Map3k5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Map3k5
Entrez Gene ID	365057
Full Name	mitogen-activated protein kinase kinase kinase 5
Synonyms	Ask1,RGD1306565
General protein information	Preferred Names mitogen-activated protein kinase kinase kinase 5 Names mitogen-activated protein kinase kinase kinase 5 apoptosis signal regulating kinase 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1p12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001277694.1	NP_001264623.1	mitogen-activated protein kinase kinase kinase 5

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MAP3K5	XP_001171211.1
	MAP3K5	XP_002803972.1
Mus musculus (house mouse)	Map3k5	NP_032606.4
Danio rerio (zebrafish)	map3k5	NP_001155222.1
Homo sapiens (human)	MAP3K5	NP_005914.1
Rattus norvegicus (Norway rat)	Map3k5	NP_001264623.1
Gallus gallus (chicken)	MAP3K5	XP_419725.3
Xenopus tropicalis (tropical clawed frog)	LOC100497692	XP_002936311.2
Canis lupus familiaris (dog)	MAP3K5	XP_533420.4
Bos taurus (cattle)	MAP3K5	NP_001137553.1

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of Apoptosis Signal-Regulating Kinase 1 Attenuates Myocyte Hypertrophy and Fibroblast Collagen Synthesis.
Yang W, Wang BH, Wang I, Huang L, Savira F, Kompa A, Jucker BM, Willette RN, Kelly D, Krum H, Li Z, Fu Q
Heart, lung & circulation(2017 Dec)

Apoptosis signal-regulating kinase 1 inhibition attenuates cardiac hypertrophy and cardiorenal fibrosis induced by uremic toxins: Implications for cardiorenal syndrome.
Savira F, Cao L, Wang I, Yang W, Huang K, Hua Y, Jucker BM, Willette RN, Huang L, Krum H, Li Z, Fu Q, Wang BH
PloS one12(11)e0187459(2017)

Age-related changes in mitochondrial antioxidant enzyme Trx2 and TXNIP-Trx2-ASK1 signal pathways in the auditory cortex of a mimetic aging rat model: changes to Trx2 in the auditory cortex.
Sun HY, Hu YJ, Zhao XY, Zhong Y, Zeng LL, Chen XB, Yuan J, Wu J, Sun Y, Kong W, Kong WJ
The FEBS journal282(14)2758-74(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IS and PCS exhibit pro-hypertrophic and pro-fibrotic properties, at least in part, via the activation of ASK1 and its downstream pathways
Title: Apoptosis signal-regulating kinase 1 inhibition attenuates cardiac hypertrophy and cardiorenal fibrosis induced by uremic toxins: Implications for cardiorenal syndrome.

Age-related changes in Trx2 and the TXNIP-Trx2-ASK1 signal pathway in the auditory cortex
Title: Age-related changes in mitochondrial antioxidant enzyme Trx2 and TXNIP-Trx2-ASK1 signal pathways in the auditory cortex of a mimetic aging rat model: changes to Trx2 in the auditory cortex.

CTSB protein functions as a necessary modulator of hypertrophic response by regulating TNF-alpha/ASK1/JNK signaling pathway involved in cardiac remodeling.
Title: Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF-?/ASK1/JNK pathway.

Results suggest that Trx1 siRNA increases apoptotic stress-induced ASK1 activation and this represents further evidence that Trx1 is an endogenous anti-apoptotic molecule that diminishes focal cerebral ischemia/reperfusion injury
Title: Inhibition of thioredoxin-1 with siRNA exacerbates apoptosis by activating the ASK1-JNK/p38 pathway in brain of a stroke model rats.

The models confirmed the reaction order, revealed processivity in the phosphorylation of MEK6 by ASK1, and suggested that the order of phosphorylation is dictated by both binding and catalysis rates.
Title: Precisely ordered phosphorylation reactions in the p38 mitogen-activated protein (MAP) kinase cascade.

