Gene Symbol | unc-112 |
Entrez Gene ID | 179972 |
Full Name | Protein unc-112 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » unc-112 cDNA ORF clone
Gene Symbol | unc-112 |
Entrez Gene ID | 179972 |
Full Name | Protein unc-112 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_074227.6 | NP_506628.1 | Protein unc-112 |
NM_074227.7 | NP_506628.1 | Protein unc-112 |
FERMT2 | XP_001082931.1 | |
Mus musculus (house mouse) | Fermt2 | NP_666166.2 |
Bos taurus (cattle) | FERMT2 | NP_001094734.1 |
Drosophila melanogaster (fruit fly) | Fit2 | NP_648947.1 |
Drosophila melanogaster (fruit fly) | Fit1 | NP_647858.2 |
Pan troglodytes (chimpanzee) | FERMT2 | XP_003314374.1 |
Gallus gallus (chicken) | PLEKHC1 | XP_004936582.1 |
Danio rerio (zebrafish) | fermt2 | NP_001243144.1 |
Canis lupus familiaris (dog) | FERMT2 | XP_547815.5 |
Rattus norvegicus (Norway rat) | Fermt2 | NP_001011915.1 |
Caenorhabditis elegans (roundworm) | unc-112 | NP_506628.1 |
Homo sapiens (human) | FERMT2 | NP_001128471.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002054 | XP_320993.2 |
Xenopus tropicalis (tropical clawed frog) | fermt2 | XP_004917211.1 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
isolation and characterization of PAT-4 missense mutations that permit binding with UNC-112 D382V
Title: Suppressor mutations suggest a surface on PAT-4 (Integrin-linked Kinase) that interacts with UNC-112 (Kindlin).
The following model is proposed. UNC-112 exists in closed inactive and open active conformations, and upon binding of PAT-4 to the UNC-112 N-terminal half, UNC-112 is converted into the open state, able to bind to PAT-3.
Title: A molecular mechanism for the requirement of PAT-4 (integrin-linked kinase (ILK)) for the localization of UNC-112 (Kindlin) to integrin adhesion sites.
RNAi of unc-112 inhibited the overall assembly of actin cytoskeleton in somatic gonad, resulting in oocyte accumulation in the proximal gonad and distal tip cells migration defects.
Title: pat-4/ILK and unc-112/Mig-2 are required for gonad function in Caenorhabditis elegans.
UIG-1, a DH/PH domain containing protein, links a PAT-3/UNC-112 complex to the CDC-42 signaling pathway during muscle formation.
Title: Identification of a novel Cdc42 GEF that is localized to the PAT-3-mediated adhesive structure.
The following unc-112 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the unc-112 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa348360 | |
Clone ID Related Accession (Same CDS sequence) | NM_074227.6 , NM_074227.7 | |
Accession Version | NM_074227.6 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2163bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Protein unc-112 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Jun 26, 2012 this sequence version replaced NM_074227.5. COMPLETENESS: incomplete on both ends. |
1 | ATGGCACATC TTGTTGAAGG AACCTCGATT ATTGATGGAA AATGGCAATT GCCAATTTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_506628.1 |
CDS | 1..2163 |
Translation |
Target ORF information:
Target ORF information:
|
NM_074227.6 |
1 | ATGGCACATC TTGTTGAAGG AACCTCGATT ATTGATGGAA AATGGCAATT GCCAATTTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa348360 | |
Clone ID Related Accession (Same CDS sequence) | NM_074227.6 , NM_074227.7 | |
Accession Version | NM_074227.7 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2163bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Protein unc-112 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Sep 4, 2019 this sequence version replaced NM_074227.6. |
1 | ATGGCACATC TTGTTGAAGG AACCTCGATT ATTGATGGAA AATGGCAATT GCCAATTTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_506628.1 |
CDS | 26..2188 |
Translation |
Target ORF information:
Target ORF information:
|
NM_074227.7 |
1 | ATGGCACATC TTGTTGAAGG AACCTCGATT ATTGATGGAA AATGGCAATT GCCAATTTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |