Max cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Max
Entrez Gene ID	60661
Full Name	MYC associated factor X
General protein information	Preferred Names MYC associated factor X Names protein max myc-associated factor X
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q24
Summary	human homolog is a transcriptional regulator that binds Myc [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006240248.3	XP_006240310.1	protein max isoform X1
NM_022210.1	NP_071546.1	protein max

Pathways from BioSystems

Homologies

Homo sapiens (human)	MAX	NP_002373.3
Rattus norvegicus (Norway rat)	Max	NP_071546.1
Canis lupus familiaris (dog)	MAX	XP_852901.1
Bos taurus (cattle)	MAX	NP_001099103.1
Mus musculus (house mouse)	Max	NP_032584.2
Xenopus tropicalis (tropical clawed frog)	max	NP_001008208.1
Pan troglodytes (chimpanzee)	MAX	XP_003314427.1
	MAX	XP_001103369.2
Gallus gallus (chicken)	MAX	XP_003643556.2
Danio rerio (zebrafish)	max	NP_571295.1

Gene Ontology
Bibliography

Related articles in PubMed

Functional and in silico assessment of MAX variants of unknown significance.
Comino-M?ndez I, Leandro-Garc?a LJ, Montoya G, Inglada-P?rez L, de Cubas AA, Curr?s-Freixes M, Tysoe C, Izatt L, Let?n R, G?mez-Gra?a ?, Mancikova V, Apell?niz-Ruiz M, Mannelli M, Schiavi F, Favier J, Gimenez-Roqueplo AP, Timmers HJ, Roncador G, Garcia JF, Rodr?guez-Antona C, Robledo M, Casc?n A
Journal of molecular medicine (Berlin, Germany)93(11)1247-55(2015 Nov)

MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1.
Romero OA, Torres-Diz M, Pros E, Savola S, Gomez A, Moran S, Saez C, Iwakawa R, Villanueva A, Montuenga LM, Kohno T, Yokota J, Sanchez-Cespedes M
Cancer discovery4(3)292-303(2014 Mar)

The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.
Qin J, Whyte WA, Anderssen E, Apostolou E, Chen HH, Akbarian S, Bronson RT, Hochedlinger K, Ramaswamy S, Young RA, Hock H
Cell stem cell11(3)319-32(2012 Sep)

[Expression of RAD51 and MAX in pancreatic cancer rats].
Yang L, Tan X, Yang Z, Li Q, Miao X
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences35(2)146-51(2010 Feb)

Nuclear proteasomal degradation and cytoplasmic retention underlie early nuclear exclusion of transcription factor Max upon axon damage.
Petrs-Silva H, Chiarini LB, Linden R
Experimental neurology213(1)202-9(2008 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The positive rate of Max expression was significantly lower in ductal adenocarcinoma in the control group.
Title: [Expression of RAD51 and MAX in pancreatic cancer rats].

Proteosomal degradation of nuclear Max coupled with continued expression and cytoplasmic accumulation of Max, with blockade of nucleocytoplasmic transport of the newly synthesized protein, is an early event after CNS axonal damage.
Title: Nuclear proteasomal degradation and cytoplasmic retention underlie early nuclear exclusion of transcription factor Max upon axon damage.

Maximal glucose-induced expression of the L-PK gene in INS-1-derived 832/13 cells involves increased c-Myc abundance, recruitment of c-Myc, Max, and ChREBP to the promoter.
Title: c-Myc and ChREBP regulate glucose-mediated expression of the L-type pyruvate kinase gene in INS-1-derived 832/13 cells.

The regulation of Max content during liver development and its potential role in determining c-Myc localization are means by which Max may control the biological activity of the c-Myc/Max/Mad network during liver development.
Title: Coordinated regulation of c-Myc and Max in rat liver development.

The following Max gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Max cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05441	NM_022210.1 Latest version!	Rattus norvegicus MYC associated factor X (Max), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa29429	XM_006240248.3 Latest version!	Rattus norvegicus MYC associated factor X (Max), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Max ( NM_022210.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071546.1 Rattus norvegicus MYC associated factor X (Max), mRNA.

Price & Availability↑

CloneID	ORa05441
Clone ID Related Accession (Same CDS sequence)	NM_022210.1
Accession Version	NM_022210.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Rattus norvegicus(Norway rat)
Product	protein max
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D14447.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D14447.1, CB607792.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906350 [ECO:0000348] ##Evidence-Data-END##

ATGAGCGATA ACGATGACAT CGAGGTGGAG AGCGACGAAG AGCAACCGAG GTTTCAATCT 
GCGGCTGACA AACGGGCTCA CCATAATGCA CTGGAACGAA AACGTAGGGA CCACATCAAA 
GACAGCTTTC ACAGTTTGCG GGACTCAGTC CCATCACTCC AAGGAGAGAA GGCATCCCGG 
GCCCAAATCC TAGACAAAGC AACAGAGTAT ATCCAGTATA TGCGAAGGAA AAACCATACG 
CACCAGCAAG ACATTGATGA CCTCAAGCGG CAGAATGCTC TTCTGGAGCA ACAAGTCCGT 
GCACTGGAGA AGGCAAGATC AAGTGCCCAA CTGCAGACCA ACTACCCCTC CTCAGACAAC 
AGCCTCTACA CCAACGCCAA GGGCGGCACC ATCTCTGCCT TCGATGGGGG TTCAGACTCC 
AGCTCAGAGT CCGAGCCTGA GGAGCCCCAG AACAGGAAGA AACTGCGGAT GGAGGCCAGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071546.1
CDS	1..483
Translation	MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDNSLYTNAKGGTISAFDGGSDSSSESEPEEPQNRKKLRMEAS

