Cnga1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cnga1
Entrez Gene ID	85259
Full Name	cyclic nucleotide gated channel alpha 1
Synonyms	Cncg,HCN
General protein information	Preferred Names cyclic nucleotide gated channel alpha 1 Names cGMP-gated cation channel alpha-1 CNG channel alpha-1 CNG-1 CNG1 cyclic nucleotide-gated cation channel 1 cyclic nucleotide-gated channel, photoreceptor rod photoreceptor cGMP-gated channel subunit alpha
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14p11
Summary	olfactory cyclic nucleotide-gated cation channel; involved in sensory transduction [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053497.1	NP_445949.1	cGMP-gated cation channel alpha-1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Cnga1	NP_031749.2
Gallus gallus (chicken)	CNGA1	NP_990551.1
Pan troglodytes (chimpanzee)	CNGA1	XP_001152062.2
Danio rerio (zebrafish)	cnga1	XP_701036.4
Bos taurus (cattle)	CNGA1	NP_776703.1
Xenopus tropicalis (tropical clawed frog)	cnga1	XP_002933507.1
Homo sapiens (human)	CNGA1	NP_001136036.1
	CNGA1	XP_002804108.1
Canis lupus familiaris (dog)	CNGA1	NP_001003222.1
Rattus norvegicus (Norway rat)	Cnga1	NP_445949.1

Gene Ontology
Bibliography

Related articles in PubMed

Selective Modulation of Histaminergic Inputs on Projection Neurons of Cerebellum Rapidly Promotes Motor Coordination via HCN Channels.
Zhang J, Zhuang QX, Li B, Wu GY, Yung WH, Zhu JN, Wang JJ
Molecular neurobiology53(2)1386-401(2016 Mar)

Genes and mutations causing retinitis pigmentosa.
Daiger SP, Sullivan LS, Bowne SJ
Clinical genetics84(2)132-41(2013 Aug)

Insulin receptor regulates photoreceptor CNG channel activity.
Gupta VK, Rajala A, Rajala RV
American journal of physiology. Endocrinology and metabolism303(11)E1363-72(2012 Dec)

Calcium signalling remodelling and disease.
Berridge MJ
Biochemical Society transactions40(2)297-309(2012 Apr)

Role of estrogen and progesterone in the modulation of CNG-A1 and Na/K+-ATPase expression in the renal cortex.
Gracelli JB, Souza-Menezes J, Barbosa CM, Ornellas FS, Takiya CM, Alves LM, Wengert M, Feltran Gda S, Caruso-Neves C, Moyses MR, Prota LF, Morales MM
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology30(1)160-72(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Histamine depolarizes projection neurons but not interneurons in the cerebellar nuclei via the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels coupled to histamine H2 receptors.
Title: Selective Modulation of Histaminergic Inputs on Projection Neurons of Cerebellum Rapidly Promotes Motor Coordination via HCN Channels.

Insulin receptor (IR), an integral membrane protein, directly phosphorylates the CNGA1 subunit of CNG channels that in turn affects the function of these channels negatively. CNGA1 is a direct substrate of IR.
Title: Insulin receptor regulates photoreceptor CNG channel activity.

Data demonstrate that CNGA1 is expressed in rat cerebellar granule cells and forms functional channels.
Title: Functional cGMP-gated channels in cerebellar granule cells.

estrogen and progesterone act in renal tissues modulating CNG-A1 and Na/K ATPase gene expression
Title: Role of estrogen and progesterone in the modulation of CNG-A1 and Na/K+-ATPase expression in the renal cortex.

Data show robust CNGA1 (but not CNGA2 or CNGA3) channel expression principally in rat alveolar type I cells and suggest that CNGA1 channels mediate cGMP-stimulated, amiloride-insensitive, lung liquid absorption.
Title: Alveolar epithelial CNGA1 channels mediate cGMP-stimulated, amiloride-insensitive, lung liquid absorption.

The following Cnga1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cnga1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09724	NM_053497.1 Latest version!	Rattus norvegicus cyclic nucleotide gated channel subunit alpha 1 (Cnga1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cnga1 ( NM_053497.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445949.1 Rattus norvegicus cyclic nucleotide gated channel subunit alpha 1 (Cnga1), mRNA.

