Them4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Them4
Entrez Gene ID	361992
Full Name	thioesterase superfamily member 4
Synonyms	RGD1304723
General protein information	Preferred Names thioesterase superfamily member 4 Names acyl-coenzyme A thioesterase THEM4 acyl-CoA thioesterase THEM4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34

mRNA and Protein(s)

mRNA	Protein	Name
NM_001025017.1	NP_001020188.1	acyl-coenzyme A thioesterase THEM4

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	zgc:158847	NP_001074103.1
Homo sapiens (human)	THEM4	NP_444283.2
Mus musculus (house mouse)	Them4	NP_083707.1
Xenopus tropicalis (tropical clawed frog)	them4	XP_004917621.1
Pan troglodytes (chimpanzee)	THEM4	XP_513806.2
Canis lupus familiaris (dog)	THEM4	XP_851465.1
	LOC711796	XP_001108969.2
Bos taurus (cattle)	THEM4	NP_001073837.1
Rattus norvegicus (Norway rat)	Them4	NP_001020188.1

Gene Ontology
Bibliography

Related articles in PubMed

Correlation of structure and function in the human hotdog-fold enzyme hTHEM4.
Zhao H, Lim K, Choudry A, Latham JA, Pathak MC, Dominguez D, Luo L, Herzberg O, Dunaway-Mariano D
Biochemistry51(33)6490-2(2012 Aug)

Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein.
Piao L, Li Y, Yang KJ, Park KA, Byun HS, Won M, Hong J, Kim JL, Kweon GR, Hur GM, Seok JH, Cho JY, Chun T, Hess D, Sack R, Maira SM, Brazil DP, Hemmings BA, Park J
BMC cell biology1053(2009 Jul)

The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death.
Miyawaki T, Ofengeim D, Noh KM, Latuszek-Barrantes A, Hemmings BA, Follenzi A, Zukin RS
Nature neuroscience12(5)618-26(2009 May)

Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis.
Parcellier A, Tintignac LA, Zhuravleva E, Cron P, Schenk S, Bozulic L, Hemmings BA
Cellular signalling21(4)639-50(2009 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CTMP is important in the neurodegeneration that is associated with stroke and identify CTMP as a therapeutic target for the amelioration of hippocampal injury and cognitive deficits.
Title: The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death.

The following Them4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Them4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07030	NM_001025017.1 Latest version!	Rattus norvegicus thioesterase superfamily member 4 (Them4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Them4 ( NM_001025017.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001020188.1 Rattus norvegicus thioesterase superfamily member 4 (Them4), mRNA.

Price & Availability↑

CloneID	ORa07030
Clone ID Related Accession (Same CDS sequence)	NM_001025017.1
Accession Version	NM_001025017.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Rattus norvegicus(Norway rat)
Product	acyl-coenzyme A thioesterase THEM4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC093385.1. On Jun 25, 2005 this sequence version replaced XM_342292.2. ##Evidence-Data-START## Transcript exon combination :: BC093385.1, CV075202.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTTGAGAA GCTGCGCTAT GCGCCTGCGC ACTCTTGGGG CCACGCCTGC AAGGCGGCCT 
GAAGCAACGA GGAGGTTATT TTCTTCTGAG GAAGTCGTCT GTAAGGACTA TGCTCTCCCT 
AACCCCAGCT GGACTAAGGA CCTAAGACTC CTTTTTGACC AGTTCATGAA GAAATGTGAA 
GATGGCTCCT GGAAACGTTT GCCTTCATAC AGACAAAACC CTCCTCAAGC CCTTCAAGAG 
TTCCAAACCC ACTTTGTTGA CTCAAAGTTT AAGAAAGAAG AACAAATGTC AAAGGCACAA 
CAGTTCACCA GAAGCTTAGA AGAAGGACTA GGCTTTGAGT ACGCGATGTT CTATAATAAG 
GCTGAGAAGA GAATTGTCTG CTTGTTTCAA GGAGGTCTTC ACCTGCAAGG AATGCCTGGA 
TTTGTTCATG GAGGTGCCAT TGCAACCATC ATCGACATCA CTGCCGGCAT GTGTGCATTT 
TCTGAGGGCA TTGTCATGAC TGCCAATCTC AACATCGACT ATAAAAAACC TATCCCCCTT 
CTTTCTGTTG TTGTGGTAAA TAGCCAACTT CAAAAAATTG AAGGAAGGAA ACTTTTTGTT 
TCCTGTACTA TTCAAAGTAC TGATGAGAAG ACTTTACATA CACAGGCAAC AGCCTTATTT 
ATAAAGCTGG ATCCTGACAA ACCTTTGACA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020188.1
CDS	79..771
Translation	MLRSCAMRLRTLGATPARRPEATRRLFSSEEVVCKDYALPNPSWTKDLRLLFDQFMKKCEDGSWKRLPSYRQNPPQALQEFQTHFVDSKFKKEEQMSKAQQFTRSLEEGLGFEYAMFYNKAEKRIVCLFQGGLHLQGMPGFVHGGAIATIIDITAGMCAFSEGIVMTANLNIDYKKPIPLLSVVVVNSQLQKIEGRKLFVSCTIQSTDEKTLHTQATALFIKLDPDKPLT

