Gene Symbol | YKU80 |
Entrez Gene ID | 855132 |
Full Name | ATP-dependent DNA helicase YKU80 |
Synonyms | HDF2 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » YKU80 cDNA ORF clone
Gene Symbol | YKU80 |
Entrez Gene ID | 855132 |
Full Name | ATP-dependent DNA helicase YKU80 |
Synonyms | HDF2 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001182606.1 | NP_013824.1 | ATP-dependent DNA helicase YKU80 |
Saccharomyces cerevisiae (baker's yeast) | YKU80 | NP_013824.1 |
Eremothecium gossypii | AGOS_ABL030W | NP_982917.3 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.
Bowman S, Churcher C, Badcock K, Brown D, Chillingworth T, Connor R, Dedman K, Devlin K, Gentles S, Hamlin N, Hunt S, Jagels K, Lye G, Moule S, Odell C, Pearson D, Rajandream M, Rice P, Skelton J, Walsh S, Whitehead S, Barrell B
Nature387(6632 Suppl)90-3(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
the yKu-distal portion of telomeres is bound by Rap1, which in turn reduces the potential for yKu(Yku80 and Yku70 )to mediate NHEJ. These results thus propose a solution to a long-standing conundrum, namely how to accommodate the apparently conflicting functions of Ku on telomeres.
Title: Ku Binding on Telomeres Occurs at Sites Distal from the Physical Chromosome Ends.
The authors show that Sir4 - a previously identified Ku-binding protein that is a component of telomeric silent chromatin - is required for Ku-mediated telomere lengthening and telomerase recruitment.
Title: The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae.
Deletion of Est1 has a much greater impact on telomere lengthening in the presence of a Cdc13-Est2 fusion than deletion of YKU80, suggesting that any contribution that Ku may have in telomerase activation is minor compared to that of Est1.
Title: The principal role of Ku in telomere length maintenance is promotion of Est1 association with telomeres.
These findings contradict the recruitment model of Ku binding both DNA and RNA simultaneously and lead to a new model for the mechanism by which Ku's interaction with TLC1 RNA contributes to telomerase recruitment.
Title: Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model.
The TORC1 signal is transduced by the Gln3/Gat1/Ure2 pathway, which controls the levels of the Ku heterodimer, a telomere regulator.
Title: Tor complex 1 controls telomere length by affecting the level of Ku.
The following YKU80 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the YKU80 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi04102 | |
Clone ID Related Accession (Same CDS sequence) | NM_001182606.1 | |
Accession Version | NM_001182606.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1890bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | ATP-dependent DNA helicase YKU80 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001145). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTCAAGTG AGTCAACAAC TTTCATCGTG GATGTTTCAC CATCAATGAT GAAAAATAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_013824.1 |
CDS | 1..1890 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGTCAAGTG AGTCAACAAC TTTCATCGTG GATGTTTCAC CATCAATGAT GAAAAATAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII. |
Life with 6000 genes. |