Price & Availability↑

CloneID	ORa09724
Clone ID Related Accession (Same CDS sequence)	NM_053497.1
Accession Version	NM_053497.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2052bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	cGMP-gated cation channel alpha-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U93851.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U93851.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAAAAGG TGATTATCAA CACGTGGCAT TCCTTCGTAA ATATCCCCAA CGTGGTTGTA 
CCAGCTATCG AAAAGGAAAT TCGACGCATG GAAAATGGGG CGTGCAGCTC ATTTTCTGAC 
AATGACAATG GCTCTCTGTC TGAAGAATCA GAGAATGAGG ACTCTCTCTT TAGAAGCAAC 
TCATACAGAA GGCGAGGACC ATCCCAGAGG GAGCATTACT TGCCAGGCAC CATGGCTCTT 
TTCAATGTTA ACAACAGCAG CAACAAAGAC CAAGACCCAA AGGAGAAAAA GAAAAAGAAA 
AAGGAAAAGA AGAGCAAGGC CGATGATAAA AAGGAAAGTA AAAAGGACCC AGAGAAGAAA 
AAAAAGAAGG AAAAGGAAAA AGAGAAGAAA AAGGAGGAGA AACCCAAAGA AAAGAAAGAA 
GGGGAGAAAA AAGAAGTTGT GGTTATTGAT CCCTCAGGAA ACATGTACTA CAACTGGCTG 
TTTTGTATCA CTTTACCTGT GATGTACAAC TGGACGATGA TTATTGCAAG AGCATGTTTT 
GATGAACTCC AGTCTGATTA CCTAGAATAT TGGCTCATTT TTGATTACGT ATCAGATGTA 
GTCTACCTTG CTGATATGTT TGTACGGACA AGGACAGGTT ACCTGGAACA AGGGTTGCTA 
GTGAAAGACA AACTGAAACT CATAGAGAAG TACAAAGCAA ACCTGCAGTT TAAACTTGAC 
GTTCTGTCAG TGATACCGAC CGACCTGCTG TATTTCAAGT TTGGGTGGAA CTATCCAGAA 
ATCAGGTTGA ACCGGCTGTT AAGAATCTCT CGGATGTTTG AGTTCTTCCA GAGGACAGAG 
ACAAGGACCA ACTACCCGAA CATCTTTAGG ATCTCAAACC TTGTGATGTA CATTGTCATC 
ATCATCCACT GGAACGCGTG TGTGTACTAC TCCATCTCAA AAGCTATTGG ATTTGGGAAT 
GACACATGGG TCTACCCTGA TGTTAATGAT CCTGAATTTG GCCGTTTGGC TAGAAAATAC 
GTCTACAGCC TTTATTGGTC TACCTTGACT TTGACGACCA TTGGAGAAAC CCCACCCCCC 
GTGCTGGATT CCGAGTATGT CTTTGTGGTG GTAGACTTCT TAATTGGAGT TTTAATTTTT 
GCCACCATTG TCGGTAACAT AGGCTCCATG ATTTCCAATA TGAATGCAGC CCGGGCAGAA 
TTTCAATCAA GAGTTGATGC TATCAAACAG TACATGAATT TTCGAAATGT GAGCAAAGAC 
ATGGAAAAGA GAGTTATTAA ATGGTTTGAC TACCTGTGGA CTAACAAAAA GACAGTCGAT 
GAGAGAGAAG TTCTGAGATA CCTCCCTGAC AAACTCAGGG CAGAGATTGC CATCAATGTT 
CACCTAGACA CGTTAAAAAA GGTTCGTATC TTTGCTGACT GTGAGGCTGG TCTGTTGGTG 
GAGTTGGTGT TGAAATTACA ACCCCAGGTG TACAGTCCTG GAGATTACAT ATGCAAGAAA 
GGGGACATTG GGCGGGAGAT GTACATCATC AAGGAAGGCA AACTTGCTGT GGTGGCAGAC 
GACGGAATCA CACAGTTTGT GGTGTTGAGT GACGGCAGCT ACTTTGGCGA GATCAGCATT 
CTTAACATCA AAGGCAGCAA GGCTGGCAAC CGAAGAACAG CCAATATTAA GAGCATTGGC 
TACTCGGACC TGTTCTGCCT CTCAAAGGAT GACCTCATGG AAGCTCTTAC AGAGTACCCA 
GATGCCAAAA CTATGTTGGA GGAGAAAGGG AGGCAGATCT TAATGAAAGA CGGTCTACTG 
GATATAAACA TTGCGAATTT GGGCAGTGAC CCTAAAGACC TGGAAGAGAA GGTCACTCGA 
ATGGAGGGGT CAGTGGACCT CCTGCAAACA CGATTTGCCC GAATCTTGGC TGAGTATGAA 
TCGATGCAGC AGAAACTCAA GCAAAGATTA ACCAAGGTTG AGAAATTCTT GAAACCACTT 
ATTGAAACTG AATTTTCAGC CCTTGAGGAA CCCGGAGGAG AAAGTGAACC CACAGAGTCT 
CTACAGGGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445949.1
CDS	1..2052
Translation	MKKVIINTWHSFVNIPNVVVPAIEKEIRRMENGACSSFSDNDNGSLSEESENEDSLFRSNSYRRRGPSQREHYLPGTMALFNVNNSSNKDQDPKEKKKKKKEKKSKADDKKESKKDPEKKKKKEKEKEKKKEEKPKEKKEGEKKEVVVIDPSGNMYYNWLFCITLPVMYNWTMIIARACFDELQSDYLEYWLIFDYVSDVVYLADMFVRTRTGYLEQGLLVKDKLKLIEKYKANLQFKLDVLSVIPTDLLYFKFGWNYPEIRLNRLLRISRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVYYSISKAIGFGNDTWVYPDVNDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVLDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQSRVDAIKQYMNFRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLRYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGRQILMKDGLLDINIANLGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIETEFSALEEPGGESEPTESLQG

Target ORF information:

RefSeq Version	NM_053497.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclic nucleotide gated channel subunit alpha 1 (Cnga1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053497.1

ORF Insert Sequence:

ATGAAAAAGG TGATTATCAA CACGTGGCAT TCCTTCGTAA ATATCCCCAA CGTGGTTGTA 
CCAGCTATCG AAAAGGAAAT TCGACGCATG GAAAATGGGG CGTGCAGCTC ATTTTCTGAC 
AATGACAATG GCTCTCTGTC TGAAGAATCA GAGAATGAGG ACTCTCTCTT TAGAAGCAAC 
TCATACAGAA GGCGAGGACC ATCCCAGAGG GAGCATTACT TGCCAGGCAC CATGGCTCTT 
TTCAATGTTA ACAACAGCAG CAACAAAGAC CAAGACCCAA AGGAGAAAAA GAAAAAGAAA 
AAGGAAAAGA AGAGCAAGGC CGATGATAAA AAGGAAAGTA AAAAGGACCC AGAGAAGAAA 
AAAAAGAAGG AAAAGGAAAA AGAGAAGAAA AAGGAGGAGA AACCCAAAGA AAAGAAAGAA 
GGGGAGAAAA AAGAAGTTGT GGTTATTGAT CCCTCAGGAA ACATGTACTA CAACTGGCTG 
TTTTGTATCA CTTTACCTGT GATGTACAAC TGGACGATGA TTATTGCAAG AGCATGTTTT 
GATGAACTCC AGTCTGATTA CCTAGAATAT TGGCTCATTT TTGATTACGT ATCAGATGTA 
GTCTACCTTG CTGATATGTT TGTACGGACA AGGACAGGTT ACCTGGAACA AGGGTTGCTA 
GTGAAAGACA AACTGAAACT CATAGAGAAG TACAAAGCAA ACCTGCAGTT TAAACTTGAC 
GTTCTGTCAG TGATACCGAC CGACCTGCTG TATTTCAAGT TTGGGTGGAA CTATCCAGAA 
ATCAGGTTGA ACCGGCTGTT AAGAATCTCT CGGATGTTTG AGTTCTTCCA GAGGACAGAG 
ACAAGGACCA ACTACCCGAA CATCTTTAGG ATCTCAAACC TTGTGATGTA CATTGTCATC 
ATCATCCACT GGAACGCGTG TGTGTACTAC TCCATCTCAA AAGCTATTGG ATTTGGGAAT 
GACACATGGG TCTACCCTGA TGTTAATGAT CCTGAATTTG GCCGTTTGGC TAGAAAATAC 
GTCTACAGCC TTTATTGGTC TACCTTGACT TTGACGACCA TTGGAGAAAC CCCACCCCCC 
GTGCTGGATT CCGAGTATGT CTTTGTGGTG GTAGACTTCT TAATTGGAGT TTTAATTTTT 
GCCACCATTG TCGGTAACAT AGGCTCCATG ATTTCCAATA TGAATGCAGC CCGGGCAGAA 
TTTCAATCAA GAGTTGATGC TATCAAACAG TACATGAATT TTCGAAATGT GAGCAAAGAC 
ATGGAAAAGA GAGTTATTAA ATGGTTTGAC TACCTGTGGA CTAACAAAAA GACAGTCGAT 
GAGAGAGAAG TTCTGAGATA CCTCCCTGAC AAACTCAGGG CAGAGATTGC CATCAATGTT 
CACCTAGACA CGTTAAAAAA GGTTCGTATC TTTGCTGACT GTGAGGCTGG TCTGTTGGTG 
