Glrx3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Glrx3
Entrez Gene ID	30926
Full Name	glutaredoxin 3
Synonyms	PICOT,Txnl2
General protein information	Preferred Names glutaredoxin 3 Names glutaredoxin-3 PKC-interacting cousin of thioredoxin PKC-theta-interacting protein PKCq-interacting protein thioredoxin-like protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 F4

mRNA and Protein(s)

mRNA	Protein	Name
NM_023140.4	NP_075629.2	glutaredoxin-3
XM_006507916.3	XP_006507979.1	glutaredoxin-3 isoform X1
NM_001348093.1	NP_001335022.1	glutaredoxin-3 isoform 2
NM_023140.5	NP_075629.2	glutaredoxin-3 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	GLRX3	NP_006532.2
Mus musculus (house mouse)	Glrx3	NP_075629.2
Oryza sativa (rice)	Os10g0500700	NP_001064982.1
Xenopus tropicalis (tropical clawed frog)	glrx3	NP_001017209.1
Pan troglodytes (chimpanzee)	GLRX3	XP_508113.2
Canis lupus familiaris (dog)	GLRX3	XP_535061.2
Caenorhabditis elegans (roundworm)	glrx-3	NP_001023756.1
	GLRX3	XP_001090479.1
Bos taurus (cattle)	GLRX3	NP_001030273.1
Magnaporthe oryzae (rice blast fungus)	MGG_06356	XP_003717224.1
Rattus norvegicus (Norway rat)	Glrx3	NP_116003.2
Gallus gallus (chicken)	GLRX3	NP_001264313.1
Saccharomyces cerevisiae (baker's yeast)	GRX4	NP_011101.3
Schizosaccharomyces pombe (fission yeast)	grx4	NP_596647.1
Neurospora crassa	NCU09803	XP_964063.1
Danio rerio (zebrafish)	glrx3	NP_001005950.1
Saccharomyces cerevisiae (baker's yeast)	GRX3	NP_010383.3
Kluyveromyces lactis	KLLA0C17842g	XP_452997.1
Eremothecium gossypii	AGOS_AGR111W	NP_986777.1
Arabidopsis thaliana (thale cress)	AT4G04950	NP_192404.1

Gene Ontology
Bibliography

Related articles in PubMed

PICOT alleviates myocardial ischemia-reperfusion injury by reducing intracellular levels of reactive oxygen species.
Kim J, Kim J, Kook H, Park WJ
Biochemical and biophysical research communications485(4)807-813(2017 04)

Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation.
Pham K, Dong J, Jiang X, Qu Y, Yu H, Yang Y, Olea W, Marini JC, Chan L, Wang J, Wehrens XH, Cui X, Li Y, Hadsell DL, Cheng N
American journal of physiology. Endocrinology and metabolism312(3)E136-E149(2017 Mar)

Caspase-3-mediated cleavage of PICOT in apoptosis.
Yun N, Kim C, Cha H, Park WJ, Shibayama H, Park IS, Oh YJ
Biochemical and biophysical research communications432(3)533-8(2013 Mar)

A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis.
Cheng NH, Zhang W, Chen WQ, Jin J, Cui X, Butte NF, Chan L, Hirschi KD
The FEBS journal278(14)2525-2539(2011 Jul)

PICOT is a molecule which binds to anamorsin.
Saito Y, Shibayama H, Tanaka H, Tanimura A, Matsumura I, Kanakura Y
Biochemical and biophysical research communications408(2)329-33(2011 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that protein kinase C-interacting cousin of thioredoxin (PICOT) alleviates myocardial I/R injury by regulating intracellular reactive oxygen species (ROS) and free iron levels, and suggest that PICOT presents a therapeutic strategy for myocardial I/R injury.
Title: PICOT alleviates myocardial ischemia-reperfusion injury by reducing intracellular levels of reactive oxygen species.

Grx3 is a key regulator of ROS in vivo and is involved in pregnancy-dependent mammary gland development and secretory activation through modulating cellular ROS.
Title: Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation.

investigation of role of Grx3: embryos absent Grx3 were small, morphological defects, early embryonic lethality; mRNA ubiquitously expressed in developing embryos, adult tissues; induced during oxidative stress; necessary for cell cycle progression
Title: A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis.

These data suggest that AM and PICOT might play cooperatively essential roles in embryogenesis as iron-sulfur cluster proteins.
Title: PICOT is a molecule which binds to anamorsin.

Demonstrated a differential expression of PICOT in various cell types, with a predominant cytosolic staining of epithelial cells and low or undetectable levels of PICOT in the stroma.
Title: Widespread expression of PICOT in mouse and human tissues with predominant localization to epithelium.

The following Glrx3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Glrx3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu15596	NM_023140.5 Latest version!	Mus musculus glutaredoxin 3 (Glrx3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu39702	NM_001348093.1 Latest version!	Mus musculus glutaredoxin 3 (Glrx3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu39702	XM_006507916.3 Latest version!	Mus musculus glutaredoxin 3 (Glrx3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu15596	NM_023140.4	Mus musculus glutaredoxin 3 (Glrx3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Glrx3 ( NM_023140.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_075629.2 Mus musculus glutaredoxin 3 (Glrx3), mRNA.

Price & Availability↑

CloneID	OMu15596
Clone ID Related Accession (Same CDS sequence)	NM_023140.4 , NM_023140.5
Accession Version	NM_023140.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	glutaredoxin-3
Comment

ATGGCGGCGG GGGCGGCCGA GGCAGGCGAG GCAGCCGTGG CAGTGGTGGA AGTCGGCTCT 
GCCCAGCAGT TTGAAGAGCT ACTGCGCCTC AAAACCAAGT CACTCCTTGT GGTTCATTTC 
TGGGCACCAT GGGCTCCACA GTGTGTACAG ATGAACGATG TCATGGCAGA GTTAGCTAAA 
GAACACCCTC ATGTTTCATT TGTGAAGCTG GAAGCCGAAG CTGTTCCTGA AGTATCTGAA 
AAATATGAAA TTAGCTCTGT CCCCACCTTC CTGTTCTTCA AGAATTCTCA GAAAGTCGAC 
CGGTTAGATG GTGCACATGC CCCAGAGTTG ACCAAAAAAG TCCAGCGACA CGTGTCTAGC 
GGAGCCTTTC CTCCTAGTAC TAATGAACAT CTTAAAGAAG ACCTCAGCCT TCGCCTGAAA 
AAGCTGACTC ACGCTGCCCC CTGCATGCTG TTCATGAAGG GAACACCTCA AGAACCACGC 
TGTGGTTTCA GCAAGCAGAT GGTGGAAATC CTTCACAAAC ACAATATTCA GTTCAGCAGC 
TTTGATATCT TCTCAGATGA AGAAGTTCGA CAGGGGCTCA AAACGTACTC TAATTGGCCC 
ACCTATCCTC AGCTCTATGT TTCTGGAGAG CTAATAGGAG GACTTGACAT AATTAAGGAG 
CTGGAAGCAT CAGAAGAGCT GGACACGATC TGTCCCAAAG CACCCAAGTT AGAGGAAAGG 
CTCAAAGTGC TGACCAATAA AGCTTCCGTG ATGCTCTTTA TGAAAGGAAA CAAACAGGAA 
GCAAAATGTG GATTCAGCAA ACAAATTCTG GAAATACTGA ATAGTACTGG GGTTGAATAT 
GAAACTTTTG ATATACTGGA AGATGAAGAA GTGCGTCAGG GATTAAAAAC GTTCTCAAAT 
TGGCCAACCT ACCCTCAGCT GTATGTGAGA GGGGATCTTG TTGGAGGATT GGATATTGTC 
AAGGAACTGA AAGACAACGG TGAATTGCTG CCTATACTGA AAGGAGAAAA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075629.2
Translation	MAAGAAEAGEAAVAVVEVGSAQQFEELLRLKTKSLLVVHFWAPWAPQCVQMNDVMAELAKEHPHVSFVKLEAEAVPEVSEKYEISSVPTFLFFKNSQKVDRLDGAHAPELTKKVQRHVSSGAFPPSTNEHLKEDLSLRLKKLTHAAPCMLFMKGTPQEPRCGFSKQMVEILHKHNIQFSSFDIFSDEEVRQGLKTYSNWPTYPQLYVSGELIGGLDIIKELEASEELDTICPKAPKLEERLKVLTNKASVMLFMKGNKQEAKCGFSKQILEILNSTGVEYETFDILEDEEVRQGLKTFSNWPTYPQLYVRGDLVGGLDIVKELKDNGELLPILKGEN

Target ORF information:

RefSeq Version	NM_023140.4
Organism	Mus musculus(House mouse)
Definition	Mus musculus glutaredoxin 3 (Glrx3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023140.4

ORF Insert Sequence:

ATGGCGGCGG GGGCGGCCGA GGCAGGCGAG GCAGCCGTGG CAGTGGTGGA AGTCGGCTCT 
GCCCAGCAGT TTGAAGAGCT ACTGCGCCTC AAAACCAAGT CACTCCTTGT GGTTCATTTC 
TGGGCACCAT GGGCTCCACA GTGTGTACAG ATGAACGATG TCATGGCAGA GTTAGCTAAA 
GAACACCCTC ATGTTTCATT TGTGAAGCTG GAAGCCGAAG CTGTTCCTGA AGTATCTGAA 
AAATATGAAA TTAGCTCTGT CCCCACCTTC CTGTTCTTCA AGAATTCTCA GAAAGTCGAC 
CGGTTAGATG GTGCACATGC CCCAGAGTTG ACCAAAAAAG TCCAGCGACA CGTGTCTAGC 
GGAGCCTTTC CTCCTAGTAC TAATGAACAT CTTAAAGAAG ACCTCAGCCT TCGCCTGAAA 
AAGCTGACTC ACGCTGCCCC CTGCATGCTG TTCATGAAGG GAACACCTCA AGAACCACGC 
TGTGGTTTCA GCAAGCAGAT GGTGGAAATC CTTCACAAAC ACAATATTCA GTTCAGCAGC 
TTTGATATCT TCTCAGATGA AGAAGTTCGA CAGGGGCTCA AAACGTACTC TAATTGGCCC 
ACCTATCCTC AGCTCTATGT TTCTGGAGAG CTAATAGGAG GACTTGACAT AATTAAGGAG 
CTGGAAGCAT CAGAAGAGCT GGACACGATC TGTCCCAAAG CACCCAAGTT AGAGGAAAGG 
CTCAAAGTGC TGACCAATAA AGCTTCCGTG ATGCTCTTTA TGAAAGGAAA CAAACAGGAA 
GCAAAATGTG GATTCAGCAA ACAAATTCTG GAAATACTGA ATAGTACTGG GGTTGAATAT 
GAAACTTTTG ATATACTGGA AGATGAAGAA GTGCGTCAGG GATTAAAAAC GTTCTCAAAT 
TGGCCAACCT ACCCTCAGCT GTATGTGAGA GGGGATCTTG TTGGAGGATT GGATATTGTC 
AAGGAACTGA AAGACAACGG TGAATTGCTG CCTATACTGA AAGGAGAAAA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Glrx3 ( NM_023140.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_075629.2 Mus musculus glutaredoxin 3 (Glrx3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu15596
Clone ID Related Accession (Same CDS sequence)	NM_023140.4 , NM_023140.5
Accession Version	NM_023140.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	glutaredoxin-3 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY771451.1, AK152446.1, AK017371.1 and AC131791.4. On Feb 8, 2017 this sequence version replaced NM_023140.4. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG GGGCGGCCGA GGCAGGCGAG GCAGCCGTGG CAGTGGTGGA AGTCGGCTCT 
GCCCAGCAGT TTGAAGAGCT ACTGCGCCTC AAAACCAAGT CACTCCTTGT GGTTCATTTC 
TGGGCACCAT GGGCTCCACA GTGTGTACAG ATGAACGATG TCATGGCAGA GTTAGCTAAA 
GAACACCCTC ATGTTTCATT TGTGAAGCTG GAAGCCGAAG CTGTTCCTGA AGTATCTGAA 
AAATATGAAA TTAGCTCTGT CCCCACCTTC CTGTTCTTCA AGAATTCTCA GAAAGTCGAC 
CGGTTAGATG GTGCACATGC CCCAGAGTTG ACCAAAAAAG TCCAGCGACA CGTGTCTAGC 
GGAGCCTTTC CTCCTAGTAC TAATGAACAT CTTAAAGAAG ACCTCAGCCT TCGCCTGAAA 
AAGCTGACTC ACGCTGCCCC CTGCATGCTG TTCATGAAGG GAACACCTCA AGAACCACGC 
TGTGGTTTCA GCAAGCAGAT GGTGGAAATC CTTCACAAAC ACAATATTCA GTTCAGCAGC 
TTTGATATCT TCTCAGATGA AGAAGTTCGA CAGGGGCTCA AAACGTACTC TAATTGGCCC 
ACCTATCCTC AGCTCTATGT TTCTGGAGAG CTAATAGGAG GACTTGACAT AATTAAGGAG 
CTGGAAGCAT CAGAAGAGCT GGACACGATC TGTCCCAAAG CACCCAAGTT AGAGGAAAGG 
CTCAAAGTGC TGACCAATAA AGCTTCCGTG ATGCTCTTTA TGAAAGGAAA CAAACAGGAA 
GCAAAATGTG GATTCAGCAA ACAAATTCTG GAAATACTGA ATAGTACTGG GGTTGAATAT 
GAAACTTTTG ATATACTGGA AGATGAAGAA GTGCGTCAGG GATTAAAAAC GTTCTCAAAT 
TGGCCAACCT ACCCTCAGCT GTATGTGAGA GGGGATCTTG TTGGAGGATT GGATATTGTC 
AAGGAACTGA AAGACAACGG TGAATTGCTG CCTATACTGA AAGGAGAAAA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075629.2
CDS	102..1115
Translation	MAAGAAEAGEAAVAVVEVGSAQQFEELLRLKTKSLLVVHFWAPWAPQCVQMNDVMAELAKEHPHVSFVKLEAEAVPEVSEKYEISSVPTFLFFKNSQKVDRLDGAHAPELTKKVQRHVSSGAFPPSTNEHLKEDLSLRLKKLTHAAPCMLFMKGTPQEPRCGFSKQMVEILHKHNIQFSSFDIFSDEEVRQGLKTYSNWPTYPQLYVSGELIGGLDIIKELEASEELDTICPKAPKLEERLKVLTNKASVMLFMKGNKQEAKCGFSKQILEILNSTGVEYETFDILEDEEVRQGLKTFSNWPTYPQLYVRGDLVGGLDIVKELKDNGELLPILKGEN

Target ORF information:

RefSeq Version	NM_023140.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutaredoxin 3 (Glrx3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023140.5

ORF Insert Sequence:

ATGGCGGCGG GGGCGGCCGA GGCAGGCGAG GCAGCCGTGG CAGTGGTGGA AGTCGGCTCT 
GCCCAGCAGT TTGAAGAGCT ACTGCGCCTC AAAACCAAGT CACTCCTTGT GGTTCATTTC 
TGGGCACCAT GGGCTCCACA GTGTGTACAG ATGAACGATG TCATGGCAGA GTTAGCTAAA 
GAACACCCTC ATGTTTCATT TGTGAAGCTG GAAGCCGAAG CTGTTCCTGA AGTATCTGAA 
AAATATGAAA TTAGCTCTGT CCCCACCTTC CTGTTCTTCA AGAATTCTCA GAAAGTCGAC 
CGGTTAGATG GTGCACATGC CCCAGAGTTG ACCAAAAAAG TCCAGCGACA CGTGTCTAGC 
GGAGCCTTTC CTCCTAGTAC TAATGAACAT CTTAAAGAAG ACCTCAGCCT TCGCCTGAAA 
AAGCTGACTC ACGCTGCCCC CTGCATGCTG TTCATGAAGG GAACACCTCA AGAACCACGC 
TGTGGTTTCA GCAAGCAGAT GGTGGAAATC CTTCACAAAC ACAATATTCA GTTCAGCAGC 
TTTGATATCT TCTCAGATGA AGAAGTTCGA CAGGGGCTCA AAACGTACTC TAATTGGCCC 
ACCTATCCTC AGCTCTATGT TTCTGGAGAG CTAATAGGAG GACTTGACAT AATTAAGGAG 
CTGGAAGCAT CAGAAGAGCT GGACACGATC TGTCCCAAAG CACCCAAGTT AGAGGAAAGG 
CTCAAAGTGC TGACCAATAA AGCTTCCGTG ATGCTCTTTA TGAAAGGAAA CAAACAGGAA 
GCAAAATGTG GATTCAGCAA ACAAATTCTG GAAATACTGA ATAGTACTGG GGTTGAATAT 
GAAACTTTTG ATATACTGGA AGATGAAGAA GTGCGTCAGG GATTAAAAAC GTTCTCAAAT 
TGGCCAACCT ACCCTCAGCT GTATGTGAGA GGGGATCTTG TTGGAGGATT GGATATTGTC 
AAGGAACTGA AAGACAACGG TGAATTGCTG CCTATACTGA AAGGAGAAAA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Glrx3 ( NM_001348093.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001335022.1 Mus musculus glutaredoxin 3 (Glrx3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu39702
Clone ID Related Accession (Same CDS sequence)	XM_006507916.3 , NM_001348093.1
Accession Version	NM_001348093.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Mus musculus(house mouse)
Product	glutaredoxin-3 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC131791.4. Transcript Variant: This variant (2) uses an alternate exon in the 5' region and a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGTTCA TGAAGGGAAC ACCTCAAGAA CCACGCTGTG GTTTCAGCAA GCAGATGGTG 
GAAATCCTTC ACAAACACAA TATTCAGTTC AGCAGCTTTG ATATCTTCTC AGATGAAGAA 
GTTCGACAGG GGCTCAAAAC GTACTCTAAT TGGCCCACCT ATCCTCAGCT CTATGTTTCT 
GGAGAGCTAA TAGGAGGACT TGACATAATT AAGGAGCTGG AAGCATCAGA AGAGCTGGAC 
ACGATCTGTC CCAAAGCACC CAAGTTAGAG GAAAGGCTCA AAGTGCTGAC CAATAAAGCT 
TCCGTGATGC TCTTTATGAA AGGAAACAAA CAGGAAGCAA AATGTGGATT CAGCAAACAA 
ATTCTGGAAA TACTGAATAG TACTGGGGTT GAATATGAAA CTTTTGATAT ACTGGAAGAT 
GAAGAAGTGC GTCAGGGATT AAAAACGTTC TCAAATTGGC CAACCTACCC TCAGCTGTAT 
GTGAGAGGGG ATCTTGTTGG AGGATTGGAT ATTGTCAAGG AACTGAAAGA CAACGGTGAA 