The following Map3k5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Map3k5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11921	NM_001277694.1 Latest version!	Rattus norvegicus mitogen-activated protein kinase kinase kinase 5 (Map3k5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$727.30 $1039.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Map3k5 ( NM_001277694.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001264623.1 Rattus norvegicus mitogen-activated protein kinase kinase kinase 5 (Map3k5), mRNA.

Price & Availability↑

CloneID	ORa11921
Clone ID Related Accession (Same CDS sequence)	NM_001277694.1
Accession Version	NM_001277694.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4146bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Rattus norvegicus(Norway rat)
Product	mitogen-activated protein kinase kinase kinase 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAHX01001718.1, AAHX01001720.1, AAHX01001722.1, AAHX01001723.1, AAHX01001725.1, AAHX01001729.1, AAHX01001731.1, AAHX01001733.1, AAHX01001734.1 and AAHX01001736.1. On or before Apr 14, 2013 this sequence version replaced XR_145729.1, XR_146724.1. Sequence Note: The RefSeq transcript and protein were derived from the alternate Celera genome sequence. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGGCACCG AAGCCGGCGA GGGCATCACT TTCTCCGTGC CGCCCATTTT GTCCGCGGGT 
TTCTGCCCCA TCCCGGAGGG CGGCAGCTGC CGGAGGGGAG GAGGAGCGGC GACGGCGGCG 
GAGGGCGAGC CGAGCCTGCA GCCCTTGCTT ATGCCGCCGC CGCCACCACC GCCGGGCAGT 
TTCTGGAACG TGGAGAGCGC GGCGGCTCCT GGCACCAGCT GCCCTACCAC CGCCCCCGGG 
AGCAGCGCCA CCCGAGGCCG GGGCAACTCT GGCAGCGGGG GCGGCCGGCG TACCACCGTG 
GCGTATGTGA TCAACGAGGC GAGCCAGGGG CAGCTGGTGG TGGCGGAGAG CGAGGCCCTG 
CAGAGCCTGC GGGAGGCGTG CGAGGCGGTG GGCGCCACCC TGGAGACCCT GCATTTCGGG 
AAGCTGGACT TTGGGGAAAC CACCGTGCTG GACCGTTTTT ACAACGCTGA CATCGCCGTG 
GTAGAGATGA GTGACGCCTT CCGGCAGCCT TCCCTGTTTT ATCATCTCGG AGTGAGAGAG 
AGCTTCAGCA TGGCCAACAA CATCATCCTC TACTGCGATA CTAATTCAGA CTCGCTTCAG 
TCCCTGAAGG AAATCATTTG CCAGAAGAAC ACAGTGTGCA CTGGGAACTA CACCTTCATC 
CCCTACATGG TGACACCACA CAACAAGGTC TACTGCTGTG ACAGCAGCTT CATGAAGGGC 
CTGACCGAGC TCATGCAGCC CAACTTCGAG CTCCTGCTGG GGCCGATCTG CTTACCTCTC 
GTGGACCGTT TCGTTCAGCT CCTGAAGGTG GCGCAAGCCA GTTCCAGCCA GTACTTCCGG 
GAATCTATAC TCAACGACAT CAGGAAAGCT CGGAATCTGT ACACTGGTAA AGAGTTGGCG 
