC developmental biology10120(2010 Dec)

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Ivanov IP, Atkins JF
Nucleic acids research35(6)1842-58(2007)

Assignment of zebrafish genetic linkage groups to chromosomes.
Phillips RB, Amores A, Morasch MR, Wilson C, Postlethwait JH
Cytogenetic and genome research114(2)155-62(2006)

Mitochondrial localization of antizyme is determined by context-dependent alternative utilization of two AUG initiation codons.
Gandre S, Bercovich Z, Kahana C
Mitochondrion2(4)245-56(2003 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following oaz1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the oaz1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa98443	NM_194264.2 Latest version!	Danio rerio ornithine decarboxylase antizyme 1a (oaz1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

oaz1a ( NM_194264.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_919240.2 Danio rerio ornithine decarboxylase antizyme 1a (oaz1a), mRNA.

Price & Availability↑

CloneID	ODa98443
Clone ID Related Accession (Same CDS sequence)	NM_194264.2
Accession Version	NM_194264.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 645bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Danio rerio(zebrafish)
Product	ornithine decarboxylase antizyme 1a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EH453522.1, BC163939.1 and EH612461.1. On Dec 20, 2008 this sequence version replaced NM_194264.1. ##Evidence-Data-START## Transcript exon combination :: BC056307.1, AB017117.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## ribosomal slippage :: PMID: 10600644 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTTAAAT CCAACCTTCA GACGATACTG AATAGCCACT GTTTTGTCAG AGAAAAAGAG 
AGTAATATAC CCAAGATGCC AGTGATCGAA CTGACCCGTA ATAAACCCGA GAGTGAAAGT 
TCCCATCGCT GCAGTAACCC GTGTCCGGGG CCTCTGTGGT GTTCCGATGT CCCTCTCCCA 
CCCCTGAAGA TCCCAGGTGG GCGAGGGAAT GATCAGCGGG ATCACAGTCT TTCAGCTAAG 
CTATTCTATT CTGATGCTCA GTTACTGGTT CTTGAGGAAG CCCCTCAGTC GAACAGCCGT 
GTACGTTTTT TGCTCTTTGA GCGGCGTTGC TCTGTGAGCA AGCACTTAGT CTGGAGGGGG 
GCACTGAAGG GGACAAACCT TTACATCGAA ATCCCCACTG GTGTCCTCCC AGAAGGGAGC 
AAAGATAGTT TTTCACTTTT GCTGGAGTTT GCAGAAGAAA AGTTACAGGT TGATCACGTT 
TTCATCTGCT TCCATAAGAG CCGAGATGAC AGAGCATCGC TGCTGCGGAC ATTCAGTTTC 
ATGGGCTTTG AGATTGTGAG ACCAGGTCAT CCCCTCGTCC CAACCCGCCC CGACGCTTTC 
TTCATGGCTT ACAGAATCGA AAGAGACTCC GATGGTGACG AATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_919240.2
CDS	join(81..245,247..726)
Translation	MVKSNLQTILNSHCFVREKESNIPKMPVIELTRNKPESESSHRCSNPCPGPLWCSDVPLPPLKIPGGRGNDQRDHSLSAKLFYSDAQLLVLEEAPQSNSRVRFLLFERRCSVSKHLVWRGALKGTNLYIEIPTGVLPEGSKDSFSLLLEFAEEKLQVDHVFICFHKSRDDRASLLRTFSFMGFEIVRPGHPLVPTRPDAFFMAYRIERDSDGDE

Target ORF information:

RefSeq Version	NM_194264.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio ornithine decarboxylase antizyme 1a (oaz1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_194264.2

ORF Insert Sequence:

ATGGTTAAAT CCAACCTTCA GACGATACTG AATAGCCACT GTTTTGTCAG AGAAAAAGAG 
AGTAATATAC CCAAGATGCC AGTGATCGAA CTGACCCGTA ATAAACCCGA GAGTGAAAGT 
TCCCATCGCT GCAGTAACCC GTGTCCGGGG CCTCTGTGGT GTTCCGATGT CCCTCTCCCA 
CCCCTGAAGA TCCCAGGTGG GCGAGGGAAT GATCAGCGGG ATCACAGTCT TTCAGCTAAG 
CTATTCTATT CTGATGCTCA GTTACTGGTT CTTGAGGAAG CCCCTCAGTC GAACAGCCGT 
GTACGTTTTT TGCTCTTTGA GCGGCGTTGC TCTGTGAGCA AGCACTTAGT CTGGAGGGGG 
GCACTGAAGG GGACAAACCT TTACATCGAA ATCCCCACTG GTGTCCTCCC AGAAGGGAGC 
AAAGATAGTT TTTCACTTTT GCTGGAGTTT GCAGAAGAAA AGTTACAGGT TGATCACGTT 
TTCATCTGCT TCCATAAGAG CCGAGATGAC AGAGCATCGC TGCTGCGGAC ATTCAGTTTC 
ATGGGCTTTG AGATTGTGAG ACCAGGTCAT CCCCTCGTCC CAACCCGCCC CGACGCTTTC 
TTCATGGCTT ACAGAATCGA AAGAGACTCC GATGGTGACG AATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

Molecular dissection of the migrating posterior lateral line primordium during early development in zebrafish.
BMC developmental biology10120(2010 Dec)
Gallardo VE,Liang J,Behra M,Elkahloun A,Villablanca EJ,Russo V,Allende ML,Burgess SM

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Nucleic acids research35(6)1842-58(2007)
Ivanov IP,Atkins JF

Assignment of zebrafish genetic linkage groups to chromosomes.
Cytogenetic and genome research114(2)155-62(2006)
Phillips RB,Amores A,Morasch MR,Wilson C,Postlethwait JH

Mitochondrial localization of antizyme is determined by context-dependent alternative utilization of two AUG initiation codons.
Mitochondrion2(4)245-56(2003 Mar)
Gandre S,Bercovich Z,Kahana C

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oaz1a cDNA ORF clone, Danio rerio(zebrafish)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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