TTGCTGCCTA TACTGAAAGG AGAAAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001335022.1
CDS	635..1204
Translation	MLFMKGTPQEPRCGFSKQMVEILHKHNIQFSSFDIFSDEEVRQGLKTYSNWPTYPQLYVSGELIGGLDIIKELEASEELDTICPKAPKLEERLKVLTNKASVMLFMKGNKQEAKCGFSKQILEILNSTGVEYETFDILEDEEVRQGLKTFSNWPTYPQLYVRGDLVGGLDIVKELKDNGELLPILKGEN

Target ORF information:

RefSeq Version	NM_001348093.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutaredoxin 3 (Glrx3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001348093.1

ORF Insert Sequence:

ATGCTGTTCA TGAAGGGAAC ACCTCAAGAA CCACGCTGTG GTTTCAGCAA GCAGATGGTG 
GAAATCCTTC ACAAACACAA TATTCAGTTC AGCAGCTTTG ATATCTTCTC AGATGAAGAA 
GTTCGACAGG GGCTCAAAAC GTACTCTAAT TGGCCCACCT ATCCTCAGCT CTATGTTTCT 
GGAGAGCTAA TAGGAGGACT TGACATAATT AAGGAGCTGG AAGCATCAGA AGAGCTGGAC 
ACGATCTGTC CCAAAGCACC CAAGTTAGAG GAAAGGCTCA AAGTGCTGAC CAATAAAGCT 
TCCGTGATGC TCTTTATGAA AGGAAACAAA CAGGAAGCAA AATGTGGATT CAGCAAACAA 
ATTCTGGAAA TACTGAATAG TACTGGGGTT GAATATGAAA CTTTTGATAT ACTGGAAGAT 
GAAGAAGTGC GTCAGGGATT AAAAACGTTC TCAAATTGGC CAACCTACCC TCAGCTGTAT 
GTGAGAGGGG ATCTTGTTGG AGGATTGGAT ATTGTCAAGG AACTGAAAGA CAACGGTGAA 
TTGCTGCCTA TACTGAAAGG AGAAAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Glrx3 ( XM_006507916.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006507979.1 Mus musculus glutaredoxin 3 (Glrx3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu39702
Clone ID Related Accession (Same CDS sequence)	XM_006507916.3 , NM_001348093.1
Accession Version	XM_006507916.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	glutaredoxin-3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006507916.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGTTCA TGAAGGGAAC ACCTCAAGAA CCACGCTGTG GTTTCAGCAA GCAGATGGTG 
GAAATCCTTC ACAAACACAA TATTCAGTTC AGCAGCTTTG ATATCTTCTC AGATGAAGAA 
GTTCGACAGG GGCTCAAAAC GTACTCTAAT TGGCCCACCT ATCCTCAGCT CTATGTTTCT 
GGAGAGCTAA TAGGAGGACT TGACATAATT AAGGAGCTGG AAGCATCAGA AGAGCTGGAC 
ACGATCTGTC CCAAAGCACC CAAGTTAGAG GAAAGGCTCA AAGTGCTGAC CAATAAAGCT 
TCCGTGATGC TCTTTATGAA AGGAAACAAA CAGGAAGCAA AATGTGGATT CAGCAAACAA 
ATTCTGGAAA TACTGAATAG TACTGGGGTT GAATATGAAA CTTTTGATAT ACTGGAAGAT 
GAAGAAGTGC GTCAGGGATT AAAAACGTTC TCAAATTGGC CAACCTACCC TCAGCTGTAT 
GTGAGAGGGG ATCTTGTTGG AGGATTGGAT ATTGTCAAGG AACTGAAAGA CAACGGTGAA 
TTGCTGCCTA TACTGAAAGG AGAAAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006507979.1
CDS	547..1116
Translation	MLFMKGTPQEPRCGFSKQMVEILHKHNIQFSSFDIFSDEEVRQGLKTYSNWPTYPQLYVSGELIGGLDIIKELEASEELDTICPKAPKLEERLKVLTNKASVMLFMKGNKQEAKCGFSKQILEILNSTGVEYETFDILEDEEVRQGLKTFSNWPTYPQLYVRGDLVGGLDIVKELKDNGELLPILKGEN