GCTGAGCTGG CGAGGATCCG GCAGCGGGTA GACAATATTG AAGTTCTGAC GGCAGACATT 
GTTATCAACC TGTTGCTTTC CTACAGAGAT ATCCAGGACT ATGACTCCAT AGTGAAGCTG 
GTAGAGACCT TAGAAAAACT ACCGACCTTC GATCTGGCCT CGCACCACCA CGTGAAGTTT 
CATTATGCCT TTGCACTGAA CAGGAGAAAT CTCCCTGGAG ACAGAGCAAA AGCTCTTGAC 
ATCATGATCC CCATGGTGCA AAGTGAAGAG CAAGTTGCTT CGGATATGTA CTGTCTCGTT 
GGCCGAATCT ACAAAGACAT GTTTTTGGAT TCAAATTTCA CTGACACCGA AAGCAGGGAC 
CATGGAGCAT CTTGGTTCAA AAAGGCGTTT GAGTCTGAGC CAACACTACA GTCAGGAATT 
AATTACGCAG TCCTCTTGCT GGCGGCTGGG CACCAGTTTG AATCTTCTTT TGAGCTTCGG 
AAAGTTGGAG TTAAACTGAG CAGCCTTCTG GGTAAAAAGG GGAACTTGGA GAAACTCCAG 
AGCTACTGGG AAGTCGGATT TTTTCTGGGA GCCAGCGTCC TGGCCAACGA CCATCTGAGG 
GTCATTCAGG CATCTGAGAA ACTGTTCAGA CTGAAGACGC CAGCGTGGTA CCTCAAGTCT 
ATTGTGGAGA CCATTTTGAT ATATAAGCAT TTTGTGAAAC TGACCACAGA GCAGCCCACA 
GCCAAGCAGG AGCTCGTGGA CTTCTGGATG GATTTCCTGG TGGAGGCCAC AAAGACAGAT 
GTTACTGTCG TTAGATTTCC AGTGTTAATA TTAGAGCCAA CGAAAATCTA TCAGCCTTCT 
TACCTGTCGA TCAACAATGA AGTCGAGGAG AAGACGATCT CTATTTGGCA TGTCCTCCCT 
GACGACAAGA AGGGTATCCA TGAGTGGAAC TTTAACGCTT CCTCTGTCAG GGGGGTGAGT 
ATCTCCAAGT TTGAAGAACG ATGCTGTTTC CTTTATGTAC TTCACAATTC CGACGACTTC 
CAAATCTACT TCTGCACAGA ACTGCACTGT AAAAGGTTTT TCGAAATGGT GAACACCATC 
ACCGAAGAGA AGGGGAGAGG CGCGGAGGAA GGAGACTGTG AAGGTGACTC CCTAGAGTAT 
GACTACGAAC ACGATGAAAA TGGAGACAGA GTTGTGCTAG GAAAGGGGAC TTACGGGATA 
GTCTACGCAG GCCGAGACCT GAGCAACCAG GTCAGAATTG CTATTAAGGA AATCCCAGAG 
AGAGACAGCA GATACTCTCA GCCCCTGCAT GAGGAAATTG CCTTACACAA GCATCTGAAG 
CACAAGAACA TTGTCCAGTA TCTGGGCTCC TTCAGTGAGA ACGGCTTCAT CAAAATCTTC 
ATGGAGCAAG TCCCAGGAGG AAGTCTCTCT GCTCTCCTCC GTTCAAAATG GGGCCCACTA 
AAAGACAATG AGCAGACGAT TGGCTTCTAT ACGAAGCAAA TATTGGAAGG ATTAAAATAT 
CTTCATGACA ATCAGATAGT CCACCGGGAT ATAAAGGGTG ACAATGTATT GATTAATACC 
TACAGTGGCG TGCTCAAGAT CTCTGACTTT GGGACATCCA AGAGGCTTGC TGGCATAAAC 
CCGTGCACCG AAACCTTTAC AGGTACCCTT CAGTATATGG CGCCAGAAAT CATCGATAAA 
GGACCACGAG GCTATGGAAA GGCCGCCGAC ATTTGGTCAC TGGGCTGTAC GATCATCGAA 
ATGGCTACTG GAAAACCACC GTTTTATGAA CTAGGAGAGC CCCAGGCAGC CATGTTCAAG 
GTGGGGATGT TTAAGGTCCA CCCCGAGATC CCAGAGTCCA TGTCTGCCGA GGCCAAGGCG 
TTCATACTGA AGTGTTTTGA ACCAGACCCT GACAAGAGAG CCTGTGCTAA TGACCTGCTT 
GTTGATGAGT TCCTAAAAGT TTCCAGCAAA AAGAAGAAGA CACAGCCCAA ACTCTCGGGT 
ATGTGGTTGC ACGGAGAGGA GTATCTTAGA AGCATCTCGC TGCCGGTCCC TGTCCTGGTA 
GAAGACACCA GCAGCAGCAG CGAGTATGGC TCCGTTTCTC CGGACACAGA GCTGAAGGCC 
GACCCCTTCT CCTTCAAAAC CAGAGCTAAG TCCTGTGGAG AAAAGGACGG GAAAGGGATC 
