Gene Symbol | grx4 |
Entrez Gene ID | 2540578 |
Full Name | glutaredoxin Grx4 |
Gene Type | protein-coding |
Organism | Schizosaccharomyces pombe(fission yeast) |
ORF » Species Summary » Schizosaccharomyces pombe » grx4 cDNA ORF clone
Gene Symbol | grx4 |
Entrez Gene ID | 2540578 |
Full Name | glutaredoxin Grx4 |
Gene Type | protein-coding |
Organism | Schizosaccharomyces pombe(fission yeast) |
mRNA | Protein | Name |
---|---|---|
NM_001022569.2 | NP_596647.1 | glutaredoxin Grx4 |
Homo sapiens (human) | GLRX3 | NP_006532.2 |
Mus musculus (house mouse) | Glrx3 | NP_075629.2 |
Oryza sativa (rice) | Os10g0500700 | NP_001064982.1 |
Xenopus tropicalis (tropical clawed frog) | glrx3 | NP_001017209.1 |
Pan troglodytes (chimpanzee) | GLRX3 | XP_508113.2 |
Canis lupus familiaris (dog) | GLRX3 | XP_535061.2 |
Caenorhabditis elegans (roundworm) | glrx-3 | NP_001023756.1 |
GLRX3 | XP_001090479.1 | |
Bos taurus (cattle) | GLRX3 | NP_001030273.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_06356 | XP_003717224.1 |
Rattus norvegicus (Norway rat) | Glrx3 | NP_116003.2 |
Gallus gallus (chicken) | GLRX3 | NP_001264313.1 |
Saccharomyces cerevisiae (baker's yeast) | GRX4 | NP_011101.3 |
Schizosaccharomyces pombe (fission yeast) | grx4 | NP_596647.1 |
Neurospora crassa | NCU09803 | XP_964063.1 |
Danio rerio (zebrafish) | glrx3 | NP_001005950.1 |
Saccharomyces cerevisiae (baker's yeast) | GRX3 | NP_010383.3 |
Kluyveromyces lactis | KLLA0C17842g | XP_452997.1 |
Eremothecium gossypii | AGOS_AGR111W | NP_986777.1 |
Arabidopsis thaliana (thale cress) | AT4G04950 | NP_192404.1 |
The genome sequence of Schizosaccharomyces pombe.
Wood V, Gwilliam R, Rajandream MA, Lyne M, Lyne R, Stewart A, Sgouros J, Peat N, Hayles J, Baker S, Basham D, Bowman S, Brooks K, Brown D, Brown S, Chillingworth T, Churcher C, Collins M, Connor R, Cronin A, Davis P, Feltwell T, Fraser A, Gentles S, Goble A, Hamlin N, Harris D, Hidalgo J, Hodgson G, Holroyd S, Hornsby T, Howarth S, Huckle EJ, Hunt S, Jagels K, James K, Jones L, Jones M, Leather S, McDonald S, McLean J, Mooney P, Moule S, Mungall K, Murphy L, Niblett D, Odell C, Oliver K, O'Neil S, Pearson D, Quail MA, Rabbinowitsch E, Rutherford K, Rutter S, Saunders D, Seeger K, Sharp S, Skelton J, Simmonds M, Squares R, Squares S, Stevens K, Taylor K, Taylor RG, Tivey A, Walsh S, Warren T, Whitehead S, Woodward J, Volckaert G, Aert R, Robben J, Grymonprez B, Weltjens I, Vanstreels E, Rieger M, Sch?fer M, M?ller-Auer S, Gabel C, Fuchs M, D?sterh?ft A, Fritzc C, Holzer E, Moestl D, Hilbert H, Borzym K, Langer I, Beck A, Lehrach H, Reinhardt R, Pohl TM, Eger P, Zimmermann W, Wedler H, Wambutt R, Purnelle B, Goffeau A, Cadieu E, Dr?ano S, Gloux S, Lelaure V, Mottier S, Galibert F, Aves SJ, Xiang Z, Hunt C, Moore K, Hurst SM, Lucas M, Rochet M, Gaillardin C, Tallada VA, Garzon A, Thode G, Daga RR, Cruzado L, Jimenez J, S?nchez M, del Rey F, Benito J, Dom?nguez A, Revuelta JL, Moreno S, Armstrong J, Forsburg SL, Cerutti L, Lowe T, McCombie WR, Paulsen I, Potashkin J, Shpakovski GV, Ussery D, Barrell BG, Nurse P, Cerrutti L
Nature415(6874)871-80(2002 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Study aimed to biochemically define these protein-protein and protein-metal interactions. Grx4 was found to bind a [2Fe-2S] cluster with spectroscopic features similar to other CGFS glutaredoxins. Grx4 and Php4 also copurify as a complex with a [2Fe-2S] cluster that is spectroscopically distinct from the cluster on Grx4these results show that Grx4 controls Php4 function through binding of a bridging [2Fe-2S] cluster.
Title: Schizosaccharomyces pombe Grx4 regulates the transcriptional repressor Php4 via [2Fe-2S] cluster binding.
Grx4 independently governs the Php4 and Fep1 repressors through metal transfer. total or partial disassembly of the Grx4-Fra2 cluster actively participates in iron-containing Fep1 activation
Title: A cascade of iron-containing proteins governs the genetic iron starvation response to promote iron uptake and inhibit iron storage in fission yeast.
These results suggest that the ability of Grx4 to bind iron, most likely Fe-S cofactor, could be critical in interacting with and modulating the activity of Fep1.
Title: Multi-domain CGFS-type glutaredoxin Grx4 regulates iron homeostasis via direct interaction with a repressor Fep1 in fission yeast.
Results describe the first example of a monothiol glutaredoxin (Grx4)that acts as an inhibitory partner for an iron-regulated transcription factor under conditions of low iron levels.
Title: Grx4 monothiol glutaredoxin is required for iron limitation-dependent inhibition of Fep1.
Grx4 and Crm1 are novel components involved in the mechanism by which Php4 is inactivated by iron in a Fep1-independent manner.
Title: Both Php4 function and subcellular localization are regulated by iron via a multistep mechanism involving the glutaredoxin Grx4 and the exportin Crm1.
The following grx4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the grx4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSc100802 | |
Clone ID Related Accession (Same CDS sequence) | NM_001022569.2 | |
Accession Version | NM_001022569.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-04-02 | |
Organism | Schizosaccharomyces pombe(fission yeast) | |
Product | glutaredoxin Grx4 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. This record is derived from an annotated genomic sequence (NC_003423). On Dec 10, 2012 this sequence version replaced NM_001022569.1. |
1 | ATGAGCGTCG AAATTACTTT TGTTGAACAA TTTCAAGAGA TATTGCAAAA TGGAAAAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_596647.1 |
CDS | 411..1145 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001022569.2 |
1 | ATGAGCGTCG AAATTACTTT TGTTGAACAA TTTCAAGAGA TATTGCAAAA TGGAAAAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The genome sequence of Schizosaccharomyces pombe. |