Target ORF information:

RefSeq Version	NM_022210.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MYC associated factor X (Max), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022210.1

ORF Insert Sequence:

ATGAGCGATA ACGATGACAT CGAGGTGGAG AGCGACGAAG AGCAACCGAG GTTTCAATCT 
GCGGCTGACA AACGGGCTCA CCATAATGCA CTGGAACGAA AACGTAGGGA CCACATCAAA 
GACAGCTTTC ACAGTTTGCG GGACTCAGTC CCATCACTCC AAGGAGAGAA GGCATCCCGG 
GCCCAAATCC TAGACAAAGC AACAGAGTAT ATCCAGTATA TGCGAAGGAA AAACCATACG 
CACCAGCAAG ACATTGATGA CCTCAAGCGG CAGAATGCTC TTCTGGAGCA ACAAGTCCGT 
GCACTGGAGA AGGCAAGATC AAGTGCCCAA CTGCAGACCA ACTACCCCTC CTCAGACAAC 
AGCCTCTACA CCAACGCCAA GGGCGGCACC ATCTCTGCCT TCGATGGGGG TTCAGACTCC 
AGCTCAGAGT CCGAGCCTGA GGAGCCCCAG AACAGGAAGA AACTGCGGAT GGAGGCCAGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Max ( XM_006240248.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006240310.1 Rattus norvegicus MYC associated factor X (Max), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa29429
Clone ID Related Accession (Same CDS sequence)	XM_006240248.3
Accession Version	XM_006240248.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	protein max isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006240248.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCGATA ACGATGACAT CGAGGTGGAG AGCGACGCTG ACAAACGGGC TCACCATAAT 
GCACTGGAAC GAAAACGTAG GGACCACATC AAAGACAGCT TTCACAGTTT GCGGGACTCA 
GTCCCATCAC TCCAAGGAGA GAAGGCATCC CGGGCCCAAA TCCTAGACAA AGCAACAGAG 
TATATCCAGT ATATGCGAAG GAAAAACCAT ACGCACCAGC AAGACATTGA TGACCTCAAG 
CGGCAGAATG CTCTTCTGGA GCAACAAGTC CGTGCACTGG AGAAGGCAAG ATCAAGTGCC 
CAACTGCAGA CCAACTACCC CTCCTCAGAC AACAGCCTCT ACACCAACGC CAAGGGCGGC 
ACCATCTCTG CCTTCGATGG GGGTTCAGAC TCCAGCTCAG AGTCCGAGCC TGAGGAGCCC 
CAGAACAGGA AGAAACTGCG GATGGAGGCC AGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006240310.1
CDS	229..684
Translation	MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDNSLYTNAKGGTISAFDGGSDSSSESEPEEPQNRKKLRMEAS

Target ORF information:

RefSeq Version	XM_006240248.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MYC associated factor X (Max), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006240248.3

ORF Insert Sequence:

ATGAGCGATA ACGATGACAT CGAGGTGGAG AGCGACGCTG ACAAACGGGC TCACCATAAT 
GCACTGGAAC GAAAACGTAG GGACCACATC AAAGACAGCT TTCACAGTTT GCGGGACTCA 
GTCCCATCAC TCCAAGGAGA GAAGGCATCC CGGGCCCAAA TCCTAGACAA AGCAACAGAG 
TATATCCAGT ATATGCGAAG GAAAAACCAT ACGCACCAGC AAGACATTGA TGACCTCAAG 
CGGCAGAATG CTCTTCTGGA GCAACAAGTC CGTGCACTGG AGAAGGCAAG ATCAAGTGCC 
CAACTGCAGA CCAACTACCC CTCCTCAGAC AACAGCCTCT ACACCAACGC CAAGGGCGGC 
ACCATCTCTG CCTTCGATGG GGGTTCAGAC TCCAGCTCAG AGTCCGAGCC TGAGGAGCCC 
CAGAACAGGA AGAAACTGCG GATGGAGGCC AGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional and in silico assessment of MAX variants of unknown significance.
Journal of molecular medicine (Berlin, Germany)93(11)1247-55(2015 Nov)
Comino-M?ndez I,Leandro-Garc?a LJ,Montoya G,Inglada-P?rez L,de Cubas AA,Curr?s-Freixes M,Tysoe C,Izatt L,Let?n R,G?mez-Gra?a ?,Mancikova V,Apell?niz-Ruiz M,Mannelli M,Schiavi F,Favier J,Gimenez-Roqueplo AP,Timmers HJ,Roncador G,Garcia JF,Rodr?guez-Antona C,Robledo M,Casc?n A

MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1.
Cancer discovery4(3)292-303(2014 Mar)
Romero OA,Torres-Diz M,Pros E,Savola S,Gomez A,Moran S,Saez C,Iwakawa R,Villanueva A,Montuenga LM,Kohno T,Yokota J,Sanchez-Cespedes M

The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.
Cell stem cell11(3)319-32(2012 Sep)
Qin J,Whyte WA,Anderssen E,Apostolou E,Chen HH,Akbarian S,Bronson RT,Hochedlinger K,Ramaswamy S,Young RA,Hock H

[Expression of RAD51 and MAX in pancreatic cancer rats].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences35(2)146-51(2010 Feb)
Yang L,Tan X,Yang Z,Li Q,Miao X

Nuclear proteasomal degradation and cytoplasmic retention underlie early nuclear exclusion of transcription factor Max upon axon damage.
Experimental neurology213(1)202-9(2008 Sep)
Petrs-Silva H,Chiarini LB,Linden R