Ubqln2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ubqln2
Entrez Gene ID	317396
Full Name	ubiquilin 2
Synonyms	RGD1563566
General protein information	Preferred Names ubiquilin 2 Names ubiquilin-2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108251.1	NP_001101721.1	ubiquilin-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	UBQLN2	NP_038472.2
Rattus norvegicus (Norway rat)	Ubqln2	NP_001101721.1
Bos taurus (cattle)	UBQLN2	NP_001192611.1
Mus musculus (house mouse)	Ubqln2	NP_061268.2
Caenorhabditis elegans (roundworm)	ubql-1	NP_740883.1
Arabidopsis thaliana (thale cress)	AT2G17190	NP_565407.1
Oryza sativa (rice)	Os10g0542200	NP_001065193.1
	LOC707967	XP_001096401.2
Pan troglodytes (chimpanzee)	UBQLN2	XP_003317539.1
Canis lupus familiaris (dog)	UBQLN2	XP_549029.3
Arabidopsis thaliana (thale cress)	DSK2	NP_179311.1
Oryza sativa (rice)	Os03g0131300	NP_001048862.1

Gene Ontology
Bibliography

Related articles in PubMed

The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles.
Topalidou I, Cattin-Ortol? J, Pappas AL, Cooper K, Merrihew GE, MacCoss MJ, Ailion M
PLoS genetics12(5)e1006074(2016 May)

Pathogenic Ubqln2 gains toxic properties to induce neuron death.
Wu Q, Liu M, Huang C, Liu X, Huang B, Li N, Zhou H, Xia XG
Acta neuropathologica129(3)417-28(2015 Mar)

Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation.
Xia Y, Yan LH, Huang B, Liu M, Liu X, Huang C
Journal of neurochemistry129(1)99-106(2014 Apr)

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.
Deng HX, Chen W, Hong ST, Boycott KM, Gorrie GH, Siddique N, Yang Y, Fecto F, Shi Y, Zhai H, Jiang H, Hirano M, Rampersaud E, Jansen GH, Donkervoort S, Bigio EH, Brooks BR, Ajroud K, Sufit RL, Haines JL, Mugnaini E, Pericak-Vance MA, Siddique T
Nature477(7363)211-5(2011 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our findings in Ubqln2 transgenic and knockout rats collectively suggest that pathogenic Ubqln2 causes neuron death mainly through a gain of unrevealed functions rather than a loss of physiological functions
Title: Pathogenic Ubqln2 gains toxic properties to induce neuron death.

The following Ubqln2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ubqln2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa41429	NM_001108251.1 Latest version!	Rattus norvegicus ubiquilin 2 (Ubqln2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$377.30 $539.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ubqln2 ( NM_001108251.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101721.1 Rattus norvegicus ubiquilin 2 (Ubqln2), mRNA.

Price & Availability↑

CloneID	ORa41429
Clone ID Related Accession (Same CDS sequence)	NM_001108251.1
Accession Version	NM_001108251.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1917bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-17
Organism	Rattus norvegicus(Norway rat)
Product	ubiquilin-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474063.2. On or before Oct 4, 2007 this sequence version replaced XM_228806.4, XM_001061090.1.

ATGGCTGAGA ACGGCGAGAG CAGCGGCCCC CCGCGCCCCT CCCGCGGCCC TGCTGCGGCC 
CCAGGCGCGG CCAACCCGCC AGCCGAGCCC AAAATCATCA AAGTCACTGT GAAGACCCCC 
AAAGAGAAGG AGGAGTTCGC GGTGCCCGAG AACAGCACCG TGCAGCAGTT CAAGGAAGCG 
ATTTCTAAAC GCTTCAAATC GCAAACCGAT CAGCTCGTGC TGATTTTCGC TGGAAAAATC 
CTGAAAGATC AAGACACCTT GATCCAGCAT GGCATCCATG ATGGACTGAC TGTTCACCTG 
GTTATCAAAA GCCAGAACCG TCCGCAGGGC CAGGCCACCA CGCAGCCCAG CACTACTGCG 
GGAACGAGCA CGACGACCAC GACCACCACC ACGGCGGCGG CGCCGCCGGC GGCGACTACA 
TCATCGGCTC CCAGGTGTAG CACCACAGCT ACTACCACAA ATAGCAGCAA CTTGGGGCTC 
GGAAGCCTTG CCAGCCTTGG TAACCTGGGT TTGAACTCGT CCAACTTCAC CGAGCTTCAG 
AACCAGATGC AGCAGCAGCT CTTGGCCAGC CCCGAGATGA TGATCCAGAT CATGGAAAAT 
CCCTTTGTTC AGAGCATGCT TTCGAATCCT GATCTGATGA GGCAGCTCAT CATGGCCAAT 
CCACAGATGC AACAATTGAT CCAGAGAAAC CCAGAAATCA GCCACCTACT GAACAACCCA 
GATATAATGA GGCAGACTCT CGAAATCGCC AGGAATCCTG CCATGATGCA AGAGATGATG 
AGAAATCAAG ACCTGGCTCT CAGTAATCTC GAAAGCATCC CAGGTGGCTA CAATGCTCTG 
CGGCGCATGT ACACTGACAT TCAAGAACCC ATGCTGAATG CCGCACAGGA GCAGTTTGGG 
GGCAATCCGT TTGCCACGGT GGGGAGCAGT TCCTCCTCAG GGGAAGGTAC TCAGCCTTCC 
CGCACGGAGA ATCGGGATCC GCTGCCTAAT CCTTGGGCAC CACCGCCAAC TACCCAGACC 
TCTGCGACGA CCACCACCAC GACCACAAGC AGTGGCACTG TGGCTGGCAG CAACACCAGC 
AGCACTACGG CCGGGAACAC CATGGCTGCA GCTAATTATG TGGCCAGCAT CTTCAGCACC 
CCAGGAATGC AGAGCCTGCT GCAGCAGATA ACTGAAAATC CCCAGCTGAT TCAGAATATG 
CTGTCTGCAC CCTACATGAG AAGCATGATG CAGTCGCTGA GCCAGAATCC AGATATGGCT 
GCCCAGATGA TGCTGAGTAG CCCACTGTTT ACGGCGAATC CTCAGCTGCA GGAGCAGATG 
CGTCCACAGC TCCCGAATTT CCTGCAGCAG ATGCAGAGTC CAGAAACCAT CGCGGCCATG 
TCAAACCCGA GAGCGATGCA AGCGCTACTG CAGATCCAGC AGGGGCTACA GACACTAGCC 
ACTGAAGCAC CTGGCCTCAT TCCAGGCTTC ACTCCAGGTG TGGGGGTGGG AGTGCTGGGA 
ACGGCCATAA CCCCTGTGGG CCCAGTCACT CCCATAGGGC CCATCGGTCC TATCGTTCCT 
TTCACCCCCA TAGGCCCCAT CGGGCCTATA GGACCCACTG GCCCTGCCAG CTCCCCTGGC 
TCGACCGGCA CCGGGATCCC GCCTGCAACC ACTGTGTCCA GCTCTGCACC TACTGAAACC 
ATAAGTCCAA CATCAGAATC TGGACCCAGC CAGCAGTTCA TTCAGCAAAT GGTGCAGGCT 
CTCACTGGAG GAAGTCCTCC ACAGCCGCCG AATCCTGAAG TGAGATTTCA GCAGCAACTG 
GAACAGCTCA ACGCCATGGG GTTCTTAAAC CGCGAAGCAA ACTTGCAGGC CCTAATAGCA 
ACAGGAGGCG ACATCAACGC GGCCATTGAG AGGCTGCTGG GCTCTCAGCC ATCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101721.1
CDS	289..2205
Translation	MAENGESSGPPRPSRGPAAAPGAANPPAEPKIIKVTVKTPKEKEEFAVPENSTVQQFKEAISKRFKSQTDQLVLIFAGKILKDQDTLIQHGIHDGLTVHLVIKSQNRPQGQATTQPSTTAGTSTTTTTTTTAAAPPAATTSSAPRCSTTATTTNSSNLGLGSLASLGNLGLNSSNFTELQNQMQQQLLASPEMMIQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHLLNNPDIMRQTLEIARNPAMMQEMMRNQDLALSNLESIPGGYNALRRMYTDIQEPMLNAAQEQFGGNPFATVGSSSSSGEGTQPSRTENRDPLPNPWAPPPTTQTSATTTTTTTSSGTVAGSNTSSTTAGNTMAAANYVASIFSTPGMQSLLQQITENPQLIQNMLSAPYMRSMMQSLSQNPDMAAQMMLSSPLFTANPQLQEQMRPQLPNFLQQMQSPETIAAMSNPRAMQALLQIQQGLQTLATEAPGLIPGFTPGVGVGVLGTAITPVGPVTPIGPIGPIVPFTPIGPIGPIGPTGPASSPGSTGTGIPPATTVSSSAPTETISPTSESGPSQQFIQQMVQALTGGSPPQPPNPEVRFQQQLEQLNAMGFLNREANLQALIATGGDINAAIERLLGSQPS

Target ORF information:

RefSeq Version	NM_001108251.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ubiquilin 2 (Ubqln2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108251.1

ORF Insert Sequence:

ATGGCTGAGA ACGGCGAGAG CAGCGGCCCC CCGCGCCCCT CCCGCGGCCC TGCTGCGGCC 
CCAGGCGCGG CCAACCCGCC AGCCGAGCCC AAAATCATCA AAGTCACTGT GAAGACCCCC 
AAAGAGAAGG AGGAGTTCGC GGTGCCCGAG AACAGCACCG TGCAGCAGTT CAAGGAAGCG 
ATTTCTAAAC GCTTCAAATC GCAAACCGAT CAGCTCGTGC TGATTTTCGC TGGAAAAATC 
CTGAAAGATC AAGACACCTT GATCCAGCAT GGCATCCATG ATGGACTGAC TGTTCACCTG 
GTTATCAAAA GCCAGAACCG TCCGCAGGGC CAGGCCACCA CGCAGCCCAG CACTACTGCG 
GGAACGAGCA CGACGACCAC GACCACCACC ACGGCGGCGG CGCCGCCGGC GGCGACTACA 
TCATCGGCTC CCAGGTGTAG CACCACAGCT ACTACCACAA ATAGCAGCAA CTTGGGGCTC 
GGAAGCCTTG CCAGCCTTGG TAACCTGGGT TTGAACTCGT CCAACTTCAC CGAGCTTCAG 
AACCAGATGC AGCAGCAGCT CTTGGCCAGC CCCGAGATGA TGATCCAGAT CATGGAAAAT 
CCCTTTGTTC AGAGCATGCT TTCGAATCCT GATCTGATGA GGCAGCTCAT CATGGCCAAT 
CCACAGATGC AACAATTGAT CCAGAGAAAC CCAGAAATCA GCCACCTACT GAACAACCCA 
GATATAATGA GGCAGACTCT CGAAATCGCC AGGAATCCTG CCATGATGCA AGAGATGATG 
AGAAATCAAG ACCTGGCTCT CAGTAATCTC GAAAGCATCC CAGGTGGCTA CAATGCTCTG 
CGGCGCATGT ACACTGACAT TCAAGAACCC ATGCTGAATG CCGCACAGGA GCAGTTTGGG 
GGCAATCCGT TTGCCACGGT GGGGAGCAGT TCCTCCTCAG GGGAAGGTAC TCAGCCTTCC 
CGCACGGAGA ATCGGGATCC GCTGCCTAAT CCTTGGGCAC CACCGCCAAC TACCCAGACC 
TCTGCGACGA CCACCACCAC GACCACAAGC AGTGGCACTG TGGCTGGCAG CAACACCAGC 
AGCACTACGG CCGGGAACAC CATGGCTGCA GCTAATTATG TGGCCAGCAT CTTCAGCACC 
CCAGGAATGC AGAGCCTGCT GCAGCAGATA ACTGAAAATC CCCAGCTGAT TCAGAATATG 
CTGTCTGCAC CCTACATGAG AAGCATGATG CAGTCGCTGA GCCAGAATCC AGATATGGCT 
GCCCAGATGA TGCTGAGTAG CCCACTGTTT ACGGCGAATC CTCAGCTGCA GGAGCAGATG 
CGTCCACAGC TCCCGAATTT CCTGCAGCAG ATGCAGAGTC CAGAAACCAT CGCGGCCATG 
TCAAACCCGA GAGCGATGCA AGCGCTACTG CAGATCCAGC AGGGGCTACA GACACTAGCC 
ACTGAAGCAC CTGGCCTCAT TCCAGGCTTC ACTCCAGGTG TGGGGGTGGG AGTGCTGGGA 
ACGGCCATAA CCCCTGTGGG CCCAGTCACT CCCATAGGGC CCATCGGTCC TATCGTTCCT 
TTCACCCCCA TAGGCCCCAT CGGGCCTATA GGACCCACTG GCCCTGCCAG CTCCCCTGGC 
TCGACCGGCA CCGGGATCCC GCCTGCAACC ACTGTGTCCA GCTCTGCACC TACTGAAACC 
ATAAGTCCAA CATCAGAATC TGGACCCAGC CAGCAGTTCA TTCAGCAAAT GGTGCAGGCT 
CTCACTGGAG GAAGTCCTCC ACAGCCGCCG AATCCTGAAG TGAGATTTCA GCAGCAACTG 
GAACAGCTCA ACGCCATGGG GTTCTTAAAC CGCGAAGCAA ACTTGCAGGC CCTAATAGCA 
ACAGGAGGCG ACATCAACGC GGCCATTGAG AGGCTGCTGG GCTCTCAGCC ATCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles.
PLoS genetics12(5)e1006074(2016 May)
Topalidou I,Cattin-Ortol? J,Pappas AL,Cooper K,Merrihew GE,MacCoss MJ,Ailion M

Pathogenic Ubqln2 gains toxic properties to induce neuron death.
Acta neuropathologica129(3)417-28(2015 Mar)
Wu Q,Liu M,Huang C,Liu X,Huang B,Li N,Zhou H,Xia XG

Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation.
Journal of neurochemistry129(1)99-106(2014 Apr)
Xia Y,Yan LH,Huang B,Liu M,Liu X,Huang C

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.
Nature477(7363)211-5(2011 Aug)
Deng HX,Chen W,Hong ST,Boycott KM,Gorrie GH,Siddique N,Yang Y,Fecto F,Shi Y,Zhai H,Jiang H,Hirano M,Rampersaud E,Jansen GH,Donkervoort S,Bigio EH,Brooks BR,Ajroud K,Sufit RL,Haines JL,Mugnaini E,Pericak-Vance MA,Siddique T

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Ubqln2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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