GAGTTGGTGT TGAAATTACA ACCCCAGGTG TACAGTCCTG GAGATTACAT ATGCAAGAAA 
GGGGACATTG GGCGGGAGAT GTACATCATC AAGGAAGGCA AACTTGCTGT GGTGGCAGAC 
GACGGAATCA CACAGTTTGT GGTGTTGAGT GACGGCAGCT ACTTTGGCGA GATCAGCATT 
CTTAACATCA AAGGCAGCAA GGCTGGCAAC CGAAGAACAG CCAATATTAA GAGCATTGGC 
TACTCGGACC TGTTCTGCCT CTCAAAGGAT GACCTCATGG AAGCTCTTAC AGAGTACCCA 
GATGCCAAAA CTATGTTGGA GGAGAAAGGG AGGCAGATCT TAATGAAAGA CGGTCTACTG 
GATATAAACA TTGCGAATTT GGGCAGTGAC CCTAAAGACC TGGAAGAGAA GGTCACTCGA 
ATGGAGGGGT CAGTGGACCT CCTGCAAACA CGATTTGCCC GAATCTTGGC TGAGTATGAA 
TCGATGCAGC AGAAACTCAA GCAAAGATTA ACCAAGGTTG AGAAATTCTT GAAACCACTT 
ATTGAAACTG AATTTTCAGC CCTTGAGGAA CCCGGAGGAG AAAGTGAACC CACAGAGTCT 
CTACAGGGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selective Modulation of Histaminergic Inputs on Projection Neurons of Cerebellum Rapidly Promotes Motor Coordination via HCN Channels.
Molecular neurobiology53(2)1386-401(2016 Mar)
Zhang J,Zhuang QX,Li B,Wu GY,Yung WH,Zhu JN,Wang JJ

Genes and mutations causing retinitis pigmentosa.
Clinical genetics84(2)132-41(2013 Aug)
Daiger SP,Sullivan LS,Bowne SJ

Insulin receptor regulates photoreceptor CNG channel activity.
American journal of physiology. Endocrinology and metabolism303(11)E1363-72(2012 Dec)
Gupta VK,Rajala A,Rajala RV

Calcium signalling remodelling and disease.
Biochemical Society transactions40(2)297-309(2012 Apr)
Berridge MJ

Role of estrogen and progesterone in the modulation of CNG-A1 and Na/K+-ATPase expression in the renal cortex.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology30(1)160-72(2012)
Gracelli JB,Souza-Menezes J,Barbosa CM,Ornellas FS,Takiya CM,Alves LM,Wengert M,Feltran Gda S,Caruso-Neves C,Moyses MR,Prota LF,Morales MM

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Cnga1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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