Target ORF information:

RefSeq Version	XM_006507916.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutaredoxin 3 (Glrx3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006507916.3

ORF Insert Sequence:

ATGCTGTTCA TGAAGGGAAC ACCTCAAGAA CCACGCTGTG GTTTCAGCAA GCAGATGGTG 
GAAATCCTTC ACAAACACAA TATTCAGTTC AGCAGCTTTG ATATCTTCTC AGATGAAGAA 
GTTCGACAGG GGCTCAAAAC GTACTCTAAT TGGCCCACCT ATCCTCAGCT CTATGTTTCT 
GGAGAGCTAA TAGGAGGACT TGACATAATT AAGGAGCTGG AAGCATCAGA AGAGCTGGAC 
ACGATCTGTC CCAAAGCACC CAAGTTAGAG GAAAGGCTCA AAGTGCTGAC CAATAAAGCT 
TCCGTGATGC TCTTTATGAA AGGAAACAAA CAGGAAGCAA AATGTGGATT CAGCAAACAA 
ATTCTGGAAA TACTGAATAG TACTGGGGTT GAATATGAAA CTTTTGATAT ACTGGAAGAT 
GAAGAAGTGC GTCAGGGATT AAAAACGTTC TCAAATTGGC CAACCTACCC TCAGCTGTAT 
GTGAGAGGGG ATCTTGTTGG AGGATTGGAT ATTGTCAAGG AACTGAAAGA CAACGGTGAA 
TTGCTGCCTA TACTGAAAGG AGAAAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PICOT alleviates myocardial ischemia-reperfusion injury by reducing intracellular levels of reactive oxygen species.
Biochemical and biophysical research communications485(4)807-813(2017 04)
Kim J,Kim J,Kook H,Park WJ

Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation.
American journal of physiology. Endocrinology and metabolism312(3)E136-E149(2017 Mar)
Pham K,Dong J,Jiang X,Qu Y,Yu H,Yang Y,Olea W,Marini JC,Chan L,Wang J,Wehrens XH,Cui X,Li Y,Hadsell DL,Cheng N

Caspase-3-mediated cleavage of PICOT in apoptosis.
Biochemical and biophysical research communications432(3)533-8(2013 Mar)
Yun N,Kim C,Cha H,Park WJ,Shibayama H,Park IS,Oh YJ

A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis.
The FEBS journal278(14)2525-2539(2011 Jul)
Cheng NH,Zhang W,Chen WQ,Jin J,Cui X,Butte NF,Chan L,Hirschi KD

PICOT is a molecule which binds to anamorsin.
Biochemical and biophysical research communications408(2)329-33(2011 May)
Saito Y,Shibayama H,Tanaka H,Tanimura A,Matsumura I,Kanakura Y

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Glrx3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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