Nrg2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nrg2
Entrez Gene ID	432361
Full Name	neuregulin 2
Synonyms	NTAK_alpha2a,Ntak
General protein information	Preferred Names neuregulin 2 Names pro-neuregulin-2, membrane-bound isoform NTAK alpha1 neural- and thymus-derived activator for ErbB kinases pro-NRG2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18p11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001136151.1	NP_001129623.1	pro-neuregulin-2, membrane-bound isoform

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NRG2	XP_003310900.1
Mus musculus (house mouse)	Nrg2	NP_001161363.1
Danio rerio (zebrafish)	nrg2a	NP_001092724.1
Bos taurus (cattle)	NRG2	XP_003586358.1
Gallus gallus (chicken)	NRG2	XP_003642089.1
Homo sapiens (human)	NRG2	NP_053585.1
Canis lupus familiaris (dog)	NRG2	XP_856139.1
Rattus norvegicus (Norway rat)	Nrg2	NP_001129623.1
Danio rerio (zebrafish)	nrg2b	NP_001138563.1

Gene Ontology
Bibliography

Related articles in PubMed

NTAK/neuregulin-2 secreted by astrocytes promotes survival and neurite outgrowth of neurons via ErbB3.
Nakano N, Kanekiyo K, Nakagawa T, Asahi M, Ide C
Neuroscience letters62288-94(2016 05)

Bidirectional Signaling of Neuregulin-2 Mediates Formation of GABAergic Synapses and Maturation of Glutamatergic Synapses in Newborn Granule Cells of Postnatal Hippocampus.
Lee KH, Lee H, Yang CH, Ko JS, Park CH, Woo RS, Kim JY, Sun W, Kim JH, Ho WK, Lee SH
The Journal of neuroscience : the official journal of the Society for Neuroscience35(50)16479-93(2015 Dec)

A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.
Vullhorst D, Mitchell RM, Keating C, Roychowdhury S, Karavanova I, Tao-Cheng JH, Buonanno A
Nature communications67222(2015 Jun)

Neuregulins and cancer.
Montero JC, Rodr?guez-Barrueco R, Oca?a A, D?az-Rodr?guez E, Espar?s-Ogando A, Pandiella A
Clinical cancer research : an official journal of the American Association for Cancer Research14(11)3237-41(2008 Jun)

Schwann cell-derived neuregulin-2alpha can function as a cell-attached activator of muscle acetylcholine receptor expression.
Ponomareva ON, Fischer TM, Lai C, Rimer M
Glia54(6)630-7(2006 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NTAK/NRG2 secreted from astrocytes bound to ErbB3 on neurons, and promoted neuronal survival and neurite extension in vitro.
Title: NTAK/neuregulin-2 secreted by astrocytes promotes survival and neurite outgrowth of neurons via ErbB3.

These results imply that NRG2 may play a critical role in network integration of newborn neurons
Title: Bidirectional Signaling of Neuregulin-2 Mediates Formation of GABAergic Synapses and Maturation of Glutamatergic Synapses in Newborn Granule Cells of Postnatal Hippocampus.

Findings reveal an intimate reciprocal relationship between ErbB4 and GluN2b NMDA receptors via NRG2/ErbB4 signaling.
Title: A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.

These results provide a potential role for the previously reported, paradoxical perisynaptic accumulation of Nrg-2alpha, the isoform with the least AChR-inducing activity when presented in a soluble form.
Title: Schwann cell-derived neuregulin-2alpha can function as a cell-attached activator of muscle acetylcholine receptor expression.

In neuronal primary cultures from developing rat hippocampus, neuregulin 2 (NRG-2) is restricted to neuronal somas and dendrites.
Title: Neuregulin-2 is developmentally regulated and targeted to dendrites of central neurons.

