Kcnn2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnn2
Entrez Gene ID	54262
Full Name	potassium calcium-activated channel subfamily N member 2
Synonyms	KCa2.2,SK2,SKCa 2,SKCa2
General protein information	Preferred Names potassium calcium-activated channel subfamily N member 2 Names small conductance calcium-activated potassium channel protein 2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18q11
Summary	small-conductance, calcium-activated potassium channel [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017601013.1	XP_017456502.1	small conductance calcium-activated potassium channel protein 2 isoform X2
NM_019314.2	NP_062187.1	small conductance calcium-activated potassium channel protein 2 isoform 2
XM_006254683.3	XP_006254745.1	small conductance calcium-activated potassium channel protein 2 isoform X1
NM_001309404.1	NP_001296333.1	small conductance calcium-activated potassium channel protein 2 isoform 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	KCNN2	NP_991361.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010503	XP_314474.4
Xenopus tropicalis (tropical clawed frog)	kcnn1	NP_001072484.1
Mus musculus (house mouse)	Kcnn2	NP_536713.1
Drosophila melanogaster (fruit fly)	SK	NP_001259252.1
Gallus gallus (chicken)	KCNN2	NP_990129.1
Danio rerio (zebrafish)	kcnn1a	NP_001121720.1
Caenorhabditis elegans (roundworm)	kcnl-2	NP_871792.1
Caenorhabditis elegans (roundworm)	kcnl-2	NP_492234.2
Rattus norvegicus (Norway rat)	Kcnn2	NP_062187.1

Gene Ontology
Bibliography

Related articles in PubMed

Tremor dominant Kyoto (Trdk) rats carry a missense mutation in the gene encoding the SK2 subunit of small-conductance Ca
Kuramoto T, Yokoe M, Kunisawa N, Ohashi K, Miyake T, Higuchi Y, Yoshimi K, Mashimo T, Tanaka M, Kuwamura M, Kaneko S, Shimizu S, Serikawa T, Ohno Y
Brain research167638-45(2017 Dec)

SK2 channels regulate mitochondrial respiration and mitochondrial Ca
Honrath B, Matschke L, Meyer T, Magerhans L, Perocchi F, Ganjam GK, Zischka H, Krasel C, Gerding A, Bakker BM, B?nemann M, Strack S, Decher N, Culmsee C, Dolga AM
Cell death and differentiation24(5)761-773(2017 May)

Downregulation of Endothelial Transient Receptor Potential Vanilloid Type 4 Channel and Small-Conductance of Ca2+-Activated K+ Channels Underpins Impaired Endothelium-Dependent Hyperpolarization in Hypertension.
Seki T, Goto K, Kiyohara K, Kansui Y, Murakami N, Haga Y, Ohtsubo T, Matsumura K, Kitazono T
Hypertension (Dallas, Tex. : 1979)69(1)143-153(2017 01)

Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current.
Yu CC, Ko JS, Ai T, Tsai WC, Chen Z, Rubart M, Vatta M, Everett TH 4th, George AL Jr, Chen PS
Heart rhythm13(8)1716-23(2016 08)

Apamin-Sensitive K+ Current Upregulation in Volume-Overload Heart Failure is Associated with the Decreased Interaction of CK2 with SK2.
Yang D, Wang T, Ni Y, Song B, Ning F, Hu P, Luo L, Wang Y, Ma A
The Journal of membrane biology248(6)1181-9(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

EDH-mediated responses are impaired in superior mesenteric arteries of SHRSP because of a reduction in both TRPV4 and SKCa input to EDH.
Title: Downregulation of Endothelial Transient Receptor Potential Vanilloid Type 4 Channel and Small-Conductance of Ca2+-Activated K+ Channels Underpins Impaired Endothelium-Dependent Hyperpolarization in Hypertension.

Apamin-Sensitive K+ Current Upregulation in Volume-Overload Heart Failure is Associated with the Decreased Interaction of CK2 with SK2.
Title: Apamin-Sensitive K+ Current Upregulation in Volume-Overload Heart Failure is Associated with the Decreased Interaction of CK2 with SK2.

This study demonistrated that SK1 and SK2 transcripts showed strong expression starting from E15 in the striatum and decreased throughout pre- and postnatal development.
Title: Developmental mapping of small-conductance calcium-activated potassium channel expression in the rat nervous system.

Sarcoplasmic reticulum Ca(2+) release is both necessary and sufficient for the activation of SK channels in rat ventricular myocytes.
Title: Sarcoplasmic reticulum Ca?? release is both necessary and sufficient for SK channel activation in ventricular myocytes.

SK2 and SK3 channels are expressed in different populations of motoneurons in rats and mice but not in cats
Title: Expression of postsynaptic Ca2+-activated K+ (SK) channels at C-bouton synapses in mammalian lumbar -motoneurons.