Target ORF information:

RefSeq Version	NM_001025017.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus thioesterase superfamily member 4 (Them4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025017.1

ORF Insert Sequence:

ATGTTGAGAA GCTGCGCTAT GCGCCTGCGC ACTCTTGGGG CCACGCCTGC AAGGCGGCCT 
GAAGCAACGA GGAGGTTATT TTCTTCTGAG GAAGTCGTCT GTAAGGACTA TGCTCTCCCT 
AACCCCAGCT GGACTAAGGA CCTAAGACTC CTTTTTGACC AGTTCATGAA GAAATGTGAA 
GATGGCTCCT GGAAACGTTT GCCTTCATAC AGACAAAACC CTCCTCAAGC CCTTCAAGAG 
TTCCAAACCC ACTTTGTTGA CTCAAAGTTT AAGAAAGAAG AACAAATGTC AAAGGCACAA 
CAGTTCACCA GAAGCTTAGA AGAAGGACTA GGCTTTGAGT ACGCGATGTT CTATAATAAG 
GCTGAGAAGA GAATTGTCTG CTTGTTTCAA GGAGGTCTTC ACCTGCAAGG AATGCCTGGA 
TTTGTTCATG GAGGTGCCAT TGCAACCATC ATCGACATCA CTGCCGGCAT GTGTGCATTT 
TCTGAGGGCA TTGTCATGAC TGCCAATCTC AACATCGACT ATAAAAAACC TATCCCCCTT 
CTTTCTGTTG TTGTGGTAAA TAGCCAACTT CAAAAAATTG AAGGAAGGAA ACTTTTTGTT 
TCCTGTACTA TTCAAAGTAC TGATGAGAAG ACTTTACATA CACAGGCAAC AGCCTTATTT 
ATAAAGCTGG ATCCTGACAA ACCTTTGACA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Correlation of structure and function in the human hotdog-fold enzyme hTHEM4.
Biochemistry51(33)6490-2(2012 Aug)
Zhao H,Lim K,Choudry A,Latham JA,Pathak MC,Dominguez D,Luo L,Herzberg O,Dunaway-Mariano D

Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein.
BMC cell biology1053(2009 Jul)
Piao L,Li Y,Yang KJ,Park KA,Byun HS,Won M,Hong J,Kim JL,Kweon GR,Hur GM,Seok JH,Cho JY,Chun T,Hess D,Sack R,Maira SM,Brazil DP,Hemmings BA,Park J

The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death.
Nature neuroscience12(5)618-26(2009 May)
Miyawaki T,Ofengeim D,Noh KM,Latuszek-Barrantes A,Hemmings BA,Follenzi A,Zukin RS

Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis.
Cellular signalling21(4)639-50(2009 Apr)
Parcellier A,Tintignac LA,Zhuravleva E,Cron P,Schenk S,Bozulic L,Hemmings BA

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Them4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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