The following Nrg2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nrg2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04203	NM_001136151.1 Latest version!	Rattus norvegicus neuregulin 2 (Nrg2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nrg2 ( NM_001136151.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001129623.1 Rattus norvegicus neuregulin 2 (Nrg2), mRNA.

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CloneID	ORa04203
Clone ID Related Accession (Same CDS sequence)	NM_001136151.1
Accession Version	NM_001136151.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2583bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	pro-neuregulin-2, membrane-bound isoform
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D89996.1. On or before Oct 25, 2008 this sequence version replaced XM_001063076.1, XM_344662.3, XM_001053475.1. ##Evidence-Data-START## Transcript exon combination :: D89996.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCGGCAGG TTTGCTGCTC AGCGCTGCCG CCGCCACTGG AGAAGGCTCG GTGCAGCAGC 
TACAGCTACA GCGACAGCAG CAGCAGCAGC AGCAGCAACA ACAGCAGCAG CAGCACCAGC 
AGCAGAAGCA GCAGCAGAAG CAGCAGCAGA AGCAGCAGAG GCAGCACCAC CACCACCAGC 
AGCAGCGAGA ACAGCGGCAG CAACAGCGGC AGCATCTTCC GTCCCGCTGC GCCCCCAGAG 
CCGCGGCCGC AGCCACAGCC GCAGCCCCGC AGCCCCGCAG CCCGGAGAGC CGCCGCCCGC 
TCGCGAGCCG CAGCCGCCGG CGGCATGAGG CGCGACCCGG CCCCCGGCTC CTCGATGCTG 
CTCTTCGGTG TGTCACTCGC CTGCTACTCG CCCAGCCTCA AGTCCGTGCA GGACCAGGCG 
TACAAGGCAC CCGTGGTGGT GGAGGGCAAG GTACAGGGAC TGGCCCCGGC AGGCGGTTCC 
AGCTCTAACA GCACCCGAGA GCCTCCCGCC TCGGGTCGGG TGGCGCTGGT GAAGGTGCTG 
GACAAGTGGC CGCTCCGGAG CGGGGGGCTG CAGCGCGAGC AGGTGATCAG CGTGGGCTCC 
TGCGCGCCGC TCGAAAGGAA CCAGCGCTAC ATCTTTTTCC TGGAGCCCAC CGAGCAGCCC 
TTAGTTTTTA AGACAGCCTT TGCCCCGGTC GACCCTAACG GCAAAAACAT CAAGAAAGAG 
GTGGGCAAGA TCCTGTGCAC TGACTGCGCA ACCCGGCCCA AGCTGAAGAA GATGAAGAGT 
CAGACAGGAG AGGTGGGCGA GAAGCAGTCG CTCAAGTGTG AGGCGGCGGC GGGGAACCCC 
CAGCCCTCCT ATCGATGGTT CAAGGACGGC AAGGAGCTCA ACCGGAGTCG TGACATTCGC 
ATCAAGTATG GCAACGGCAG AAAGAACTCA CGGCTACAGT TCAACAAAGT GAAGGTGGAG 
GACGCTGGAG AGTACGTCTG TGAGGCTGAG AACATCCTTG GGAAGGACAC TGTGAGGGGC 
CGGCTCCATG TCAACAGTGT GAGCACCACT CTGTCGTCCT GGTCGGGGCA CGCCCGGAAG 
TGCAATGAGA CAGCCAAGTC CTACTGTGTG AATGGAGGCG TGTGCTACTA CATCGAAGGC 
ATCAACCAAC TCTCCTGCAA ATGTCCAAAC GGATTCTTCG GACAGAGATG TTTGGAGAAA 
CTGCCTTTGC GATTGTACAT GCCAGATCCT AAGCAAAAGG CTGAGGAGCT GTACCAGAAG 