CGGACGCTGT TCCTGGGCAT TCCGGATGAA AACTTTGAAG ATCACAGTGC GCCCCCGTCC 
CCTGAAGAGA AAGACTCCGG CTTTTTTATG CTGAGAAAGG ATAGCGAAAG GCGGGCGACC 
CTTCACAGGA TCCTGACAGA AGACCAGGAC AAGGTTGTGA GGAACCTAAT GGAGTCTCTG 
GCCCAGGGTC CTGAAGAGCC TAAACTCAAG TGGGAACACA TCACAACTCT CATCTCAAGC 
CTCAGAGAGT TTGTGAGGTC CACTGACCGG AAAATCATAG CCACTACACT GTCCAGGCTC 
AAGCTGGAGC TGGACTTCGA CAGCCATGGC ATCAGCCAGG TGCAGGTGGT CCTCTTTGGC 
TTCCAGGATG CGGTCAATAA AGTTCTCCGG AATCATAACA TCAAGCCACA CTGGATGTTT 
GCCTTGGACA GTATCATTCG GAAGGCTGTG CAGACAGCTA TCACCATCCT GGTTCCAGAG 
TTGAGGCCAC ATTTCAGCCT CGCGTCGGAG AGCGACACGG CGGATCCGGA AGACTTGGAT 
GTCGACGATG AACACGAGGA ATCGCCTTCG AATCAAACCG CGCGGAGGCC CCAACCCGTC 
GCGGAGGATG CCGTGGCTAC CTCAGGGGTG AGCACGCTCA GCTCCACCGT ATCCCATGAT 
TCCCAGAATG CACACCGCTC GCTGAATGTG CAGCTTGGGA GGATGAAGAT GGAAACTAAC 
AGATTACTTG AAGAGTTGGT TCGGAAAGAG AAAGAGTTGC AGGCACTCCT TCATCAAGCC 
ATTGAAGAAA AGGACCAAGA AATTAAGCAC CTGAGACTTA AGTCCCAACC CATAGATACC 
CCTGGGTTTC CCGTGTGCCA CCTGAACGCT CCTGGTACAG CCATTGAAGA CTCTGAACTT 
ACTGGCTGGC TGAGGGAAAA TGGAGCTGAC GAAGACACTA TAAGTCGGTT TCTGGCTGAG 
GATTACACGC TGGTGGATGT CCTTTACTAC GTCACGCGTG ACGACTTGAA GTGCCTCCGA 
CTAAGGGGAG GGATGCTGTG CACGCTGTGG AAGGCCATCA TTGACTTTCG GAACAAAGGG 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001264623.1
CDS	1..4146
Translation	MGTEAGEGITFSVPPILSAGFCPIPEGGSCRRGGGAATAAEGEPSLQPLLMPPPPPPPGSFWNVESAAAPGTSCPTTAPGSSATRGRGNSGSGGGRRTTVAYVINEASQGQLVVAESEALQSLREACEAVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTVCTGNYTFIPYMVTPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFVQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEEQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHLRVIQASEKLFRLKTPAWYLKSIVETILIYKHFVKLTTEQPTAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFNASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKRFFEMVNTITEEKGRGAEEGDCEGDSLEYDYEHDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSGMWLHGEEYLRSISLPVPVLVEDTSSSSEYGSVSPDTELKADPFSFKTRAKSCGEKDGKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKVVRNLMESLAQGPEEPKLKWEHITTLISSLREFVRSTDRKIIATTLSRLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADPEDLDVDDEHEESPSNQTARRPQPVAEDAVATSGVSTLSSTVSHDSQNAHRSLNVQLGRMKMETNRLLEELVRKEKELQALLHQAIEEKDQEIKHLRLKSQPIDTPGFPVCHLNAPGTAIEDSELTGWLRENGADEDTISRFLAEDYTLVDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKGA

Target ORF information:

RefSeq Version	NM_001277694.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen-activated protein kinase kinase kinase 5 (Map3k5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001277694.1

ORF Insert Sequence:

ATGGGCACCG AAGCCGGCGA GGGCATCACT TTCTCCGTGC CGCCCATTTT GTCCGCGGGT 
TTCTGCCCCA TCCCGGAGGG CGGCAGCTGC CGGAGGGGAG GAGGAGCGGC GACGGCGGCG 
GAGGGCGAGC CGAGCCTGCA GCCCTTGCTT ATGCCGCCGC CGCCACCACC GCCGGGCAGT 
TTCTGGAACG TGGAGAGCGC GGCGGCTCCT GGCACCAGCT GCCCTACCAC CGCCCCCGGG 
AGCAGCGCCA CCCGAGGCCG GGGCAACTCT GGCAGCGGGG GCGGCCGGCG TACCACCGTG 
GCGTATGTGA TCAACGAGGC GAGCCAGGGG CAGCTGGTGG TGGCGGAGAG CGAGGCCCTG 
CAGAGCCTGC GGGAGGCGTG CGAGGCGGTG GGCGCCACCC TGGAGACCCT GCATTTCGGG 
AAGCTGGACT TTGGGGAAAC CACCGTGCTG GACCGTTTTT ACAACGCTGA CATCGCCGTG 
GTAGAGATGA GTGACGCCTT CCGGCAGCCT TCCCTGTTTT ATCATCTCGG AGTGAGAGAG 
AGCTTCAGCA TGGCCAACAA CATCATCCTC TACTGCGATA CTAATTCAGA CTCGCTTCAG 
TCCCTGAAGG AAATCATTTG CCAGAAGAAC ACAGTGTGCA CTGGGAACTA CACCTTCATC 
CCCTACATGG TGACACCACA CAACAAGGTC TACTGCTGTG ACAGCAGCTT CATGAAGGGC 
CTGACCGAGC TCATGCAGCC CAACTTCGAG CTCCTGCTGG GGCCGATCTG CTTACCTCTC 
GTGGACCGTT TCGTTCAGCT CCTGAAGGTG GCGCAAGCCA GTTCCAGCCA GTACTTCCGG 
GAATCTATAC TCAACGACAT CAGGAAAGCT CGGAATCTGT ACACTGGTAA AGAGTTGGCG 
GCTGAGCTGG CGAGGATCCG GCAGCGGGTA GACAATATTG AAGTTCTGAC GGCAGACATT 
GTTATCAACC TGTTGCTTTC CTACAGAGAT ATCCAGGACT ATGACTCCAT AGTGAAGCTG 
GTAGAGACCT TAGAAAAACT ACCGACCTTC GATCTGGCCT CGCACCACCA CGTGAAGTTT 
CATTATGCCT TTGCACTGAA CAGGAGAAAT CTCCCTGGAG ACAGAGCAAA AGCTCTTGAC 
ATCATGATCC CCATGGTGCA AAGTGAAGAG CAAGTTGCTT CGGATATGTA CTGTCTCGTT 
GGCCGAATCT ACAAAGACAT GTTTTTGGAT TCAAATTTCA CTGACACCGA AAGCAGGGAC 
CATGGAGCAT CTTGGTTCAA AAAGGCGTTT GAGTCTGAGC CAACACTACA GTCAGGAATT 
AATTACGCAG TCCTCTTGCT GGCGGCTGGG CACCAGTTTG AATCTTCTTT TGAGCTTCGG 
AAAGTTGGAG TTAAACTGAG CAGCCTTCTG GGTAAAAAGG GGAACTTGGA GAAACTCCAG 
AGCTACTGGG AAGTCGGATT TTTTCTGGGA GCCAGCGTCC TGGCCAACGA CCATCTGAGG 
GTCATTCAGG CATCTGAGAA ACTGTTCAGA CTGAAGACGC CAGCGTGGTA CCTCAAGTCT 