The following Kcnn2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnn2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa43411	NM_019314.2 Latest version!	Rattus norvegicus potassium calcium-activated channel subfamily N member 2 (Kcnn2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$342.30 $489.00
ORa43412	NM_001309404.1 Latest version!	Rattus norvegicus potassium calcium-activated channel subfamily N member 2 (Kcnn2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
ORa38362	XM_006254683.3 Latest version!	Rattus norvegicus potassium calcium-activated channel subfamily N member 2 (Kcnn2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$475.30 $679.00
ORa59304	XM_017601013.1 Latest version!	Rattus norvegicus potassium calcium-activated channel subfamily N member 2 (Kcnn2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$475.30 $679.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnn2 ( NM_019314.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062187.1 Rattus norvegicus potassium calcium-activated channel subfamily N member 2 (Kcnn2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa43411
Clone ID Related Accession (Same CDS sequence)	NM_019314.2
Accession Version	NM_019314.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1743bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Rattus norvegicus(Norway rat)
Product	small conductance calcium-activated potassium channel protein 2 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07031919.1 and AABR07031920.1. On Jun 2, 2015 this sequence version replaced NM_019314.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U69882.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCAGCT GCAGGTACAA CGGGGGCGTC ATGCGTCCGC TCAGCAACTT GAGCTCGTCC 
CGCCGGAACC TGCACGAGAT GGACTCAGAG GCTCAGCCCC TGCAGCCCCC AGCGTCGGTT 
GTAGGAGGAG GTGGTGGTGC GTCCTCCCCG TCTGCTGCCG CCGCCGCCTC ATCCTCAGCC 
CCAGAGATCG TGGTGTCTAA GCCGGAGCAC AACAATTCTA ACAACCTGGC GCTCTACGGA 
ACTGGCGGCG GAGGCAGCAC CGGAGGCGGC GGCGGCGGCG GCGGCGGCGG CGGCGGCAGC 
GGGCATGGCA GCAGCAGCGG CACTAAGTCC AGCAAAAAGA AGAACCAGAA CATCGGCTAT 
AAGCTGGGCC ATCGGCGTGC CCTGTTTGAG AAGCGCAAGC GGCTCAGCGA CTATGCGCTC 
ATCTTCGGCA TGTTCGGCAT CGTGGTCATG GTCATCGAGA CCGAGCTGTC GTGGGGCGCC 
TACGACAAGG CGTCGCTGTA TTCTTTAGCT CTGAAATGCC TTATCAGTCT CTCCACGATC 
ATCCTGCTTG GTCTGATCAT CGTATACCAC GCCAGGGAAA TACAGTTATT CATGGTGGAC 
AATGGAGCAG ATGACTGGAG AATAGCCATG ACTTATGAGC GTATTTTCTT CATCTGCTTG 
GAAATACTGG TGTGTGCTAT TCATCCCATC CCTGGGAATT ATACGTTCAC ATGGACAGCC 
CGGCTTGCCT TCTCCTATGC CCCTTCCACA ACCACTGCAG ACGTGGATAT TATTTTATCT 
ATACCAATGT TCTTAAGACT CTATCTGATT GCCAGAGTCA TGCTATTACA TAGCAAACTT 
TTCACCGATG CCTCCTCTAG AAGCATTGGG GCACTTAATA AGATAAACTT CAATACGCGT 
TTTGTTATGA AGACTTTAAT GACTATCTGC CCAGGAACTG TGCTCTTGGT TTTTAGTATC 
TCGTTATGGA TAATTGCCGC ATGGACTGTC CGAGCTTGTG AAAGGTACCA TGATCAACAG 
GATGTCACTA GCAACTTCCT TGGAGCAATG TGGTTGATAT CAATAACTTT TCTCTCCATT 
GGTTATGGTG ACATGGTACC TAACACATAC TGTGGGAAAG GAGTCTGCTT GCTTACCGGA 
ATAATGGGTG CAGGTTGCAC AGCCTTGGTG GTAGCCGTAG TGGCAAGAAA GCTAGAACTT 
ACCAAAGCAG AAAAGCATGT GCACAATTTC ATGATGGATA CTCAGCTGAC CAAAAGAGTA 
AAAAACGCAG CCGCCAATGT ACTCAGGGAA ACGTGGTTAA TCTACAAAAA CACAAAGCTA 
GTGAAAAAGA TCGACCATGC AAAAGTAAGG AAGCATCAAC GGAAATTCTT ACAAGCTATT 
CATCAATTAA GAAGTGTGAA GATGGAACAG AGGAAACTGA ATGACCAAGC GAATACTCTA 
GTGGATCTGG CAAAGACCCA GAATATCATG TATGATATGA TTTCCGACTT AAATGAAAGG 
AGTGAAGACT TTGAGAAAAG GATCGTCACC CTGGAAACAA AATTAGAAAC TTTGATTGGT 
AGCATTCATG CCCTCCCTGG GCTTATCAGC CAGACCATCA GACAGCAGCA AAGGGACTTC 
ATAGAGACAC AGATGGAGAA CTATGACAAG CATGTCACCT ACAATGCTGA GCGTTCCCGG 
TCCTCGTCCA GGAGGCGGCG GTCCTCCTCC ACAGCGCCAC CAACTTCATC TGAGAGTAGC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062187.1
CDS	1..1743
Translation	MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS

Target ORF information:

RefSeq Version	NM_019314.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium calcium-activated channel subfamily N member 2 (Kcnn2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019314.2

ORF Insert Sequence:

ATGAGCAGCT GCAGGTACAA CGGGGGCGTC ATGCGTCCGC TCAGCAACTT GAGCTCGTCC 
CGCCGGAACC TGCACGAGAT GGACTCAGAG GCTCAGCCCC TGCAGCCCCC AGCGTCGGTT 
GTAGGAGGAG GTGGTGGTGC GTCCTCCCCG TCTGCTGCCG CCGCCGCCTC ATCCTCAGCC 
CCAGAGATCG TGGTGTCTAA GCCGGAGCAC AACAATTCTA ACAACCTGGC GCTCTACGGA 
ACTGGCGGCG GAGGCAGCAC CGGAGGCGGC GGCGGCGGCG GCGGCGGCGG CGGCGGCAGC 
GGGCATGGCA GCAGCAGCGG CACTAAGTCC AGCAAAAAGA AGAACCAGAA CATCGGCTAT 
AAGCTGGGCC ATCGGCGTGC CCTGTTTGAG AAGCGCAAGC GGCTCAGCGA CTATGCGCTC 
ATCTTCGGCA TGTTCGGCAT CGTGGTCATG GTCATCGAGA CCGAGCTGTC GTGGGGCGCC 
TACGACAAGG CGTCGCTGTA TTCTTTAGCT CTGAAATGCC TTATCAGTCT CTCCACGATC 
ATCCTGCTTG GTCTGATCAT CGTATACCAC GCCAGGGAAA TACAGTTATT CATGGTGGAC 
AATGGAGCAG ATGACTGGAG AATAGCCATG ACTTATGAGC GTATTTTCTT CATCTGCTTG 
GAAATACTGG TGTGTGCTAT TCATCCCATC CCTGGGAATT ATACGTTCAC ATGGACAGCC 
CGGCTTGCCT TCTCCTATGC CCCTTCCACA ACCACTGCAG ACGTGGATAT TATTTTATCT 
ATACCAATGT TCTTAAGACT CTATCTGATT GCCAGAGTCA TGCTATTACA TAGCAAACTT 
TTCACCGATG CCTCCTCTAG AAGCATTGGG GCACTTAATA AGATAAACTT CAATACGCGT 
TTTGTTATGA AGACTTTAAT GACTATCTGC CCAGGAACTG TGCTCTTGGT TTTTAGTATC 
TCGTTATGGA TAATTGCCGC ATGGACTGTC CGAGCTTGTG AAAGGTACCA TGATCAACAG 
GATGTCACTA GCAACTTCCT TGGAGCAATG TGGTTGATAT CAATAACTTT TCTCTCCATT 
GGTTATGGTG ACATGGTACC TAACACATAC TGTGGGAAAG GAGTCTGCTT GCTTACCGGA 
ATAATGGGTG CAGGTTGCAC AGCCTTGGTG GTAGCCGTAG TGGCAAGAAA GCTAGAACTT 
ACCAAAGCAG AAAAGCATGT GCACAATTTC ATGATGGATA CTCAGCTGAC CAAAAGAGTA 
AAAAACGCAG CCGCCAATGT ACTCAGGGAA ACGTGGTTAA TCTACAAAAA CACAAAGCTA 
GTGAAAAAGA TCGACCATGC AAAAGTAAGG AAGCATCAAC GGAAATTCTT ACAAGCTATT 
CATCAATTAA GAAGTGTGAA GATGGAACAG AGGAAACTGA ATGACCAAGC GAATACTCTA 
GTGGATCTGG CAAAGACCCA GAATATCATG TATGATATGA TTTCCGACTT AAATGAAAGG 
AGTGAAGACT TTGAGAAAAG GATCGTCACC CTGGAAACAA AATTAGAAAC TTTGATTGGT 
AGCATTCATG CCCTCCCTGG GCTTATCAGC CAGACCATCA GACAGCAGCA AAGGGACTTC 
ATAGAGACAC AGATGGAGAA CTATGACAAG CATGTCACCT ACAATGCTGA GCGTTCCCGG 
TCCTCGTCCA GGAGGCGGCG GTCCTCCTCC ACAGCGCCAC CAACTTCATC TGAGAGTAGC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnn2 ( NM_001309404.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001296333.1 Rattus norvegicus potassium calcium-activated channel subfamily N member 2 (Kcnn2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa43412
Clone ID Related Accession (Same CDS sequence)	NM_001309404.1
Accession Version	NM_001309404.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1752bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Rattus norvegicus(Norway rat)
Product	small conductance calcium-activated potassium channel protein 2 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07031919.1 and AABR07031920.1. On Jun 2, 2015 this sequence version replaced XM_006254682.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: JN857942.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCAGCT GCAGGTACAA CGGGGGCGTC ATGCGTCCGC TCAGCAACTT GAGCTCGTCC 
CGCCGGAACC TGCACGAGAT GGACTCAGAG GCTCAGCCCC TGCAGCCCCC AGCGTCGGTT 
GTAGGAGGAG GTGGTGGTGC GTCCTCCCCG TCTGCTGCCG CCGCCGCCTC ATCCTCAGCC 
CCAGAGATCG TGGTGTCTAA GCCGGAGCAC AACAATTCTA ACAACCTGGC GCTCTACGGA 
ACTGGCGGCG GAGGCAGCAC CGGAGGCGGC GGCGGCGGCG GCGGCGGCGG CGGCGGCAGC 
GGGCATGGCA GCAGCAGCGG CACTAAGTCC AGCAAAAAGA AGAACCAGAA CATCGGCTAT 
AAGCTGGGCC ATCGGCGTGC CCTGTTTGAG AAGCGCAAGC GGCTCAGCGA CTATGCGCTC 
ATCTTCGGCA TGTTCGGCAT CGTGGTCATG GTCATCGAGA CCGAGCTGTC GTGGGGCGCC 
TACGACAAGG CGTCGCTGTA TTCTTTAGCT CTGAAATGCC TTATCAGTCT CTCCACGATC 
ATCCTGCTTG GTCTGATCAT CGTATACCAC GCCAGGGAAA TACAGTTATT CATGGTGGAC 
AATGGAGCAG ATGACTGGAG AATAGCCATG ACTTATGAGC GTATTTTCTT CATCTGCTTG 
GAAATACTGG TGTGTGCTAT TCATCCCATC CCTGGGAATT ATACGTTCAC ATGGACAGCC 
CGGCTTGCCT TCTCCTATGC CCCTTCCACA ACCACTGCAG ACGTGGATAT TATTTTATCT 
ATACCAATGT TCTTAAGACT CTATCTGATT GCCAGAGTCA TGCTATTACA TAGCAAACTT 
TTCACCGATG CCTCCTCTAG AAGCATTGGG GCACTTAATA AGATAAACTT CAATACGCGT 
TTTGTTATGA AGACTTTAAT GACTATCTGC CCAGGAACTG TGCTCTTGGT TTTTAGTATC 
TCGTTATGGA TAATTGCCGC ATGGACTGTC CGAGCTTGTG AAAGGTACCA TGATCAACAG 
GATGTCACTA GCAACTTCCT TGGAGCAATG TGGTTGATAT CAATAACTTT TCTCTCCATT 
GGTTATGGTG ACATGGTACC TAACACATAC TGTGGGAAAG GAGTCTGCTT GCTTACCGGA 
ATAATGGGTG CAGGTTGCAC AGCCTTGGTG GTAGCCGTAG TGGCAAGAAA GCTAGAACTT 
ACCAAAGCAG AAAAGCATGT GCACAATTTC ATGATGGATA CTCAGCTGAC CAAAAGAGTA 
AAAAACGCAG CCGCCAATGT ACTCAGGGAA ACGTGGTTAA TCTACAAAAA CACAAAGCTA 
GTGAAAAAGA TCGACCATGC AAAAGTAAGG AAGCATCAAC GGAAATTCTT ACAAGCTATT 
CATCAAGCTC GGAAATTAAG AAGTGTGAAG ATGGAACAGA GGAAACTGAA TGACCAAGCG 
AATACTCTAG TGGATCTGGC AAAGACCCAG AATATCATGT ATGATATGAT TTCCGACTTA 
AATGAAAGGA GTGAAGACTT TGAGAAAAGG ATCGTCACCC TGGAAACAAA ATTAGAAACT 
TTGATTGGTA GCATTCATGC CCTCCCTGGG CTTATCAGCC AGACCATCAG ACAGCAGCAA 
AGGGACTTCA TAGAGACACA GATGGAGAAC TATGACAAGC ATGTCACCTA CAATGCTGAG 
CGTTCCCGGT CCTCGTCCAG GAGGCGGCGG TCCTCCTCCA CAGCGCCACC AACTTCATCT 
GAGAGTAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001296333.1
CDS	1..1752
Translation	MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQARKLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS

Target ORF information:

RefSeq Version	NM_001309404.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium calcium-activated channel subfamily N member 2 (Kcnn2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001309404.1

ORF Insert Sequence:

ATGAGCAGCT GCAGGTACAA CGGGGGCGTC ATGCGTCCGC TCAGCAACTT GAGCTCGTCC 
CGCCGGAACC TGCACGAGAT GGACTCAGAG GCTCAGCCCC TGCAGCCCCC AGCGTCGGTT 
GTAGGAGGAG GTGGTGGTGC GTCCTCCCCG TCTGCTGCCG CCGCCGCCTC ATCCTCAGCC 
CCAGAGATCG TGGTGTCTAA GCCGGAGCAC AACAATTCTA ACAACCTGGC GCTCTACGGA 
ACTGGCGGCG GAGGCAGCAC CGGAGGCGGC GGCGGCGGCG GCGGCGGCGG CGGCGGCAGC 
GGGCATGGCA GCAGCAGCGG CACTAAGTCC AGCAAAAAGA AGAACCAGAA CATCGGCTAT 
AAGCTGGGCC ATCGGCGTGC CCTGTTTGAG AAGCGCAAGC GGCTCAGCGA CTATGCGCTC 
ATCTTCGGCA TGTTCGGCAT CGTGGTCATG GTCATCGAGA CCGAGCTGTC GTGGGGCGCC 
TACGACAAGG CGTCGCTGTA TTCTTTAGCT CTGAAATGCC TTATCAGTCT CTCCACGATC 
ATCCTGCTTG GTCTGATCAT CGTATACCAC GCCAGGGAAA TACAGTTATT CATGGTGGAC 
AATGGAGCAG ATGACTGGAG AATAGCCATG ACTTATGAGC GTATTTTCTT CATCTGCTTG 
GAAATACTGG TGTGTGCTAT TCATCCCATC CCTGGGAATT ATACGTTCAC ATGGACAGCC 
CGGCTTGCCT TCTCCTATGC CCCTTCCACA ACCACTGCAG ACGTGGATAT TATTTTATCT 
ATACCAATGT TCTTAAGACT CTATCTGATT GCCAGAGTCA TGCTATTACA TAGCAAACTT 
TTCACCGATG CCTCCTCTAG AAGCATTGGG GCACTTAATA AGATAAACTT CAATACGCGT 
TTTGTTATGA AGACTTTAAT GACTATCTGC CCAGGAACTG TGCTCTTGGT TTTTAGTATC 
TCGTTATGGA TAATTGCCGC ATGGACTGTC CGAGCTTGTG AAAGGTACCA TGATCAACAG 
GATGTCACTA GCAACTTCCT TGGAGCAATG TGGTTGATAT CAATAACTTT TCTCTCCATT 
GGTTATGGTG ACATGGTACC TAACACATAC TGTGGGAAAG GAGTCTGCTT GCTTACCGGA 
ATAATGGGTG CAGGTTGCAC AGCCTTGGTG GTAGCCGTAG TGGCAAGAAA GCTAGAACTT 
ACCAAAGCAG AAAAGCATGT GCACAATTTC ATGATGGATA CTCAGCTGAC CAAAAGAGTA 
AAAAACGCAG CCGCCAATGT ACTCAGGGAA ACGTGGTTAA TCTACAAAAA CACAAAGCTA 
GTGAAAAAGA TCGACCATGC AAAAGTAAGG AAGCATCAAC GGAAATTCTT ACAAGCTATT 
CATCAAGCTC GGAAATTAAG AAGTGTGAAG ATGGAACAGA GGAAACTGAA TGACCAAGCG 
AATACTCTAG TGGATCTGGC AAAGACCCAG AATATCATGT ATGATATGAT TTCCGACTTA 
AATGAAAGGA GTGAAGACTT TGAGAAAAGG ATCGTCACCC TGGAAACAAA ATTAGAAACT 
TTGATTGGTA GCATTCATGC CCTCCCTGGG CTTATCAGCC AGACCATCAG ACAGCAGCAA 
AGGGACTTCA TAGAGACACA GATGGAGAAC TATGACAAGC ATGTCACCTA CAATGCTGAG 
CGTTCCCGGT CCTCGTCCAG GAGGCGGCGG TCCTCCTCCA CAGCGCCACC AACTTCATCT 
GAGAGTAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnn2 ( XM_006254683.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006254745.1 Rattus norvegicus potassium calcium-activated channel subfamily N member 2 (Kcnn2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa38362
Clone ID Related Accession (Same CDS sequence)	XM_006254683.3
Accession Version	XM_006254683.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2577bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	small conductance calcium-activated potassium channel protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006254683.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTCGGGA GAACGTGCAA ATGTGATGTC ATGCCCATTG TTTTGGTGCG CCCAACCAAT 
CGGACTCGCC GCCTGGATTC TACCGGAGCC GGCATGGGCC CTTCCTCGCA CCAGCAGCAG 
GAGTCCCCGC TCCCGACCAT AACGCATTGC GCAGGGTGCA CCACCGCCTG GTCTCCCTGC 
AGCTTTAACA GGTCTGACAT GGAAACCCCA TTGCAGTTCC AGCGCGGCTT CTTCCCAGAG 
CAGCCGCCGC CACCGCCGCG CTCCTCACAC CTGCATTGCC AGCAGCAGCA ACAGAGCCAG 
GACAAACCGT GCGCGCCCTT CGCGCCCCTC CCGCACCCTC ACCACCACCC GCACCTCGCG 
CACCAGCAGC CGGGCAGCGG TGGTAGCAGC CCATGCCTCC GGTGCAACAG CTGCGCCTCC 
TCCGGTGCCC CGGAGGCGGG GGCGGGGGCG GGGGATAACC TGTCCCTGCT GCTCCGCACC 
TCATCGCCCG GCGGCGCTTT CCGGACCCGC ACCTCCTCGC CGCTGTCGGG CTCTTCGTGC 
TGTTGCTGCT GCTCGTCGCG CCGGGGCAGC CAGCTCAATG TGAGCGAGCT GACGCCGTCC 
AGCCATGCCA GTGCGCTCCG GCAGCAGTAC GCGCAGCAGC CCGCGTCCGC CTCCCTGTAC 
CACCAGTGCC ACAGCCTGCA GCCCGCCGCC AGCCCCACAG GCAGCCTGGG CAGCCTGGGC 
TCCGGGCCCC CTCTCTCGCA CCACCACCAC CACCCGCACC CGGCGCACCA CCAGCATCAC 
CAACCCCAGG CGCGCCGCGA GAGCAACCCC TTCACCGAAA TAGCCATGAG CAGCTGCAGG 
TACAACGGGG GCGTCATGCG TCCGCTCAGC AACTTGAGCT CGTCCCGCCG GAACCTGCAC 
GAGATGGACT CAGAGGCTCA GCCCCTGCAG CCCCCAGCGT CGGTTGTAGG AGGAGGTGGT 
GGTGCGTCCT CCCCGTCTGC TGCCGCCGCC GCCTCATCCT CAGCCCCAGA GATCGTGGTG 
TCTAAGCCGG AGCACAACAA TTCTAACAAC CTGGCGCTCT ACGGAACTGG CGGCGGAGGC 
AGCACCGGAG GCGGCGGCGG CGGCGGCGGC GGCGGCGGCG GCAGCGGGCA TGGCAGCAGC 
AGCGGCACTA AGTCCAGCAA AAAGAAGAAC CAGAACATCG GCTATAAGCT GGGCCATCGG 
CGTGCCCTGT TTGAGAAGCG CAAGCGGCTC AGCGACTATG CGCTCATCTT CGGCATGTTC 
GGCATCGTGG TCATGGTCAT CGAGACCGAG CTGTCGTGGG GCGCCTACGA CAAGGCGTCG 
CTGTATTCTT TAGCTCTGAA ATGCCTTATC AGTCTCTCCA CGATCATCCT GCTTGGTCTG 
ATCATCGTAT ACCACGCCAG GGAAATACAG TTATTCATGG TGGACAATGG AGCAGATGAC 
TGGAGAATAG CCATGACTTA TGAGCGTATT TTCTTCATCT GCTTGGAAAT ACTGGTGTGT 
GCTATTCATC CCATCCCTGG GAATTATACG TTCACATGGA CAGCCCGGCT TGCCTTCTCC 
TATGCCCCTT CCACAACCAC TGCAGACGTG GATATTATTT TATCTATACC AATGTTCTTA 
AGACTCTATC TGATTGCCAG AGTCATGCTA TTACATAGCA AACTTTTCAC CGATGCCTCC 
TCTAGAAGCA TTGGGGCACT TAATAAGATA AACTTCAATA CGCGTTTTGT TATGAAGACT 
TTAATGACTA TCTGCCCAGG AACTGTGCTC TTGGTTTTTA GTATCTCGTT ATGGATAATT 
GCCGCATGGA CTGTCCGAGC TTGTGAAAGG TACCATGATC AACAGGATGT CACTAGCAAC 
TTCCTTGGAG CAATGTGGTT GATATCAATA ACTTTTCTCT CCATTGGTTA TGGTGACATG 
GTACCTAACA CATACTGTGG GAAAGGAGTC TGCTTGCTTA CCGGAATAAT GGGTGCAGGT 
TGCACAGCCT TGGTGGTAGC CGTAGTGGCA AGAAAGCTAG AACTTACCAA AGCAGAAAAG 
CATGTGCACA ATTTCATGAT GGATACTCAG CTGACCAAAA GAGTAAAAAA CGCAGCCGCC 
AATGTACTCA GGGAAACGTG GTTAATCTAC AAAAACACAA AGCTAGTGAA AAAGATCGAC 
CATGCAAAAG TAAGGAAGCA TCAACGGAAA TTCTTACAAG CTATTCATCA AGCTCGGAAA 
TTAAGAAGTG TGAAGATGGA ACAGAGGAAA CTGAATGACC AAGCGAATAC TCTAGTGGAT 
CTGGCAAAGA CCCAGAATAT CATGTATGAT ATGATTTCCG ACTTAAATGA AAGGAGTGAA 
GACTTTGAGA AAAGGATCGT CACCCTGGAA ACAAAATTAG AAACTTTGAT TGGTAGCATT 
CATGCCCTCC CTGGGCTTAT CAGCCAGACC ATCAGACAGC AGCAAAGGGA CTTCATAGAG 
ACACAGATGG AGAACTATGA CAAGCATGTC ACCTACAATG CTGAGCGTTC CCGGTCCTCG 
TCCAGGAGGC GGCGGTCCTC CTCCACAGCG CCACCAACTT CATCTGAGAG TAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006254745.1
CDS	1801..4377
Translation	MFGRTCKCDVMPIVLVRPTNRTRRLDSTGAGMGPSSHQQQESPLPTITHCAGCTTAWSPCSFNRSDMETPLQFQRGFFPEQPPPPPRSSHLHCQQQQQSQDKPCAPFAPLPHPHHHPHLAHQQPGSGGSSPCLRCNSCASSGAPEAGAGAGDNLSLLLRTSSPGGAFRTRTSSPLSGSSCCCCCSSRRGSQLNVSELTPSSHASALRQQYAQQPASASLYHQCHSLQPAASPTGSLGSLGSGPPLSHHHHHPHPAHHQHHQPQARRESNPFTEIAMSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQARKLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS

Target ORF information:

RefSeq Version	XM_006254683.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium calcium-activated channel subfamily N member 2 (Kcnn2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006254683.3

ORF Insert Sequence:

ATGTTCGGGA GAACGTGCAA ATGTGATGTC ATGCCCATTG TTTTGGTGCG CCCAACCAAT 
CGGACTCGCC GCCTGGATTC TACCGGAGCC GGCATGGGCC CTTCCTCGCA CCAGCAGCAG 
GAGTCCCCGC TCCCGACCAT AACGCATTGC GCAGGGTGCA CCACCGCCTG GTCTCCCTGC 
AGCTTTAACA GGTCTGACAT GGAAACCCCA TTGCAGTTCC AGCGCGGCTT CTTCCCAGAG 
CAGCCGCCGC CACCGCCGCG CTCCTCACAC CTGCATTGCC AGCAGCAGCA ACAGAGCCAG 
GACAAACCGT GCGCGCCCTT CGCGCCCCTC CCGCACCCTC ACCACCACCC GCACCTCGCG 
CACCAGCAGC CGGGCAGCGG TGGTAGCAGC CCATGCCTCC GGTGCAACAG CTGCGCCTCC 
TCCGGTGCCC CGGAGGCGGG GGCGGGGGCG GGGGATAACC TGTCCCTGCT GCTCCGCACC 
TCATCGCCCG GCGGCGCTTT CCGGACCCGC ACCTCCTCGC CGCTGTCGGG CTCTTCGTGC 
TGTTGCTGCT GCTCGTCGCG CCGGGGCAGC CAGCTCAATG TGAGCGAGCT GACGCCGTCC 
AGCCATGCCA GTGCGCTCCG GCAGCAGTAC GCGCAGCAGC CCGCGTCCGC CTCCCTGTAC 
CACCAGTGCC ACAGCCTGCA GCCCGCCGCC AGCCCCACAG GCAGCCTGGG CAGCCTGGGC 
TCCGGGCCCC CTCTCTCGCA CCACCACCAC CACCCGCACC CGGCGCACCA CCAGCATCAC 
CAACCCCAGG CGCGCCGCGA GAGCAACCCC TTCACCGAAA TAGCCATGAG CAGCTGCAGG 
TACAACGGGG GCGTCATGCG TCCGCTCAGC AACTTGAGCT CGTCCCGCCG GAACCTGCAC 
GAGATGGACT CAGAGGCTCA GCCCCTGCAG CCCCCAGCGT CGGTTGTAGG AGGAGGTGGT 
GGTGCGTCCT CCCCGTCTGC TGCCGCCGCC GCCTCATCCT CAGCCCCAGA GATCGTGGTG 
TCTAAGCCGG AGCACAACAA TTCTAACAAC CTGGCGCTCT ACGGAACTGG CGGCGGAGGC 
AGCACCGGAG GCGGCGGCGG CGGCGGCGGC GGCGGCGGCG GCAGCGGGCA TGGCAGCAGC 
AGCGGCACTA AGTCCAGCAA AAAGAAGAAC CAGAACATCG GCTATAAGCT GGGCCATCGG 
CGTGCCCTGT TTGAGAAGCG CAAGCGGCTC AGCGACTATG CGCTCATCTT CGGCATGTTC 
GGCATCGTGG TCATGGTCAT CGAGACCGAG CTGTCGTGGG GCGCCTACGA CAAGGCGTCG 
CTGTATTCTT TAGCTCTGAA ATGCCTTATC AGTCTCTCCA CGATCATCCT GCTTGGTCTG 
ATCATCGTAT ACCACGCCAG GGAAATACAG TTATTCATGG TGGACAATGG AGCAGATGAC 
TGGAGAATAG CCATGACTTA TGAGCGTATT TTCTTCATCT GCTTGGAAAT ACTGGTGTGT 
GCTATTCATC CCATCCCTGG GAATTATACG TTCACATGGA CAGCCCGGCT TGCCTTCTCC 
TATGCCCCTT CCACAACCAC TGCAGACGTG GATATTATTT TATCTATACC AATGTTCTTA 
AGACTCTATC TGATTGCCAG AGTCATGCTA TTACATAGCA AACTTTTCAC CGATGCCTCC 
TCTAGAAGCA TTGGGGCACT TAATAAGATA AACTTCAATA CGCGTTTTGT TATGAAGACT 
TTAATGACTA TCTGCCCAGG AACTGTGCTC TTGGTTTTTA GTATCTCGTT ATGGATAATT 
GCCGCATGGA CTGTCCGAGC TTGTGAAAGG TACCATGATC AACAGGATGT CACTAGCAAC 
TTCCTTGGAG CAATGTGGTT GATATCAATA ACTTTTCTCT CCATTGGTTA TGGTGACATG 
GTACCTAACA CATACTGTGG GAAAGGAGTC TGCTTGCTTA CCGGAATAAT GGGTGCAGGT 
TGCACAGCCT TGGTGGTAGC CGTAGTGGCA AGAAAGCTAG AACTTACCAA AGCAGAAAAG 
CATGTGCACA ATTTCATGAT GGATACTCAG CTGACCAAAA GAGTAAAAAA CGCAGCCGCC 
AATGTACTCA GGGAAACGTG GTTAATCTAC AAAAACACAA AGCTAGTGAA AAAGATCGAC 
CATGCAAAAG TAAGGAAGCA TCAACGGAAA TTCTTACAAG CTATTCATCA AGCTCGGAAA 
TTAAGAAGTG TGAAGATGGA ACAGAGGAAA CTGAATGACC AAGCGAATAC TCTAGTGGAT 
CTGGCAAAGA CCCAGAATAT CATGTATGAT ATGATTTCCG ACTTAAATGA AAGGAGTGAA 
GACTTTGAGA AAAGGATCGT CACCCTGGAA ACAAAATTAG AAACTTTGAT TGGTAGCATT 
CATGCCCTCC CTGGGCTTAT CAGCCAGACC ATCAGACAGC AGCAAAGGGA CTTCATAGAG 
ACACAGATGG AGAACTATGA CAAGCATGTC ACCTACAATG CTGAGCGTTC CCGGTCCTCG 
TCCAGGAGGC GGCGGTCCTC CTCCACAGCG CCACCAACTT CATCTGAGAG TAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnn2 ( XM_017601013.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017456502.1 Rattus norvegicus potassium calcium-activated channel subfamily N member 2 (Kcnn2), transcript variant X2, mRNA.

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CloneID	ORa59304
Clone ID Related Accession (Same CDS sequence)	XM_017601013.1
Accession Version	XM_017601013.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2568bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	small conductance calcium-activated potassium channel protein 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTCGGGA GAACGTGCAA ATGTGATGTC ATGCCCATTG TTTTGGTGCG CCCAACCAAT 
CGGACTCGCC GCCTGGATTC TACCGGAGCC GGCATGGGCC CTTCCTCGCA CCAGCAGCAG 
GAGTCCCCGC TCCCGACCAT AACGCATTGC GCAGGGTGCA CCACCGCCTG GTCTCCCTGC 
AGCTTTAACA GGTCTGACAT GGAAACCCCA TTGCAGTTCC AGCGCGGCTT CTTCCCAGAG 
CAGCCGCCGC CACCGCCGCG CTCCTCACAC CTGCATTGCC AGCAGCAGCA ACAGAGCCAG 
GACAAACCGT GCGCGCCCTT CGCGCCCCTC CCGCACCCTC ACCACCACCC GCACCTCGCG 
CACCAGCAGC CGGGCAGCGG TGGTAGCAGC CCATGCCTCC GGTGCAACAG CTGCGCCTCC 
TCCGGTGCCC CGGAGGCGGG GGCGGGGGCG GGGGATAACC TGTCCCTGCT GCTCCGCACC 
TCATCGCCCG GCGGCGCTTT CCGGACCCGC ACCTCCTCGC CGCTGTCGGG CTCTTCGTGC 
TGTTGCTGCT GCTCGTCGCG CCGGGGCAGC CAGCTCAATG TGAGCGAGCT GACGCCGTCC 
AGCCATGCCA GTGCGCTCCG GCAGCAGTAC GCGCAGCAGC CCGCGTCCGC CTCCCTGTAC 
CACCAGTGCC ACAGCCTGCA GCCCGCCGCC AGCCCCACAG GCAGCCTGGG CAGCCTGGGC 
TCCGGGCCCC CTCTCTCGCA CCACCACCAC CACCCGCACC CGGCGCACCA CCAGCATCAC 
CAACCCCAGG CGCGCCGCGA GAGCAACCCC TTCACCGAAA TAGCCATGAG CAGCTGCAGG 
TACAACGGGG GCGTCATGCG TCCGCTCAGC AACTTGAGCT CGTCCCGCCG GAACCTGCAC 
GAGATGGACT CAGAGGCTCA GCCCCTGCAG CCCCCAGCGT CGGTTGTAGG AGGAGGTGGT 
GGTGCGTCCT CCCCGTCTGC TGCCGCCGCC GCCTCATCCT CAGCCCCAGA GATCGTGGTG 
TCTAAGCCGG AGCACAACAA TTCTAACAAC CTGGCGCTCT ACGGAACTGG CGGCGGAGGC 
AGCACCGGAG GCGGCGGCGG CGGCGGCGGC GGCGGCGGCG GCAGCGGGCA TGGCAGCAGC 
AGCGGCACTA AGTCCAGCAA AAAGAAGAAC CAGAACATCG GCTATAAGCT GGGCCATCGG 
CGTGCCCTGT TTGAGAAGCG CAAGCGGCTC AGCGACTATG CGCTCATCTT CGGCATGTTC 
GGCATCGTGG TCATGGTCAT CGAGACCGAG CTGTCGTGGG GCGCCTACGA CAAGGCGTCG 
CTGTATTCTT TAGCTCTGAA ATGCCTTATC AGTCTCTCCA CGATCATCCT GCTTGGTCTG 
ATCATCGTAT ACCACGCCAG GGAAATACAG TTATTCATGG TGGACAATGG AGCAGATGAC 
TGGAGAATAG CCATGACTTA TGAGCGTATT TTCTTCATCT GCTTGGAAAT ACTGGTGTGT 
GCTATTCATC CCATCCCTGG GAATTATACG TTCACATGGA CAGCCCGGCT TGCCTTCTCC 
TATGCCCCTT CCACAACCAC TGCAGACGTG GATATTATTT TATCTATACC AATGTTCTTA 
AGACTCTATC TGATTGCCAG AGTCATGCTA TTACATAGCA AACTTTTCAC CGATGCCTCC 
TCTAGAAGCA TTGGGGCACT TAATAAGATA AACTTCAATA CGCGTTTTGT TATGAAGACT 
TTAATGACTA TCTGCCCAGG AACTGTGCTC TTGGTTTTTA GTATCTCGTT ATGGATAATT 
GCCGCATGGA CTGTCCGAGC TTGTGAAAGG TACCATGATC AACAGGATGT CACTAGCAAC 
TTCCTTGGAG CAATGTGGTT GATATCAATA ACTTTTCTCT CCATTGGTTA TGGTGACATG 
GTACCTAACA CATACTGTGG GAAAGGAGTC TGCTTGCTTA CCGGAATAAT GGGTGCAGGT 
TGCACAGCCT TGGTGGTAGC CGTAGTGGCA AGAAAGCTAG AACTTACCAA AGCAGAAAAG 
CATGTGCACA ATTTCATGAT GGATACTCAG CTGACCAAAA GAGTAAAAAA CGCAGCCGCC 
AATGTACTCA GGGAAACGTG GTTAATCTAC AAAAACACAA AGCTAGTGAA AAAGATCGAC 
CATGCAAAAG TAAGGAAGCA TCAACGGAAA TTCTTACAAG CTATTCATCA ATTAAGAAGT 
GTGAAGATGG AACAGAGGAA ACTGAATGAC CAAGCGAATA CTCTAGTGGA TCTGGCAAAG 
ACCCAGAATA TCATGTATGA TATGATTTCC GACTTAAATG AAAGGAGTGA AGACTTTGAG 
AAAAGGATCG TCACCCTGGA AACAAAATTA GAAACTTTGA TTGGTAGCAT TCATGCCCTC 
CCTGGGCTTA TCAGCCAGAC CATCAGACAG CAGCAAAGGG ACTTCATAGA GACACAGATG 
GAGAACTATG ACAAGCATGT CACCTACAAT GCTGAGCGTT CCCGGTCCTC GTCCAGGAGG 
CGGCGGTCCT CCTCCACAGC GCCACCAACT TCATCTGAGA GTAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017456502.1
CDS	1801..4368
Translation	MFGRTCKCDVMPIVLVRPTNRTRRLDSTGAGMGPSSHQQQESPLPTITHCAGCTTAWSPCSFNRSDMETPLQFQRGFFPEQPPPPPRSSHLHCQQQQQSQDKPCAPFAPLPHPHHHPHLAHQQPGSGGSSPCLRCNSCASSGAPEAGAGAGDNLSLLLRTSSPGGAFRTRTSSPLSGSSCCCCCSSRRGSQLNVSELTPSSHASALRQQYAQQPASASLYHQCHSLQPAASPTGSLGSLGSGPPLSHHHHHPHPAHHQHHQPQARRESNPFTEIAMSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS

Target ORF information:

RefSeq Version	XM_017601013.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium calcium-activated channel subfamily N member 2 (Kcnn2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017601013.1

ORF Insert Sequence:

ATGTTCGGGA GAACGTGCAA ATGTGATGTC ATGCCCATTG TTTTGGTGCG CCCAACCAAT 
CGGACTCGCC GCCTGGATTC TACCGGAGCC GGCATGGGCC CTTCCTCGCA CCAGCAGCAG 
GAGTCCCCGC TCCCGACCAT AACGCATTGC GCAGGGTGCA CCACCGCCTG GTCTCCCTGC 
AGCTTTAACA GGTCTGACAT GGAAACCCCA TTGCAGTTCC AGCGCGGCTT CTTCCCAGAG 
CAGCCGCCGC CACCGCCGCG CTCCTCACAC CTGCATTGCC AGCAGCAGCA ACAGAGCCAG 
GACAAACCGT GCGCGCCCTT CGCGCCCCTC CCGCACCCTC ACCACCACCC GCACCTCGCG 
CACCAGCAGC CGGGCAGCGG TGGTAGCAGC CCATGCCTCC GGTGCAACAG CTGCGCCTCC 
TCCGGTGCCC CGGAGGCGGG GGCGGGGGCG GGGGATAACC TGTCCCTGCT GCTCCGCACC 
TCATCGCCCG GCGGCGCTTT CCGGACCCGC ACCTCCTCGC CGCTGTCGGG CTCTTCGTGC 
TGTTGCTGCT GCTCGTCGCG CCGGGGCAGC CAGCTCAATG TGAGCGAGCT GACGCCGTCC 
AGCCATGCCA GTGCGCTCCG GCAGCAGTAC GCGCAGCAGC CCGCGTCCGC CTCCCTGTAC 
CACCAGTGCC ACAGCCTGCA GCCCGCCGCC AGCCCCACAG GCAGCCTGGG CAGCCTGGGC 
TCCGGGCCCC CTCTCTCGCA CCACCACCAC CACCCGCACC CGGCGCACCA CCAGCATCAC 
CAACCCCAGG CGCGCCGCGA GAGCAACCCC TTCACCGAAA TAGCCATGAG CAGCTGCAGG 
TACAACGGGG GCGTCATGCG TCCGCTCAGC AACTTGAGCT CGTCCCGCCG GAACCTGCAC 
GAGATGGACT CAGAGGCTCA GCCCCTGCAG CCCCCAGCGT CGGTTGTAGG AGGAGGTGGT 
GGTGCGTCCT CCCCGTCTGC TGCCGCCGCC GCCTCATCCT CAGCCCCAGA GATCGTGGTG 
TCTAAGCCGG AGCACAACAA TTCTAACAAC CTGGCGCTCT ACGGAACTGG CGGCGGAGGC 
AGCACCGGAG GCGGCGGCGG CGGCGGCGGC GGCGGCGGCG GCAGCGGGCA TGGCAGCAGC 
AGCGGCACTA AGTCCAGCAA AAAGAAGAAC CAGAACATCG GCTATAAGCT GGGCCATCGG 
CGTGCCCTGT TTGAGAAGCG CAAGCGGCTC AGCGACTATG CGCTCATCTT CGGCATGTTC 
GGCATCGTGG TCATGGTCAT CGAGACCGAG CTGTCGTGGG GCGCCTACGA CAAGGCGTCG 
CTGTATTCTT TAGCTCTGAA ATGCCTTATC AGTCTCTCCA CGATCATCCT GCTTGGTCTG 
ATCATCGTAT ACCACGCCAG GGAAATACAG TTATTCATGG TGGACAATGG AGCAGATGAC 
TGGAGAATAG CCATGACTTA TGAGCGTATT TTCTTCATCT GCTTGGAAAT ACTGGTGTGT 
GCTATTCATC CCATCCCTGG GAATTATACG TTCACATGGA CAGCCCGGCT TGCCTTCTCC 
TATGCCCCTT CCACAACCAC TGCAGACGTG GATATTATTT TATCTATACC AATGTTCTTA 
AGACTCTATC TGATTGCCAG AGTCATGCTA TTACATAGCA AACTTTTCAC CGATGCCTCC 
TCTAGAAGCA TTGGGGCACT TAATAAGATA AACTTCAATA CGCGTTTTGT TATGAAGACT 
TTAATGACTA TCTGCCCAGG AACTGTGCTC TTGGTTTTTA GTATCTCGTT ATGGATAATT 
GCCGCATGGA CTGTCCGAGC TTGTGAAAGG TACCATGATC AACAGGATGT CACTAGCAAC 
TTCCTTGGAG CAATGTGGTT GATATCAATA ACTTTTCTCT CCATTGGTTA TGGTGACATG 
GTACCTAACA CATACTGTGG GAAAGGAGTC TGCTTGCTTA CCGGAATAAT GGGTGCAGGT 
TGCACAGCCT TGGTGGTAGC CGTAGTGGCA AGAAAGCTAG AACTTACCAA AGCAGAAAAG 
CATGTGCACA ATTTCATGAT GGATACTCAG CTGACCAAAA GAGTAAAAAA CGCAGCCGCC 
AATGTACTCA GGGAAACGTG GTTAATCTAC AAAAACACAA AGCTAGTGAA AAAGATCGAC 
CATGCAAAAG TAAGGAAGCA TCAACGGAAA TTCTTACAAG CTATTCATCA ATTAAGAAGT 
GTGAAGATGG AACAGAGGAA ACTGAATGAC CAAGCGAATA CTCTAGTGGA TCTGGCAAAG 
ACCCAGAATA TCATGTATGA TATGATTTCC GACTTAAATG AAAGGAGTGA AGACTTTGAG 
AAAAGGATCG TCACCCTGGA AACAAAATTA GAAACTTTGA TTGGTAGCAT TCATGCCCTC 
CCTGGGCTTA TCAGCCAGAC CATCAGACAG CAGCAAAGGG ACTTCATAGA GACACAGATG 
GAGAACTATG ACAAGCATGT CACCTACAAT GCTGAGCGTT CCCGGTCCTC GTCCAGGAGG 
CGGCGGTCCT CCTCCACAGC GCCACCAACT TCATCTGAGA GTAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tremor dominant Kyoto (Trdk) rats carry a missense mutation in the gene encoding the SK2 subunit of small-conductance Ca
Brain research167638-45(2017 Dec)
Kuramoto T,Yokoe M,Kunisawa N,Ohashi K,Miyake T,Higuchi Y,Yoshimi K,Mashimo T,Tanaka M,Kuwamura M,Kaneko S,Shimizu S,Serikawa T,Ohno Y

SK2 channels regulate mitochondrial respiration and mitochondrial Ca
Cell death and differentiation24(5)761-773(2017 May)
Honrath B,Matschke L,Meyer T,Magerhans L,Perocchi F,Ganjam GK,Zischka H,Krasel C,Gerding A,Bakker BM,B?nemann M,Strack S,Decher N,Culmsee C,Dolga AM

Downregulation of Endothelial Transient Receptor Potential Vanilloid Type 4 Channel and Small-Conductance of Ca2+-Activated K+ Channels Underpins Impaired Endothelium-Dependent Hyperpolarization in Hypertension.
Hypertension (Dallas, Tex. : 1979)69(1)143-153(2017 01)
Seki T,Goto K,Kiyohara K,Kansui Y,Murakami N,Haga Y,Ohtsubo T,Matsumura K,Kitazono T

Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current.
Heart rhythm13(8)1716-23(2016 08)
Yu CC,Ko JS,Ai T,Tsai WC,Chen Z,Rubart M,Vatta M,Everett TH 4th,George AL Jr,Chen PS

Apamin-Sensitive K+ Current Upregulation in Volume-Overload Heart Failure is Associated with the Decreased Interaction of CK2 with SK2.
The Journal of membrane biology248(6)1181-9(2015 Dec)
Yang D,Wang T,Ni Y,Song B,Ning F,Hu P,Luo L,Wang Y,Ma A

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Kcnn2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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