AGAGTCCTGA CAATTACCGG CATCTGTGTG GCTCTGCTGG TCGTGGGCAT CGTCTGTGTG 
GTCGCCTACT GCAAGACTAA AAAACAGAGG AGGCAAATGC ATCACCATCT CCGGCAGAAC 
ATGTGTCCGG CCCACCAGAA CCGAAGCCTG GCCAATGGGC CCAGCCACCC TCGGCTGGAC 
CCTGAGGAGA TCCAGATGGC AGATTACATT TCCAAAAATG TGCCAGCTAC AGACCATGTG 
ATCCGGAGGG AAGCTGAGAC CACATTTTCT GGGAGCCACT CCTGTTCACC CTCTCACCAC 
TGTTCCACAG CCACACCCAC CTCCAGCCAC AGACATGAGA GCCACACGTG GAGCTTGGAA 
CGTTCGGAGA GCCTGACCTC GGATTCCCAG TCAGGCATCA TGCTATCATC AGTGGGCACC 
AGCAAGTGCA ACAGCCCAGC ATGTGTGGAG GCACGGGCAC GGAGGGCAGC AGCCTACAGC 
CAGGAGGAGC GACGCAGGGC TGCCATGCCA CCCTACCACG ACTCCATAGA CTCGCTGCGT 
GACTCCCCAC ACAGTGAGAG GTACGTGTCA GCCCTGACCA CGCCCGCGCG CCTTTCGCCC 
GTGGACTTCC ACTACTCGCT GGCCACCCAG GTGCCGACTT TCGAGATCAC GTCGCCCAAC 
TCTGCCCACG CCGTGTCGCT GCCACCCGCA GCGCCCATCA GCTACCGCCT AGCGGAGCAG 
CAGCCGCTCC TGCGGCACCC AGCGCCGCCC GGCCCGGGGC CAGGGCCCGG AGCGGACATG 
CAGCGCAGCT ACGACAGCTA CTACTACCCG GCGGCGGGGC CCGGGCCGCG GCGCGGCGCC 
TGCGCGCTGG GAGGCAGTTT GGGCAGCCTG CCCGCCAGCC CCTTCCGCAT CCCGGAGGAC 
GACGAGTACG AGACCACGCA GGAGTGCGCG CCCCCGCCAC CGCCGCGGCC GCGCACGCGC 
GGCGCGTCCC GCAGGACGTC GGCGGGGCCG CGGCGCTGGC GGCGCTCCCG CCTCAACGGG 
TTGGCTGCGC AGCGCGCACG CGCAGCGCGG GACTCGCTGT CGTTGAGCAG CGGTTCGGGC 
TGCGGCTCGG CGTCGGCCTC GGACGACGAT GCGGACGACG CGGACGGGGC GCTGGCGGCC 
GAGAGCACGC CTTTCCTCGG CCTGCGAGCG GCGCACGACG CGCTGCGCTC GGACTCGCCG 
CCGCTCTGCC CGGCGGCGGA CAGCAGGACT TACTACTCCC TGGACAGCCA CAGCACGCGC 
GCCAGCAGCA GACACAGCCG GGGGCCGCCC ACGAGGGCAA AGCAGGACTC CGGGCCCCTC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129623.1
CDS	233..2815
Translation	MRQVCCSALPPPLEKARCSSYSYSDSSSSSSSNNSSSSTSSRSSSRSSSRSSRGSTTTTSSSENSGSNSGSIFRPAAPPEPRPQPQPQPRSPAARRAAARSRAAAAGGMRRDPAPGSSMLLFGVSLACYSPSLKSVQDQAYKAPVVVEGKVQGLAPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVGSCAPLERNQRYIFFLEPTEQPLVFKTAFAPVDPNGKNIKKEVGKILCTDCATRPKLKKMKSQTGEVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLHVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRRQMHHHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRREAETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYSQEERRRAAMPPYHDSIDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGADMQRSYDSYYYPAAGPGPRRGACALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRTRGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGCGSASASDDDADDADGALAAESTPFLGLRAAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPTRAKQDSGPL

Target ORF information:

RefSeq Version	NM_001136151.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neuregulin 2 (Nrg2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001136151.1

ORF Insert Sequence:

ATGCGGCAGG TTTGCTGCTC AGCGCTGCCG CCGCCACTGG AGAAGGCTCG GTGCAGCAGC 
TACAGCTACA GCGACAGCAG CAGCAGCAGC AGCAGCAACA ACAGCAGCAG CAGCACCAGC 
AGCAGAAGCA GCAGCAGAAG CAGCAGCAGA AGCAGCAGAG GCAGCACCAC CACCACCAGC 
AGCAGCGAGA ACAGCGGCAG CAACAGCGGC AGCATCTTCC GTCCCGCTGC GCCCCCAGAG 
CCGCGGCCGC AGCCACAGCC GCAGCCCCGC AGCCCCGCAG CCCGGAGAGC CGCCGCCCGC 
TCGCGAGCCG CAGCCGCCGG CGGCATGAGG CGCGACCCGG CCCCCGGCTC CTCGATGCTG 
CTCTTCGGTG TGTCACTCGC CTGCTACTCG CCCAGCCTCA AGTCCGTGCA GGACCAGGCG 
TACAAGGCAC CCGTGGTGGT GGAGGGCAAG GTACAGGGAC TGGCCCCGGC AGGCGGTTCC 
AGCTCTAACA GCACCCGAGA GCCTCCCGCC TCGGGTCGGG TGGCGCTGGT GAAGGTGCTG 
GACAAGTGGC CGCTCCGGAG CGGGGGGCTG CAGCGCGAGC AGGTGATCAG CGTGGGCTCC 
TGCGCGCCGC TCGAAAGGAA CCAGCGCTAC ATCTTTTTCC TGGAGCCCAC CGAGCAGCCC 
TTAGTTTTTA AGACAGCCTT TGCCCCGGTC GACCCTAACG GCAAAAACAT CAAGAAAGAG 
GTGGGCAAGA TCCTGTGCAC TGACTGCGCA ACCCGGCCCA AGCTGAAGAA GATGAAGAGT 
CAGACAGGAG AGGTGGGCGA GAAGCAGTCG CTCAAGTGTG AGGCGGCGGC GGGGAACCCC 
CAGCCCTCCT ATCGATGGTT CAAGGACGGC AAGGAGCTCA ACCGGAGTCG TGACATTCGC 
ATCAAGTATG GCAACGGCAG AAAGAACTCA CGGCTACAGT TCAACAAAGT GAAGGTGGAG 
GACGCTGGAG AGTACGTCTG TGAGGCTGAG AACATCCTTG GGAAGGACAC TGTGAGGGGC 
CGGCTCCATG TCAACAGTGT GAGCACCACT CTGTCGTCCT GGTCGGGGCA CGCCCGGAAG 
TGCAATGAGA CAGCCAAGTC CTACTGTGTG AATGGAGGCG TGTGCTACTA CATCGAAGGC 
ATCAACCAAC TCTCCTGCAA ATGTCCAAAC GGATTCTTCG GACAGAGATG TTTGGAGAAA 
CTGCCTTTGC GATTGTACAT GCCAGATCCT AAGCAAAAGG CTGAGGAGCT GTACCAGAAG 
AGAGTCCTGA CAATTACCGG CATCTGTGTG GCTCTGCTGG TCGTGGGCAT CGTCTGTGTG 
GTCGCCTACT GCAAGACTAA AAAACAGAGG AGGCAAATGC ATCACCATCT CCGGCAGAAC 
ATGTGTCCGG CCCACCAGAA CCGAAGCCTG GCCAATGGGC CCAGCCACCC TCGGCTGGAC 
CCTGAGGAGA TCCAGATGGC AGATTACATT TCCAAAAATG TGCCAGCTAC AGACCATGTG 
ATCCGGAGGG AAGCTGAGAC CACATTTTCT GGGAGCCACT CCTGTTCACC CTCTCACCAC 
TGTTCCACAG CCACACCCAC CTCCAGCCAC AGACATGAGA GCCACACGTG GAGCTTGGAA 
CGTTCGGAGA GCCTGACCTC GGATTCCCAG TCAGGCATCA TGCTATCATC AGTGGGCACC 
AGCAAGTGCA ACAGCCCAGC ATGTGTGGAG GCACGGGCAC GGAGGGCAGC AGCCTACAGC 
CAGGAGGAGC GACGCAGGGC TGCCATGCCA CCCTACCACG ACTCCATAGA CTCGCTGCGT 