ATTGTGGAGA CCATTTTGAT ATATAAGCAT TTTGTGAAAC TGACCACAGA GCAGCCCACA 
GCCAAGCAGG AGCTCGTGGA CTTCTGGATG GATTTCCTGG TGGAGGCCAC AAAGACAGAT 
GTTACTGTCG TTAGATTTCC AGTGTTAATA TTAGAGCCAA CGAAAATCTA TCAGCCTTCT 
TACCTGTCGA TCAACAATGA AGTCGAGGAG AAGACGATCT CTATTTGGCA TGTCCTCCCT 
GACGACAAGA AGGGTATCCA TGAGTGGAAC TTTAACGCTT CCTCTGTCAG GGGGGTGAGT 
ATCTCCAAGT TTGAAGAACG ATGCTGTTTC CTTTATGTAC TTCACAATTC CGACGACTTC 
CAAATCTACT TCTGCACAGA ACTGCACTGT AAAAGGTTTT TCGAAATGGT GAACACCATC 
ACCGAAGAGA AGGGGAGAGG CGCGGAGGAA GGAGACTGTG AAGGTGACTC CCTAGAGTAT 
GACTACGAAC ACGATGAAAA TGGAGACAGA GTTGTGCTAG GAAAGGGGAC TTACGGGATA 
GTCTACGCAG GCCGAGACCT GAGCAACCAG GTCAGAATTG CTATTAAGGA AATCCCAGAG 
AGAGACAGCA GATACTCTCA GCCCCTGCAT GAGGAAATTG CCTTACACAA GCATCTGAAG 
CACAAGAACA TTGTCCAGTA TCTGGGCTCC TTCAGTGAGA ACGGCTTCAT CAAAATCTTC 
ATGGAGCAAG TCCCAGGAGG AAGTCTCTCT GCTCTCCTCC GTTCAAAATG GGGCCCACTA 
AAAGACAATG AGCAGACGAT TGGCTTCTAT ACGAAGCAAA TATTGGAAGG ATTAAAATAT 
CTTCATGACA ATCAGATAGT CCACCGGGAT ATAAAGGGTG ACAATGTATT GATTAATACC 
TACAGTGGCG TGCTCAAGAT CTCTGACTTT GGGACATCCA AGAGGCTTGC TGGCATAAAC 
CCGTGCACCG AAACCTTTAC AGGTACCCTT CAGTATATGG CGCCAGAAAT CATCGATAAA 
GGACCACGAG GCTATGGAAA GGCCGCCGAC ATTTGGTCAC TGGGCTGTAC GATCATCGAA 
ATGGCTACTG GAAAACCACC GTTTTATGAA CTAGGAGAGC CCCAGGCAGC CATGTTCAAG 
GTGGGGATGT TTAAGGTCCA CCCCGAGATC CCAGAGTCCA TGTCTGCCGA GGCCAAGGCG 
TTCATACTGA AGTGTTTTGA ACCAGACCCT GACAAGAGAG CCTGTGCTAA TGACCTGCTT 
GTTGATGAGT TCCTAAAAGT TTCCAGCAAA AAGAAGAAGA CACAGCCCAA ACTCTCGGGT 
ATGTGGTTGC ACGGAGAGGA GTATCTTAGA AGCATCTCGC TGCCGGTCCC TGTCCTGGTA 
GAAGACACCA GCAGCAGCAG CGAGTATGGC TCCGTTTCTC CGGACACAGA GCTGAAGGCC 
GACCCCTTCT CCTTCAAAAC CAGAGCTAAG TCCTGTGGAG AAAAGGACGG GAAAGGGATC 
CGGACGCTGT TCCTGGGCAT TCCGGATGAA AACTTTGAAG ATCACAGTGC GCCCCCGTCC 
CCTGAAGAGA AAGACTCCGG CTTTTTTATG CTGAGAAAGG ATAGCGAAAG GCGGGCGACC 
CTTCACAGGA TCCTGACAGA AGACCAGGAC AAGGTTGTGA GGAACCTAAT GGAGTCTCTG 
GCCCAGGGTC CTGAAGAGCC TAAACTCAAG TGGGAACACA TCACAACTCT CATCTCAAGC 