GACTCCCCAC ACAGTGAGAG GTACGTGTCA GCCCTGACCA CGCCCGCGCG CCTTTCGCCC 
GTGGACTTCC ACTACTCGCT GGCCACCCAG GTGCCGACTT TCGAGATCAC GTCGCCCAAC 
TCTGCCCACG CCGTGTCGCT GCCACCCGCA GCGCCCATCA GCTACCGCCT AGCGGAGCAG 
CAGCCGCTCC TGCGGCACCC AGCGCCGCCC GGCCCGGGGC CAGGGCCCGG AGCGGACATG 
CAGCGCAGCT ACGACAGCTA CTACTACCCG GCGGCGGGGC CCGGGCCGCG GCGCGGCGCC 
TGCGCGCTGG GAGGCAGTTT GGGCAGCCTG CCCGCCAGCC CCTTCCGCAT CCCGGAGGAC 
GACGAGTACG AGACCACGCA GGAGTGCGCG CCCCCGCCAC CGCCGCGGCC GCGCACGCGC 
GGCGCGTCCC GCAGGACGTC GGCGGGGCCG CGGCGCTGGC GGCGCTCCCG CCTCAACGGG 
TTGGCTGCGC AGCGCGCACG CGCAGCGCGG GACTCGCTGT CGTTGAGCAG CGGTTCGGGC 
TGCGGCTCGG CGTCGGCCTC GGACGACGAT GCGGACGACG CGGACGGGGC GCTGGCGGCC 
GAGAGCACGC CTTTCCTCGG CCTGCGAGCG GCGCACGACG CGCTGCGCTC GGACTCGCCG 
CCGCTCTGCC CGGCGGCGGA CAGCAGGACT TACTACTCCC TGGACAGCCA CAGCACGCGC 
GCCAGCAGCA GACACAGCCG GGGGCCGCCC ACGAGGGCAA AGCAGGACTC CGGGCCCCTC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NTAK/neuregulin-2 secreted by astrocytes promotes survival and neurite outgrowth of neurons via ErbB3.
Neuroscience letters62288-94(2016 05)
Nakano N,Kanekiyo K,Nakagawa T,Asahi M,Ide C

Bidirectional Signaling of Neuregulin-2 Mediates Formation of GABAergic Synapses and Maturation of Glutamatergic Synapses in Newborn Granule Cells of Postnatal Hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience35(50)16479-93(2015 Dec)
Lee KH,Lee H,Yang CH,Ko JS,Park CH,Woo RS,Kim JY,Sun W,Kim JH,Ho WK,Lee SH

A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.
Nature communications67222(2015 Jun)
Vullhorst D,Mitchell RM,Keating C,Roychowdhury S,Karavanova I,Tao-Cheng JH,Buonanno A

Neuregulins and cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research14(11)3237-41(2008 Jun)
Montero JC,Rodr?guez-Barrueco R,Oca?a A,D?az-Rodr?guez E,Espar?s-Ogando A,Pandiella A

Schwann cell-derived neuregulin-2alpha can function as a cell-attached activator of muscle acetylcholine receptor expression.
Glia54(6)630-7(2006 Nov)
Ponomareva ON,Fischer TM,Lai C,Rimer M

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Nrg2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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