CTCAGAGAGT TTGTGAGGTC CACTGACCGG AAAATCATAG CCACTACACT GTCCAGGCTC 
AAGCTGGAGC TGGACTTCGA CAGCCATGGC ATCAGCCAGG TGCAGGTGGT CCTCTTTGGC 
TTCCAGGATG CGGTCAATAA AGTTCTCCGG AATCATAACA TCAAGCCACA CTGGATGTTT 
GCCTTGGACA GTATCATTCG GAAGGCTGTG CAGACAGCTA TCACCATCCT GGTTCCAGAG 
TTGAGGCCAC ATTTCAGCCT CGCGTCGGAG AGCGACACGG CGGATCCGGA AGACTTGGAT 
GTCGACGATG AACACGAGGA ATCGCCTTCG AATCAAACCG CGCGGAGGCC CCAACCCGTC 
GCGGAGGATG CCGTGGCTAC CTCAGGGGTG AGCACGCTCA GCTCCACCGT ATCCCATGAT 
TCCCAGAATG CACACCGCTC GCTGAATGTG CAGCTTGGGA GGATGAAGAT GGAAACTAAC 
AGATTACTTG AAGAGTTGGT TCGGAAAGAG AAAGAGTTGC AGGCACTCCT TCATCAAGCC 
ATTGAAGAAA AGGACCAAGA AATTAAGCAC CTGAGACTTA AGTCCCAACC CATAGATACC 
CCTGGGTTTC CCGTGTGCCA CCTGAACGCT CCTGGTACAG CCATTGAAGA CTCTGAACTT 
ACTGGCTGGC TGAGGGAAAA TGGAGCTGAC GAAGACACTA TAAGTCGGTT TCTGGCTGAG 
GATTACACGC TGGTGGATGT CCTTTACTAC GTCACGCGTG ACGACTTGAA GTGCCTCCGA 
CTAAGGGGAG GGATGCTGTG CACGCTGTGG AAGGCCATCA TTGACTTTCG GAACAAAGGG 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of Apoptosis Signal-Regulating Kinase 1 Attenuates Myocyte Hypertrophy and Fibroblast Collagen Synthesis.
Heart, lung & circulation(2017 Dec)
Yang W,Wang BH,Wang I,Huang L,Savira F,Kompa A,Jucker BM,Willette RN,Kelly D,Krum H,Li Z,Fu Q

Apoptosis signal-regulating kinase 1 inhibition attenuates cardiac hypertrophy and cardiorenal fibrosis induced by uremic toxins: Implications for cardiorenal syndrome.
PloS one12(11)e0187459(2017)
Savira F,Cao L,Wang I,Yang W,Huang K,Hua Y,Jucker BM,Willette RN,Huang L,Krum H,Li Z,Fu Q,Wang BH

Age-related changes in mitochondrial antioxidant enzyme Trx2 and TXNIP-Trx2-ASK1 signal pathways in the auditory cortex of a mimetic aging rat model: changes to Trx2 in the auditory cortex.
The FEBS journal282(14)2758-74(2015 Jul)
Sun HY,Hu YJ,Zhao XY,Zhong Y,Zeng LL,Chen XB,Yuan J,Wu J,Sun Y,Kong W,Kong WJ

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Map3k5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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